| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kaisa Lehti, Nina F Rose, Sara Valavaara, Stephen J Weiss, Jorma Keski-Oj. MT1-MMP promotes vascular smooth muscle dedifferentiation through LRP1 processing. Journal of cell science. vol 122. issue Pt 1. 2009-03-16. PMID:19066283. |
herein, we demonstrate that the loss of the vsmc differentiated phenotype, as the repression of contractile-protein expression, is correlated with a dramatic upregulation of the membrane-anchored matrix metalloproteinase mt1-mmp (also known as mmp14 and membrane-type 1 matrix metalloproteinase). |
2009-03-16 |
2023-08-12 |
Not clear |
| Juha Hakulinen, Lotta Sankkila, Nami Sugiyama, Kaisa Lehti, Jorma Keski-Oj. Secretion of active membrane type 1 matrix metalloproteinase (MMP-14) into extracellular space in microvesicular exosomes. Journal of cellular biochemistry. vol 105. issue 5. 2009-02-03. PMID:18802920. |
membrane type 1 matrix metalloproteinase (mt1-mmp, mmp14) is an efficient extracellular matrix (ecm) degrading enzyme that plays important roles in tissue homeostasis and cell invasion. |
2009-02-03 |
2023-08-12 |
human |
| Sahza Hatibović-Kofman, Lin Raimundo, Lei Zheng, Lawrence Chong, Manfred Friedman, Jens Ove Andrease. Fracture resistance and histological findings of immature teeth treated with mineral trioxide aggregate. Dental traumatology : official publication of International Association for Dental Traumatology. vol 24. issue 3. 2008-09-02. PMID:18410392. |
one tooth from each group was selected randomly for a histological study, examining matrix metalloproteinases (mmp2 and mmp14) and tissue inhibitor of metalloproteinase (timp). |
2008-09-02 |
2023-08-12 |
Not clear |
| Paola Piantoni, Massimo Bionaz, Daniel E Graugnard, Kristy M Daniels, R Michael Akers, Juan J Loo. Gene expression ratio stability evaluation in prepubertal bovine mammary tissue from calves fed different milk replacers reveals novel internal controls for quantitative polymerase chain reaction. The Journal of nutrition. vol 138. issue 6. 2008-06-23. PMID:18492850. |
genes evaluated were ubiquitously expressed transcript, protein phosphatase 1 regulatory (inhibitor) subunit 11 (ppp1r11), matrix metallopeptidase 14 (mmp14), clpb caseinolytic peptidase b, saps domain family member 1 (saps1), mitochondrial gtpase 1 (mtg1), mitochondrial ribosomal protein l39, ribosomal protein s15a (rps15a), and actin beta (actb). |
2008-06-23 |
2023-08-12 |
human |
| Dominique Trudel, Yves Fradet, François Meyer, François Harel, Bernard Têt. Membrane-type-1 matrix metalloproteinase, matrix metalloproteinase 2, and tissue inhibitor of matrix proteinase 2 in prostate cancer: identification of patients with poor prognosis by immunohistochemistry. Human pathology. vol 39. issue 5. 2008-06-16. PMID:18329693. |
membrane-type-1 mmp (mmp14) activates mmp2 using pro-mmp2 specific inhibitor, tissue inhibitor of matrix proteinase 2 (timp2), as a receptor. |
2008-06-16 |
2023-08-12 |
Not clear |
| Svetlana Kondratiev, Douglas R Gnepp, Evgeny Yakirevich, Edmond Sabo, Donald J Annino, Elie Rebeiz, Nora V Lave. Expression and prognostic role of MMP2, MMP9, MMP13, and MMP14 matrix metalloproteinases in sinonasal and oral malignant melanomas. Human pathology. vol 39. issue 3. 2008-05-21. PMID:18045645. |
expression and prognostic role of mmp2, mmp9, mmp13, and mmp14 matrix metalloproteinases in sinonasal and oral malignant melanomas. |
2008-05-21 |
2023-08-12 |
Not clear |
| S Uttamsingh, X Bao, K T Nguyen, M Bhanot, J Gong, J L-K Chan, F Liu, T T Chu, L-H Wan. Synergistic effect between EGF and TGF-beta1 in inducing oncogenic properties of intestinal epithelial cells. Oncogene. vol 27. issue 18. 2008-05-19. PMID:17982486. |
egf and tgf-beta1 synergistically induced the expression of a series of proteases including matrix metalloproteinase (mmp) 1 (collagenase), mmp3, mmp9, mmp10, mmp14 and cathepsin. |
2008-05-19 |
2023-08-12 |
human |
| Vikas Misra, Hannah Lee, Anju Singh, Kewu Huang, Rajesh K Thimmulappa, Wayne Mitzner, Shyam Biswal, Clarke G Tankersle. Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes. Physiological genomics. vol 31. issue 3. 2008-01-16. PMID:17726092. |
the matrix metalloproteinase 14 gene (mmp14), critical to alveolar structural integrity, was also downregulated with aging in d2 mice only. |
2008-01-16 |
2023-08-12 |
mouse |
| Ikuo Yana, Hiroshi Sagara, Satoshi Takaki, Kiyoshi Takatsu, Kenji Nakamura, Kazuki Nakao, Motoya Katsuki, Shun-ichiro Taniguchi, Takanori Aoki, Hiroshi Sato, Stephen J Weiss, Motoharu Seik. Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells. Journal of cell science. vol 120. issue Pt 9. 2007-10-02. PMID:17405818. |
the membrane-anchored matrix metalloproteinase mt1-mmp (also known as mmp14) plays a key role in the angiogenic process, but the mechanisms underlying its spatiotemporal regulation in the in vivo setting have not been defined. |
2007-10-02 |
2023-08-12 |
Not clear |
| Massimiliano De Bortoli, Robert C Castellino, Darlene G Skapura, Jianhe J Shen, Jack M Su, Heidi V Russell, M John Hicks, Tsz-Kwong Man, John Y H Ki. Patched haploinsufficient mouse rhabdomyosarcoma overexpress secreted phosphoprotein 1 and matrix metalloproteinases. European journal of cancer (Oxford, England : 1990). vol 43. issue 8. 2007-08-20. PMID:17467979. |
overexpressed genes include secreted phosphoprotein 1 (spp1, osteopontin), and matrix metalloproteinases-2 and -14 (mmp2 and mmp14). |
2007-08-20 |
2023-08-12 |
mouse |
| Svetlana N Popova, Malgorzata Barczyk, Carl-Fredrik Tiger, Wouter Beertsen, Paola Zigrino, Attila Aszodi, Nicolai Miosge, Erik Forsberg, Donald Gullber. Alpha11 beta1 integrin-dependent regulation of periodontal ligament function in the erupting mouse incisor. Molecular and cellular biology. vol 27. issue 12. 2007-07-09. PMID:17420280. |
analysis of matrix metalloproteinase in vitro and in vivo revealed disturbed mmp13 and mmp14 synthesis in alpha11(-/-) cells. |
2007-07-09 |
2023-08-12 |
mouse |
| Yiqin Zhang, Henry J Klassen, Budd A Tucker, Maria-Thereza R Perez, Michael J Youn. CNS progenitor cells promote a permissive environment for neurite outgrowth via a matrix metalloproteinase-2-dependent mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 17. 2007-05-15. PMID:17460063. |
transplantation of retinal progenitor cells induced increased matrix metalloproteinase-2 (mmp2) secretion, partly from activated glial cells, which was then activated by neuronally expressed mmp14. |
2007-05-15 |
2023-08-12 |
mouse |
| Walter Adriani, Damiana Leo, Maria Guarino, Alessia Natoli, Emma Di Consiglio, Giovanna De Angelis, Elsa Traina, Emanuela Testai, Carla Perrone-Capano, Giovanni Laviol. Short-term effects of adolescent methylphenidate exposure on brain striatal gene expression and sexual/endocrine parameters in male rats. Annals of the New York Academy of Sciences. vol 1074. 2007-01-10. PMID:17105903. |
these genes include matrix proteases (adam-1, mmp14), their inhibitors (timp-2, timp-3), the hyaluronan-mediated motility receptor (rhamm), and growth factors (transforming growth factor-beta3 [tgf-beta3] and fibroblast growth factor 14 [fgf14]). |
2007-01-10 |
2023-08-12 |
rat |
| Wen G Jiang, Gaynor Davies, Tracey A Martin, Christian Parr, Gareth Watkins, Malcolm D Mason, Robert E Manse. Expression of membrane type-1 matrix metalloproteinase, MT1-MMP in human breast cancer and its impact on invasiveness of breast cancer cells. International journal of molecular medicine. vol 17. issue 4. 2006-08-07. PMID:16525713. |
mt1-mmp (membrane type-1 matrix metalloproteinase), otherwise known as mmp14 is a proteolytic enzyme known to be involved in degradating extracellular matrix and assist progression of cancer invasion and progression. |
2006-08-07 |
2023-08-12 |
human |
| Sandra Bloethner, Bowang Chen, Kari Hemminki, Jan Müller-Berghaus, Selma Ugurel, Dirk Schadendorf, Rajiv Kuma. Effect of common B-RAF and N-RAS mutations on global gene expression in melanoma cell lines. Carcinogenesis. vol 26. issue 7. 2005-07-29. PMID:15760917. |
upregulated genes in cell lines with mutations included dual-specificity phosphatase 6 (dusp6), sprouty 2 (spry2), v-akt murine thymoma viral oncogene homolog 3 (akt3) and matrix metalloproteinase 14 (mmp14); downregulated genes included interleukin 18 (il18), krüppel-like factor 5 (klf5) and inhibitor of dna binding 2 (id2). |
2005-07-29 |
2023-08-12 |
human |
| Cristina Martinez, Sumit Bhattacharya, Tom Freeman, Michael Churchman, Mohammad Ilya. Expression profiling of murine intestinal adenomas reveals early deregulation of multiple matrix metalloproteinase (Mmp) genes. The Journal of pathology. vol 206. issue 1. 2005-05-17. PMID:15809971. |
notably, three members of the matrix metalloproteinase (mmp) gene family (mmp10, mmp13, and mmp14) were consistently up-regulated in tumour tissue. |
2005-05-17 |
2023-08-12 |
mouse |
| Huei-Wen Chen, Sung-Liang Yu, Jeremy J W Chen, Han-Ni Li, Yi-Chen Lin, Pei-Li Yao, Han-Yi Chou, Chiang-Ting Chien, Wen-Jone Chen, Yuan-Teh Lee, Pan-Chyr Yan. Anti-invasive gene expression profile of curcumin in lung adenocarcinoma based on a high throughput microarray analysis. Molecular pharmacology. vol 65. issue 1. 2004-02-18. PMID:14722241. |
below sublethal concentrations of curcumin (10 microm), several invasion-related genes were suppressed, including matrix metalloproteinase 14 (mmp14; 0.65-fold), neuronal cell adhesion molecule (0.54-fold), and integrins alpha6 (0.67-fold) and beta4 (0.63-fold). |
2004-02-18 |
2023-08-12 |
Not clear |
| Ichiro Sekiya, Jussi T Vuoristo, Benjamin L Larson, Darwin J Procko. In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 7. 2002-04-25. PMID:11917104. |
sox4, vascular endothelial growth factor (vegf), and matrix metalloproteinase 14 (mmp14) increased at day 1 and decreased thereafter, suggesting roles early in chondrogenesis. |
2002-04-25 |
2023-08-12 |
human |
| W R English, B Holtz, G Vogt, V Knäuper, G Murph. Characterization of the role of the "MT-loop": an eight-amino acid insertion specific to progelatinase A (MMP2) activating membrane-type matrix metalloproteinases. The Journal of biological chemistry. vol 276. issue 45. 2001-12-05. PMID:11555661. |
progelatinase a (progla) activation is thought to be initiated almost exclusively by the type i transmembrane members of the membrane type matrix metalloproteinase family (mt-mmp): mt1, -2, -3, and -5-mmp (mmp14, -15, -16, and -24). |
2001-12-05 |
2023-08-12 |
Not clear |
| G E Terp, I T Christensen, F S Jørgense. Structural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexes. Journal of biomolecular structure & dynamics. vol 17. issue 6. 2000-12-28. PMID:10949161. |
a general approach to the homology modeling of matrix metalloproteinases, exemplified by the modeling of mmp2, mmp9, mmp12 and mmp14 is described. |
2000-12-28 |
2023-08-12 |
Not clear |