| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jordi Gonzalez-Molina, Silvia Gramolelli, Zehuan Liao, Joseph W Carlson, Päivi M Ojala, Kaisa Leht. MMP14 in Sarcoma: A Regulator of Tumor Microenvironment Communication in Connective Tissues. Cells. vol 8. issue 9. 2020-05-18. PMID:31466240. |
the expression and function of the membrane-type matrix metalloproteinase mmp14 is closely related to the mesenchymal cell phenotype, and it is highly expressed in most sarcomas. |
2020-05-18 |
2023-08-13 |
Not clear |
| Jordi Gonzalez-Molina, Silvia Gramolelli, Zehuan Liao, Joseph W Carlson, Päivi M Ojala, Kaisa Leht. MMP14 in Sarcoma: A Regulator of Tumor Microenvironment Communication in Connective Tissues. Cells. vol 8. issue 9. 2020-05-18. PMID:31466240. |
mmp14 regulates the activity of multiple extracellular and plasma membrane proteins, influencing cell-cell and cell-extracellular matrix (ecm) communication. |
2020-05-18 |
2023-08-13 |
Not clear |
| Haoyong Li, Qi Li, Zhe Ma, Zhiyan Zhou, Jinfeng Fan, Yingxia Jin, Yaoxi Wu, Fan Cheng, Peiyu Lian. AID modulates carcinogenesis network via DNA demethylation in bladder urothelial cell carcinoma. Cell death & disease. vol 10. issue 4. 2020-05-15. PMID:30874539. |
after a pipeline of bioinformatics analyses, we identified three tumour-associated factors, namely, matrix metallopeptidase 14 (mmp14), c-x-c motif chemokine ligand 12 and wntless wnt ligand secretion mediator, which were further confirmed in human bucc tissues. |
2020-05-15 |
2023-08-13 |
human |
| Pilar Puerto-Camacho, Ana Teresa Amaral, Salah-Eddine Lamhamedi-Cherradi, Brian A Menegaz, Helena Castillo-Ecija, José Luis Ordóñez, Saioa Domínguez, Carmen Jordan-Perez, Juan Diaz-Martin, Laura Romero-Pérez, Maria Lopez-Alvarez, Gema Civantos-Jubera, María José Robles-Frías, Michele Biscuola, Cristina Ferrer, Jaume Mora, Branko Cuglievan, Keri Schadler, Oliver Seifert, Roland Kontermann, Klaus Pfizenmaier, Laureano Simón, Myriam Fabre, Ángel M Carcaboso, Joseph A Ludwig, Enrique de Álav. Preclinical Efficacy of Endoglin-Targeting Antibody-Drug Conjugates for the Treatment of Ewing Sarcoma. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 25. issue 7. 2020-05-11. PMID:30420447. |
it exists both as a transmembrane cell surface protein, where it primarily interacts with tgfβ, and as a soluble matricellular protein (seng) when cleaved by matrix metalloproteinase 14 (mmp14). |
2020-05-11 |
2023-08-13 |
Not clear |
| Hyun-Ouk Kim, Jong-Woo Lim, Jihye Choi, Hwunjae Lee, Hye Young Son, Jihye Kim, Geunseon Park, Haejin Chun, Daesub Song, Yong-Min Huh, Seungjoo Haa. Anchored protease-activatable polymersomes for molecular diagnostics of metastatic cancer cells. Journal of materials chemistry. B. vol 5. issue 48. 2020-04-08. PMID:32264571. |
we designed unique protease-activatable polymersomes (peptisomes) for high sensitivity, in situ quantitative analysis of activating membrane-type 1 matrix metalloproteinases (mt1-mmp, mmp14). |
2020-04-08 |
2023-08-13 |
Not clear |
| Roxana Solga, Juliane Behrens, Anja Ziemann, Adrien Riou, Carolin Berwanger, Lore Becker, Lillian Garrett, Martin Hrabe de Angelis, Lisa Fischer, Roland Coras, Katalin Barkovits, Katrin Marcus, Esther Mahabir, Ludwig Eichinger, Rolf Schröder, Angelika A Noegel, Christoph S Cleme. CRN2 binds to TIMP4 and MMP14 and promotes perivascular invasion of glioblastoma cells. European journal of cell biology. vol 98. issue 5-8. 2020-04-01. PMID:31677819. |
we identified two important factors of the tumour microenvironment, the tissue inhibitor of matrix metalloproteinase 4 (timp4) and the matrix metalloproteinase 14 (mmp14, synonym: mt1-mmp), as novel binding partners of crn2. |
2020-04-01 |
2023-08-13 |
mouse |
| Qing Zhang, Lei Lou, Xiaoli Cai, Zengfang Hao, Saisai Nie, Ying Liu, Lingrui Su, Wenxin Wu, Haitao Shen, Yuehong L. Clinical significance of AJUBA, YAP1, and MMP14 expression in esophageal squamous cell carcinoma. International journal of clinical and experimental pathology. vol 11. issue 12. 2020-03-25. PMID:31949690. |
in this study, we explored the role of ajuba, yes-associated protein 1 (yap1), and matrix metalloproteinase 14 (mmp14) in the clinical presentation and survival of escc. |
2020-03-25 |
2023-08-13 |
Not clear |
| Damien Planchon, Eduardo Rios Morris, Mallory Genest, Franck Comunale, Sophie Vacher, Ivan Bièche, Evgeny V Denisov, Lubov A Tashireva, Vladimir M Perelmuter, Stefan Linder, Philippe Chavrier, Stéphane Bodin, Cécile Gauthier-Rouvièr. MT1-MMP targeting to endolysosomes is mediated by upregulation of flotillins. Journal of cell science. vol 131. issue 17. 2019-12-03. PMID:30111578. |
these processes rely on extracellular matrix (ecm) degradation mediated by organelles termed invadopodia, to which the transmembrane matrix metalloproteinase mt1-mmp (also known as mmp14) is delivered from its reservoir, the rab7-containing endolysosomes. |
2019-12-03 |
2023-08-13 |
Not clear |
| Tácia Tavares Aquinas Liguori, Gabriel Romero Liguori, Luiz Felipe Pinho Moreira, Martin Conrad Harmse. Fibroblast growth factor-2, but not the adipose tissue-derived stromal cells secretome, inhibits TGF-β1-induced differentiation of human cardiac fibroblasts into myofibroblasts. Scientific reports. vol 8. issue 1. 2019-11-25. PMID:30413733. |
the treatment with fgf-2 increased matrix metalloproteinases gene expression (mmp1, p < 0.0001; mmp14, p = 0.0027) and decreased the expression of tissue inhibitor of metalloproteinase gene timp2 (p = 0.0023). |
2019-11-25 |
2023-08-13 |
human |
| Despina Bazou, Mei Rosa Ng, Jonathan W Song, Shan Min Chin, Nir Maimon, Lance L Mun. Flow-induced HDAC1 phosphorylation and nuclear export in angiogenic sprouting. Scientific reports. vol 6. 2019-11-20. PMID:27669993. |
furthermore, we show that hdac1 inhibition decreases endothelial morphogenesis and matrix metalloproteinase-14 (mmp14) expression. |
2019-11-20 |
2023-08-13 |
Not clear |
| Valeria Arkadash, Evette S Radisky, Niv Pap. Combinatorial engineering of N-TIMP2 variants that selectively inhibit MMP9 and MMP14 function in the cell. Oncotarget. vol 9. issue 62. 2019-11-20. PMID:30174795. |
here, we used a combination of yeast surface display and dual-color selective library screening to obtain selective inhibitors for each of the matrix metalloproteinases (mmps) mmp14 and mmp9 by modifying the non-specific n-terminal domain of the tissue inhibitor of metalloproteinase-2 (n-timp2). |
2019-11-20 |
2023-08-13 |
Not clear |
| Kyu-Yeon Han, Jin-Hong Chang, Dimitri T Aza. MMP14-Containing Exosomes Cleave VEGFR1 and Promote VEGFA-Induced Migration and Proliferation of Vascular Endothelial Cells. Investigative ophthalmology & visual science. vol 60. issue 6. 2019-10-14. PMID:31117124. |
investigate the impact matrix metalloproteinase 14 (mmp14) delivered via exosomes produced by corneal fibroblasts on vascular endothelial growth factor receptor 1 (vegfr1) cleavage on endothelial cells, and other key processes of angiogenesis. |
2019-10-14 |
2023-08-13 |
Not clear |
| Alexander Braun, Matthew J Farber, Zachary A Klase, Peter B Berget, Kenneth A Myer. A cell surface display fluorescent biosensor for measuring MMP14 activity in real-time. Scientific reports. vol 8. issue 1. 2019-10-02. PMID:29651043. |
here, we describe the development of a plasmid-based fluorescent biosensor engineered to measure the location and activity of matrix metalloprotease-14 (mmp14). |
2019-10-02 |
2023-08-13 |
Not clear |
| Marte Sneeggen, Nina Marie Pedersen, Coen Campsteijn, Ellen Margrethe Haugsten, Harald Stenmark, Kay Oliver Schin. WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling. Nature communications. vol 10. issue 1. 2019-08-19. PMID:31253801. |
the membrane-bound matrix metalloproteinase mt1-mmp (mmp14) is internalized by endocytosis and recycled in endosomal compartments. |
2019-08-19 |
2023-08-13 |
Not clear |
| Pirita Pekkonen, Sanni Alve, Giuseppe Balistreri, Silvia Gramolelli, Olga Tatti-Bugaeva, Ilkka Paatero, Otso Niiranen, Krista Tuohinto, Nina Perälä, Adewale Taiwo, Nadezhda Zinovkina, Pauliina Repo, Katherine Icay, Johanna Ivaska, Pipsa Saharinen, Sampsa Hautaniemi, Kaisa Lehti, Päivi M Ojal. Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation. eLife. vol 7. 2019-07-05. PMID:29712618. |
notably, the expansively growing metastatic melanoma cells adopted an invasively sprouting phenotype in 3d matrix that was dependent on mmp14, notch3 and β1-integrin. |
2019-07-05 |
2023-08-13 |
mouse |
| Ivo J H M de Vos, Evelyn Yaqiong Tao, Sheena Li Ming Ong, Julian L Goggi, Thomas Scerri, Gabrielle R Wilson, Chernis Guai Mun Low, Arnette Shi Wei Wong, Dominic Grussu, Alexander P A Stegmann, Michel van Geel, Renske Janssen, David J Amor, Melanie Bahlo, Norris R Dunn, Thomas J Carney, Paul J Lockhart, Barry J Coull, Maurice A M van Steense. Functional analysis of a hypomorphic allele shows that MMP14 catalytic activity is the prime determinant of the Winchester syndrome phenotype. Human molecular genetics. vol 27. issue 16. 2019-03-08. PMID:29741626. |
to date, only one missense mutation in mmp14, encoding the membrane-bound matrix metalloprotease 14, has been reported in ws patients. |
2019-03-08 |
2023-08-13 |
human |
| Nadine Knutti, Otmar Huber, Karlheinz Friedric. CD147 (EMMPRIN) controls malignant properties of breast cancer cells by interdependent signaling of Wnt and JAK/STAT pathways. Molecular and cellular biochemistry. vol 451. issue 1-2. 2019-03-08. PMID:30022447. |
increased invasiveness coincided with elevated expression of wnt-target genes and established invasion driver matrix metalloproteinase mmp14. |
2019-03-08 |
2023-08-13 |
Not clear |
| Jesus Delgado-Calle, Benjamin Hancock, Elive F Likine, Amy Y Sato, Kevin McAndrews, Carolina Sanudo, Angela Bruzzaniti, Jose A Riancho, James R Tonra, Teresita Bellid. MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 32. issue 5. 2018-12-31. PMID:29401593. |
we report that matrix metalloproteinase 14 (mmp14) expression/activity are increased in bones from mice with genetic constitutive activation (ca) of the pth receptor 1 (pth1r) in ots (capth1r |
2018-12-31 |
2023-08-13 |
mouse |
| Yanan Duan, Yinghui Dong, Rongguang Dang, Zhihui Hu, Ye Yang, Yueyun Hu, Jianxin Chen. MiR-122 inhibits epithelial mesenchymal transition by regulating P4HA1 in ovarian cancer cells. Cell biology international. vol 42. issue 11. 2018-12-17. PMID:30136751. |
mir-122 also suppressed epithelial mesenchymal transition (emt), evidenced by expression changes of e-cadherin, vimentin, matrix metalloproteinase (mmp)2, and mmp14. |
2018-12-17 |
2023-08-13 |
mouse |
| Nasreen Akhta. Hijacking a Morphogenesis Proteinase for Cancer Cell Invasion. Developmental cell. vol 47. issue 2. 2018-12-14. PMID:30352172. |
(2018) identify the matrix metalloproteinase mmp14 as a key driver of mammary invasion common to both development and cancer but expose an underlying twist. |
2018-12-14 |
2023-08-13 |
Not clear |