| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Guang Yang, Yan-Yu Li, Dong-Xue Zhao, Wei Cui, Han Li, Xin-Yu Li, Yu-Xin Li, Dun Wan. Repurposing of a monoamine oxidase A inhibitor‑heptamethine carbocyanine dye conjugate for paclitaxel‑resistant non‑small cell lung cancer. Oncology reports. vol 45. issue 3. 2021-10-22. PMID:33650669. |
gene expression profiling of paclitaxel‑resistant nsclc cells following treatment with g10 demonstrated that the expression of genes associated with the extracellular matrix was significantly affected, particularly the metastasis‑related genes matrix metallopeptidase (mmp)2, mmp14 and col6a, which exhibited notably reduced expression. |
2021-10-22 |
2023-08-13 |
mouse |
| Aiman Ali, Andresa Borges Soares, Denise Eymael, Marco Magalhae. Expression of invadopodia markers can identify oral lesions with a high risk of malignant transformation. The journal of pathology. Clinical research. vol 7. issue 1. 2021-10-13. PMID:33001588. |
all samples were stained for cortactin, tyrosine kinase substrate with five sh3 domains (tks5) and matrix metallopeptidase 14 (mmp14) using fihc, imaged using confocal microscopy and analyzed using a multichannel colocalization analysis. |
2021-10-13 |
2023-08-13 |
Not clear |
| Tereza Andreou, Jennifer Williams, Rebecca J Brownlie, Robert J Salmond, Erica Watson, Gary Shaw, Alan Melcher, Heiko Wurdak, Susan C Short, Mihaela Lorge. Hematopoietic stem cell gene therapy targeting TGFβ enhances the efficacy of irradiation therapy in a preclinical glioblastoma model. Journal for immunotherapy of cancer. vol 9. issue 3. 2021-10-06. PMID:33707311. |
because myeloid cells are ubiquitously present in the body, we recently established a lentiviral vector containing matrix metalloproteinase 14 (mmp14) promoter, which is active specifically in tumor-infiltrating myeloid cells as opposed to myeloid cells in other tissues, and resulted in a specific delivery of transgenes to brain metastases in hsc gene therapy. |
2021-10-06 |
2023-08-13 |
mouse |
| Minde Li, Shaoyang Li, Lin Zhou, Le Yang, Xiao Wu, Bin Tang, Shenhao Xie, Linchun Fang, Suyue Zheng, Tao Hon. Immune Infiltration of MMP14 in Pan Cancer and Its Prognostic Effect on Tumors. Frontiers in oncology. vol 11. 2021-10-05. PMID:34604053. |
matrix metalloproteinase 14 (mmp14) is a member of the mmp family, which interacts with tissue inhibitors of metalloproteinase (timps), and is involved in normal physiological functions such as cell migration, invasion, metastasis, angiogenesis, and proliferation, as well as tumor genesis and progression. |
2021-10-05 |
2023-08-13 |
Not clear |
| Vinay J, Debakanta Mishra, Dinesh Meher, Sashibhusan Dash, Kusumbati Besra, Niharika Pattnaik, Shivaram Prasad Singh, Manjusha Dixi. Genetic association of MMP14 promoter variants and their functional significance in gallbladder cancer pathogenesis. Journal of human genetics. vol 66. issue 10. 2021-09-27. PMID:33727629. |
although matrix metalloproteinase-14 (mmp14) is known modulator of tumour microenvironment and tumorigenesis and tcga data also suggests its upregulation yet, its role in genetic predisposition for gbc is completely unknown. |
2021-09-27 |
2023-08-13 |
human |
| Markus Mukenhirn, Francesco Muraca, Delia Bucher, Edgar Asberger, Elisa Cappio Barazzone, Elisabetta Ada Cavalcanti-Adam, Steeve Boulan. Role of Clathrin Light Chains in Regulating Invadopodia Formation. Cells. vol 10. issue 2. 2021-08-26. PMID:33672612. |
we demonstrate that clca/b deletion impacts the intracellular trafficking and recovery of the matrix metalloproteinase 14 (mmp14) leading to its accumulation at the plasma membrane and induction of invadopodia formation. |
2021-08-26 |
2023-08-13 |
Not clear |
| Xikai Wang, Qinghe Meng, Yuanyuan Wang, Yanlu Ga. Overexpression of MMP14 predicts the poor prognosis in gastric cancer: Meta-analysis and database validation. Medicine. vol 100. issue 32. 2021-08-23. PMID:34397871. |
plenty of studies have showed matrix metalloproteinase 14 (mmp14) expression might be associated with the prognosis of gastric cancer (gc). |
2021-08-23 |
2023-08-13 |
Not clear |
| Guidong Shi, Yicun Wang, Zhanwen Wang, Andrew R Thoreson, Daniel S Jacobson, Peter C Amadio, Atta Behfar, Steven L Moran, Chunfeng Zha. A novel engineered purified exosome product patch for tendon healing: An explant in an ex vivo model. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 39. issue 8. 2021-08-09. PMID:32936480. |
quantitative reverse transcription polymerase chain reaction showed that tepep patch increased the expression of collagen type iii, matrix metallopeptidase 2 (mmp2), mmp3, mmp14, and reduced the expression of transforming growth factor β1, interleukin 6. |
2021-08-09 |
2023-08-13 |
Not clear |
| Ellen M Adams, Simone Pezzotti, Jonas Ahlers, Maximilian Rüttermann, Maxim Levin, Adi Goldenzweig, Yoav Peleg, Sarel J Fleishman, Irit Sagi, Martina Havenit. Local Mutations Can Serve as a Game Changer for Global Protein Solvent Interaction. JACS Au. vol 1. issue 7. 2021-08-03. PMID:34337607. |
here we show by a combined computational design, experimental, and molecular dynamics (md) study that local mutations have not only a local but also a global effect on the solvent: in the specific case of the matrix metalloprotease mmp14, we found that the nature of local mutations, coupled with surface morphology, have the ability to influence large patches of the water hydrogen-bonding network at the protein surface, which is correlated with stability. |
2021-08-03 |
2023-08-13 |
Not clear |
| Christopher D Kegelman, Jennifer C Coulombe, Kelsey M Jordan, Daniel J Horan, Ling Qin, Alexander G Robling, Virginia L Ferguson, Teresita M Bellido, Joel D Boercke. YAP and TAZ Mediate Osteocyte Perilacunar/Canalicular Remodeling. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 35. issue 1. 2021-07-28. PMID:31610061. |
consistent with recent studies identifying tgf-β as a key inducer of osteocyte expression of matrix-remodeling enzymes, yap/taz deletion in vivo decreased osteocyte expression of matrix proteases mmp13, mmp14, and ctsk. |
2021-07-28 |
2023-08-13 |
mouse |
| Lingxin Zhu, Yi Tang, Xiao-Yan Li, Evan T Keller, Jingwen Yang, Jung-Sun Cho, Tamar Y Feinberg, Stephen J Weis. Osteoclast-mediated bone resorption is controlled by a compensatory network of secreted and membrane-tethered metalloproteinases. Science translational medicine. vol 12. issue 529. 2021-06-23. PMID:32024800. |
here, we identify a cathepsin k-independent collagenolytic system in osteoclasts that is composed of a functionally redundant network of the secreted matrix metalloproteinase mmp9 and the membrane-anchored matrix metalloproteinase mmp14. |
2021-06-23 |
2023-08-13 |
mouse |
| Pinfang Kang, Jiahui Wang, Dian Fang, Tingting Fang, Ying Yu, Weiping Zhang, Lin Shen, Zhenghong Li, Hongju Wang, Hongwei Ye, Qin Ga. Activation of ALDH2 attenuates high glucose induced rat cardiomyocyte fibrosis and necroptosis. Free radical biology & medicine. vol 146. 2021-06-18. PMID:31689484. |
in contrast to normal glucose group, in hg group, with the decreases of aldh2 activity, mrna and protein levels, the cardiomyocytes viability was decreased, reactive oxygen species (ros), the inflammation factors - tumor necrosis factor-α (tnf-α), interleukin-6 (il-6), interleukin-1β (il-1β) levels, collagen i (col i) and col iii mrna expressions and tissue inhibitors of matrix metalloproteinase 4 (timp4) protein expression were increased, while matrix metalloproteinase 14 (mmp14) protein level, the ratio of mmp14/timp4 were decreased, and the necroptosis key factors - the receptor interacting protein 1 (rip1), rip3 and mixed lineage kinase domain-like protein (mlkl) at mrna and protein expressions were increased, the inflammasome core proteins - nlrp3 and asc protein expressions were also increased, the apoptosis rate and necrosis rate were also increased. |
2021-06-18 |
2023-08-13 |
rat |
| Olivia R Grafinger, Genya Gorshtein, Tyler Stirling, Megan I Brasher, Marc G Coppolin. β1 integrin-mediated signaling regulates MT1-MMP phosphorylation to promote tumor cell invasion. Journal of cell science. vol 133. issue 9. 2021-06-18. PMID:32205364. |
ecm degradation at invadopodia is mediated by matrix metalloproteinases (mmps), and recent findings indicate that membrane-anchored membrane type 1-matrix metalloproteinase (mt1-mmp, also known as mmp14) has a primary role in this process. |
2021-06-18 |
2023-08-13 |
Not clear |
| Marilyn Janice Oentaryo, Anna Chung-Kwan Tse, Chi Wai Le. Neuronal MT1-MMP mediates ECM clearance and Lrp4 cleavage for agrin deposition and signaling in presynaptic development. Journal of cell science. vol 133. issue 15. 2021-06-18. PMID:32591486. |
here, we report that the proteolytic activity of neuronal membrane-type 1 matrix metalloproteinase (mt1-mmp; also known as mmp14) facilitates agrin deposition and signaling during presynaptic development at nmjs. |
2021-06-18 |
2023-08-13 |
Not clear |
| Luis Placido, Yair Romero, Mariel Maldonado, Fernanda Toscano-Marquez, Remedios Ramírez, Jazmín Calyeca, Ana L Mora, Moisés Selman, Annie Pard. Loss of MT1-MMP in Alveolar Epithelial Cells Exacerbates Pulmonary Fibrosis. International journal of molecular sciences. vol 22. issue 6. 2021-04-23. PMID:33805743. |
previous studies indicate that matrix metalloproteinase 14 (mmp14) is increased in the lung epithelium in patients with ipf, however, the role of this membrane-type matrix metalloproteinase has not been elucidated. |
2021-04-23 |
2023-08-13 |
mouse |
| J-F Wang, Y-Q Gong, Y-H He, W-W Ying, X-S Li, X-F Zhou, L-Q Zho. High expression of MMP14 is associated with progression and poor short-term prognosis in muscle-invasive bladder cancer. European review for medical and pharmacological sciences. vol 24. issue 12. 2021-04-14. PMID:32633349. |
to evaluate the short-term prognostic value of matrix metalloproteinase 14 (mmp14) in muscle-invasive bladder cancer (mibc). |
2021-04-14 |
2023-08-13 |
Not clear |
| Petra Sántha, Daniela Lenggenhager, Anette Finstadsveen, Linda Dorg, Kristin Tøndel, Manoj Amrutkar, Ivar P Gladhaug, Caroline Verbek. Morphological Heterogeneity in Pancreatic Cancer Reflects Structural and Functional Divergence. Cancers. vol 13. issue 4. 2021-03-10. PMID:33672734. |
twenty-six features involved in key biological processes in pc were analyzed (immuno-)histochemically and morphometrically: cancer cell proliferation (ki67) and migration (collagen fiber alignment, mmp14), cancer stem cells (cd44, cd133, aldh1), amount, composition and spatial arrangement of extracellular matrix (epithelial proximity, total collagen, collagen i and iii, fibronectin, hyaluronan), cancer-associated fibroblasts (density, αsma), and cancer-stroma interactions (integrins α2, α5, α1; caveolin-1). |
2021-03-10 |
2023-08-13 |
human |
| Yuhai Zhang, Yuling Hong, Dan Wang, Linshan Duan, Yanling Liu, Long Li, Di Liu, Kunbin Zhuang, Chaoxin Wei, Guogeng Zheng, Chunyong Huo, Guoyan Li. Hsa_circ_0076305 induces migration-proliferation dichotomy in gastric cancer. Oncology letters. vol 21. issue 3. 2021-02-23. PMID:33613709. |
in addition, circpgc degrades the extracellular matrix and basement membrane through matrix metallopeptidase (mmp)9 and mmp14, providing a microenvironment that facilitates cell migration. |
2021-02-23 |
2023-08-13 |
Not clear |
| Takumi Yamane, Ryosuke Konno, Ken Iwatsuki, Yuichi Oish. Negative effects of a low-quality protein diet on wound healing via modulation of the MMP2 activity in rats. Amino acids. vol 52. issue 4. 2021-01-11. PMID:32130517. |
our results also showed that both matrix metalloproteinase (mmp) 2 activity and mmp14 mrna levels were significantly increased in the skin of the gluten group, compared with the casein group. |
2021-01-11 |
2023-08-13 |
rat |
| Minchae Kim, Sora Lee, Chang Seok K. Cellular Behavior of RAW264.7 Cells in 3D Poly(ethylene glycol) Hydrogel Niches. ACS biomaterials science & engineering. vol 5. issue 2. 2021-01-06. PMID:33405849. |
interestingly, we observed the significant upregulation of matrix metalloproteinases (mmps) (i.e., mmp9 and mmp14) as well as m1 polarization markers (i.e., inos, cox2, tnf-α) in 3d, whereas m2 polarization markers (i.e., cd206, arg1, tgf-β) were downregulated. |
2021-01-06 |
2023-08-13 |
Not clear |