| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ellen M Adams, Simone Pezzotti, Jonas Ahlers, Maximilian Rüttermann, Maxim Levin, Adi Goldenzweig, Yoav Peleg, Sarel J Fleishman, Irit Sagi, Martina Havenit. Local Mutations Can Serve as a Game Changer for Global Protein Solvent Interaction. JACS Au. vol 1. issue 7. 2021-08-03. PMID:34337607. |
here we show by a combined computational design, experimental, and molecular dynamics (md) study that local mutations have not only a local but also a global effect on the solvent: in the specific case of the matrix metalloprotease mmp14, we found that the nature of local mutations, coupled with surface morphology, have the ability to influence large patches of the water hydrogen-bonding network at the protein surface, which is correlated with stability. |
2021-08-03 |
2023-08-13 |
Not clear |
| Christopher D Kegelman, Jennifer C Coulombe, Kelsey M Jordan, Daniel J Horan, Ling Qin, Alexander G Robling, Virginia L Ferguson, Teresita M Bellido, Joel D Boercke. YAP and TAZ Mediate Osteocyte Perilacunar/Canalicular Remodeling. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 35. issue 1. 2021-07-28. PMID:31610061. |
consistent with recent studies identifying tgf-β as a key inducer of osteocyte expression of matrix-remodeling enzymes, yap/taz deletion in vivo decreased osteocyte expression of matrix proteases mmp13, mmp14, and ctsk. |
2021-07-28 |
2023-08-13 |
mouse |
| Lingxin Zhu, Yi Tang, Xiao-Yan Li, Evan T Keller, Jingwen Yang, Jung-Sun Cho, Tamar Y Feinberg, Stephen J Weis. Osteoclast-mediated bone resorption is controlled by a compensatory network of secreted and membrane-tethered metalloproteinases. Science translational medicine. vol 12. issue 529. 2021-06-23. PMID:32024800. |
here, we identify a cathepsin k-independent collagenolytic system in osteoclasts that is composed of a functionally redundant network of the secreted matrix metalloproteinase mmp9 and the membrane-anchored matrix metalloproteinase mmp14. |
2021-06-23 |
2023-08-13 |
mouse |
| Pinfang Kang, Jiahui Wang, Dian Fang, Tingting Fang, Ying Yu, Weiping Zhang, Lin Shen, Zhenghong Li, Hongju Wang, Hongwei Ye, Qin Ga. Activation of ALDH2 attenuates high glucose induced rat cardiomyocyte fibrosis and necroptosis. Free radical biology & medicine. vol 146. 2021-06-18. PMID:31689484. |
in contrast to normal glucose group, in hg group, with the decreases of aldh2 activity, mrna and protein levels, the cardiomyocytes viability was decreased, reactive oxygen species (ros), the inflammation factors - tumor necrosis factor-α (tnf-α), interleukin-6 (il-6), interleukin-1β (il-1β) levels, collagen i (col i) and col iii mrna expressions and tissue inhibitors of matrix metalloproteinase 4 (timp4) protein expression were increased, while matrix metalloproteinase 14 (mmp14) protein level, the ratio of mmp14/timp4 were decreased, and the necroptosis key factors - the receptor interacting protein 1 (rip1), rip3 and mixed lineage kinase domain-like protein (mlkl) at mrna and protein expressions were increased, the inflammasome core proteins - nlrp3 and asc protein expressions were also increased, the apoptosis rate and necrosis rate were also increased. |
2021-06-18 |
2023-08-13 |
rat |
| Olivia R Grafinger, Genya Gorshtein, Tyler Stirling, Megan I Brasher, Marc G Coppolin. β1 integrin-mediated signaling regulates MT1-MMP phosphorylation to promote tumor cell invasion. Journal of cell science. vol 133. issue 9. 2021-06-18. PMID:32205364. |
ecm degradation at invadopodia is mediated by matrix metalloproteinases (mmps), and recent findings indicate that membrane-anchored membrane type 1-matrix metalloproteinase (mt1-mmp, also known as mmp14) has a primary role in this process. |
2021-06-18 |
2023-08-13 |
Not clear |
| Marilyn Janice Oentaryo, Anna Chung-Kwan Tse, Chi Wai Le. Neuronal MT1-MMP mediates ECM clearance and Lrp4 cleavage for agrin deposition and signaling in presynaptic development. Journal of cell science. vol 133. issue 15. 2021-06-18. PMID:32591486. |
here, we report that the proteolytic activity of neuronal membrane-type 1 matrix metalloproteinase (mt1-mmp; also known as mmp14) facilitates agrin deposition and signaling during presynaptic development at nmjs. |
2021-06-18 |
2023-08-13 |
Not clear |
| Luis Placido, Yair Romero, Mariel Maldonado, Fernanda Toscano-Marquez, Remedios Ramírez, Jazmín Calyeca, Ana L Mora, Moisés Selman, Annie Pard. Loss of MT1-MMP in Alveolar Epithelial Cells Exacerbates Pulmonary Fibrosis. International journal of molecular sciences. vol 22. issue 6. 2021-04-23. PMID:33805743. |
previous studies indicate that matrix metalloproteinase 14 (mmp14) is increased in the lung epithelium in patients with ipf, however, the role of this membrane-type matrix metalloproteinase has not been elucidated. |
2021-04-23 |
2023-08-13 |
mouse |
| J-F Wang, Y-Q Gong, Y-H He, W-W Ying, X-S Li, X-F Zhou, L-Q Zho. High expression of MMP14 is associated with progression and poor short-term prognosis in muscle-invasive bladder cancer. European review for medical and pharmacological sciences. vol 24. issue 12. 2021-04-14. PMID:32633349. |
to evaluate the short-term prognostic value of matrix metalloproteinase 14 (mmp14) in muscle-invasive bladder cancer (mibc). |
2021-04-14 |
2023-08-13 |
Not clear |
| Petra Sántha, Daniela Lenggenhager, Anette Finstadsveen, Linda Dorg, Kristin Tøndel, Manoj Amrutkar, Ivar P Gladhaug, Caroline Verbek. Morphological Heterogeneity in Pancreatic Cancer Reflects Structural and Functional Divergence. Cancers. vol 13. issue 4. 2021-03-10. PMID:33672734. |
twenty-six features involved in key biological processes in pc were analyzed (immuno-)histochemically and morphometrically: cancer cell proliferation (ki67) and migration (collagen fiber alignment, mmp14), cancer stem cells (cd44, cd133, aldh1), amount, composition and spatial arrangement of extracellular matrix (epithelial proximity, total collagen, collagen i and iii, fibronectin, hyaluronan), cancer-associated fibroblasts (density, αsma), and cancer-stroma interactions (integrins α2, α5, α1; caveolin-1). |
2021-03-10 |
2023-08-13 |
human |
| Yuhai Zhang, Yuling Hong, Dan Wang, Linshan Duan, Yanling Liu, Long Li, Di Liu, Kunbin Zhuang, Chaoxin Wei, Guogeng Zheng, Chunyong Huo, Guoyan Li. Hsa_circ_0076305 induces migration-proliferation dichotomy in gastric cancer. Oncology letters. vol 21. issue 3. 2021-02-23. PMID:33613709. |
in addition, circpgc degrades the extracellular matrix and basement membrane through matrix metallopeptidase (mmp)9 and mmp14, providing a microenvironment that facilitates cell migration. |
2021-02-23 |
2023-08-13 |
Not clear |
| Takumi Yamane, Ryosuke Konno, Ken Iwatsuki, Yuichi Oish. Negative effects of a low-quality protein diet on wound healing via modulation of the MMP2 activity in rats. Amino acids. vol 52. issue 4. 2021-01-11. PMID:32130517. |
our results also showed that both matrix metalloproteinase (mmp) 2 activity and mmp14 mrna levels were significantly increased in the skin of the gluten group, compared with the casein group. |
2021-01-11 |
2023-08-13 |
rat |
| Minchae Kim, Sora Lee, Chang Seok K. Cellular Behavior of RAW264.7 Cells in 3D Poly(ethylene glycol) Hydrogel Niches. ACS biomaterials science & engineering. vol 5. issue 2. 2021-01-06. PMID:33405849. |
interestingly, we observed the significant upregulation of matrix metalloproteinases (mmps) (i.e., mmp9 and mmp14) as well as m1 polarization markers (i.e., inos, cox2, tnf-α) in 3d, whereas m2 polarization markers (i.e., cd206, arg1, tgf-β) were downregulated. |
2021-01-06 |
2023-08-13 |
Not clear |
| Hongqi Xiao, Ming Li. Circular RNA hsa_circ_0053277 promotes the development of colorectal cancer by upregulating matrix metallopeptidase 14 via miR-2467-3p sequestration. Journal of cellular physiology. vol 235. issue 3. 2020-12-16. PMID:31549406. |
matrix metalloproteinase 14 (mmp14) expression was notably upregulated in crc cells and mmp14 was a downstream target gene of mir-2467-3p. |
2020-12-16 |
2023-08-13 |
human |
| Ye Jin, Zhi-Yong Liang, Wei-Xun Zhou, Li Zho. High MMP14 expression is predictive of poor prognosis in resectable hepatocellular carcinoma. Pathology. vol 52. issue 3. 2020-12-14. PMID:32122646. |
matrix metalloproteinase 14 (mmp14) has been found to play multiple biological roles in cancers, including hepatocellular carcinoma (hcc). |
2020-12-14 |
2023-08-13 |
Not clear |
| Lauren E King, Hui-Hua Zhang, Cathryn M Gould, Daniel W Thomas, Lachlan W Whitehead, Kaylene J Simpson, Antony W Burgess, Maree C Fau. Genes regulating membrane-associated E-cadherin and proliferation in adenomatous polyposis coli mutant colon cancer cells: High content siRNA screen. PloS one. vol 15. issue 10. 2020-12-09. PMID:33057364. |
among the genes whose depletion promotes membrane-associated e-cadherin, we identified zeb1, the microrna200 family, and proteins such as a ubiquitin ligase ube2e3, cdk8, sorting nexin 27 (snx27) and the matrix metalloproteinases, mmp14 and mmp19. |
2020-12-09 |
2023-08-13 |
Not clear |
| Ilja L Kruglikov, Nolwenn Joffin, Philipp E Schere. The MMP14-caveolin axis and its potential relevance for lipoedema. Nature reviews. Endocrinology. vol 16. issue 11. 2020-12-04. PMID:32792644. |
we suggest that lipoedema is an oestrogen-dependent disorder of adipose tissue, which is triggered by a dysfunction of caveolin 1 (cav1) and subsequent uncoupling of feedback mechanisms between cav1, the matrix metalloproteinase mmp14 and oestrogen receptors. |
2020-12-04 |
2023-08-13 |
Not clear |
| Lena Claesson-Wels. How the matrix metalloproteinase MMP14 contributes to the progression of colorectal cancer. The Journal of clinical investigation. vol 130. issue 3. 2020-10-27. PMID:32015228. |
how the matrix metalloproteinase mmp14 contributes to the progression of colorectal cancer. |
2020-10-27 |
2023-08-13 |
mouse |
| Lena Claesson-Wels. How the matrix metalloproteinase MMP14 contributes to the progression of colorectal cancer. The Journal of clinical investigation. vol 130. issue 3. 2020-10-27. PMID:32015228. |
these tumors showed downregulated levels of the transcription factor prospero homeobox protein 1 (prox1), which relieved repression of the matrix metalloproteinase mmp14. |
2020-10-27 |
2023-08-13 |
mouse |
| Kuo-Shun Hsu, Wataru Otsu, Yao Li, Heuy-Ching Wang, Shuibing Chen, Stephen H Tsang, Jen-Zen Chuang, Ching-Hwa Sun. CLIC4 regulates late endosomal trafficking and matrix degradation activity of MMP14 at focal adhesions in RPE cells. Scientific reports. vol 9. issue 1. 2020-10-22. PMID:31439888. |
clic4 regulates late endosomal trafficking and matrix degradation activity of mmp14 at focal adhesions in rpe cells. |
2020-10-22 |
2023-08-13 |
human |
| Kuo-Shun Hsu, Wataru Otsu, Yao Li, Heuy-Ching Wang, Shuibing Chen, Stephen H Tsang, Jen-Zen Chuang, Ching-Hwa Sun. CLIC4 regulates late endosomal trafficking and matrix degradation activity of MMP14 at focal adhesions in RPE cells. Scientific reports. vol 9. issue 1. 2020-10-22. PMID:31439888. |
we show that membrane-type matrix metalloproteinase 14 (mmp14) is central to ecm degradation at the focal adhesions in human arpe19 cells. |
2020-10-22 |
2023-08-13 |
human |