| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Allyson C Banville, Brad H Nelso. Breaching B cell tolerance in the tumor microenvironment. Cancer cell. vol 40. issue 4. 2022-04-12. PMID:35413269. |
report that autoantibodies produced by tumor-infiltrating b cells in human ovarian cancer frequently recognize the self-protein matrix metalloproteinase 14 (mmp14) through two distinct mechanisms of tolerance disruption. |
2022-04-12 |
2023-08-13 |
human |
| Sara M Centuori, Deepta Bhattachary. Locally produced autoantibodies in cancer. Cell. vol 185. issue 7. 2022-04-01. PMID:35364029. |
in a new study by mazor et al., matrix metalloproteinase 14 (mmp14), a self-antigen that is overexpressed by ovarian cancers, is shown to drive b cell activation and autoantibody production in tertiary lymphoid structures (mazor et al., 2022). |
2022-04-01 |
2023-08-13 |
Not clear |
| Danfeng Guo, Xiaodan Zhang, Honglei Cui, Dongsheng Yu, Huapeng Zhang, Xiaoyi Shi, Chun Pang, Jie Li, Wenzhi Guo, Shuijun Zhan. ACADL Functions as a Tumor Suppressor in Hepatocellular Carcinoma Metastasis by Inhibiting Matrix Metalloproteinase 14. Frontiers in oncology. vol 12. 2022-02-17. PMID:35174091. |
expression of matrix metalloproteinase-14 (mmp14) was negatively associated with the content of acadl in hcc specimens. |
2022-02-17 |
2023-08-13 |
Not clear |
| Yang Li, Min Li, Caijie Qu, Yongxi Li, Zhanli Tang, Zhike Zhou, Zengzhao Yu, Xu Wang, Linlin Xin, Tongxin Sh. The Polygenic Map of Keloid Fibroblasts Reveals Fibrosis-Associated Gene Alterations in Inflammation and Immune Responses. Frontiers in immunology. vol 12. 2022-01-27. PMID:35082796. |
for example, il17ra is involved in il-17 signal transduction, timp2 and mmp14 activate extracellular matrix metalloproteinases, and tnc, itgb2, and itga4 interact with cell surface integrins. |
2022-01-27 |
2023-08-13 |
Not clear |
| Xueqing Zhou, Shuya Yang, Qianqian Liu, Ran Wei, Jing Liu, Naixiang Luo, Wenhui Li. [Leptin promotes the proliferation and migration of MDA-MB-231 breast cancer cells by up regulating MMP14]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 1. 2022-01-26. PMID:35078574. |
objective to investigate the effect of matrix metalloproteinase 14 (mmp14) on the proliferation and migration of mda-mb-231 human breast cancer cells treated with leptin. |
2022-01-26 |
2023-08-13 |
human |
| Bailey D Peck, Kevin A Murach, R Grace Walton, Alexander J Simmons, Douglas E Long, Kate Kosmac, Cory M Dungan, Philip A Kern, Marcas M Bamman, Charlotte A Peterso. A muscle cell-macrophage axis involving matrix metalloproteinase 14 facilitates extracellular matrix remodeling with mechanical loading. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36. issue 2. 2022-01-19. PMID:35044708. |
in a large cohort of older adults, transcriptomics revealed that genes involved in ecm remodeling, including matrix metalloproteinase 14 (mmp14), were the most upregulated following 14 weeks of progressive resistance exercise training (prt). |
2022-01-19 |
2023-08-13 |
mouse |
| Eleni Petra, Justyna Siwy, Antonia Vlahou, Joachim Jankowsk. Urine peptidome in combination with transcriptomics analysis highlights MMP7, MMP14 and PCSK5 for further investigation in chronic kidney disease. PloS one. vol 17. issue 1. 2022-01-19. PMID:35045102. |
through investigating ckd-associated transcriptomics datasets, several proteases are highlighted including members of matrix metalloproteinases (mmp7, mmp14) and serine proteases (pcsk5); laying the foundation for further studies towards elucidating their role in ckd pathophysiology. |
2022-01-19 |
2023-08-13 |
Not clear |
| Chun-Long Zheng, Qiang Lu, Nian Zhang, Peng-Yu Jing, Ji-Peng Zhang, Wu-Ping Wang, Gui-Zhen L. Comprehensive Analysis of the Immune and Prognostic Implication of MMP14 in Lung Cancer. Disease markers. vol 2021. 2021-12-08. PMID:34868395. |
matrix metalloproteinase 14 (mmp14) has been reported to be dysregulated in many types of tumors and involved in the development and progression of tumors. |
2021-12-08 |
2023-08-13 |
Not clear |
| Yimin Huang, Baole Zhang, Hannah Haneke, Verena Haage, Malgorzata Lubas, Yang Yuan, Pengfei Xia, Edyta Motta, Cynthia Nanvuma, Omar Dzaye, Feng Hu, Helmut Kettenman. Glial cell line-derived neurotrophic factor increases matrix metallopeptidase 9 and 14 expression in microglia and promotes microglia-mediated glioma progression. Journal of neuroscience research. vol 99. issue 4. 2021-11-30. PMID:33404121. |
here we show that gdnf increases matrix metalloproteinase (mmp) 9 and mmp14 expression in cultured microglial cells from mixed sexes of neonatal mice. |
2021-11-30 |
2023-08-13 |
mouse |
| Elke Pach, Maike Kümper, Julia E Fromme, Jan Zamek, Fabian Metzen, Manuel Koch, Cornelia Mauch, Paola Zigrin. Extracellular Matrix Remodeling by Fibroblast-MMP14 Regulates Melanoma Growth. International journal of molecular sciences. vol 22. issue 22. 2021-11-30. PMID:34830157. |
one of these proteases is the matrix metalloproteinase 14 (mmp14). |
2021-11-30 |
2023-08-13 |
mouse |
| Elke Pach, Maike Kümper, Julia E Fromme, Jan Zamek, Fabian Metzen, Manuel Koch, Cornelia Mauch, Paola Zigrin. Extracellular Matrix Remodeling by Fibroblast-MMP14 Regulates Melanoma Growth. International journal of molecular sciences. vol 22. issue 22. 2021-11-30. PMID:34830157. |
this study shows that loss of fibroblast-mmp14 affects melanoma growth through altering the peritumoral extracellular matrix (ecm) composition, with collagen xiv being a modulator of melanoma progression and a new proteolytic substrate to mmp14. |
2021-11-30 |
2023-08-13 |
mouse |
| Akikazu Harada, Shinji Matsumoto, Yoshiaki Yasumizu, Kensaku Shojima, Toshiyuki Akama, Hidetoshi Eguchi, Akira Kikuch. Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion. eLife. vol 10. 2021-11-20. PMID:34590580. |
specific localization of arl4c, iqgap1, and mmp14 was the active site of invasion, which induced degradation of the extracellular matrix. |
2021-11-20 |
2023-08-13 |
mouse |
| Xiao-Guang Yang, Yan-Yu Li, Dong-Xue Zhao, Wei Cui, Han Li, Xin-Yu Li, Yu-Xin Li, Dun Wan. Repurposing of a monoamine oxidase A inhibitor‑heptamethine carbocyanine dye conjugate for paclitaxel‑resistant non‑small cell lung cancer. Oncology reports. vol 45. issue 3. 2021-10-22. PMID:33650669. |
gene expression profiling of paclitaxel‑resistant nsclc cells following treatment with g10 demonstrated that the expression of genes associated with the extracellular matrix was significantly affected, particularly the metastasis‑related genes matrix metallopeptidase (mmp)2, mmp14 and col6a, which exhibited notably reduced expression. |
2021-10-22 |
2023-08-13 |
mouse |
| Aiman Ali, Andresa Borges Soares, Denise Eymael, Marco Magalhae. Expression of invadopodia markers can identify oral lesions with a high risk of malignant transformation. The journal of pathology. Clinical research. vol 7. issue 1. 2021-10-13. PMID:33001588. |
all samples were stained for cortactin, tyrosine kinase substrate with five sh3 domains (tks5) and matrix metallopeptidase 14 (mmp14) using fihc, imaged using confocal microscopy and analyzed using a multichannel colocalization analysis. |
2021-10-13 |
2023-08-13 |
Not clear |
| Tereza Andreou, Jennifer Williams, Rebecca J Brownlie, Robert J Salmond, Erica Watson, Gary Shaw, Alan Melcher, Heiko Wurdak, Susan C Short, Mihaela Lorge. Hematopoietic stem cell gene therapy targeting TGFβ enhances the efficacy of irradiation therapy in a preclinical glioblastoma model. Journal for immunotherapy of cancer. vol 9. issue 3. 2021-10-06. PMID:33707311. |
because myeloid cells are ubiquitously present in the body, we recently established a lentiviral vector containing matrix metalloproteinase 14 (mmp14) promoter, which is active specifically in tumor-infiltrating myeloid cells as opposed to myeloid cells in other tissues, and resulted in a specific delivery of transgenes to brain metastases in hsc gene therapy. |
2021-10-06 |
2023-08-13 |
mouse |
| Minde Li, Shaoyang Li, Lin Zhou, Le Yang, Xiao Wu, Bin Tang, Shenhao Xie, Linchun Fang, Suyue Zheng, Tao Hon. Immune Infiltration of MMP14 in Pan Cancer and Its Prognostic Effect on Tumors. Frontiers in oncology. vol 11. 2021-10-05. PMID:34604053. |
matrix metalloproteinase 14 (mmp14) is a member of the mmp family, which interacts with tissue inhibitors of metalloproteinase (timps), and is involved in normal physiological functions such as cell migration, invasion, metastasis, angiogenesis, and proliferation, as well as tumor genesis and progression. |
2021-10-05 |
2023-08-13 |
Not clear |
| Vinay J, Debakanta Mishra, Dinesh Meher, Sashibhusan Dash, Kusumbati Besra, Niharika Pattnaik, Shivaram Prasad Singh, Manjusha Dixi. Genetic association of MMP14 promoter variants and their functional significance in gallbladder cancer pathogenesis. Journal of human genetics. vol 66. issue 10. 2021-09-27. PMID:33727629. |
although matrix metalloproteinase-14 (mmp14) is known modulator of tumour microenvironment and tumorigenesis and tcga data also suggests its upregulation yet, its role in genetic predisposition for gbc is completely unknown. |
2021-09-27 |
2023-08-13 |
human |
| Markus Mukenhirn, Francesco Muraca, Delia Bucher, Edgar Asberger, Elisa Cappio Barazzone, Elisabetta Ada Cavalcanti-Adam, Steeve Boulan. Role of Clathrin Light Chains in Regulating Invadopodia Formation. Cells. vol 10. issue 2. 2021-08-26. PMID:33672612. |
we demonstrate that clca/b deletion impacts the intracellular trafficking and recovery of the matrix metalloproteinase 14 (mmp14) leading to its accumulation at the plasma membrane and induction of invadopodia formation. |
2021-08-26 |
2023-08-13 |
Not clear |
| Xikai Wang, Qinghe Meng, Yuanyuan Wang, Yanlu Ga. Overexpression of MMP14 predicts the poor prognosis in gastric cancer: Meta-analysis and database validation. Medicine. vol 100. issue 32. 2021-08-23. PMID:34397871. |
plenty of studies have showed matrix metalloproteinase 14 (mmp14) expression might be associated with the prognosis of gastric cancer (gc). |
2021-08-23 |
2023-08-13 |
Not clear |
| Guidong Shi, Yicun Wang, Zhanwen Wang, Andrew R Thoreson, Daniel S Jacobson, Peter C Amadio, Atta Behfar, Steven L Moran, Chunfeng Zha. A novel engineered purified exosome product patch for tendon healing: An explant in an ex vivo model. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 39. issue 8. 2021-08-09. PMID:32936480. |
quantitative reverse transcription polymerase chain reaction showed that tepep patch increased the expression of collagen type iii, matrix metallopeptidase 2 (mmp2), mmp3, mmp14, and reduced the expression of transforming growth factor β1, interleukin 6. |
2021-08-09 |
2023-08-13 |
Not clear |