All Relations between mmp14 and matrix compartment

Publication Sentence Publish Date Extraction Date Species
Eleni Petra, Justyna Siwy, Antonia Vlahou, Joachim Jankowsk. Urine peptidome in combination with transcriptomics analysis highlights MMP7, MMP14 and PCSK5 for further investigation in chronic kidney disease. PloS one. vol 17. issue 1. 2022-01-19. PMID:35045102. through investigating ckd-associated transcriptomics datasets, several proteases are highlighted including members of matrix metalloproteinases (mmp7, mmp14) and serine proteases (pcsk5); laying the foundation for further studies towards elucidating their role in ckd pathophysiology. 2022-01-19 2023-08-13 Not clear
Chun-Long Zheng, Qiang Lu, Nian Zhang, Peng-Yu Jing, Ji-Peng Zhang, Wu-Ping Wang, Gui-Zhen L. Comprehensive Analysis of the Immune and Prognostic Implication of MMP14 in Lung Cancer. Disease markers. vol 2021. 2021-12-08. PMID:34868395. matrix metalloproteinase 14 (mmp14) has been reported to be dysregulated in many types of tumors and involved in the development and progression of tumors. 2021-12-08 2023-08-13 Not clear
Yimin Huang, Baole Zhang, Hannah Haneke, Verena Haage, Malgorzata Lubas, Yang Yuan, Pengfei Xia, Edyta Motta, Cynthia Nanvuma, Omar Dzaye, Feng Hu, Helmut Kettenman. Glial cell line-derived neurotrophic factor increases matrix metallopeptidase 9 and 14 expression in microglia and promotes microglia-mediated glioma progression. Journal of neuroscience research. vol 99. issue 4. 2021-11-30. PMID:33404121. here we show that gdnf increases matrix metalloproteinase (mmp) 9 and mmp14 expression in cultured microglial cells from mixed sexes of neonatal mice. 2021-11-30 2023-08-13 mouse
Elke Pach, Maike Kümper, Julia E Fromme, Jan Zamek, Fabian Metzen, Manuel Koch, Cornelia Mauch, Paola Zigrin. Extracellular Matrix Remodeling by Fibroblast-MMP14 Regulates Melanoma Growth. International journal of molecular sciences. vol 22. issue 22. 2021-11-30. PMID:34830157. one of these proteases is the matrix metalloproteinase 14 (mmp14). 2021-11-30 2023-08-13 mouse
Elke Pach, Maike Kümper, Julia E Fromme, Jan Zamek, Fabian Metzen, Manuel Koch, Cornelia Mauch, Paola Zigrin. Extracellular Matrix Remodeling by Fibroblast-MMP14 Regulates Melanoma Growth. International journal of molecular sciences. vol 22. issue 22. 2021-11-30. PMID:34830157. this study shows that loss of fibroblast-mmp14 affects melanoma growth through altering the peritumoral extracellular matrix (ecm) composition, with collagen xiv being a modulator of melanoma progression and a new proteolytic substrate to mmp14. 2021-11-30 2023-08-13 mouse
Akikazu Harada, Shinji Matsumoto, Yoshiaki Yasumizu, Kensaku Shojima, Toshiyuki Akama, Hidetoshi Eguchi, Akira Kikuch. Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion. eLife. vol 10. 2021-11-20. PMID:34590580. specific localization of arl4c, iqgap1, and mmp14 was the active site of invasion, which induced degradation of the extracellular matrix. 2021-11-20 2023-08-13 mouse
Xiao-Guang Yang, Yan-Yu Li, Dong-Xue Zhao, Wei Cui, Han Li, Xin-Yu Li, Yu-Xin Li, Dun Wan. Repurposing of a monoamine oxidase A inhibitor‑heptamethine carbocyanine dye conjugate for paclitaxel‑resistant non‑small cell lung cancer. Oncology reports. vol 45. issue 3. 2021-10-22. PMID:33650669. gene expression profiling of paclitaxel‑resistant nsclc cells following treatment with g10 demonstrated that the expression of genes associated with the extracellular matrix was significantly affected, particularly the metastasis‑related genes matrix metallopeptidase (mmp)2, mmp14 and col6a, which exhibited notably reduced expression. 2021-10-22 2023-08-13 mouse
Aiman Ali, Andresa Borges Soares, Denise Eymael, Marco Magalhae. Expression of invadopodia markers can identify oral lesions with a high risk of malignant transformation. The journal of pathology. Clinical research. vol 7. issue 1. 2021-10-13. PMID:33001588. all samples were stained for cortactin, tyrosine kinase substrate with five sh3 domains (tks5) and matrix metallopeptidase 14 (mmp14) using fihc, imaged using confocal microscopy and analyzed using a multichannel colocalization analysis. 2021-10-13 2023-08-13 Not clear
Tereza Andreou, Jennifer Williams, Rebecca J Brownlie, Robert J Salmond, Erica Watson, Gary Shaw, Alan Melcher, Heiko Wurdak, Susan C Short, Mihaela Lorge. Hematopoietic stem cell gene therapy targeting TGFβ enhances the efficacy of irradiation therapy in a preclinical glioblastoma model. Journal for immunotherapy of cancer. vol 9. issue 3. 2021-10-06. PMID:33707311. because myeloid cells are ubiquitously present in the body, we recently established a lentiviral vector containing matrix metalloproteinase 14 (mmp14) promoter, which is active specifically in tumor-infiltrating myeloid cells as opposed to myeloid cells in other tissues, and resulted in a specific delivery of transgenes to brain metastases in hsc gene therapy. 2021-10-06 2023-08-13 mouse
Minde Li, Shaoyang Li, Lin Zhou, Le Yang, Xiao Wu, Bin Tang, Shenhao Xie, Linchun Fang, Suyue Zheng, Tao Hon. Immune Infiltration of MMP14 in Pan Cancer and Its Prognostic Effect on Tumors. Frontiers in oncology. vol 11. 2021-10-05. PMID:34604053. matrix metalloproteinase 14 (mmp14) is a member of the mmp family, which interacts with tissue inhibitors of metalloproteinase (timps), and is involved in normal physiological functions such as cell migration, invasion, metastasis, angiogenesis, and proliferation, as well as tumor genesis and progression. 2021-10-05 2023-08-13 Not clear
Vinay J, Debakanta Mishra, Dinesh Meher, Sashibhusan Dash, Kusumbati Besra, Niharika Pattnaik, Shivaram Prasad Singh, Manjusha Dixi. Genetic association of MMP14 promoter variants and their functional significance in gallbladder cancer pathogenesis. Journal of human genetics. vol 66. issue 10. 2021-09-27. PMID:33727629. although matrix metalloproteinase-14 (mmp14) is known modulator of tumour microenvironment and tumorigenesis and tcga data also suggests its upregulation yet, its role in genetic predisposition for gbc is completely unknown. 2021-09-27 2023-08-13 human
Markus Mukenhirn, Francesco Muraca, Delia Bucher, Edgar Asberger, Elisa Cappio Barazzone, Elisabetta Ada Cavalcanti-Adam, Steeve Boulan. Role of Clathrin Light Chains in Regulating Invadopodia Formation. Cells. vol 10. issue 2. 2021-08-26. PMID:33672612. we demonstrate that clca/b deletion impacts the intracellular trafficking and recovery of the matrix metalloproteinase 14 (mmp14) leading to its accumulation at the plasma membrane and induction of invadopodia formation. 2021-08-26 2023-08-13 Not clear
Xikai Wang, Qinghe Meng, Yuanyuan Wang, Yanlu Ga. Overexpression of MMP14 predicts the poor prognosis in gastric cancer: Meta-analysis and database validation. Medicine. vol 100. issue 32. 2021-08-23. PMID:34397871. plenty of studies have showed matrix metalloproteinase 14 (mmp14) expression might be associated with the prognosis of gastric cancer (gc). 2021-08-23 2023-08-13 Not clear
Guidong Shi, Yicun Wang, Zhanwen Wang, Andrew R Thoreson, Daniel S Jacobson, Peter C Amadio, Atta Behfar, Steven L Moran, Chunfeng Zha. A novel engineered purified exosome product patch for tendon healing: An explant in an ex vivo model. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 39. issue 8. 2021-08-09. PMID:32936480. quantitative reverse transcription polymerase chain reaction showed that tepep patch increased the expression of collagen type iii, matrix metallopeptidase 2 (mmp2), mmp3, mmp14, and reduced the expression of transforming growth factor β1, interleukin 6. 2021-08-09 2023-08-13 Not clear
Ellen M Adams, Simone Pezzotti, Jonas Ahlers, Maximilian Rüttermann, Maxim Levin, Adi Goldenzweig, Yoav Peleg, Sarel J Fleishman, Irit Sagi, Martina Havenit. Local Mutations Can Serve as a Game Changer for Global Protein Solvent Interaction. JACS Au. vol 1. issue 7. 2021-08-03. PMID:34337607. here we show by a combined computational design, experimental, and molecular dynamics (md) study that local mutations have not only a local but also a global effect on the solvent: in the specific case of the matrix metalloprotease mmp14, we found that the nature of local mutations, coupled with surface morphology, have the ability to influence large patches of the water hydrogen-bonding network at the protein surface, which is correlated with stability. 2021-08-03 2023-08-13 Not clear
Christopher D Kegelman, Jennifer C Coulombe, Kelsey M Jordan, Daniel J Horan, Ling Qin, Alexander G Robling, Virginia L Ferguson, Teresita M Bellido, Joel D Boercke. YAP and TAZ Mediate Osteocyte Perilacunar/Canalicular Remodeling. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 35. issue 1. 2021-07-28. PMID:31610061. consistent with recent studies identifying tgf-β as a key inducer of osteocyte expression of matrix-remodeling enzymes, yap/taz deletion in vivo decreased osteocyte expression of matrix proteases mmp13, mmp14, and ctsk. 2021-07-28 2023-08-13 mouse
Lingxin Zhu, Yi Tang, Xiao-Yan Li, Evan T Keller, Jingwen Yang, Jung-Sun Cho, Tamar Y Feinberg, Stephen J Weis. Osteoclast-mediated bone resorption is controlled by a compensatory network of secreted and membrane-tethered metalloproteinases. Science translational medicine. vol 12. issue 529. 2021-06-23. PMID:32024800. here, we identify a cathepsin k-independent collagenolytic system in osteoclasts that is composed of a functionally redundant network of the secreted matrix metalloproteinase mmp9 and the membrane-anchored matrix metalloproteinase mmp14. 2021-06-23 2023-08-13 mouse
Pinfang Kang, Jiahui Wang, Dian Fang, Tingting Fang, Ying Yu, Weiping Zhang, Lin Shen, Zhenghong Li, Hongju Wang, Hongwei Ye, Qin Ga. Activation of ALDH2 attenuates high glucose induced rat cardiomyocyte fibrosis and necroptosis. Free radical biology & medicine. vol 146. 2021-06-18. PMID:31689484. in contrast to normal glucose group, in hg group, with the decreases of aldh2 activity, mrna and protein levels, the cardiomyocytes viability was decreased, reactive oxygen species (ros), the inflammation factors - tumor necrosis factor-α (tnf-α), interleukin-6 (il-6), interleukin-1β (il-1β) levels, collagen i (col i) and col iii mrna expressions and tissue inhibitors of matrix metalloproteinase 4 (timp4) protein expression were increased, while matrix metalloproteinase 14 (mmp14) protein level, the ratio of mmp14/timp4 were decreased, and the necroptosis key factors - the receptor interacting protein 1 (rip1), rip3 and mixed lineage kinase domain-like protein (mlkl) at mrna and protein expressions were increased, the inflammasome core proteins - nlrp3 and asc protein expressions were also increased, the apoptosis rate and necrosis rate were also increased. 2021-06-18 2023-08-13 rat
Olivia R Grafinger, Genya Gorshtein, Tyler Stirling, Megan I Brasher, Marc G Coppolin. β1 integrin-mediated signaling regulates MT1-MMP phosphorylation to promote tumor cell invasion. Journal of cell science. vol 133. issue 9. 2021-06-18. PMID:32205364. ecm degradation at invadopodia is mediated by matrix metalloproteinases (mmps), and recent findings indicate that membrane-anchored membrane type 1-matrix metalloproteinase (mt1-mmp, also known as mmp14) has a primary role in this process. 2021-06-18 2023-08-13 Not clear
Marilyn Janice Oentaryo, Anna Chung-Kwan Tse, Chi Wai Le. Neuronal MT1-MMP mediates ECM clearance and Lrp4 cleavage for agrin deposition and signaling in presynaptic development. Journal of cell science. vol 133. issue 15. 2021-06-18. PMID:32591486. here, we report that the proteolytic activity of neuronal membrane-type 1 matrix metalloproteinase (mt1-mmp; also known as mmp14) facilitates agrin deposition and signaling during presynaptic development at nmjs. 2021-06-18 2023-08-13 Not clear