| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Caleb Seth Bailey, Julia Elaine Jagielo-Miller, Peggy Sue Keller, Ethan Phares Glaser, Abigail Lowe Wilcox, Mark Alan Prendergas. Ethanol sustains phosphorylated tau protein in the cultured neonatal rat hippocampus: Implications for fetal alcohol spectrum disorders. Alcohol (Fayetteville, N.Y.). 2022-08-14. PMID:35964913. |
ethanol sustains phosphorylated tau protein in the cultured neonatal rat hippocampus: implications for fetal alcohol spectrum disorders. |
2022-08-14 |
2023-08-14 |
rat |
| Caleb Seth Bailey, Julia Elaine Jagielo-Miller, Peggy Sue Keller, Ethan Phares Glaser, Abigail Lowe Wilcox, Mark Alan Prendergas. Ethanol sustains phosphorylated tau protein in the cultured neonatal rat hippocampus: Implications for fetal alcohol spectrum disorders. Alcohol (Fayetteville, N.Y.). 2022-08-14. PMID:35964913. |
the role of the tau protein in the hippocampus is likely to be involved. |
2022-08-14 |
2023-08-14 |
rat |
| Caleb Seth Bailey, Julia Elaine Jagielo-Miller, Peggy Sue Keller, Ethan Phares Glaser, Abigail Lowe Wilcox, Mark Alan Prendergas. Ethanol sustains phosphorylated tau protein in the cultured neonatal rat hippocampus: Implications for fetal alcohol spectrum disorders. Alcohol (Fayetteville, N.Y.). 2022-08-14. PMID:35964913. |
this is the first study to show that etoh exposure sustains tau threonine231 phosphorylation in the perinatal hippocampus regardless of total tau expression. |
2022-08-14 |
2023-08-14 |
rat |
| Tiantian Guo, Xinjia Pan, Guangtong Jiang, Denghong Zhang, Jinghui Qi, Lin Shao, Zhanxiang Wang, Huaxi Xu, Yingjun Zha. Downregulating PTBP1 fails to convert astrocytes into hippocampal neurons and to alleviate symptoms in Alzheimer's mouse models. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-08-09. PMID:35944999. |
here, we demonstrate that ptbp1 downregulation using an astrocyte specific aav-mediated shrna system fails to convert hippocampal astrocytes into neurons in both male and female wt, and β-amyloid (5×fad) and tau (ps19) alzheimer's disease (ad) mouse models, and fails to reverse synaptic/cognitive deficits and ad-associated pathology in male mice. |
2022-08-09 |
2023-08-14 |
mouse |
| Jingqin Luo, Folasade Agboola, Elizabeth Grant, John C Morris, Colin L Masters, Marilyn S Albert, Sterling C Johnson, Eric M McDade, Anne M Fagan, Tammie L S Benzinger, Jason Hassenstab, Randall J Bateman, Richard J Perrin, Guoqiao Wang, Yan Li, Brian Gordon, Carlos Cruchaga, Gregory S Day, Johannes Levin, Jonathan Vöglein, Takeshi Ikeuchi, Kazushi Suzuki, Ricardo F Allegri, Chengjie Xion. Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan. Brain : a journal of neurology. 2022-08-04. PMID:35925685. |
the temporal evolutions and relative orderings of alzheimer disease biomarkers, including csf amyloid-β42 (aβ42), aβ40, total tau (tau) and phosphorylated tau181 (ptau181), standardized uptake value ratio (suvr) from the molecular imaging of cerebral fibrillar amyloid-β with pet using the 11c-pittsburgh compound-b (pib), mri-based hippocampal volume and cortical thickness and cognition have been hypothesized but not yet fully tested with longitudinal data for all major biomarker modalities among cognitively normal individuals across the adult lifespan starting from 18 years. |
2022-08-04 |
2023-08-14 |
human |
| Jingqin Luo, Folasade Agboola, Elizabeth Grant, John C Morris, Colin L Masters, Marilyn S Albert, Sterling C Johnson, Eric M McDade, Anne M Fagan, Tammie L S Benzinger, Jason Hassenstab, Randall J Bateman, Richard J Perrin, Guoqiao Wang, Yan Li, Brian Gordon, Carlos Cruchaga, Gregory S Day, Johannes Levin, Jonathan Vöglein, Takeshi Ikeuchi, Kazushi Suzuki, Ricardo F Allegri, Chengjie Xion. Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan. Brain : a journal of neurology. 2022-08-04. PMID:35925685. |
the earliest acceleration of longitudinal change occurred for csf aβ42 and aβ42/aβ40 ratio (with an increase) and for tau, and ptau181 (with a decrease) at the next baseline age interval of 45-50 years, followed by an accelerated increase for pib suvr at the baseline age of 50-55 years and an accelerated decrease for hippocampal volume at the baseline age of 55-60 years and finally by an accelerated decline for cortical thickness and cognition at the baseline age of 65-70 years. |
2022-08-04 |
2023-08-14 |
human |
| Jingqin Luo, Folasade Agboola, Elizabeth Grant, John C Morris, Colin L Masters, Marilyn S Albert, Sterling C Johnson, Eric M McDade, Anne M Fagan, Tammie L S Benzinger, Jason Hassenstab, Randall J Bateman, Richard J Perrin, Guoqiao Wang, Yan Li, Brian Gordon, Carlos Cruchaga, Gregory S Day, Johannes Levin, Jonathan Vöglein, Takeshi Ikeuchi, Kazushi Suzuki, Ricardo F Allegri, Chengjie Xion. Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan. Brain : a journal of neurology. 2022-08-04. PMID:35925685. |
another acceleration in the rate of change occurred at the baseline age of 65-70 years for aβ42/aβ40 ratio, tau, ptau181, pib suvr and hippocampal volume. |
2022-08-04 |
2023-08-14 |
human |
| Burak Tan, Ercan Babur, Nihal Toy, Buse Günaydın, Nurcan Dursun, Cem Süe. Tau Protein is Differentially Phosphorylated in Young- and Old- Aged Rats with Experimentally Induced Hyperthyroidism. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-07-29. PMID:35904470. |
to clarify this issue, ltp and accompanying phosphorylation of tau protein in different residues were investigated in the hippocampus of young and old rats with experimentally induced hyperthyroidism. |
2022-07-29 |
2023-08-14 |
rat |
| Paola C Bello-Medina, Karina Corona-Cervantes, Norma Gabriela Zavala Torres, Antonio González, Marcel Pérez-Morales, Diego A González-Franco, Astrid Gómez, Jaime García-Mena, Sofía Díaz-Cintra, Gustavo Pacheco-Lópe. Chronic-Antibiotics Induced Gut Microbiota Dysbiosis Rescues Memory Impairment and Reduces β-Amyloid Aggregation in a Preclinical Alzheimer's Disease Model. International journal of molecular sciences. vol 23. issue 15. 2022-07-28. PMID:35897785. |
we assessed in offspring (f1) 3xtg, the effect of bgm dysbiosisdysbiosis in mothers (f0) at gestation and f1 from lactation up to the age of 5 months on aβ and tau levels in the hippocampus, as well as on spatial memory at the early symptomatic stage of ad. |
2022-07-28 |
2023-08-14 |
mouse |
| Paola C Bello-Medina, Karina Corona-Cervantes, Norma Gabriela Zavala Torres, Antonio González, Marcel Pérez-Morales, Diego A González-Franco, Astrid Gómez, Jaime García-Mena, Sofía Díaz-Cintra, Gustavo Pacheco-Lópe. Chronic-Antibiotics Induced Gut Microbiota Dysbiosis Rescues Memory Impairment and Reduces β-Amyloid Aggregation in a Preclinical Alzheimer's Disease Model. International journal of molecular sciences. vol 23. issue 15. 2022-07-28. PMID:35897785. |
on pd150, we observed a delay in spatial memory impairment and aβ deposits, but not in tau and ptau protein in the hippocampus at the early symptomatic stage of ad. |
2022-07-28 |
2023-08-14 |
mouse |
| Sanaz Arezoumandan, Sharon X Xie, Katheryn A Q Cousins, Dawn J Mechanic-Hamilton, Claire S Peterson, Camille Y Huang, Daniel T Ohm, Ranjit Ittyerah, Corey T McMillan, David A Wolk, Paul Yushkevich, John Q Trojanowski, Edward B Lee, Murray Grossman, Jeffrey S Phillips, David J Irwi. Regional distribution and maturation of tau pathology among phenotypic variants of Alzheimer's disease. Acta neuropathologica. 2022-07-23. PMID:35871112. |
here, we investigated the distribution and burden of phosphorylated and c-terminally cleaved tau pathologies across hippocampal subfields and cortical regions among phenotypic variants of alzheimer's disease (ad). |
2022-07-23 |
2023-08-14 |
Not clear |
| Alexandria B Marciante, John Howard, Mia N Kelly, Juan Santiago Moreno, Latoya L Allen, Elisa J Gonzalez-Rothi, Gordon S Mitchel. Dose-dependent Phosphorylation of Endogenous Tau by Intermittent Hypoxia in Rat Brain. Journal of applied physiology (Bethesda, Md. : 1985). 2022-07-21. PMID:35861520. |
we hypothesized cih characteristic of moderate sleep apnea would increase dysregulation of phosphorylated tau (phospho-tau) species in sprague-dawley rat hippocampus and pre-frontal cortex. |
2022-07-21 |
2023-08-14 |
human |
| Parul Katiyar, Aaina Singh Rathore, Somesh Banerjee, Sandip Nathani, Walia Zahra, Surya Pratap Singh, Debabrata Sircar, Partha Ro. Wheatgrass extract imparts neuroprotective actions against scopolamine-induced amnesia in mice. Food & function. 2022-07-21. PMID:35861716. |
wheatgrass treatment of mice also regulated the phosphorylation of tau protein and simultaneously prevented its aggregation in the hippocampal region of the brain. |
2022-07-21 |
2023-08-14 |
mouse |
| Diego Sepulveda-Falla, Justin S Sanchez, Maria Camila Almeida, Daniela Boassa, Juliana Acosta-Uribe, Clara Vila-Castelar, Liliana Ramirez-Gomez, Ana Baena, David Aguillon, Nelson David Villalba-Moreno, Jessica Lisa Littau, Andres Villegas, Thomas G Beach, Charles L White, Mark Ellisman, Susanne Krasemann, Markus Glatzel, Keith A Johnson, Reisa A Sperling, Eric M Reiman, Joseph F Arboleda-Velasquez, Kenneth S Kosik, Francisco Lopera, Yakeel T Quiro. Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer's dementia. Acta neuropathologica. 2022-07-15. PMID:35838824. |
the frontal cortex and the hippocampus, less affected than the occipital cortex by tau pathology, contained related orphan receptor b (rorb) positive neurons, homeostatic astrocytes and higher apoe expression. |
2022-07-15 |
2023-08-14 |
Not clear |
| Ying Han, Le Chen, Jingyun Liu, Jie Chen, Chunyang Wang, Yu Guo, Xuebin Yu, Chenghong Zhang, Haiying Chu, Haiying M. A Class I HDAC Inhibitor Rescues Synaptic Damage and Neuron Loss in APP-Transfected Cells and APP/PS1 Mice through the GRIP1/AMPA Pathway. Molecules (Basel, Switzerland). vol 27. issue 13. 2022-07-09. PMID:35807406. |
in vivo, bg45 alleviated the apoptosis-mediated loss of hippocampal neurons, upregulated synapse-related proteins, reduced aβ deposition and phosphorylation of tau, and increased the levels of the synapse-related genes grik2, scn3b, syp, grm2, and grid2ip. |
2022-07-09 |
2023-08-14 |
mouse |
| Lin Wang, Bi-Qiang Zhou, Ying-Hong Li, Qian-Qian Jiang, Wei-Hong Cong, Ke-Ji Chen, Xiao-Min Wen, Zheng-Zhi W. Lactoferrin modification of berberine nanoliposomes enhances the neuroprotective effects in a mouse model of Alzheimer's disease. Neural regeneration research. vol 18. issue 1. 2022-07-08. PMID:35799547. |
lactoferrin-modified berberine nanoliposomes inhibited acetylcholinesterase activity and apoptosis in the hippocampus, reduced tau over-phosphorylation in the cerebral cortex, and improved mouse behavior. |
2022-07-08 |
2023-08-14 |
mouse |
| Chih-Hsin Lin, Yu-Shao Hsieh, Ying-Chieh Sun, Wun-Han Huang, Shu-Ling Chen, Zheng-Kui Weng, Te-Hsien Lin, Yih-Ru Wu, Kuo-Hsuan Chang, Hei-Jen Huang, Guan-Chiun Lee, Hsiu Mei Hsieh-Li, Guey-Jen Lee-Che. Virtual Screening and Testing of GSK-3 Inhibitors Using Human SH-SY5Y Cells Expressing Tau Folding Reporter and Mouse Hippocampal Primary Culture under Tau Cytotoxicity. Biomolecules & therapeutics. 2022-07-05. PMID:35790892. |
virtual screening and testing of gsk-3 inhibitors using human sh-sy5y cells expressing tau folding reporter and mouse hippocampal primary culture under tau cytotoxicity. |
2022-07-05 |
2023-08-14 |
mouse |
| Meng Yang, Jing Wan. Berberine Ameliorates Cognitive Disorder via GSK3β/PGC-1α Signaling in APP/PS1 Mice. Journal of nutritional science and vitaminology. vol 68. issue 3. 2022-06-29. PMID:35768254. |
additionally, bbr significantly alleviated neuronal damage and reduced the levels of hyperphosphorylated tau at sites of thr205 and thr231 in hippocampus. |
2022-06-29 |
2023-08-14 |
mouse |
| Chao He, Ai-Hong Yuan, Jun Yang, Yin-Qiu Fan, Hong-Yu Xi. [Electroacupuncture improves learning-memory ability by down-regulating expression of hippocampal Aβ1-42 and Tau and NF-κB proteins in diabetic rats with cognitive impairment]. Zhen ci yan jiu = Acupuncture research. vol 47. issue 6. 2022-06-28. PMID:35764514. |
[electroacupuncture improves learning-memory ability by down-regulating expression of hippocampal aβ1-42 and tau and nf-κb proteins in diabetic rats with cognitive impairment]. |
2022-06-28 |
2023-08-14 |
rat |
| Ryszard Pluta, Sławomir Januszewski, Stanisław J Czuczwa. Molecular Hydrogen Neuroprotection in Post-Ischemic Neurodegeneration in the Form of Alzheimer's Disease Proteinopathy: Underlying Mechanisms and Potential for Clinical Implementation-Fantasy or Reality? International journal of molecular sciences. vol 23. issue 12. 2022-06-24. PMID:35743035. |
the death of pyramidal neurons in especially the ca1 area of the hippocampus, increased permeability of the blood-brain barrier, neuroinflammation, amyloid accumulation, tau protein dysfunction, brain atrophy, cognitive deficits and dementia are considered an integral part of the phenomena occurring during brain neurodegeneration after ischemia. |
2022-06-24 |
2023-08-14 |
Not clear |