| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christian Conze, Marina Rierola, Nataliya I Trushina, Michael Peters, Dennis Janning, Max Holzer, Jürgen J Heinisch, Thomas Arendt, Lidia Bakota, Roland Brand. Caspase-cleaved tau is senescence-associated and induces a toxic gain of function by putting a brake on axonal transport. Molecular psychiatry. 2022-04-08. PMID:35393558. |
here we report that the proportion of tau that is proteolytically cleaved at the caspase-3 site (tauc3) doubles in the hippocampus of senescent mice. |
2022-04-08 |
2023-08-13 |
mouse |
| Shihong Li, Qiuzhi Zhou, Enjie Liu, Huiyun Du, Nana Yu, Haitao Yu, Weijin Wang, Mengzhu Li, Ying Weng, Yang Gao, Guilin Pi, Xin Wang, Dan Ke, Jian-Zhi Wan. Alzheimer-like tau accumulation in dentate gyrus mossy cells induces spatial cognitive deficits by disrupting multiple memory-related signaling and inhibiting local neural circuit. Aging cell. 2022-03-31. PMID:35355405. |
in the current study, we observed a prominent accumulation of the ad-like hyperphosphorylated and truncated tau (htau n368) proteins in hippocampal dentate gyrus (dg) mossy cells of 3xtg-ad mice. |
2022-03-31 |
2023-08-13 |
mouse |
| Simon Dujardin, Analiese Fernandes, Riley Bannon, Caitlin Commins, Mark De Los Santos, Tarun V Kamath, Mansuo Hayashi, Bradley T Hyma. Tau propagation is dependent on the genetic background of mouse strains. Brain communications. vol 4. issue 2. 2022-03-30. PMID:35350555. |
we virally expressed human tau locally in the hippocampus and the entorhinal cortex neurons and monitored the cell-to-cell tau protein spread by immunolabelling. |
2022-03-30 |
2023-08-13 |
mouse |
| Emrah Düzel, Gabriel Ziegler, David Berron, Anne Maass, Hartmut Schütze, Arturo Cardenas-Blanco, Wenzel Glanz, Coraline Metzger, Laura Dobisch, Martin Reuter, Annika Spottke, Frederic Brosseron, Klaus Fliessbach, Michael T Heneka, Christoph Laske, Oliver Peters, Josef Priller, Eike Jakob Spruth, Alfredo Ramirez, Oliver Speck, Anja Schneider, Stefan Teipel, Ingo Kilimann, Wiltfang Jens, Björn-Hendrik Schott, Lukas Preis, Daria Gref, Franziska Maier, Matthias H Munk, Nina Roy, Tomasso Ballarini, Renat Yakupov, John Dylan Haynes, Peter Dechent, Klaus Scheffler, Michael Wagner, Frank Jesse. Amyloid pathology but not APOE ε4 status is permissive for tau-related hippocampal dysfunction. Brain : a journal of neurology. 2022-03-30. PMID:35352105. |
apoe status (presence of the e4 allele), a known genetic risk factor for alzheimer's disease, did not mediate the relationship between tau pathology and hippocampal function and memory performance. |
2022-03-30 |
2023-08-13 |
human |
| Emrah Düzel, Gabriel Ziegler, David Berron, Anne Maass, Hartmut Schütze, Arturo Cardenas-Blanco, Wenzel Glanz, Coraline Metzger, Laura Dobisch, Martin Reuter, Annika Spottke, Frederic Brosseron, Klaus Fliessbach, Michael T Heneka, Christoph Laske, Oliver Peters, Josef Priller, Eike Jakob Spruth, Alfredo Ramirez, Oliver Speck, Anja Schneider, Stefan Teipel, Ingo Kilimann, Wiltfang Jens, Björn-Hendrik Schott, Lukas Preis, Daria Gref, Franziska Maier, Matthias H Munk, Nina Roy, Tomasso Ballarini, Renat Yakupov, John Dylan Haynes, Peter Dechent, Klaus Scheffler, Michael Wagner, Frank Jesse. Amyloid pathology but not APOE ε4 status is permissive for tau-related hippocampal dysfunction. Brain : a journal of neurology. 2022-03-30. PMID:35352105. |
thus, our data show that the presence of amyloid pathology is associated with a linear relationship between tau pathology, hippocampal dysfunction and memory impairment, although the actual severity of amyloid pathology is uncorrelated. |
2022-03-30 |
2023-08-13 |
human |
| Lorena Xolalpa-Cueva, Carlos Antonio García-Carlos, Rocío Villaseñor-Zepeda, Erika Orta-Salazar, Sofia Díaz-Cintra, Fernando Peña-Ortega, George Perry, Siddhartha Mondragón-Rodrígue. Hyperphosphorylated Tau Relates to Improved Cognitive Performance and Reduced Hippocampal Excitability in the Young rTg4510 Mouse Model of Tauopathy. Journal of Alzheimer's disease : JAD. 2022-03-28. PMID:35342085. |
hyperphosphorylated tau relates to improved cognitive performance and reduced hippocampal excitability in the young rtg4510 mouse model of tauopathy. |
2022-03-28 |
2023-08-13 |
mouse |
| Kurt A Jellinge. Heterogeneity of Multiple System Atrophy: An Update. Biomedicines. vol 10. issue 3. 2022-03-25. PMID:35327402. |
in addition to rare combined or "mixed" msa, there is a broad spectrum of atypical msa variants, such as those with a different age at onset and disease duration, "minimal change" or prodromal forms, msa variants with lewy body disease or severe hippocampal pathology, rare forms with an unusual tau pathology or spinal myoclonus, an increasing number of msa cases with cognitive impairment/dementia, rare familial forms, and questionable conjugal msa. |
2022-03-25 |
2023-08-13 |
Not clear |
| Abi Nader Clément, Federica Ribaldi, Giovanni B Frisoni, Valentina Garibotto, Philippe Robert, Nicholas Ayache, Marco Lorenz. SimulAD: a dynamical model for personalized simulation and disease staging in Alzheimer's disease. Neurobiology of aging. vol 113. 2022-03-23. PMID:35320737. |
ds correlated with mmse (ρ = -0.55), hippocampal atrophy (ρ = -0.62), glucose hypometabolism (ρ = -0.67), amyloid burden (ρ = 0.31) and tau deposition (ρ = 0.62) (p-values < 0.01). |
2022-03-23 |
2023-08-13 |
human |
| Wiesje Pelkmans, Ellen M Vromen, Ellen Dicks, Philip Scheltens, Charlotte E Teunissen, Frederik Barkhof, Wiesje M van der Flier, Betty M Tijm. Grey matter network markers identify individuals with prodromal Alzheimer's disease who will show rapid clinical decline. Brain communications. vol 4. issue 2. 2022-03-21. PMID:35310828. |
csf tau phosphorylated at threonine 181 (p-tau181) levels and hippocampal volume]. |
2022-03-21 |
2023-08-13 |
Not clear |
| Sonja Fixemer, Corrado Ameli, Gaël Hammer, Luis Salamanca, Oihane Uriarte Huarte, Chantal Schwartz, Jean-Jacques Gérardy, Naguib Mechawar, Alexander Skupin, Michel Mittelbronn, David S Bouvie. Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies. Acta neuropathologica communications. vol 10. issue 1. 2022-03-17. PMID:35296366. |
microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with alzheimer's disease and dementia with lewy bodies. |
2022-03-17 |
2023-08-13 |
Not clear |
| Sha Sha, Xiao-Na Xing, Tao Wang, Ying Li, Rong-Wei Zhang, Xue-Li Shen, Yun-Peng Cao, Le Q. DNA vaccines targeting amyloid-β oligomer ameliorate cognitive deficits of aged APP/PS1/tau triple-transgenic mouse models of Alzheimer's disease. Neural regeneration research. vol 17. issue 10. 2022-03-09. PMID:35259854. |
our results showed that the p(aβ3-10)10-mt vaccine effectively reduced aβ oligomer levels and plaque deposition in the cerebral cortex and hippocampus, decreased the levels tau protein variants, reduced synaptic loss, protected synaptic function, reduced neuron loss, and ameliorated memory impairment without causing any cerebral hemorrhaging. |
2022-03-09 |
2023-08-13 |
mouse |
| Qing Wang, Gengsheng Chen, Suzanne E Schindler, Jon Christensen, Nicole S McKay, Jingxia Liu, Sicheng Wang, Zhexian Sun, Jason Hassenstab, Yi Su, Shaney Flores, Russ Hornbeck, Lisa Cash, Carlos Cruchaga, Anne M Fagan, Zhude Tu, John C Morris, Mark A Mintun, Yong Wang, Tammie L S Benzinge. Baseline Microglial Activation Correlates With Brain Amyloidosis and Longitudinal Cognitive Decline in Alzheimer Disease. Neurology(R) neuroimmunology & neuroinflammation. vol 9. issue 3. 2022-03-09. PMID:35260470. |
this study aims to quantify microglial activation in individuals with alzheimer disease (ad) using the 18-kda translocator protein (tspo) pet imaging in the hippocampus and precuneus, the 2 ad-vulnerable regions, and to evaluate the association of baseline neuroinflammation with amyloidosis, tau, and longitudinal cognitive decline. |
2022-03-09 |
2023-08-13 |
Not clear |
| Reza Yekta, Leila Sadeghi, Gholamreza Dehgha. The role of non-enzymatic glycation on Tau-DNA interactions: Kinetic and mechanistic approaches. International journal of biological macromolecules. 2022-03-08. PMID:35257729. |
the study of hippocampal cells under hyperglycemic conditions showed that near to 70% of tau proteins glycated in these cells, although the expression of tau remained unaffected. |
2022-03-08 |
2023-08-13 |
Not clear |
| Gabriel Boer Grigoletti-Lima, Marcelo Gustavo Lopes, Ana Tereza Barufi Franco, Aparecida Marcela Damico, Patrìcia Aline Boer, José Antonio Rocha Gontij. Severe Gestational Low-Protein Intake Impacts Hippocampal Cellularity, Tau, and Amyloid-β Levels, and Memory Performance in Male Adult Offspring: An Alzheimer-Simile Disease Model? Journal of Alzheimer's disease reports. vol 6. issue 1. 2022-03-04. PMID:35243209. |
severe gestational low-protein intake impacts hippocampal cellularity, tau, and amyloid-β levels, and memory performance in male adult offspring: an alzheimer-simile disease model? |
2022-03-04 |
2023-08-13 |
Not clear |
| Bin Qiu, Zhaohui Zhong, Shawn Righter, Yuxue Xu, Jun Wang, Ran Deng, Chao Wang, Kent E Williams, Yao-Ying Ma, Gavriil Tsechpenakis, Tiebing Liang, Weidong Yon. FKBP51 modulates hippocampal size and function in post-translational regulation of Parkin. Cellular and molecular life sciences : CMLS. vol 79. issue 3. 2022-03-04. PMID:35244772. |
ko has more flattened hippocampus using ai-assisted measurement both pyramidal cell layer (pcl) of ca and granular cell layer (gcl) of dg distinguishable as two layers: deep cell layer and superficial layer. distinct map2 expression between deep and superficial layer between ko and wt, higher parkin expression in ko brain mechanism of fkbp51 inhibition resulting in parkin, map2, tau, and tubulin expression differences between ko and wt mice, and resulting neurite outgrowth differences. |
2022-03-04 |
2023-08-13 |
mouse |
| Ping Xu, Liang Xu, Shuyun Huang, Danfeng Li, Yanping Liu, Hongmin Guo, Niuniu Dai, Zongyuan Hong, Shuzhi Zhon. Analysis of the Molecular Mechanism of Punicalagin in the Treatment of Alzheimer's Disease by Computer-Aided Drug Research Technology. ACS omega. vol 7. issue 7. 2022-02-28. PMID:35224375. |
the amyloid β protein (aβ) in the hippocampus was examined by immunohistochemistry, and the phosphorylation of serine at position 404 of the tau protein (tau-ps404) was examined by western blot in the mouse brain. |
2022-02-28 |
2023-08-13 |
mouse |
| Li-Fan Lin, Yun-Ting Jhao, Chuang-Hsin Chiu, Lu-Han Sun, Ta-Kai Chou, Chyng-Yann Shiue, Cheng-Yi Cheng, Kuo-Hsing M. Bezafibrate Exerts Neuroprotective Effects in a Rat Model of Sporadic Alzheimer's Disease. Pharmaceuticals (Basel, Switzerland). vol 15. issue 2. 2022-02-26. PMID:35215222. |
stz-icv administration induced significant cognitive impairment and substantial neuronal loss, tau pathology, glucose hypometabolism, and microgliosis in the cortex and hippocampus, while bezafibrate effectively attenuated these abnormalities. |
2022-02-26 |
2023-08-13 |
mouse |
| Tomohiro Umeda, Rumi Uekado, Keiko Shigemori, Hiroshi Eguchi, Takami Tomiyam. Nasal Rifampicin Halts the Progression of Tauopathy by Inhibiting Tau Oligomer Propagation in Alzheimer Brain Extract-Injected Mice. Biomedicines. vol 10. issue 2. 2022-02-25. PMID:35203506. |
a tau oligomer-rich fraction prepared from the brain of an ad patient was injected into a unilateral hippocampus of tau264 mice that express both 3-repeat and 4-repeat wild-type human tau. |
2022-02-25 |
2023-08-13 |
mouse |
| Sang-Seo Park, Hye-Sang Park, Chang-Ju Kim, Seung-Soo Baek, Song-Young Park, Cody Philip Anderson, Myung-Ki Kim, Ik-Ryeul Park, Tae-Woon Ki. Combined effects of Aerobic exercise and 40Hz light flicker exposure on early cognitive impairments in Alzheimer's disease of 3xTg mice. Journal of applied physiology (Bethesda, Md. : 1985). 2022-02-24. PMID:35201933. |
spatial learning and memory, long-term memory, hippocampal aβ, tau, neuroinflammation, pro-inflammatory cytokine expression, mitochondrial function, and neuroplasticity, were analyzed. |
2022-02-24 |
2023-08-13 |
mouse |
| Noorul Hasan, Saima Zameer, Abul Kalam Najmi, Suhel Parvez, Mohd Akhta. Roflumilast Reduces Pathological Symptoms of Sporadic Alzheimer's Disease in Rats Produced by Intracerebroventricular Streptozotocin by Inhibiting NF-κB/BACE-1 Mediated Aβ Production in the Hippocampus and Activating the cAMP/BDNF Signalling Pathway. Neurotoxicity research. 2022-02-22. PMID:35192144. |
rfm was found to significantly reduce icv-stz-induced neuroinflammation, amyloidogenesis, oxidative stress cholinergic impairments, gsk-3β, and phosphorylated tau levels in the rat hippocampus. |
2022-02-22 |
2023-08-13 |
rat |