| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ilie Cosmin Stancu, Chritica Lodder, Pablo Botella Lucena, Sarah Vanherle, Manuel Gutiérrez de Ravé, Dick Terwel, Astrid Bottelbergs, Ilse Dewachte. The NLRP3 inflammasome modulates tau pathology and neurodegeneration in a tauopathy model. Glia. 2022-02-17. PMID:35174546. |
we furthermore assessed the effect of nlrp3 deficiency on tau propagation and associated hippocampal atrophy. |
2022-02-17 |
2023-08-13 |
mouse |
| Ilie Cosmin Stancu, Chritica Lodder, Pablo Botella Lucena, Sarah Vanherle, Manuel Gutiérrez de Ravé, Dick Terwel, Astrid Bottelbergs, Ilse Dewachte. The NLRP3 inflammasome modulates tau pathology and neurodegeneration in a tauopathy model. Glia. 2022-02-17. PMID:35174546. |
nlrp3 deficiency significantly decreased prion-like seeding and propagation of tau pathology, reflected in decreased tau pathology in ipsi- and contralateral hippocampus and cortex in tau.nlrp3-/- following tau seeding. |
2022-02-17 |
2023-08-13 |
mouse |
| Xiao-Bo Yang, Heng-Bing Zu, Yong-Fei Zhao, Kai Ya. Agomelatine Prevents Amyloid Plaque Deposition, Tau Phosphorylation, and Neuroinflammation in APP/PS1 Mice. Frontiers in aging neuroscience. vol 13. 2022-02-14. PMID:35153715. |
in this study, we found that agomelatine attenuated spatial memory deficit, amyloid-β (aβ) deposition, tau phosphorylation, and neuroinflammation in the hippocampus of app/ps1 mice. |
2022-02-14 |
2023-08-13 |
mouse |
| Marta Scarioni, Priya Gami-Patel, Carel F W Peeters, Florianne de Koning, Harro Seelaar, Merel O Mol, John C van Swieten, Annemieke J M Rozemuller, Jeroen J M Hoozemans, Yolande A L Pijnenburg, Anke A Dijkstr. Psychiatric symptoms of frontotemporal dementia and subcortical (co-)pathology burden: new insights. Brain : a journal of neurology. 2022-02-09. PMID:35136978. |
in subcortical regions, the presence of psychiatric symptoms showed positive correlations with increased hippocampal pathology burden: hallucinations with tdp-43 in the granular layer (r = 0.33), mania with tdp-43 in ca1 (r = 0.35), depression with tdp-43 in ca3 and with parahippocampal tau (r = 0.30 and r = 0.23), and delusions with ca3 tau (r = 0.26) and subicular amyloid-beta (r = 0.25). |
2022-02-09 |
2023-08-13 |
Not clear |
| Alexander Neumann, Michelle Vangoidsenhoven, Fahri Küçükali, Stephanie J B Vos, Mara Ten Kate, Frederik Barkhof, Henrik Zetterberg, Lars Bertram, Pieter Jelle Visser, Christine Van Broeckhoven, Kristel Sleeger. Exome-wide rare variant analysis of Alzheimer's disease biomarkers: The EMIF-AD multimodal biomarker discovery study. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108853. |
we performed an exome-wide rare variant analysis of six biomarkers measured in cerebrospinal fluid (β-amyloid, total tau/phosphorylated tau, nfl, ykl-40, and neurogranin) and hippocampal volume as measured by mri. |
2022-02-03 |
2023-08-13 |
Not clear |
| Eduardo R Zimmer, Bruna Bellaver, Wagner Scheeren Brum, Pamela C L Ferreira, Guilherme Povala, Andreia Silva da Rocha, Débora Guerini de Souza, Marco Antônio De Bastian. Tau pathology reshapes GFAP-positive astrocytes phenotype. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109062. |
here, we aimed at evaluating hippocampal astrocyte phenotypes in the presence of tau pathology in a transgenic human tau mouse model. |
2022-02-03 |
2023-08-13 |
mouse |
| Eduardo R Zimmer, Bruna Bellaver, Wagner Scheeren Brum, Pamela C L Ferreira, Guilherme Povala, Andreia Silva da Rocha, Débora Guerini de Souza, Marco Antônio De Bastian. Tau pathology reshapes GFAP-positive astrocytes phenotype. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109062. |
we hypothesize that hippocampal astrocytes will respond to tau pathology by assuming a reactive phenotype. |
2022-02-03 |
2023-08-13 |
mouse |
| Sanaz Arezoumandan, Katheryn A Q Cousins, Jeffrey S Phillips, Daniel T Ohm, Claire Peterson, Ranjit Ittyerah, Corey T McMillan, David A Wolk, Paul A Yushkevich, John Q Trojanowski, Eddie B Lee, Murray Grossman, David J Irwi. Regional distribution of tau pathology in subfields of hippocampus among phenotypic variants of AD and FTLD-tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109105. |
regional distribution of tau pathology in subfields of hippocampus among phenotypic variants of ad and ftld-tau. |
2022-02-03 |
2023-08-13 |
Not clear |
| Sanaz Arezoumandan, Katheryn A Q Cousins, Jeffrey S Phillips, Daniel T Ohm, Claire Peterson, Ranjit Ittyerah, Corey T McMillan, David A Wolk, Paul A Yushkevich, John Q Trojanowski, Eddie B Lee, Murray Grossman, David J Irwi. Regional distribution of tau pathology in subfields of hippocampus among phenotypic variants of AD and FTLD-tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109105. |
moreover, previous work finds relative sparing of the hippocampal formation compared to typical amnestic ad (aad); however, there is limited data on the regional patterns of tau pathology across subfields of the hippocampus in naad or comparisons with clinically-similar non-amnestic forms of frontotemporal lobar degeneration tauopathies (ftld-tau). |
2022-02-03 |
2023-08-13 |
Not clear |
| Sanaz Arezoumandan, Katheryn A Q Cousins, Jeffrey S Phillips, Daniel T Ohm, Claire Peterson, Ranjit Ittyerah, Corey T McMillan, David A Wolk, Paul A Yushkevich, John Q Trojanowski, Eddie B Lee, Murray Grossman, David J Irwi. Regional distribution of tau pathology in subfields of hippocampus among phenotypic variants of AD and FTLD-tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109105. |
here, we perform detailed postmortem comparisons of pathologic burden within the well-established anatomic framework of spreading ad tau pathology within hippocampal subfields to test for divergent microscopic patterns of disease between non-amnestic tauopathies (naad, ftld-tau) and amnestic ad. |
2022-02-03 |
2023-08-13 |
Not clear |
| Marangelie Criado-Marrero, Lindsey B Shelton, Laura J Blai. Reduction in Aha1 chaperone preserves hippocampal neurons and prevents tau-related pathology in rTg4510 tau transgenic mice. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109351. |
reduction in aha1 chaperone preserves hippocampal neurons and prevents tau-related pathology in rtg4510 tau transgenic mice. |
2022-02-03 |
2023-08-13 |
mouse |
| Mohaddeseh Sadat Alavi, Sahar Fanoudi, Mahmoud Hosseini, Hamid R Sadeghni. Beneficial effects of levetiracetam in streptozotocin-induced rat model of Alzheimer's disease. Metabolic brain disease. 2022-01-31. PMID:35098412. |
in addition, lev suppressed stz-induced hippocampal neuronal loss, while restored alterations in the redox status (lipid peroxides and glutathione), ache activity, proinflammatory cytokines (il-1β, il-6, tnf-α), and hyperphosphorylation of tau linked to stz administration. |
2022-01-31 |
2023-08-13 |
rat |
| Mohaddeseh Sadat Alavi, Sahar Fanoudi, Mahmoud Hosseini, Hamid R Sadeghni. Beneficial effects of levetiracetam in streptozotocin-induced rat model of Alzheimer's disease. Metabolic brain disease. 2022-01-31. PMID:35098412. |
in conclusion, our study demonstrated that lev alleviated hippocampal cell death and memory deficits in stz-ad rats, through mitigating oxidative damage, suppression of proinflammatory cytokines expression, and inhibition of abnormal tau hyperphosphorylation. |
2022-01-31 |
2023-08-13 |
rat |
| Xiaoqian Peng, Li Chen, Zijuan Wang, Yingying He, John Bosco Ruganzu, Hongsong Guo, Xiao Zhang, Shengfeng Ji, Liming Zheng, Weina Yan. Tanshinone IIA regulates glycogen synthase kinase-3β-related signaling pathway and ameliorates memory impairment in APP/PS1 transgenic mice. European journal of pharmacology. 2022-01-29. PMID:35090935. |
additionally, tan iia markedly attenuated tau hyperphosphorylation and prevented neuronal loss and apoptosis in the parietal cortex and hippocampus. |
2022-01-29 |
2023-08-13 |
mouse |
| Maha A Hegazy, Doaa A Abdelmonsif, Teshreen M Zeitoun, Norhan S El-Sayed, Doaa M Sam. Swimming exercise versus L-carnosine supplementation for Alzheimer's dementia in rats: implication of circulating and hippocampal FNDC5/irisin. Journal of physiology and biochemistry. 2022-01-29. PMID:35091983. |
hippocampal tissues were used to assess expression of fndc5/irisin, bdnf and proteins related to insulin signalling, in addition to β-amyloid peptide and phosphorylated tau protein levels. |
2022-01-29 |
2023-08-13 |
rat |
| Maha A Hegazy, Doaa A Abdelmonsif, Teshreen M Zeitoun, Norhan S El-Sayed, Doaa M Sam. Swimming exercise versus L-carnosine supplementation for Alzheimer's dementia in rats: implication of circulating and hippocampal FNDC5/irisin. Journal of physiology and biochemistry. 2022-01-29. PMID:35091983. |
exercise and carnosine intake almost normalized hippocampal fndc5/irisin expression which was associated with reduced soluble β-amyloid peptide and phosphorylated tau protein, improved bdnf and insulin signalling proteins, with corresponding mitigated cognitive impairments. |
2022-01-29 |
2023-08-13 |
rat |
| Munehisa Maeshiba, Hiroshi Kajiya, Takashi Tsutsumi, Keisuke Migita, Kazuko Goto-T, Yuri Kono, Takashi Tsuzuki, Jun Ohn. Occlusal disharmony transiently decrease cognition via cognitive suppressor molecules and partially restores cognitive ability via clearance molecules. Biochemical and biophysical research communications. vol 594. 2022-01-25. PMID:35078110. |
the expression levels of amyloid-β and phosphorylated tau were significantly upregulated 1 week after hyperocclusal loading in the hippocampus of 2-month-old mice but were constant in 12-month-old mice. |
2022-01-25 |
2023-08-13 |
mouse |
| Anton Meinicke, Wolfgang Härtig, Karsten Winter, Joana Puchta, Bianca Mages, Dominik Michalski, Alexander Emmer, Markus Otto, Karl-Titus Hoffmann, Willi Reimann, Matthias Krause, Stefan Scho. Surfactant Protein-G in Wildtype and 3xTg-AD Mice: Localization in the Forebrain, Age-Dependent Hippocampal Dot-like Deposits and Brain Content. Biomolecules. vol 12. issue 1. 2022-01-21. PMID:35053244. |
exploring whether sp-g might play a role in alzheimer's disease (ad), 3xtg-ad mice were investigated and displayed age-dependent hippocampal deposits of β-amyloid and hyperphosphorylated tau separately from clustered, sp-g-containing dots with additional reelin-ir-which was used as established marker for disease progression in this specific context. |
2022-01-21 |
2023-08-13 |
mouse |
| Pol Andrés-Benito, Margarita Carmona, Mónica Jordán, Joaquín Fernández-Irigoyen, Enrique Santamaría, José Antoni Del Rio, Isidro Ferre. Host Tau Genotype Specifically Designs and Regulates Tau Seeding and Spreading and Host Tau Transformation Following Intrahippocampal Injection of Identical Tau AD Inoculum. International journal of molecular sciences. vol 23. issue 2. 2022-01-21. PMID:35054902. |
the brains of three adult murine genotypes expressing different forms of tau-wt (murine 4rtau), htau (homozygous transgenic mice knock-out for murine tau protein and heterozygous expressing human forms of 3rtau and 4rtau proteins), and mtwt (homozygous transgenic mice knock-out for murine tau protein)-were analyzed following unilateral hippocampal inoculation of sarkosyl-insoluble tau fractions from the same ad and control cases. |
2022-01-21 |
2023-08-13 |
mouse |
| Melanie Alpaugh, Maria Masnata, Aurelie de Rus Jacquet, Eva Lepinay, Hélèna L Denis, Martine Saint-Pierre, Peter Davies, Emmanuel Planel, Francesca Cicchett. Passive immunization against phosphorylated tau improves features of Huntington's disease pathology. Molecular therapy : the journal of the American Society of Gene Therapy. 2022-01-20. PMID:35051614. |
after 12 weeks of treatment, motor impairments, cognitive performance and general health were improved in zq175 mice along with a significant reduction in hippocampal ps202 tau levels. |
2022-01-20 |
2023-08-13 |
mouse |