| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xin Ren, Ya Wen, Mu Yuan, Chang Li, Jiejie Zhang, Siyu Li, Xiaowei Zhang, Liang Wang, Shan Wan. Cerebroprotein hydrolysate-I ameliorates cognitive dysfunction in APP/PS1 mice by inhibiting ferroptosis via the p53/SAT1/ALOX15 signalling pathway. European journal of pharmacology. 2024-07-20. PMID:39032765. |
ch-i significantly improved cognitive deficits and attenuated beta-amyloid (aβ) aggregation and tau phosphorylation in the hippocampus of app/ps1 mice. |
2024-07-20 |
2024-07-24 |
mouse |
| Nick Corriveau-Lecavalier, Hugo Botha, Jonathan Graff-Radford, Aaron R Switzer, Scott A Przybelski, Heather J Wiste, Melissa E Murray, Robert Ross Reichard, Dennis W Dickson, Aivi T Nguyen, Vijay K Ramanan, Stuart J McCarter, Bradley F Boeve, Mary M Machulda, Julie A Fields, Nikki H Stricker, Peter T Nelson, Michel J Grothe, David S Knopman, Val J Lowe, Ronald C Petersen, Clifford R Jack, David T Jone. Clinical criteria for a limbic-predominant amnestic neurodegenerative syndrome. Brain communications. vol 6. issue 4. 2024-07-18. PMID:39021510. |
the criteria incorporate core, standard and advanced features, including older age at evaluation, mild clinical syndrome, disproportionate hippocampal atrophy, impaired semantic memory, limbic hypometabolism, absence of neocortical degeneration and low likelihood of neocortical tau, with degrees of certainty (highest, high, moderate and low). |
2024-07-18 |
2024-07-20 |
Not clear |
| Na Zhao, Xiu Chen, Qiu-Gu Chen, Xue-Ting Liu, Fan Geng, Meng-Meng Zhu, Fu-Ling Yan, Zhi-Jun Zhang, Qing-Guo Re. NLRP3-mediated autophagy dysfunction links gut microbiota dysbiosis to tau pathology in chronic sleep deprivation. Zoological research. vol 45. issue 4. 2024-07-15. PMID:39004863. |
our findings demonstrated that chronic sd in mice not only led to cognitive decline but also induced gut microbiota dysbiosis, elevated nlrp3 inflammasome expression, gsk-3β activation, autophagy dysfunction, and tau hyperphosphorylation in the hippocampus. |
2024-07-15 |
2024-07-18 |
mouse |
| Nina Engels-Domínguez, Joost M Riphagen, Maxime Van Egroo, Elouise A Koops, Lindsay F Smegal, J Alex Becker, Prokopis C Prokopiou, Elisenda Bueichekú, Kenneth K Kwong, Dorene M Rentz, David H Salat, Reisa A Sperling, Keith A Johnson, Heidi I L Jacob. Lower Locus Coeruleus Integrity Signals Elevated Entorhinal Tau and Clinical Progression in Asymptomatic Older Individuals. Annals of neurology. 2024-07-15. PMID:39007398. |
we compared the accuracy of magnetic resonance imaging (mri)-derived locus coeruleus integrity, neocortical beta-amyloid burden by positron emission tomography (pet), and hippocampal volume in identifying elevated entorhinal tau signal in asymptomatic individuals who are considered beta-amyloid pet-negative. |
2024-07-15 |
2024-07-18 |
Not clear |
| Franca Orsini, Marco Bosica, Annacarla Martucci, Massimiliano De Paola, Davide Comolli, Rosaria Pascente, Gianluigi Forloni, Paul E Fraser, Ottavio Arancio, Luana Fiorit. SARS-CoV-2 Nucleocapsid Protein Induces Tau Pathological Changes That Can Be Counteracted by SUMO2. International journal of molecular sciences. vol 25. issue 13. 2024-07-13. PMID:39000276. |
to test this hypothesis, we investigated whether ncap interacts with tau and localizes to sgs in hippocampal neurons in vitro and in vivo. |
2024-07-13 |
2024-07-15 |
mouse |
| Franca Orsini, Marco Bosica, Annacarla Martucci, Massimiliano De Paola, Davide Comolli, Rosaria Pascente, Gianluigi Forloni, Paul E Fraser, Ottavio Arancio, Luana Fiorit. SARS-CoV-2 Nucleocapsid Protein Induces Tau Pathological Changes That Can Be Counteracted by SUMO2. International journal of molecular sciences. vol 25. issue 13. 2024-07-13. PMID:39000276. |
we also found that ncap induces hyperphosphorylation of tau and causes cognitive impairment in mice infected with ncap in their hippocampus. |
2024-07-13 |
2024-07-15 |
mouse |
| Jenni Harve. Novel Leptin-Based Therapeutic Strategies to Limit Synaptic Dysfunction in Alzheimer's Disease. International journal of molecular sciences. vol 25. issue 13. 2024-07-13. PMID:39000459. |
increasing evidence indicates that in the early pre-clinical stages of ad, phosphorylation and build-up of tau drives impairments in hippocampal excitatory synaptic function, which ultimately leads to cognitive deficits. |
2024-07-13 |
2024-07-15 |
Not clear |
| Youngnam Kang, Hiroki Toyoda, Mitsuru Sait. Search for unknown neural link between the masticatory and cognitive brain systems to clarify the involvement of its impairment in the pathogenesis of Alzheimer's disease. Frontiers in cellular neuroscience. vol 18. 2024-07-12. PMID:38994328. |
neuronal degeneration of the two neuronal nuclei leads to a decrease in neurotrophic factors such as brain-derived neurotrophic factor (bdnf) in the hippocampus and cerebral cortex, which results in the accumulation of aβ and hyperphosphorylated tau protein and ultimately causes neuronal cell death in those cortices. |
2024-07-12 |
2024-07-14 |
human |
| Michiko Terada, Kayo Mitsukawa, Masanori Nakakariya, Tatsuki Koike, Haruhide Kimur. Effects of an OX2R agonist on migration and removal of tau from mouse brain. Scientific reports. vol 14. issue 1. 2024-07-10. PMID:38987562. |
diurnal rhythm of tau release into hippocampal isf correlated well with neuronal activity and wakefulness in wild-type mice. |
2024-07-10 |
2024-07-13 |
mouse |
| Michiko Terada, Kayo Mitsukawa, Masanori Nakakariya, Tatsuki Koike, Haruhide Kimur. Effects of an OX2R agonist on migration and removal of tau from mouse brain. Scientific reports. vol 14. issue 1. 2024-07-10. PMID:38987562. |
in both wild-type and human p301s tau transgenic mice, ox-201 induced wakefulness and promoted tau release into hippocampal isf. |
2024-07-10 |
2024-07-13 |
mouse |
| Michiko Terada, Kayo Mitsukawa, Masanori Nakakariya, Tatsuki Koike, Haruhide Kimur. Effects of an OX2R agonist on migration and removal of tau from mouse brain. Scientific reports. vol 14. issue 1. 2024-07-10. PMID:38987562. |
ox-201 treatment over 2 months did not alter hippocampal tau levels. |
2024-07-10 |
2024-07-13 |
mouse |
| Paras S Minhas, Jeffrey R Jones, Amira Latif-Hernandez, Yuki Sugiura, Aarooran S Durairaj, Takeshi Uenaka, Qian Wang, Siddhita D Mhatre, Ling Liu, Travis Conley, Hannah Ennerfelt, Yoo Jin Jung, Praveena Prasad, Brenita C Jenkins, Ryan Goodman, Traci Newmeyer, Kelly Heard, Austin Kang, Edward N Wilson, Erik M Ullian, Geidy E Serrano, Thomas G Beach, Joshua D Rabinowitz, Marius Wernig, Makoto Suematsu, Frank M Longo, Melanie R McReynolds, Fred H Gage, Katrin I Andreasso. Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies. bioRxiv : the preprint server for biology. 2024-07-09. PMID:38979192. |
here, we report that inhibition of indoleamine-2,3-dioxygenase 1 (ido1), which metabolizes tryptophan to kynurenine (kyn) in the first step of the kynurenine pathway, rescues hippocampal memory function and plasticity in preclinical models of amyloid and tau pathology by restoring astrocytic metabolic support of neurons. |
2024-07-09 |
2024-07-12 |
Not clear |
| Naif H Ali, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Najah R Hadi, Abdullah A Assiri, Mohammed Alrouji, Nermeen N Welson, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batih. Hypoglycemia and Alzheimer Disease Risk: The Possible Role of Dasiglucagon. Cellular and molecular neurobiology. vol 44. issue 1. 2024-07-08. PMID:38977507. |
glucagon/glp-1 has been shown to promote synaptogenesis, hippocampal synaptic plasticity, and learning and memory, while attenuating amyloid and tau pathologies. |
2024-07-08 |
2024-07-12 |
Not clear |
| Ryszard Plut. A Look at the Etiology of Alzheimer's Disease based on the Brain Ischemia Model. Current Alzheimer research. 2024-07-04. PMID:38963100. |
studies have shown changes typical of ad in the course of brain neurodegeneration post-ischemia, i.e., progressive brain and hippocampal atrophy, increased amyloid production, and modification of tau protein. |
2024-07-04 |
2024-07-10 |
Not clear |
| Dong Kyu Kim, Kyujin Suh, Junho Park, Sang-Eun Lee, Jihui Han, Sunghoe Chang, Youngsoo Kim, Inhee Mook-Jun. FGFR3 drives Aβ-induced tau uptake. Experimental & molecular medicine. 2024-07-01. PMID:38951140. |
knockdown of fgfr3 in the hippocampus reduces tau aggregation by decreasing tau uptake and improving memory function in ad model mice. |
2024-07-01 |
2024-07-04 |
mouse |
| Mohamed Aghyad Al Kabbani, Christoph Köhler, Hans Zempe. Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice. Neural regeneration research. 2024-06-27. PMID:38934386. |
to investigate tau localization, phosphorylation, and effects on tubulin ptms, we expressed wild-type or p301l-tau in human mapt-ko induced pluripotent stem cell-derived neurons (ineurons) and studied tau in neurons in the hippocampus of mice transgenic for human p301l-tau (pr5 mice). |
2024-06-27 |
2024-06-29 |
mouse |
| Mohamed Aghyad Al Kabbani, Christoph Köhler, Hans Zempe. Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice. Neural regeneration research. 2024-06-27. PMID:38934386. |
p301l-tau-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical at8-phosphorylation of tau and increased polyglutamylation, but reduced acetylation, of microtubules compared with non-transgenic littermates. |
2024-06-27 |
2024-06-29 |
mouse |
| Bingyi Wang, Siyu Liu, Kaimin Hao, YaruWang Wang, Zongjing Li, Yuanyuan Lou, Yuan Chang, Wenxiu Q. HDAC6 modulates the cognitive behavioral function and hippocampal tissue pathological changes of APP/PS1 transgenic mice through HSP90-HSF1 pathway. Experimental brain research. 2024-06-27. PMID:38935089. |
the aim of this study was to investigate histone deacetylase 6 (hdac6) modifies the heat shock protein 90 (hsp90) and heat shock transcription factor 1 (hsf1) affect the levels of pathological markers such as aβ oligomers (aβo) and tau phosphorylation (p-tau) in app/ps1 double transgenic mice hippocampal tissues or ht22 neurons as well as the changes in cognitive behavioral functions of mice. |
2024-06-27 |
2024-06-29 |
mouse |
| Sosuke Yagishita, Megumi Shibata, Akiko Furuno, Shuji Wakatsuki, Toshiyuki Arak. Neuronal Excitation Induces Tau Protein Dephosphorylation via Protein Phosphatase 1 Activation to Promote Its Binding with Stable Microtubules. Neurology international. vol 16. issue 3. 2024-06-26. PMID:38921953. |
in an in vivo experiment, we demonstrated that the exposure of mice to a new environment activates protein phosphatase 1 in the mouse hippocampus and induces tau protein dephosphorylation. |
2024-06-26 |
2024-06-29 |
mouse |
| Mengyun Qiao, Haitao Yang, Li Liu, Tao Yu, Haihua Wang, Xiao Chen, Yi Zhang, Airu Duan, Shujun Lyu, Siyu Wu, Jingwei Xiao, Bin L. Chronic Lead Exposure in Adult Mice: Associations with miR-671/CDR1as Regulation, NF-κB Signaling, and Alzheimer's Disease-like Pathology. Toxics. vol 12. issue 6. 2024-06-26. PMID:38922090. |
at the molecular level, a significant upregulation of ad-associated genes, namely amyloid precursor protein (app), β-secretase 1 (bace1), and tau, was observed in the hippocampal tissue of pb-exposed mice. |
2024-06-26 |
2024-06-29 |
mouse |