| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kurt A Jellinge. Behavioral disorders in dementia with Lewy bodies: old and new knowledge. Journal of neural transmission (Vienna, Austria : 1996). 2024-09-05. PMID:39237792. |
early rbd in autopsy-confirmed dlb is associated with lower braak neuritic stages, whereas those without rbd has greater atrophy of hippocampus and increased tau burden. |
2024-09-05 |
2024-09-08 |
Not clear |
| Dah-Eun Chloe Chung, Xue Deng, Hari K Yalamanchili, Jean-Pierre Revelli, Alexander L Han, Bakhos Tadros, Ronald Richman, Michelle Dias, Fatemeh Alavi Naini, Steven Boeynaems, Bradley T Hyman, Huda Y Zoghb. The big tau splice isoform resists Alzheimer's-related pathological changes. bioRxiv : the preprint server for biology. 2024-08-30. PMID:39211086. |
in alzheimer's disease (ad), the microtubule-binding protein tau becomes abnormally hyperphosphorylated and aggregated in selective brain regions such as the cortex and hippocampus |
2024-08-30 |
2024-09-04 |
Not clear |
| J A Noche, C Vanderlip, S Wright, L Sordo, E Head, Cel Star. Myo-inositol and total NAA in the hippocampus are linked to CSF tau pathology in cognitively normal older adults. bioRxiv : the preprint server for biology. 2024-08-30. PMID:39211099. |
myo-inositol and total naa in the hippocampus are linked to csf tau pathology in cognitively normal older adults. |
2024-08-30 |
2024-09-04 |
Not clear |
| Jeremiah Pfitzer, Priyanka D Pinky, Savannah Perman, Emma Redmon, Luca Cmelak, Vishnu Suppiramaniam, Vladimir Coric, Irfan A Qureshi, Michael W Gramlich, Miranda N Ree. Troriluzole rescues glutamatergic deficits, amyloid and tau pathology, and synaptic and memory impairments in 3xTg-AD mice. Journal of neurochemistry. 2024-08-30. PMID:39214859. |
we observed that 3xtg hippocampal cultures exhibited increased vglut1 associated with an increase in glutamate release, similar to prior observations in cultures from tau mouse models. |
2024-08-30 |
2024-09-04 |
mouse |
| Itaru Nishida, Kaoru Yamada, Asami Sakamoto, Tomoko Wakabayashi, Takeshi Iwatsub. Chronic Neuronal Hyperexcitation Exacerbates Tau Propagation in a Mouse Model of Tauopathy. International journal of molecular sciences. vol 25. issue 16. 2024-08-29. PMID:39201689. |
in this study, we investigated how tau propagation from the entorhinal cortex to the hippocampus, the neuronal circuit most susceptible to tau pathology in ad, is affected by the selective stimulation of neuronal activity along this circuit. |
2024-08-29 |
2024-09-04 |
mouse |
| Itaru Nishida, Kaoru Yamada, Asami Sakamoto, Tomoko Wakabayashi, Takeshi Iwatsub. Chronic Neuronal Hyperexcitation Exacerbates Tau Propagation in a Mouse Model of Tauopathy. International journal of molecular sciences. vol 25. issue 16. 2024-08-29. PMID:39201689. |
using a mouse model of seed-induced propagation combined with optogenetics, we found that the chronic stimulation of this neuronal connection over a 4-week period resulted in a significant increase in insoluble tau accumulation in both the entorhinal cortex and hippocampus. |
2024-08-29 |
2024-09-04 |
mouse |
| Itaru Nishida, Kaoru Yamada, Asami Sakamoto, Tomoko Wakabayashi, Takeshi Iwatsub. Chronic Neuronal Hyperexcitation Exacerbates Tau Propagation in a Mouse Model of Tauopathy. International journal of molecular sciences. vol 25. issue 16. 2024-08-29. PMID:39201689. |
importantly, the ratio of tau accumulation in the hippocampus relative to that in the entorhinal cortex, serving as an indicator of transcellular spreading, was significantly higher in mice subjected to chronic stimulation. |
2024-08-29 |
2024-09-04 |
mouse |
| Michela Marcatti, Batbayar Tumurbaatar, Michela Borghi, Jutatip Guptarak, Wen-Ru Zhang, Balaji Krishnan, Rakez Kayed, Anna Fracassi, Giulio Taglialatel. Inhibition of Calcineurin with FK506 Reduces Tau Levels and Attenuates Synaptic Impairment Driven by Tau Oligomers in the Hippocampus of Male Mouse Models. International journal of molecular sciences. vol 25. issue 16. 2024-08-29. PMID:39201779. |
inhibition of calcineurin with fk506 reduces tau levels and attenuates synaptic impairment driven by tau oligomers in the hippocampus of male mouse models. |
2024-08-29 |
2024-09-04 |
mouse |
| Cencan Xing, Xiaoshuang Zhang, Donghui Wang, Hongyu Chen, Xiaoyu Gao, Chunbin Sun, Wenhua Guo, Shah Roshan, Yingxian Li, Zhongci Hang, Shanglin Cai, Tong Lei, Wangyu Bi, Liangxuan Hou, Luping Li, Yawen Wu, Liang Li, Zehua Zeng, Hongwu D. Neuroprotective effects of mesenchymal stromal cells in mouse models of Alzheimer's Disease: The Mediating role of gut microbes and their metabolites via the Microbiome-Gut-Brain axis. Brain, behavior, and immunity. 2024-08-27. PMID:39191350. |
in comparison to saline control, mscs administration resulted in a significant reduction of behavioral disturbances, amyloid plaques, and phosphorylated tau in the hippocampus and frontal cortex, accompanied by an increase in neuronal count and nissl body density across ad-afflicted brain regions. |
2024-08-27 |
2024-08-30 |
mouse |
| Rui Chen, Chi Pan, Xinyu Mao, Yantong Zhang, Gang Chen, Mengting Xu, John Nivar, Yuanxiang Tao, Hong Cao, Jun L. Chloride intracellular channel 4 blockade improves cognition in mice with Alzheimer's disease: CLIC4 protein expression and tau protein hyperphosphorylation. International journal of biological macromolecules. 2024-08-24. PMID:39181373. |
in the present study, we showed that clic4 expression was elevated in the hippocampus of ad mice; knockdown of hippocampal clic4 alleviated aβ25-35-induced cognitive impairment in mice; overexpression of hippocampal clic4 accelerated aβ deposition and tau protein hyperphosphorylation in young ad mice (app/ps1 mice at three months of age). |
2024-08-24 |
2024-08-28 |
mouse |
| Jingjing Liu, Zhimin Zhang, Shiyin Zhong, Xin Zhang, Jirui Yang, Qiongli Zhou, Diya Wang, Xuhong Chang, Hui Wan. Fecal microbiome transplantation alleviates manganese-induced neurotoxicity by altering the composition and function of the gut microbiota via the cGAS-STING/NLRP3 pathway. The Science of the total environment. 2024-08-22. PMID:39173756. |
the results showed that the levels of tau, p-tau and aβ in the hippocampus of c57bl/6 mice were greater than those in the hippocampus of control mice after 5 weeks of continuous exposure to manganese chloride (mn content of 200 mg/l). |
2024-08-22 |
2024-08-25 |
mouse |
| Tyler R Bell, Carol E Franz, Kelsey R Thomas, Mc Kenna E Williams, Lisa T Eyler, Imanuel Lerman, Christine Fennema-Notestine, Olivia K Puckett, Stephen M Dorros, Matthew S Panizzon, Rahul C Pearce, Donald J Hagler, Michael J Lyons, Jeremy A Elman, William S Kreme. Elevated C-Reactive Protein in Older Men with Chronic Pain: Association with Plasma Amyloid Levels and Hippocampal Volume. The journals of gerontology. Series A, Biological sciences and medical sciences. 2024-08-22. PMID:39169831. |
chronic pain leads to tau accumulation and hippocampal atrophy, which may be moderated through inflammation. |
2024-08-22 |
2024-08-24 |
Not clear |
| Paras S Minhas, Jeffrey R Jones, Amira Latif-Hernandez, Yuki Sugiura, Aarooran S Durairaj, Qian Wang, Siddhita D Mhatre, Takeshi Uenaka, Joshua Crapser, Travis Conley, Hannah Ennerfelt, Yoo Jin Jung, Ling Liu, Praveena Prasad, Brenita C Jenkins, Yeonglong Albert Ay, Matthew Matrongolo, Ryan Goodman, Traci Newmeyer, Kelly Heard, Austin Kang, Edward N Wilson, Tao Yang, Erik M Ullian, Geidy E Serrano, Thomas G Beach, Marius Wernig, Joshua D Rabinowitz, Makoto Suematsu, Frank M Longo, Melanie R McReynolds, Fred H Gage, Katrin I Andreasso. Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies. Science (New York, N.Y.). vol 385. issue 6711. 2024-08-22. PMID:39172838. |
in amyloid and tau models, ido1 inhibition improves hippocampal glucose metabolism and rescues hippocampal long-term potentiation in a monocarboxylate transporter-dependent manner. |
2024-08-22 |
2024-08-25 |
mouse |
| Sushil Mahata, Suborno Jati, Daniel Munoz-Mayorga, Shandy Shahabi, Kechun Tang, Yuren Tao, Dennis Dickson, Irene Litvan, Gourisankar Ghosh, Xu Che. Chromogranin A Deficiency Attenuates Tauopathy by Altering Epinephrine-Alpha-Adrenergic Receptor Signaling. Research square. 2024-08-16. PMID:39149499. |
treatment of hippocampal slices with epi or adra1 agonist intensified, while an adra1 antagonist inhibited tau hyperphosphorylation and aggregation. |
2024-08-16 |
2024-08-18 |
mouse |
| Yucai Ye, Chaojing Fu, Yan Li, Junli Sun, Xinru Li, Shifan Chai, Shuo Li, Meng Hou, Hongyan Cai, Meina Wu, Zhaojun Wan. Alternate-day fasting improves cognitive and brain energy deficits by promoting ketone metabolism in the 3xTg mouse model of Alzheimer's disease. Experimental neurology. 2024-08-14. PMID:39142368. |
we found that adf increased circulating βohb concentrations in 3xtg mice, improved cognitive function, reduced anxiety-like behaviors, improved hippocampal synaptic plasticity, and reduced neuronal loss, aβ oligomers and tau hyperphosphorylation. |
2024-08-14 |
2024-08-17 |
mouse |
| Congcong Liu, Lanxia Meng, Yan Gao, Jiehui Chen, Min Zhu, Min Xiong, Tingting Xiao, Xiaoling Gu, Chaoyang Liu, Tao Li, Zhentao Zhan. PM2.5 triggers tau aggregation in a mouse model of tauopathy. JCI insight. vol 9. issue 14. 2024-08-12. PMID:39133647. |
injection of pm2.5-induced tau preformed fibrils (pffs) into the hippocampus of tau p301s transgenic mice promoted the aggregation of tau and induced cognitive deficits and synaptic dysfunction. |
2024-08-12 |
2024-08-16 |
mouse |
| Tourandokht Baluchnejadmojarad, Mehrdad Roghan. Exploring the molecular mechanisms underlying neuroprotective effect of ellagic acid in okadaic acid-induced Alzheimer's phenotype. Metabolic brain disease. 2024-08-12. PMID:39133454. |
additionally, ellagic acid diminished hippocampal changes of malondialdehyde (mda), protein carbonyl, reactive oxygen species (ros), glutathione (gsh), glutathione peroxidase, superoxide dismutase (sod), apoptotic factors caspases 1 and 3, tumor necrosis factor α (tnfα), and acetylcholinesterase (ache) and beta secretase 1 (bace 1) besides reversal of amp-activated protein kinase (ampk) and hyperphosphorylated tau (p-tau). |
2024-08-12 |
2024-08-14 |
rat |
| Chin-Feng Liu, Zong-Yang Young, Tsung-Wei Shih, Tzu-Ming Pan, Chun-Lin Le. Lactocaseibacillus-deglycosylated isoflavones prevent Aβ 40-induced Alzheimer's disease in a rat model. AMB Express. vol 14. issue 1. 2024-08-06. PMID:39105988. |
mechanisms of actions include the inhibition of oxidative inflammation; reduction in the expression of risk factors for tau protein and apo e protein production, the deposition of aβ40 around the hippocampus, and the expression of tlr-2 and rage proteins in astrocytes and microglia; and improvement in the memory and learning ability. |
2024-08-06 |
2024-08-08 |
rat |
| Youbin Kim, Shin-Hyeon Ryu, Junho Hyun, Young-Sin Cho, Yong-Keun Jun. TLR2 immunotherapy suppresses neuroinflammation, tau spread, and memory loss in rTg4510 mice. Brain, behavior, and immunity. 2024-08-04. PMID:39098437. |
tlr2 further mediated the tau-induced microglial activation and promoted tau uptake into neurons in neuron-microglia co-culture system and in mouse hippocampus after intracranial tau injection. |
2024-08-04 |
2024-08-07 |
mouse |
| RETRACTION: Hippocampus of Ames Dwarf Mice is Resistant to β-Amyloid-Induced Tau Hyperphosphorylation and Changes in Apoptosis-Regulatory Protein Levels. Hippocampus. 2024-08-02. PMID:39091102. |
retraction: hippocampus of ames dwarf mice is resistant to β-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels. |
2024-08-02 |
2024-08-05 |
mouse |