| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katie Bretland, Li Lin, Sarah J Terrill, Christine M Dengler-Cris. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751480. |
previously, our group showed that the neuroprotective exercise hormone irisin-a known αvβ integrin modulator, prevented age-related increases in phosphorylated tau and inflammation in hippocampus of presymptomatic-age female but not male htau tauopathy-model mice (bretland et al., 2021). |
2025-01-03 |
2025-01-05 |
mouse |
| Adel Salari, Mehrdad Roghani, Mohsen Khalil. HMG-CoA reductase inhibitor simvastatin ameliorates trimethyltin neurotoxicity and cognitive impairment through reversal of Alzheimer's-associated markers. Metabolic brain disease. vol 40. issue 1. 2024-12-20. PMID:39704877. |
in addition, hippocampal inflammatory, oxidative, and apoptotic factors were attenuated besides reduction of acetylcholinesterase (ache) activity and alzheimer's pathology factors including presenilin-1 and hyperphorphorylated tau (p-tau) upon simvastatin. |
2024-12-20 |
2024-12-22 |
rat |
| Zhihong Hu, Yan Shen, Yuanyuan Liu, Sanqiang L. The impact of sodium nitrite and intermittent fasting on neurofilament and tau protein phosphorylation, and spatial learning in rat hippocampus. Experimental brain research. vol 243. issue 1. 2024-12-19. PMID:39699656. |
the impact of sodium nitrite and intermittent fasting on neurofilament and tau protein phosphorylation, and spatial learning in rat hippocampus. |
2024-12-19 |
2024-12-21 |
rat |
| Shrinath Kadamangudi, Michela Marcatti, Wen-Ru Zhang, Anna Fracassi, Rakez Kayed, Agenor Limon, Giulio Taglialatel. Amyloid-β oligomers increase the binding and internalization of tau oligomers in human synapses. Acta neuropathologica. vol 149. issue 1. 2024-12-17. PMID:39688618. |
brain-derived tau oligomers (bdto) from ad and part pbs-soluble hippocampal fractions were co-immunoprecipitated and analyzed via mass spectrometry to compare synaptic tauo interactomes in primary and secondary tauopathies, thereby inferring the role of aβ. |
2024-12-17 |
2024-12-21 |
human |
| Klara Gawor, Sandra O Tomé, Rik Vandenberghe, Philip Van Damme, Mathieu Vandenbulcke, Markus Otto, Christine A F von Arnim, Estifanos Ghebremedhin, Alicja Ronisz, Simona Ospitalieri, Matthew Blaschko, Dietmar Rudolf Tha. Amygdala-predominant α-synuclein pathology is associated with exacerbated hippocampal neuron loss in Alzheimer's disease. Brain communications. vol 6. issue 6. 2024-12-11. PMID:39659977. |
we observed colocalization of tdp-43, aggregated α-synuclein and hyperphosphorylated tau in cytoplasmic inclusions within hippocampal and amygdala neurons of alzheimer's disease cases. |
2024-12-11 |
2024-12-13 |
Not clear |
| Klara Gawor, Sandra O Tomé, Rik Vandenberghe, Philip Van Damme, Mathieu Vandenbulcke, Markus Otto, Christine A F von Arnim, Estifanos Ghebremedhin, Alicja Ronisz, Simona Ospitalieri, Matthew Blaschko, Dietmar Rudolf Tha. Amygdala-predominant α-synuclein pathology is associated with exacerbated hippocampal neuron loss in Alzheimer's disease. Brain communications. vol 6. issue 6. 2024-12-11. PMID:39659977. |
path analysis modelling suggests that the relationship between amygdala-predominant α-synuclein pathology and ca1 neuron loss is partially mediated by hippocampal tau and tdp-43 aggregates. |
2024-12-11 |
2024-12-13 |
Not clear |
| Klara Gawor, Sandra O Tomé, Rik Vandenberghe, Philip Van Damme, Mathieu Vandenbulcke, Markus Otto, Christine A F von Arnim, Estifanos Ghebremedhin, Alicja Ronisz, Simona Ospitalieri, Matthew Blaschko, Dietmar Rudolf Tha. Amygdala-predominant α-synuclein pathology is associated with exacerbated hippocampal neuron loss in Alzheimer's disease. Brain communications. vol 6. issue 6. 2024-12-11. PMID:39659977. |
our findings suggest that alzheimer's disease cases with amygdala-predominant α-synuclein pathology may constitute a distinct group with more severe hippocampal damage, a higher tdp-43 burden and potential interactions among α-synuclein, tdp-43 and hyperphosphorylated tau. |
2024-12-11 |
2024-12-13 |
Not clear |
| Toru Tanaka, Sachiyo Ohashi, Akihiko Takashima, Shunsuke Kobayash. Effect of calcium ions on the aggregation of highly phosphorylated tau. Biochemistry and biophysics reports. vol 40. 2024-12-10. PMID:39655264. |
we further found that sarkosyl-insoluble phosphorylated tau was increased in cultured hippocampal neurons due to glutamate-induced hyperactivity. |
2024-12-10 |
2024-12-12 |
Not clear |
| Jacob Ziontz, Theresa M Harrison, Corrina Fonseca, Joseph Giorgio, Feng Han, JiaQie Lee, William J Jagus. Connectivity, Pathology, and ApoE4 Interactions Predict Longitudinal Tau Spatial Progression and Memory. Human brain mapping. vol 45. issue 17. 2024-12-09. PMID:39651679. |
we examined how baseline tau pet, aβ pet, and apoe4 genotype status interact with rsfc between hippocampus and these downstream regions to predict rate of tau accumulation in neocortex. |
2024-12-09 |
2024-12-12 |
Not clear |
| Sookhee Bang, Jeong Kuen Song, Kwan Hee Le. Hyperphosphorylated tau targeting human serum albumin Fusion protein as therapeutics for Alzheimer's diseases. IBRO neuroscience reports. vol 17. 2024-12-05. PMID:39634029. |
the hippocampal region has been a major focus of ad research because the deposits of phosphorylated tau protein in these regions are correlated with early memory deficits. |
2024-12-05 |
2024-12-07 |
mouse |
| Etienne Aumont, Marc-André Bedard, Aurélie Bussy, Jaime Fernandez Arias, Cecile Tissot, Brandon J Hall, Joseph Therriault, Nesrine Rahmouni, Jenna Stevenson, Stijn Servaes, Arthur C Macedo, Paolo Vitali, Nina Margherita Poltronetti, Olga Fliaguine, Lydia Trudel, Serge Gauthier, Mallar M Chakravarty, Pedro Rosa-Net. Hippocampal atrophy over two years in relation to tau, amyloid-β and memory in older adults. Neurobiology of aging. vol 146. 2024-12-04. PMID:39631245. |
hippocampal atrophy over two years in relation to tau, amyloid-β and memory in older adults. |
2024-12-04 |
2024-12-07 |
human |
| Etienne Aumont, Marc-André Bedard, Aurélie Bussy, Jaime Fernandez Arias, Cecile Tissot, Brandon J Hall, Joseph Therriault, Nesrine Rahmouni, Jenna Stevenson, Stijn Servaes, Arthur C Macedo, Paolo Vitali, Nina Margherita Poltronetti, Olga Fliaguine, Lydia Trudel, Serge Gauthier, Mallar M Chakravarty, Pedro Rosa-Net. Hippocampal atrophy over two years in relation to tau, amyloid-β and memory in older adults. Neurobiology of aging. vol 146. 2024-12-04. PMID:39631245. |
in this longitudinal brain imaging study, we aimed to characterize hippocampal tau accumulation and subfield atrophy relative to cortical amyloid-β and memory performance. |
2024-12-04 |
2024-12-07 |
human |
| Etienne Aumont, Marc-André Bedard, Aurélie Bussy, Jaime Fernandez Arias, Cecile Tissot, Brandon J Hall, Joseph Therriault, Nesrine Rahmouni, Jenna Stevenson, Stijn Servaes, Arthur C Macedo, Paolo Vitali, Nina Margherita Poltronetti, Olga Fliaguine, Lydia Trudel, Serge Gauthier, Mallar M Chakravarty, Pedro Rosa-Net. Hippocampal atrophy over two years in relation to tau, amyloid-β and memory in older adults. Neurobiology of aging. vol 146. 2024-12-04. PMID:39631245. |
longitudinal hippocampal tau accumulation is amyloid-β-independent and co-localized with subfield atrophy. |
2024-12-04 |
2024-12-07 |
human |
| CORRECTION to "RETRACTION: Hippocampus of Ames Dwarf Mice is Resistant to β-Amyloid-Induced Tau Hyperphosphorylation and Changes in Apoptosis-Regulatory Protein Levels". Hippocampus. 2024-11-26. PMID:39587971. |
correction to "retraction: hippocampus of ames dwarf mice is resistant to β-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels". |
2024-11-26 |
2024-11-28 |
mouse |
| Vanessa Alexandre-Silva, Beatriz Soares-Silva, Gabrielle Christine Pereira, Ana Claúdia Custódio-Silva, Patrícia Santos Carvalhinho-Lopes, Luciana Oliveira Taliano, Rafael Herling Lambertucci, Marcelo Duarte Cavalcante, Adriano Antunes de Souza Araújo, Lucindo Quintans-Júnior, José Ronaldo Dos Santos, Alessandra Mussi Ribeir. Eplingiella fruticosa leaf essential oil complexed with β-cyclodextrin exerts a neuroprotective effect in an Alzheimer's disease animal model induced by Streptozotocin. Metabolic brain disease. vol 40. issue 1. 2024-11-23. PMID:39579243. |
stz-treated rats showed memory deficits and anhedonia, accompanied by increased aβ, tau, and il-1β immunoreactivity in the olfactory bulb, cortex, hippocampus, and increased tbars levels in the hippocampus. |
2024-11-23 |
2024-11-26 |
rat |
| Vanessa Alexandre-Silva, Beatriz Soares-Silva, Gabrielle Christine Pereira, Ana Claúdia Custódio-Silva, Patrícia Santos Carvalhinho-Lopes, Luciana Oliveira Taliano, Rafael Herling Lambertucci, Marcelo Duarte Cavalcante, Adriano Antunes de Souza Araújo, Lucindo Quintans-Júnior, José Ronaldo Dos Santos, Alessandra Mussi Ribeir. Eplingiella fruticosa leaf essential oil complexed with β-cyclodextrin exerts a neuroprotective effect in an Alzheimer's disease animal model induced by Streptozotocin. Metabolic brain disease. vol 40. issue 1. 2024-11-23. PMID:39579243. |
additionally, ef treatment decreased aβ, tau, and il-1β immunoreactivity in the olfactory bulb, hippocampus and cortex (p < 0.05), and reduced tbars levels (p = 0.04) and total oxidant status in the hippocampus (p = 0.03), and increased total antioxidant status in the cortex (p = 0.04). |
2024-11-23 |
2024-11-26 |
rat |
| Marisa Denkinger, Suzanne Baker, Theresa M Harrison, Trevor Chadwick, William J Jagus. Cross-sectional and longitudinal relationships among blood-brain barrier disruption, Alzheimer's disease biomarkers, and cognition in cognitively normal older adults. Neurobiology of aging. vol 146. 2024-11-21. PMID:39571410. |
we found that greater bbbd in the hippocampus (hc) and an averaged bbbd-susceptible roi were linked to worse episodic memory, with interactions between bbbd and atrophy influencing this relationship, independent of aβ and tau. |
2024-11-21 |
2024-11-24 |
human |
| Isabel H Salas, Adrien Paumier, Tao Tao, Aksinya Derevyanko, Corey Switzler, Jillybeth Burgado, Melia Movsesian, Setareh Metanat, Trinity Dawoodtabar, Quinn Asbell, Arash Fassihi, Nicola J Alle. Astrocyte transcriptomic analysis identifies glypican 5 downregulation as a contributor to synaptic dysfunction in Alzheimer's disease models. bioRxiv : the preprint server for biology. 2024-11-18. PMID:39554197. |
to understand if synapse-supportive functions of astrocytes are altered in ad, we used astrocyte bactrap mice to generate a comprehensive dataset of hippocampal astrocyte transcriptional alterations in two mouse models of alzheimer's pathology (appswe/ps1de9 and tau p301s), characterizing sex and age-dependent changes. |
2024-11-18 |
2024-11-22 |
mouse |
| Khushboo Govind Faldu, Jigna Samir Sha. Ambroxol Improves Amyloidogenic, NF-κB, and Nrf2 Pathways in a Scopolamine-Induced Cognitive Impairment Rat Model of Alzheimer's Disease. Drug development research. vol 85. issue 7. 2024-11-13. PMID:39533780. |
analyses were carried out on ad pathological markers [amyloid beta peptide 1-40, amyloid beta peptide 1-42, acetylcholinesterase, beta-secretase 1 (bace1), total tau, and p-tau], inflammatory markers [nf-κb, tumor necrosis factor alpha (tnf-α), interleukin 6 (il-6), and interferon γ], antioxidant markers (nrf2 and heme oxygenase 1 (ho-1)], along with synaptophysin and glial fibrillary acidic protein (gfap) immunohistochemistry and histopathological assessment of the hippocampus. |
2024-11-13 |
2024-11-17 |
rat |
| Paula Merino-Serrais, José Miguel Soria, Cristina Aguirre Arrabal, Alfonso Ortigado-López, María Ángeles García Esparza, Alberto Muñoz, Félix Hernández, Jesús Ávila, Javier DeFelipe, Gonzalo León-Espinos. Protein tau phosphorylation in the proline rich region and its implication in the progression of Alzheimer's disease. Experimental neurology. 2024-11-10. PMID:39522802. |
in this study, we employed immunocytochemistry assays on hippocampal sections from ad cases and from tauopathy cases (braak stage iii) with no evidence of cognitive decline, and the p301s mouse model to investigate the colocalization patterns of tau phosphorylated (p) at specific residues (s202-t205, s214, and t231) within the proline-rich region. |
2024-11-10 |
2024-11-17 |
mouse |