Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Marisa Denkinger, Suzanne Baker, Theresa M Harrison, Trevor Chadwick, William J Jagus. Cross-sectional and longitudinal relationships among blood-brain barrier disruption, Alzheimer's disease biomarkers, and cognition in cognitively normal older adults. Neurobiology of aging. vol 146. 2024-11-21. PMID:39571410. |
we found that greater bbbd in the hippocampus (hc) and an averaged bbbd-susceptible roi were linked to worse episodic memory, with interactions between bbbd and atrophy influencing this relationship, independent of aβ and tau. |
2024-11-21 |
2024-11-24 |
human |
Isabel H Salas, Adrien Paumier, Tao Tao, Aksinya Derevyanko, Corey Switzler, Jillybeth Burgado, Melia Movsesian, Setareh Metanat, Trinity Dawoodtabar, Quinn Asbell, Arash Fassihi, Nicola J Alle. Astrocyte transcriptomic analysis identifies glypican 5 downregulation as a contributor to synaptic dysfunction in Alzheimer's disease models. bioRxiv : the preprint server for biology. 2024-11-18. PMID:39554197. |
to understand if synapse-supportive functions of astrocytes are altered in ad, we used astrocyte bactrap mice to generate a comprehensive dataset of hippocampal astrocyte transcriptional alterations in two mouse models of alzheimer's pathology (appswe/ps1de9 and tau p301s), characterizing sex and age-dependent changes. |
2024-11-18 |
2024-11-22 |
mouse |
Khushboo Govind Faldu, Jigna Samir Sha. Ambroxol Improves Amyloidogenic, NF-κB, and Nrf2 Pathways in a Scopolamine-Induced Cognitive Impairment Rat Model of Alzheimer's Disease. Drug development research. vol 85. issue 7. 2024-11-13. PMID:39533780. |
analyses were carried out on ad pathological markers [amyloid beta peptide 1-40, amyloid beta peptide 1-42, acetylcholinesterase, beta-secretase 1 (bace1), total tau, and p-tau], inflammatory markers [nf-κb, tumor necrosis factor alpha (tnf-α), interleukin 6 (il-6), and interferon γ], antioxidant markers (nrf2 and heme oxygenase 1 (ho-1)], along with synaptophysin and glial fibrillary acidic protein (gfap) immunohistochemistry and histopathological assessment of the hippocampus. |
2024-11-13 |
2024-11-17 |
rat |
Paula Merino-Serrais, José Miguel Soria, Cristina Aguirre Arrabal, Alfonso Ortigado-López, María Ángeles García Esparza, Alberto Muñoz, Félix Hernández, Jesús Ávila, Javier DeFelipe, Gonzalo León-Espinos. Protein tau phosphorylation in the proline rich region and its implication in the progression of Alzheimer's disease. Experimental neurology. 2024-11-10. PMID:39522802. |
in this study, we employed immunocytochemistry assays on hippocampal sections from ad cases and from tauopathy cases (braak stage iii) with no evidence of cognitive decline, and the p301s mouse model to investigate the colocalization patterns of tau phosphorylated (p) at specific residues (s202-t205, s214, and t231) within the proline-rich region. |
2024-11-10 |
2024-11-17 |
mouse |
Paula Merino-Serrais, José Miguel Soria, Cristina Aguirre Arrabal, Alfonso Ortigado-López, María Ángeles García Esparza, Alberto Muñoz, Félix Hernández, Jesús Ávila, Javier DeFelipe, Gonzalo León-Espinos. Protein tau phosphorylation in the proline rich region and its implication in the progression of Alzheimer's disease. Experimental neurology. 2024-11-10. PMID:39522802. |
our results show pyramidal neurons in the hippocampus of p301s mice in which tau is intensely phosphorylated at residues s202 and t205 (recognized by the at8 antibody), but with no detectable phosphorylation at s214 or t231. |
2024-11-10 |
2024-11-17 |
mouse |
Christopher Armstrong, Dan Luo, Anna Gretzinger, Deepti Pandey, Andrew Lipchik, Sokol V Todi, Aloke K Dutt. Novel Piperazine Based Compounds Target Alzheimer's Disease Relevant Amyloid β42 and Tau Derived Peptide AcPHF6, and the Lead Molecule Increases Viability in the Flies Expressing Human Tau Protein. ACS chemical neuroscience. vol 15. issue 21. 2024-11-06. PMID:39501783. |
the aggregation of amyloid β (senile plaques) and tau tangles (nfts) results in the death of neurons in the cortex and hippocampus, which manifests itself in cognitive decline and memory loss. |
2024-11-06 |
2024-11-08 |
human |
Yu-Han Chen, Zhi-Bo Wang, Xi-Peng Liu, Zhi-Qi Ma. Elevated serum sodium is linked to increased amyloid-dependent tau pathology, neurodegeneration, and cognitive impairment in Alzheimer's disease. Journal of neurochemistry. 2024-11-06. PMID:39503608. |
individuals with high serum sodium exhibited higher tau pathology, lower hippocampal volume, and more severe cognitive decline per unit increase in amyloid pet compared to those with low serum sodium (all p < 0.05). |
2024-11-06 |
2024-11-08 |
human |
Lindsay A Welikovitch, Anastasie Mate de Gerando, Anita Khasnavis, Harshil Bhavsar, Jonah C Meltzer, Luc Buée, Lori B Chibnik, Thierry Bussiere, Bradley T Hyma. Tau, synapse loss and gliosis progress in an Alzheimer's mouse model after amyloid-β immunotherapy. Brain : a journal of neurology. 2024-11-06. PMID:39504519. |
we developed a transgenic mouse model, app/ps1xtau22, with progressive cortical aβ deposition and hippocampal tau neurofibrillary inclusions to investigate how both neuropathologies act jointly to bring about neural degeneration, synapse loss, and glial phenotypes. |
2024-11-06 |
2024-11-09 |
mouse |
Masahiro Wakita, Hiroaki Yaguchi, Mika Otuski, Satoshi Tanikawa, Yasuo Miki, Ikuko Aiba, Mari Yoshida, Taichi Nomura, Hisashi Uwatoko, Yasunori Mito, Kazuyoshi Sinpo, Takeshi Ikeuchi, Shinya Tanaka, Koichi Wakabayashi, Ichiro Yab. Pathological study of progressive supranuclear palsy the cases with mutations in Bassoon. Neuropathology : official journal of the Japanese Society of Neuropathology. 2024-10-31. PMID:39478416. |
most neurons were immunopositive for four-repeat tau, whereas only a few of them harbored three-repeat tau-positive nfts in the hippocampus. |
2024-10-31 |
2024-11-02 |
Not clear |
Veronika Kulik, Melissa K Edler, Mary Ann Raghanti, Aminu Imam, Chet C Sherwoo. Amyloid-Beta, Tau, and Microglial Activation in Aged Felid Brains. The Journal of comparative neurology. vol 532. issue 11. 2024-10-30. PMID:39474737. |
we performed immunohistochemistry to detect aβ40 and aβ42 in plaques and vessels and hyperphosphorylated tau in the temporal lobe gyrus sylvius and in the ca1 and ca3 subfields of the hippocampus. |
2024-10-30 |
2024-11-02 |
Not clear |
Veronika Kulik, Melissa K Edler, Mary Ann Raghanti, Aminu Imam, Chet C Sherwoo. Amyloid-Beta, Tau, and Microglial Activation in Aged Felid Brains. The Journal of comparative neurology. vol 532. issue 11. 2024-10-30. PMID:39474737. |
although all individuals showed some degree of aβ40 and/or aβ42 immunoreactivity, only the cheetahs and clouded leopards exhibited intraneuronal hyperphosphorylated tau (i.e., pretangles), which was more common in the hippocampus. |
2024-10-30 |
2024-11-02 |
Not clear |
Javier Sanchez-Martinez, Patricio Solis-Urra, Jorge Olivares-Arancibia, Julio Plaza-Dia. Physical Exercise and Mechanism Related to Alzheimer's Disease: Is Gut-Brain Axis Involved? Brain sciences. vol 14. issue 10. 2024-10-26. PMID:39451988. |
alzheimer's disease is a progressive neurodegenerative disease characterized by structural changes in the brain, including hippocampal atrophy, cortical thinning, amyloid plaques, and tau tangles. |
2024-10-26 |
2024-10-28 |
Not clear |
Sang-Eun Lee, Soomin Park, Rian Kang, Taehoon Lee, Won Jong Yu, Sunghoe Chang, Jong-Chan Par. Hippocampal tau-induced GRIN3A deficiency in Alzheimer's disease. FEBS open bio. 2024-10-13. PMID:39396906. |
since there is no direct evidence of interaction between tauopathy and these genes in ad, further transcriptomic data (gse125957, gse56772) from tau transgenic mice and experimental validations through primary rat hippocampal neurons and induced pluripotent stem cell (ipsc)-derived brain organoids were performed. |
2024-10-13 |
2024-10-16 |
mouse |
Khadga Raj Aran, G D Gupta, Shamsher Sing. Retraction notice to "Cladribine induces apoptosis, neuroinflammation, mitochondrial oxidative stress, tau phosphorylation and Aβ (1-42) pathway in the hippocampus: An in vivo approach" [J. Chem. Neuroanat. 133 (2023) 102340]. Journal of chemical neuroanatomy. 2024-10-10. PMID:39389808. |
retraction notice to "cladribine induces apoptosis, neuroinflammation, mitochondrial oxidative stress, tau phosphorylation and aβ (1-42) pathway in the hippocampus: an in vivo approach" [j. chem. |
2024-10-10 |
2024-10-13 |
Not clear |
Tomas Kavanagh, Kaleah Balcomb, Diba Ahmadi Rastegar, Guinevere F Lourenco, Thomas Wisniewski, Glenda Halliday, Eleanor Drummon. hnRNP A1, hnRNP A2B1, and hnRNP K are dysregulated in tauopathies, but do not colocalize with tau pathology. Brain pathology (Zurich, Switzerland). 2024-10-02. PMID:39354671. |
here, we performed a neuropathological study examining the colocalization between hnrnp a1, hnrnp a2b1, hnrnp k, and phosphorylated tau in two brain regions (hippocampus and frontal cortex) in six disease groups (alzheimer's disease, mild cognitive impairment, progressive supranuclear palsy, corticobasal degeneration, pick's disease, and controls). |
2024-10-02 |
2024-10-04 |
Not clear |
Yue Xiao, Linyu Wei, Jingfen Su, Huiyang Lei, Fei Sun, Mengzhu Li, Shihong Li, Xiaochuan Wang, Jie Zheng, Jian-Zhi Wan. A tau dephosphorylation-targeting chimeraselectively recruits protein phosphatase-1 to ameliorate Alzheimer's disease and tauopathies. Cell chemical biology. 2024-10-01. PMID:39353434. |
in both cultured primary hippocampal neurons and mouse models for ad or related tauopathies, we demonstrated that single-dose d20 treatment significantly reduced ptau by dephosphorylation at multiple ad-related sites and total tau (ttau) levels were also decreased. |
2024-10-01 |
2024-10-05 |
mouse |
Xuetao Qi, Shulu Yuan, Jiuyang Ding, Weiqi Sun, Yajiao Shi, Yuanwei Xing, Zilong Liu, Yun Yao, Su Fu, Baofei Sun, Xiaolan Qi, Bing Xia, Fengyu Liu, Ming Yi, Jian Mao, You Wan, Jie Zhen. Emerging signs of Alzheimer-like tau hyperphosphorylation and neuroinflammation in the brain post recovery from COVID-19. Aging cell. 2024-09-30. PMID:39344133. |
here, using postmortem human brain samples, we found abnormal accumulation of hyperphosphorylated tau protein in the hippocampus and medial entorhinal cortex within 4-13 months post clinically recovery from acute covid-19, together with prolonged activation of glia cells and increases in inflammatory factors, even though no sars-cov-2 invasion was detected in these regions. |
2024-09-30 |
2024-10-02 |
human |
Eunjin Lee, Yujeong Lee, Seonguk Yang, Eun Ji Gong, Jaehoon Kim, Nam-Chul Ha, Dong-Gyu Jo, Mark P Mattson, Jaewon Le. Akt-activated GSK3β inhibitory peptide effectively blocks tau hyperphosphorylation. Archives of pharmacal research. 2024-09-26. PMID:39325351. |
gip effectively blocked gsk3β-induced tau phosphorylation in hippocampal homogenates and, when fused with a cell-permeable sequence, attenuated aβ-induced tau phosphorylation in human neuroblastoma cells and inhibited cell death. |
2024-09-26 |
2024-09-28 |
mouse |
Anjalika Chongtham, Abhijeet Sharma, Banshi Nath, Kaitlin Murtha, Kirill Gorbachev, Aarthi Ramakrishnan, Eric F Schmidt, Li Shen, Ana C Pereir. Common and divergent pathways in early stages of glutamate and tau-mediated toxicities in neurodegeneration. Experimental neurology. 2024-09-26. PMID:39326823. |
to investigate the impact of glutamate dyshomeostasis and tau accumulation on translational profiles of affected hippocampal neurons, we used mouse models of excitotoxicity and tau-mediated toxicities (glt-1 |
2024-09-26 |
2024-09-29 |
mouse |
Kratika Pandey, Priyanka Khare, Swaroop Kumar Pandey, Surabhi Johari, Priyanka Bhatnagar, Madhavi Sonane, Anuja Mishr. Stem Cells as a Novel Source for Regenerative Medicinal Applications in Alzheimer's Disease: An Update. Current molecular medicine. 2024-09-25. PMID:39318206. |
alzheimer's disease (ad) is a progressive neurodegenerative disorder characterized by loss of the neurons, excessive accumulation of misfolded aβ and tau proteins, and degeneration of neural synapses, primarily occurring in the neocortex and the hippocampus regions of the brain. |
2024-09-25 |
2024-09-27 |
human |