| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohamed Aghyad Al Kabbani, Christoph Köhler, Hans Zempe. Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice. Neural regeneration research. 2024-06-27. PMID:38934386. |
p301l-tau-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical at8-phosphorylation of tau and increased polyglutamylation, but reduced acetylation, of microtubules compared with non-transgenic littermates. |
2024-06-27 |
2024-06-29 |
mouse |
| Bingyi Wang, Siyu Liu, Kaimin Hao, YaruWang Wang, Zongjing Li, Yuanyuan Lou, Yuan Chang, Wenxiu Q. HDAC6 modulates the cognitive behavioral function and hippocampal tissue pathological changes of APP/PS1 transgenic mice through HSP90-HSF1 pathway. Experimental brain research. 2024-06-27. PMID:38935089. |
the aim of this study was to investigate histone deacetylase 6 (hdac6) modifies the heat shock protein 90 (hsp90) and heat shock transcription factor 1 (hsf1) affect the levels of pathological markers such as aβ oligomers (aβo) and tau phosphorylation (p-tau) in app/ps1 double transgenic mice hippocampal tissues or ht22 neurons as well as the changes in cognitive behavioral functions of mice. |
2024-06-27 |
2024-06-29 |
mouse |
| Sosuke Yagishita, Megumi Shibata, Akiko Furuno, Shuji Wakatsuki, Toshiyuki Arak. Neuronal Excitation Induces Tau Protein Dephosphorylation via Protein Phosphatase 1 Activation to Promote Its Binding with Stable Microtubules. Neurology international. vol 16. issue 3. 2024-06-26. PMID:38921953. |
in an in vivo experiment, we demonstrated that the exposure of mice to a new environment activates protein phosphatase 1 in the mouse hippocampus and induces tau protein dephosphorylation. |
2024-06-26 |
2024-06-29 |
mouse |
| Mengyun Qiao, Haitao Yang, Li Liu, Tao Yu, Haihua Wang, Xiao Chen, Yi Zhang, Airu Duan, Shujun Lyu, Siyu Wu, Jingwei Xiao, Bin L. Chronic Lead Exposure in Adult Mice: Associations with miR-671/CDR1as Regulation, NF-κB Signaling, and Alzheimer's Disease-like Pathology. Toxics. vol 12. issue 6. 2024-06-26. PMID:38922090. |
at the molecular level, a significant upregulation of ad-associated genes, namely amyloid precursor protein (app), β-secretase 1 (bace1), and tau, was observed in the hippocampal tissue of pb-exposed mice. |
2024-06-26 |
2024-06-29 |
mouse |
| Suborno Jati, Daniel Munoz-Mayorga, Shandy Shahabi, Kechun Tang, Yuren Tao, Dennis W Dickson, Irene Litvan, Gourisankar Ghosh, Sushil K Mahata, Xu Che. Chromogranin A (CgA) Deficiency Attenuates Tauopathy by Altering Epinephrine-Alpha-Adrenergic Receptor Signaling. bioRxiv : the preprint server for biology. 2024-06-25. PMID:38915622. |
treatment of hippocampal slice cultures with epi or an adra1 agonist intensified, while an adra1 antagonist inhibited, tau hyperphosphorylation and aggregation. |
2024-06-25 |
2024-06-27 |
mouse |
| Kwan Joong Kim, Zukhra Akhmedova, Ho Jin Heo, Dae-Ok Ki. Red Pine Bark Extract Alleviates Akt/GSK-3β Signaling Disruption in the Hippocampus of Streptozotocin-Induced Diabetic Sprague-Dawley Rats. Journal of microbiology and biotechnology. vol 34. issue 6. 2024-06-17. PMID:38881175. |
after 20 days of oral administration of pbe, the rat hippocampus was collected, and the production of akt, p-akt, gsk-3β, p-gsk-3β, tau, ptau, bax, and bcl-2 proteins were determined by western blot analysis. |
2024-06-17 |
2024-06-19 |
rat |
| Tomas Ondrejcak, Igor Klyubin, Neng-Wei Hu, Yin Yang, Qiancheng Zhang, Brian J Rodriguez, Michael J Rowa. Rapidly reversible persistent long-term potentiation inhibition by patient-derived brain tau and amyloid ß proteins. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 379. issue 1906. 2024-06-10. PMID:38853565. |
a single intracerebral injection of aggregates of recombinant human tau that had been prepared by either sonication of fibrils (sτas) or disulfide bond formation (otau) rapidly and persistently inhibited ltp in rat hippocampus. |
2024-06-10 |
2024-06-14 |
human |
| Ke Yu, Katherine R Yao, Miguel A Aguinaga, Jessica M Choquette, Chengliang Liu, Yuxin Wang, Dezhi Lia. G272V and P301L mutations induce isoform specific tau mislocalization to dendritic spines and synaptic dysfunctions in cellular models of 3R and 4R tau frontotemporal dementia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-06-10. PMID:38858079. |
the p301l mutation, linked to familial 4r tau ftd, induces mislocalization of 4r tau to dendritic spines in primary hippocampal cultures that were prepared from neonatal rat pups of both sexes. |
2024-06-10 |
2024-06-14 |
rat |
| Ke Yu, Katherine R Yao, Miguel A Aguinaga, Jessica M Choquette, Chengliang Liu, Yuxin Wang, Dezhi Lia. G272V and P301L mutations induce isoform specific tau mislocalization to dendritic spines and synaptic dysfunctions in cellular models of 3R and 4R tau frontotemporal dementia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-06-10. PMID:38858079. |
the overexpression of g272v 3r tau but not 4r tau proteins leads to the reduction of dendritic spine density and suppression of miniature excitatory synaptic currents (mepscs) in 5-week-old primary rat hippocampal cultures. |
2024-06-10 |
2024-06-14 |
rat |
| Can Yang, Zhixian Zhu, Gaohua Wang, Zhongchun Liu, Chang Shu, Junhui Guo, Qirong Wa. Fluoxetin suppresses tau phosphorylation and modulates the interaction between tau and tubulin in the hippocampus of CUMS rats. Neuroscience letters. 2024-06-09. PMID:38852764. |
fluoxetin suppresses tau phosphorylation and modulates the interaction between tau and tubulin in the hippocampus of cums rats. |
2024-06-09 |
2024-06-14 |
rat |
| Can Yang, Zhixian Zhu, Gaohua Wang, Zhongchun Liu, Chang Shu, Junhui Guo, Qirong Wa. Fluoxetin suppresses tau phosphorylation and modulates the interaction between tau and tubulin in the hippocampus of CUMS rats. Neuroscience letters. 2024-06-09. PMID:38852764. |
fl significantly treatment decreased tau phosphorylation (p-tau) in hippocampal tissues of rats compared to those of rats in cums group (p < 0.05). |
2024-06-09 |
2024-06-14 |
rat |
| Can Yang, Zhixian Zhu, Gaohua Wang, Zhongchun Liu, Chang Shu, Junhui Guo, Qirong Wa. Fluoxetin suppresses tau phosphorylation and modulates the interaction between tau and tubulin in the hippocampus of CUMS rats. Neuroscience letters. 2024-06-09. PMID:38852764. |
fl treatment strengthened interaction between tau and botulin in hippocampal tissues of cums rats. |
2024-06-09 |
2024-06-14 |
rat |
| Can Yang, Zhixian Zhu, Gaohua Wang, Zhongchun Liu, Chang Shu, Junhui Guo, Qirong Wa. Fluoxetin suppresses tau phosphorylation and modulates the interaction between tau and tubulin in the hippocampus of CUMS rats. Neuroscience letters. 2024-06-09. PMID:38852764. |
in conclusion, fluoxetin suppressed phosphorylation of tau and modulated the interaction between tau and tubulin in hippocampus of adult cums rats. |
2024-06-09 |
2024-06-14 |
rat |
| C F de Veij Mestdagh, M E Witte, W Scheper, A B Smit, R H Henning, R E van Kestere. Torpor induces reversible tau hyperphosphorylation and accumulation in mice expressing human tau. Acta neuropathologica communications. vol 12. issue 1. 2024-06-05. PMID:38835043. |
immunohistochemistry revealed four brain areas that show prominent tau phosphorylation: the hippocampus, posterior parietal cortex, piriform cortex and cortical amygdala. |
2024-06-05 |
2024-06-07 |
mouse |
| Rong Ye, Anna E Goodheart, Joseph J Locascio, Erin Peterec, Michael Properzi, Emma G Thibault, Erin Chuba, Keith A Johnson, Michael J Brickhouse, Alexandra Touroutoglou, John H Growdon, Bradford C Dickerson, Stephen N Gompert. Differential Vulnerability of Hippocampal Subfields to Amyloid and Tau Deposition in the Lewy Body Diseases. Neurology. vol 102. issue 12. 2024-05-30. PMID:38815233. |
differential vulnerability of hippocampal subfields to amyloid and tau deposition in the lewy body diseases. |
2024-05-30 |
2024-07-16 |
Not clear |
| Rong Ye, Anna E Goodheart, Joseph J Locascio, Erin Peterec, Michael Properzi, Emma G Thibault, Erin Chuba, Keith A Johnson, Michael J Brickhouse, Alexandra Touroutoglou, John H Growdon, Bradford C Dickerson, Stephen N Gompert. Differential Vulnerability of Hippocampal Subfields to Amyloid and Tau Deposition in the Lewy Body Diseases. Neurology. vol 102. issue 12. 2024-05-30. PMID:38815233. |
alzheimer disease (ad) copathologies of β-amyloid and tau are common in the lewy body diseases (lbd), dementia with lewy bodies (dlb) and parkinson disease (pd), and target distinct hippocampal subfields compared with lewy pathology, including subiculum and ca1. |
2024-05-30 |
2024-07-16 |
Not clear |
| Jr-Jiun Liou, Jinghang Li, Jacob Berardinelli, Hecheng Jin, Tales Santini, Jaehoon Noh, Nadim Farhat, Minjie Wu, Howard Aizenstein, Joseph M Mettenburg, William Yong, Elizabeth Head, Milos Ikonomovic, Tamer Ibrahim, Julia Kofle. Correlating hippocampal and amygdala volumes with neuropathological burden in neurodegenerative diseases using 7T postmortem MRI. medRxiv : the preprint server for health sciences. 2024-05-27. PMID:38798514. |
in ds, smaller hippocampal volume, relative to ad, appears primarily influenced by tau pathology. |
2024-05-27 |
2024-05-31 |
human |
| Samar R Saleh, Aml Abd-Elmegied, Somaya Aly Madhy, Sherine N Khattab, Eman Sheta, Fatma Y Elnozahy, Radwa A Mehanna, Doaa A Ghareeb, Nihad M Abd-Elmone. Brain-targeted Tet-1 peptide-PLGA nanoparticles for berberine delivery against STZ-induced Alzheimer's disease in a rat model: Alleviation of hippocampal synaptic dysfunction, Tau pathology and amyloidogenesis. International journal of pharmaceutics. 2024-05-11. PMID:38734273. |
brain-targeted tet-1 peptide-plga nanoparticles for berberine delivery against stz-induced alzheimer's disease in a rat model: alleviation of hippocampal synaptic dysfunction, tau pathology and amyloidogenesis. |
2024-05-11 |
2024-05-27 |
rat |
| Samar R Saleh, Aml Abd-Elmegied, Somaya Aly Madhy, Sherine N Khattab, Eman Sheta, Fatma Y Elnozahy, Radwa A Mehanna, Doaa A Ghareeb, Nihad M Abd-Elmone. Brain-targeted Tet-1 peptide-PLGA nanoparticles for berberine delivery against STZ-induced Alzheimer's disease in a rat model: Alleviation of hippocampal synaptic dysfunction, Tau pathology and amyloidogenesis. International journal of pharmaceutics. 2024-05-11. PMID:38734273. |
further, hippocampal neuroplasticity (bdnf, pcreb, and perk/erk), tau pathogenesis (pgsk3β/gsk3β, cdk5, and ptau), inflammatory, and apoptotic markers were evaluated. |
2024-05-11 |
2024-05-27 |
rat |
| Samar R Saleh, Aml Abd-Elmegied, Somaya Aly Madhy, Sherine N Khattab, Eman Sheta, Fatma Y Elnozahy, Radwa A Mehanna, Doaa A Ghareeb, Nihad M Abd-Elmone. Brain-targeted Tet-1 peptide-PLGA nanoparticles for berberine delivery against STZ-induced Alzheimer's disease in a rat model: Alleviation of hippocampal synaptic dysfunction, Tau pathology and amyloidogenesis. International journal of pharmaceutics. 2024-05-11. PMID:38734273. |
bbr and bbr/plga-tet nps attenuated stz-induced hippocampal damage, enhanced cognitive performance, and reduced aβ42, tau phosphorylation, and proinflammatory responses. |
2024-05-11 |
2024-05-27 |
rat |