All Relations between microtubule-associated protein tau and hippocampus

Publication Sentence Publish Date Extraction Date Species
Kwan Joong Kim, Zukhra Akhmedova, Ho Jin Heo, Dae-Ok Ki. Red Pine Bark Extract Alleviates Akt/GSK-3β Signaling Disruption in the Hippocampus of Streptozotocin-Induced Diabetic Sprague-Dawley Rats. Journal of microbiology and biotechnology. vol 34. issue 6. 2024-06-17. PMID:38881175. after 20 days of oral administration of pbe, the rat hippocampus was collected, and the production of akt, p-akt, gsk-3β, p-gsk-3β, tau, ptau, bax, and bcl-2 proteins were determined by western blot analysis. 2024-06-17 2024-06-19 rat
Tomas Ondrejcak, Igor Klyubin, Neng-Wei Hu, Yin Yang, Qiancheng Zhang, Brian J Rodriguez, Michael J Rowa. Rapidly reversible persistent long-term potentiation inhibition by patient-derived brain tau and amyloid ß proteins. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 379. issue 1906. 2024-06-10. PMID:38853565. a single intracerebral injection of aggregates of recombinant human tau that had been prepared by either sonication of fibrils (sτas) or disulfide bond formation (otau) rapidly and persistently inhibited ltp in rat hippocampus. 2024-06-10 2024-06-14 human
Ke Yu, Katherine R Yao, Miguel A Aguinaga, Jessica M Choquette, Chengliang Liu, Yuxin Wang, Dezhi Lia. G272V and P301L mutations induce isoform specific tau mislocalization to dendritic spines and synaptic dysfunctions in cellular models of 3R and 4R tau frontotemporal dementia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-06-10. PMID:38858079. the p301l mutation, linked to familial 4r tau ftd, induces mislocalization of 4r tau to dendritic spines in primary hippocampal cultures that were prepared from neonatal rat pups of both sexes. 2024-06-10 2024-06-14 rat
Ke Yu, Katherine R Yao, Miguel A Aguinaga, Jessica M Choquette, Chengliang Liu, Yuxin Wang, Dezhi Lia. G272V and P301L mutations induce isoform specific tau mislocalization to dendritic spines and synaptic dysfunctions in cellular models of 3R and 4R tau frontotemporal dementia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-06-10. PMID:38858079. the overexpression of g272v 3r tau but not 4r tau proteins leads to the reduction of dendritic spine density and suppression of miniature excitatory synaptic currents (mepscs) in 5-week-old primary rat hippocampal cultures. 2024-06-10 2024-06-14 rat
Can Yang, Zhixian Zhu, Gaohua Wang, Zhongchun Liu, Chang Shu, Junhui Guo, Qirong Wa. Fluoxetin suppresses tau phosphorylation and modulates the interaction between tau and tubulin in the hippocampus of CUMS rats. Neuroscience letters. 2024-06-09. PMID:38852764. fluoxetin suppresses tau phosphorylation and modulates the interaction between tau and tubulin in the hippocampus of cums rats. 2024-06-09 2024-06-14 rat
Can Yang, Zhixian Zhu, Gaohua Wang, Zhongchun Liu, Chang Shu, Junhui Guo, Qirong Wa. Fluoxetin suppresses tau phosphorylation and modulates the interaction between tau and tubulin in the hippocampus of CUMS rats. Neuroscience letters. 2024-06-09. PMID:38852764. fl significantly treatment decreased tau phosphorylation (p-tau) in hippocampal tissues of rats compared to those of rats in cums group (p < 0.05). 2024-06-09 2024-06-14 rat
Can Yang, Zhixian Zhu, Gaohua Wang, Zhongchun Liu, Chang Shu, Junhui Guo, Qirong Wa. Fluoxetin suppresses tau phosphorylation and modulates the interaction between tau and tubulin in the hippocampus of CUMS rats. Neuroscience letters. 2024-06-09. PMID:38852764. fl treatment strengthened interaction between tau and botulin in hippocampal tissues of cums rats. 2024-06-09 2024-06-14 rat
Can Yang, Zhixian Zhu, Gaohua Wang, Zhongchun Liu, Chang Shu, Junhui Guo, Qirong Wa. Fluoxetin suppresses tau phosphorylation and modulates the interaction between tau and tubulin in the hippocampus of CUMS rats. Neuroscience letters. 2024-06-09. PMID:38852764. in conclusion, fluoxetin suppressed phosphorylation of tau and modulated the interaction between tau and tubulin in hippocampus of adult cums rats. 2024-06-09 2024-06-14 rat
C F de Veij Mestdagh, M E Witte, W Scheper, A B Smit, R H Henning, R E van Kestere. Torpor induces reversible tau hyperphosphorylation and accumulation in mice expressing human tau. Acta neuropathologica communications. vol 12. issue 1. 2024-06-05. PMID:38835043. immunohistochemistry revealed four brain areas that show prominent tau phosphorylation: the hippocampus, posterior parietal cortex, piriform cortex and cortical amygdala. 2024-06-05 2024-06-07 mouse
Rong Ye, Anna E Goodheart, Joseph J Locascio, Erin Peterec, Michael Properzi, Emma G Thibault, Erin Chuba, Keith A Johnson, Michael J Brickhouse, Alexandra Touroutoglou, John H Growdon, Bradford C Dickerson, Stephen N Gompert. Differential Vulnerability of Hippocampal Subfields to Amyloid and Tau Deposition in the Lewy Body Diseases. Neurology. vol 102. issue 12. 2024-05-30. PMID:38815233. differential vulnerability of hippocampal subfields to amyloid and tau deposition in the lewy body diseases. 2024-05-30 2024-07-16 Not clear
Rong Ye, Anna E Goodheart, Joseph J Locascio, Erin Peterec, Michael Properzi, Emma G Thibault, Erin Chuba, Keith A Johnson, Michael J Brickhouse, Alexandra Touroutoglou, John H Growdon, Bradford C Dickerson, Stephen N Gompert. Differential Vulnerability of Hippocampal Subfields to Amyloid and Tau Deposition in the Lewy Body Diseases. Neurology. vol 102. issue 12. 2024-05-30. PMID:38815233. alzheimer disease (ad) copathologies of β-amyloid and tau are common in the lewy body diseases (lbd), dementia with lewy bodies (dlb) and parkinson disease (pd), and target distinct hippocampal subfields compared with lewy pathology, including subiculum and ca1. 2024-05-30 2024-07-16 Not clear
Jr-Jiun Liou, Jinghang Li, Jacob Berardinelli, Hecheng Jin, Tales Santini, Jaehoon Noh, Nadim Farhat, Minjie Wu, Howard Aizenstein, Joseph M Mettenburg, William Yong, Elizabeth Head, Milos Ikonomovic, Tamer Ibrahim, Julia Kofle. Correlating hippocampal and amygdala volumes with neuropathological burden in neurodegenerative diseases using 7T postmortem MRI. medRxiv : the preprint server for health sciences. 2024-05-27. PMID:38798514. in ds, smaller hippocampal volume, relative to ad, appears primarily influenced by tau pathology. 2024-05-27 2024-05-31 human
Samar R Saleh, Aml Abd-Elmegied, Somaya Aly Madhy, Sherine N Khattab, Eman Sheta, Fatma Y Elnozahy, Radwa A Mehanna, Doaa A Ghareeb, Nihad M Abd-Elmone. Brain-targeted Tet-1 peptide-PLGA nanoparticles for berberine delivery against STZ-induced Alzheimer's disease in a rat model: Alleviation of hippocampal synaptic dysfunction, Tau pathology and amyloidogenesis. International journal of pharmaceutics. 2024-05-11. PMID:38734273. brain-targeted tet-1 peptide-plga nanoparticles for berberine delivery against stz-induced alzheimer's disease in a rat model: alleviation of hippocampal synaptic dysfunction, tau pathology and amyloidogenesis. 2024-05-11 2024-05-27 rat
Samar R Saleh, Aml Abd-Elmegied, Somaya Aly Madhy, Sherine N Khattab, Eman Sheta, Fatma Y Elnozahy, Radwa A Mehanna, Doaa A Ghareeb, Nihad M Abd-Elmone. Brain-targeted Tet-1 peptide-PLGA nanoparticles for berberine delivery against STZ-induced Alzheimer's disease in a rat model: Alleviation of hippocampal synaptic dysfunction, Tau pathology and amyloidogenesis. International journal of pharmaceutics. 2024-05-11. PMID:38734273. further, hippocampal neuroplasticity (bdnf, pcreb, and perk/erk), tau pathogenesis (pgsk3β/gsk3β, cdk5, and ptau), inflammatory, and apoptotic markers were evaluated. 2024-05-11 2024-05-27 rat
Samar R Saleh, Aml Abd-Elmegied, Somaya Aly Madhy, Sherine N Khattab, Eman Sheta, Fatma Y Elnozahy, Radwa A Mehanna, Doaa A Ghareeb, Nihad M Abd-Elmone. Brain-targeted Tet-1 peptide-PLGA nanoparticles for berberine delivery against STZ-induced Alzheimer's disease in a rat model: Alleviation of hippocampal synaptic dysfunction, Tau pathology and amyloidogenesis. International journal of pharmaceutics. 2024-05-11. PMID:38734273. bbr and bbr/plga-tet nps attenuated stz-induced hippocampal damage, enhanced cognitive performance, and reduced aβ42, tau phosphorylation, and proinflammatory responses. 2024-05-11 2024-05-27 rat
Kayvan Khoramipour, Maryam Hossein Rezaei, Amirhossein Moslemizadeh, Mahdieh Sadat Hosseini, Narjes Ebrahimnezhad, Hamideh Bashir. Changes in the hippocampal level of tau but not beta-amyloid may mediate anxiety-like behavior improvement ensuing from exercise in diabetic female rats. Behavioral and brain functions : BBF. vol 20. issue 1. 2024-05-04. PMID:38702776. changes in the hippocampal level of tau but not beta-amyloid may mediate anxiety-like behavior improvement ensuing from exercise in diabetic female rats. 2024-05-04 2024-05-06 rat
Xiao-Hong Hu, Kai-Yue Yu, Xin-Xin Li, Jin-Nan Zhang, Juan-Juan Jiao, Zhao-Jun Wang, Hong-Yan Cai, Lei Wang, Ye-Xin He, Mei-Na W. Selective orexin 2 receptor blockade alleviates cognitive impairments and the pathological progression of Alzheimer's disease in 3xTg-AD mice. The journals of gerontology. Series A, Biological sciences and medical sciences. 2024-04-29. PMID:38682858. then, immunohistochemistry, western blotting and elisa were used to detect aβ deposition, tau phosphorylation and neuroinflammation, and electrophysiological and wheel-running activity recording were recorded to observe hippocampal synaptic plasticity and circadian rhythm. 2024-04-29 2024-05-02 mouse
Karima Schwab, Dilyara Lauer, Mandy Magbagbeolu, Franz Theuring, Anna Gasiorowska, Maciej Zadrozny, Charles R Harrington, Claude M Wischik, Grażyna Niewiadomska, Gernot Riede. Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: interference by cholinesterase inhibitors. Brain research bulletin. 2024-04-27. PMID:38677558. interference of cholinesterase inhibition with hmtm was observed also in a tau transgenic mouse model, where rivastigmine reduced the pharmacological activity of hmtm at multiple brain levels including hippocampal acetylcholine release, synaptosomal glutamate release and mitochondrial activity. 2024-04-27 2024-04-30 mouse
Bing-Yi Wang, Si-Yu Liu, Kai-Min Hao, Wen-Xiu Q. [Age-dependent expression of HSP90 in the hippocampus of APP/PS1 mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 76. issue 2. 2024-04-25. PMID:38658375. the present study aims to observe the change in expression of heat shock protein 90 (hsp90) along with amyloid-β (aβ) and phosphorylated tau (p-tau) protein levels in the hippocampus tissue of alzheimer's disease (ad) transgenic animal model with age. 2024-04-25 2024-04-28 mouse
Jayvik Joshi, Minmin Yao, Aaron Kakazu, Yuxiao Ouyang, Wenzhen Duan, Manisha Aggarwa. Distinguishing microgliosis and tau deposition in the mouse brain using paramagnetic and diamagnetic susceptibility source separation. bioRxiv : the preprint server for biology. 2024-04-25. PMID:38659855. significant bilateral increases in pcs and |dcs| were observed in specific hippocampal and cortical sub-regions of the tau mice relative to wt controls. 2024-04-25 2024-04-28 mouse