| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hai Duc Nguyen, Won Hee Jo, Ngoc Hong Minh Hoang, Byung Pal Yu, Hae Young Chung, Min-Sun Ki. 1,2-Diacetylbenzene impaired hippocampal memory by activating proinflammatory cytokines and upregulating the prolactin pathway: An in vivo and in vitro study. International immunopharmacology. vol 108. 2022-06-22. PMID:35729834. |
qpcr, western blot, morris water maze, and rnaseq analysis were used to identify the association between inflammation and hyperphosphorylated tau in male dab-treated mice (1 or 5 mg/kg/day), rats (3 mg/kg/day), in vitro bv2 microglial cells (1 or 5 µm), and the hippocampal transcriptome of male dab-treated rats. |
2022-06-22 |
2023-08-14 |
mouse |
| Maiko Ono, Masaaki Komatsu, Bin Ji, Yuhei Takado, Masafumi Shimojo, Takeharu Minamihisamatsu, Eiji Warabi, Toru Yanagawa, Gen Matsumoto, Ichio Aoki, Nicholas M Kanaan, Tetsuya Suhara, Naruhiko Sahara, Makoto Higuch. Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy. Aging cell. 2022-06-06. PMID:35662390. |
p301s mutant tau transgenic mice (line ps19) exhibited accumulation of neurofibrillary tangles with localization of p62 mostly in the brainstem, but neuronal loss with few neurofibrillary tangles in the hippocampus. |
2022-06-06 |
2023-08-14 |
mouse |
| Maiko Ono, Masaaki Komatsu, Bin Ji, Yuhei Takado, Masafumi Shimojo, Takeharu Minamihisamatsu, Eiji Warabi, Toru Yanagawa, Gen Matsumoto, Ichio Aoki, Nicholas M Kanaan, Tetsuya Suhara, Naruhiko Sahara, Makoto Higuch. Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy. Aging cell. 2022-06-06. PMID:35662390. |
in the hippocampus of ps19 mice, the p62 level was lower compared to the brainstem, and punctate accumulation of phosphorylated tau unaccompanied by co-localization of p62 was observed. |
2022-06-06 |
2023-08-14 |
mouse |
| Maiko Ono, Masaaki Komatsu, Bin Ji, Yuhei Takado, Masafumi Shimojo, Takeharu Minamihisamatsu, Eiji Warabi, Toru Yanagawa, Gen Matsumoto, Ichio Aoki, Nicholas M Kanaan, Tetsuya Suhara, Naruhiko Sahara, Makoto Higuch. Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy. Aging cell. 2022-06-06. PMID:35662390. |
in ps19 mice deficient in p62 (ps19/p62-ko), increased accumulation of phosphorylated tau, acceleration of neuronal loss, and exacerbation of neuroinflammation were observed in the hippocampus as compared with ps19 mice. |
2022-06-06 |
2023-08-14 |
mouse |
| Kai-Min Hao, Zhen Liu, Hao-Yu Wang, Wen-Xiu Q. [Time dependent expression profiling of PTK2B and its relationship with Aβ, Tau and LRP-1 in hippocampus and blood of APPswe/PS1dE9 double-transgenic mouse]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 38. issue 1. 2022-05-31. PMID:35634664. |
[time dependent expression profiling of ptk2b and its relationship with aβ, tau and lrp-1 in hippocampus and blood of appswe/ps1de9 double-transgenic mouse]. |
2022-05-31 |
2023-08-13 |
mouse |
| Md Ataur Rahman, M D Hasanur Rahman, A N M Mamun-Or-Rashid, Hongik Hwang, Sooyoung Chung, Bonglee Kim, Hyewhon Rhi. Autophagy Modulation in Aggresome Formation: Emerging Implications and Treatments of Alzheimer's Disease. Biomedicines. vol 10. issue 5. 2022-05-28. PMID:35625764. |
alzheimer's disease (ad) is one of the most prevailing neurodegenerative diseases in the world, which is characterized by memory dysfunction and the formation of tau and amyloid β (aβ) aggregates in multiple brain regions, including the hippocampus and cortex. |
2022-05-28 |
2023-08-13 |
Not clear |
| Jiayin Zheng, Yue Wang, Yue Liu, Song Han, Ying Zhang, Yanlin Luo, Yi Yan, Junfa Li, Li Zha. cPKCγ Deficiency Exacerbates Autophagy Impairment and Hyperphosphorylated Tau Buildup through the AMPK/mTOR Pathway in Mice with Type 1 Diabetes Mellitus. Neuroscience bulletin. 2022-05-21. PMID:35596894. |
in this study, we found that knockout of conventional protein kinase c (cpkc)γ significantly increased the phosphorylation of tau at ser214 and neurofibrillary tangles, but did not affect the activities of gsk-3β and pp2a in the hippocampal neurons of t1dm mice. |
2022-05-21 |
2023-08-13 |
mouse |
| Samar O El-Ganainy, Omar A Soliman, Aya A Ghazy, Maram Allam, Aya I Elbahnasi, Amira M Mansour, Mennatallah A Gowaye. Intranasal Oxytocin Attenuates Cognitive Impairment, β-Amyloid Burden and Tau Deposition in Female Rats with Alzheimer's Disease: Interplay of ERK1/2/GSK3β/Caspase-3. Neurochemical research. 2022-05-20. PMID:35596040. |
in addition, neuroprotective effects of oxytocin were examined by assessing hippocampal acetylcholinesterase activity, β-amyloid 1-42 protein, and tau levels. |
2022-05-20 |
2023-08-13 |
rat |
| Chaoli Huang, Teng He, Di Wang, Zifeng Wu, Yuanyuan Wang, Hanyu Liu, Jiali Xu, Chun Yang, Guiquan Chen, Cunming Li. PP2A-associated tau hyperphosphorylation was involved in sevoflurane induced neonatal neurotoxicity. Psychopharmacology. 2022-05-17. PMID:35579686. |
however, the exact mechanisms underlying hyperphosphorylation of tau protein in sevoflurane induced abnormalities in central nervous system (cns) development, particularly in the hippocampus, have not been fully determined. |
2022-05-17 |
2023-08-13 |
Not clear |
| Anna Mietelska-Porowska, Justyna Domańska, Andrew Want, Angelika Więckowska-Gacek, Dominik Chutorański, Maciej Koperski, Urszula Wojd. Induction of Brain Insulin Resistance and Alzheimer's Molecular Changes by Western Diet. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563135. |
ad is the main cause of progressive dementia characterized by the deposition of amyloid-β (aβ) plaques and neurofibrillary tangles consisting of the hyperphosphorylated tau (p-tau) protein in the brain, starting from the entorhinal cortex and the hippocampus. |
2022-05-14 |
2023-08-13 |
mouse |
| Anna Mietelska-Porowska, Justyna Domańska, Andrew Want, Angelika Więckowska-Gacek, Dominik Chutorański, Maciej Koperski, Urszula Wojd. Induction of Brain Insulin Resistance and Alzheimer's Molecular Changes by Western Diet. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563135. |
in this study, we report that wd-derived impairment in insulin signaling induces tau and aβ brain pathology in wild-type c57bl/6 mice, and that the entorhinal cortex is more sensitive than the hippocampus to the impairment of brain insulin signaling. |
2022-05-14 |
2023-08-13 |
mouse |
| S Tok, H Maurin, C Delay, D Crauwels, N V Manyakov, W Van Der Elst, D Moechars, W H I M Drinkenbur. Neurophysiological effects of human-derived pathological tau conformers in the APPKM670/671NL.PS1/L166P amyloid mouse model of Alzheimer's disease. Scientific reports. vol 12. issue 1. 2022-05-13. PMID:35546164. |
we also report immediate localized hippocampal dysfunction in the electroencephalography (eeg) power spectra associated with tau seeding which returned to comparable levels at 1 month-post-injection. |
2022-05-13 |
2023-08-13 |
mouse |
| Nan-Shan Chan. The strength of WWOX binding with protein partners correlates with cancer suppression and potentially with inhibition of Alzheimer's disease progression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35552574. |
gradual loss of wwox protein in the hippocampus and cortex starting from middle age may slowly induce aggregation of a protein cascade that ultimately causes accumulation of extracellular amyloid beta plaques and intracellular tau tangles, along with reduction in inhibitory gabaergic interneurons, in ad patients over 70 years old. |
2022-05-13 |
2023-08-13 |
mouse |
| Samantha K Baker, Na Wang, Guojun Bu, Chia-Chen Li. Effects of Microglia APOE Expression on Tau Pathology. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557103. |
apoe3 expressing mice had exacerbated neurodegeneration and tau accumulation in the hippocampus. |
2022-05-13 |
2023-08-13 |
mouse |
| Mike T Lin, Chung-Sik Choi, Meredith Gwin, Sarah Voth, Claire Kolb, Chun Zhou, Amy R Nelson, Althea deWeever, Anna Koloteva, Naga S Annamdevula, James M Murphy, Brant M Wagener, Jean-Francois Pittet, Ssang-Taek S Lim, Ron T Balczon, Troy T Steven. Pulmonary Endothelial Tau Aggregation After Infection. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557306. |
we previously hypothesized that the lung endothelium contributes to infection-related neurocognitive dysfunction, since bacteria-exposed endothelial cells release a form(s) of cytotoxic tau that is sufficient to impair long-term potentiation in the hippocampus. |
2022-05-13 |
2023-08-13 |
mouse |
| Elizabeth L Steuer, Lisa J Kemper, Chris J W Hlynialuk, Kailee Leinonen-Wright, Michelle L Montonye, Ian P Lapcinski, Colleen L Forster, Karen H Ashe, Peng Li. Blocking site-specific cleavage of human tau delays progression of disease-related phenotypes in genetically matched tau-transgenic mice modeling frontotemporal dementia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-05-04. PMID:35508385. |
importantly, expression of the cleavage-resistant d314e mutant delays transgene-induced tau accumulation in the post-synaptic density, brain atrophy, hippocampal neurodegeneration, and spatial memory impairment, without altering age-related progression of pathological tau conformation and phosphorylation. |
2022-05-04 |
2023-08-13 |
mouse |
| Maryam Bazrgar, Pariya Khodabakhsh, Leila Dargahi, Fatemeh Mohagheghi, Abolhassan Ahmadian. MicroRNA modulation is a potential molecular mechanism for neuroprotective effects of intranasal insulin administration in amyloid βeta oligomer induced Alzheimer's like rat model. Experimental gerontology. 2022-04-27. PMID:35476966. |
we observed memory impairment, aβ aggregation, tau hyper-phosphorylation, neuroinflammation, insulin signaling dys-regulation, and down-regulation of mir-26a, mir-124, mir-29a, mir-181b, mir-125b, mir-132, and mir-146a in the hippocampus of aβo-exposed rats 21 days after aβo injection. |
2022-04-27 |
2023-08-13 |
rat |
| Lanxia Meng, Li Zou, Min Xiong, Jiehui Chen, Xingyu Zhang, Ting Yu, Yiming Li, Congcong Liu, Guiqin Chen, Zhihao Wang, Keqiang Ye, Zhentao Zhan. A synapsin Ⅰ cleavage fragment contributes to synaptic dysfunction in Alzheimer's disease. Aging cell. 2022-04-20. PMID:35443102. |
moreover, overexpression of the aep-generated synapsin Ⅰ (83-705) fragment in the hippocampus of tau p301s transgenic mice and wild-type mice promotes synaptic dysfunction and cognitive deficits. |
2022-04-20 |
2023-08-13 |
mouse |
| Giovanni Oliveros, Charles H Wallace, Osama Chaudry, Qiao Liu, Yue Qiu, Lei Xie, Patricia Rockwell, Maria E Figueiredo-Pereira, Peter A Serran. Repurposing ibudilast to mitigate Alzheimer's disease by targeting inflammation. Brain : a journal of neurology. 2022-04-12. PMID:35411386. |
this transgenic rat model is unique as it exhibits hippocampal-dependent spatial learning and memory deficits, and alzheimer's disease pathology including hippocampal amyloid plaques, tau paired-helical filaments, neuronal loss and microgliosis, in a progressive age-dependent manner that mimics the pathology observed in alzheimer's disease patients. |
2022-04-12 |
2023-08-13 |
rat |
| Giovanni Oliveros, Charles H Wallace, Osama Chaudry, Qiao Liu, Yue Qiu, Lei Xie, Patricia Rockwell, Maria E Figueiredo-Pereira, Peter A Serran. Repurposing ibudilast to mitigate Alzheimer's disease by targeting inflammation. Brain : a journal of neurology. 2022-04-12. PMID:35411386. |
we demonstrate that ibudilast-treatment of transgenic rats mitigated hippocampal-dependent spatial memory deficits, as well as hippocampal (hilar subregion) amyloid plaque and tau paired-helical filament load, and microgliosis compared to untreated transgenic rat. |
2022-04-12 |
2023-08-13 |
rat |