| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Priya Rangan, Fleur Lobo, Edoardo Parrella, Nicolas Rochette, Marco Morselli, Terri-Leigh Stephen, Anna Laura Cremonini, Luca Tagliafico, Angelica Persia, Irene Caffa, Fiammetta Monacelli, Patrizio Odetti, Tommaso Bonfiglio, Alessio Nencioni, Martina Pigliautile, Virginia Boccardi, Patrizia Mecocci, Christian J Pike, Pinchas Cohen, Mary Jo LaDu, Matteo Pellegrini, Kyle Xia, Katelynn Tran, Brandon Ann, Dolly Chowdhury, Valter D Long. Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models. Cell reports. vol 40. issue 13. 2022-09-28. PMID:36170815. |
in 3xtg mice, long-term fmd cycles reduce hippocampal aβ load and hyperphosphorylated tau, enhance genesis of neural stem cells, decrease microglia number, and reduce expression of neuroinflammatory genes, including superoxide-generating nadph oxidase (nox2). |
2022-09-28 |
2023-08-14 |
mouse |
| Xiu Chen, Juan-Ling He, Xue-Ting Liu, Na Zhao, Fan Geng, Meng-Meng Zhu, Gong-Ping Liu, Qing-Guo Re. DI-3-n-butylphthalide mitigates stress-induced cognitive deficits in mice through inhibition of NLRP3-Mediated neuroinflammation. Neurobiology of stress. vol 20. 2022-09-26. PMID:36160816. |
the results showed that both depressive and resilient mice displayed spatial memory deficits and an accumulation of tau in the hippocampus. |
2022-09-26 |
2023-08-14 |
mouse |
| Dhwani S Korde, Christian Humpe. Spreading of P301S Aggregated Tau Investigated in Organotypic Mouse Brain Slice Cultures. Biomolecules. vol 12. issue 9. 2022-09-23. PMID:36139003. |
slices with un- and hyperphosphorylated p301s aggregated tau demonstrate significant spreading to the ventral parts of the hippocampal slices compared to empty collagen hydrogels after 8 weeks. |
2022-09-23 |
2023-08-14 |
mouse |
| Jianfeng Wu, Yi Su, Eric M Reiman, Richard J Caselli, Kewei Chen, Paul M Thompson, Junwen Wang, Yalin Wan. INVESTIGATING THE EFFECT OF TAU DEPOSITION AND APOE ON HIPPOCAMPAL MORPHOMETRY IN ALZHEIMER'S DISEASE: A FEDERATED CHOW TEST MODEL. Proceedings. IEEE International Symposium on Biomedical Imaging. vol 2022. 2022-09-23. PMID:36147309. |
investigating the effect of tau deposition and apoe on hippocampal morphometry in alzheimer's disease: a federated chow test model. |
2022-09-23 |
2023-08-14 |
Not clear |
| Churaibhon Wisessaowapak, Luksamee Worasuttayangkurn, Kanjanamas Maliphol, Watanyoo Nakareangrit, Wanida Cholpraipimolrat, Sumontha Nookabkaew, Piyajit Watcharasit, Jutamaad Satayaviva. The 28-day repeated arsenic exposure increases tau phosphorylation in the rat brain. Environmental toxicology and pharmacology. 2022-09-11. PMID:36089238. |
interestingly, we found an increase in tau phosphorylation at the tau 1 region (189-207) and s202 in the hippocampus, s404 in the cerebral cortex, and s396 and s404 in the cerebellum of arsenic-treated rats. |
2022-09-11 |
2023-08-14 |
rat |
| Pengfang Zheng, Xiaojun She, Chunping Wang, Yingwen Zhu, Bo Fu, Kefeng Ma, Honglian Yang, Xiujie Gao, Xiaofang Li, Fangshan Wu, Bo Cu. Around-the-Clock Noise Induces AD-like Neuropathology by Disrupting Autophagy Flux Homeostasis. Cells. vol 11. issue 17. 2022-09-09. PMID:36078149. |
the levels of phosphorylated tau, amyloid-β (aβ), and neuroinflammation in the cortex and hippocampus were assessed and autophagosome (ap) aggregation was observed by transmission electron microscopy. |
2022-09-09 |
2023-08-14 |
rat |
| Georgiana F Stan, Timothy W Church, Ellie Randall, Jenna R M Harvey, Jon T Brown, Kevin A Wilkinson, Jonathan G Hanley, Neil V Marrio. Tau isoform-specific enhancement of L-type calcium current and augmentation of afterhyperpolarization in rat hippocampal neurons. Scientific reports. vol 12. issue 1. 2022-09-08. PMID:36075936. |
tau isoform-specific enhancement of l-type calcium current and augmentation of afterhyperpolarization in rat hippocampal neurons. |
2022-09-08 |
2023-08-14 |
human |
| Rocío Alfaro-Ruiz, Carolina Aguado, Alejandro Martín-Belmonte, Ana Esther Moreno-Martínez, Jesús Merchán-Rubira, Félix Hernández, Jesús Ávila, Yugo Fukazawa, Rafael Lujá. Different modes of synaptic and extrasynaptic NMDA receptor alteration in the hippocampus of P301S tau transgenic mice. Brain pathology (Zurich, Switzerland). 2022-09-04. PMID:36058615. |
different modes of synaptic and extrasynaptic nmda receptor alteration in the hippocampus of p301s tau transgenic mice. |
2022-09-04 |
2023-08-14 |
mouse |
| Moorthi Ponnusamy, Shuai Wang, Melike Yuksel, Mitchell T Hansen, Danielle M Blazier, Joseph D McMillan, Xiaolin Zhang, Eric B Dammer, Lisa Collier, Gopal Thinakara. Loss of forebrain BIN1 attenuates hippocampal pathology and neuroinflammation in a tauopathy model. Brain : a journal of neurology. 2022-09-04. PMID:36059072. |
intriguingly, the loss of bin1 also mitigated tau neuropathology in select regions, including the hippocampus, entorhinal/piriform cortex, and amygdala, thus attenuating hippocampal synapse loss, neuronal death, neuroinflammation, and brain atrophy. |
2022-09-04 |
2023-08-14 |
mouse |
| Moorthi Ponnusamy, Shuai Wang, Melike Yuksel, Mitchell T Hansen, Danielle M Blazier, Joseph D McMillan, Xiaolin Zhang, Eric B Dammer, Lisa Collier, Gopal Thinakara. Loss of forebrain BIN1 attenuates hippocampal pathology and neuroinflammation in a tauopathy model. Brain : a journal of neurology. 2022-09-04. PMID:36059072. |
we conclude that forebrain neuronal bin1 expression promotes hippocampal tau pathogenesis and neuroinflammation. |
2022-09-04 |
2023-08-14 |
mouse |
| Sara R Guerreiro, Marco R Guimarães, Joana M Silva, Chrysoula Dioli, Anastasia Vamvaka-Iakovou, Raquel Sousa, Patrícia Gomes, Anastasia Megalokonomou, Carlos Campos-Marques, Ana Margarida Cunha, Armando Almeida, Nuno Sousa, Hugo Leite-Almeida, Ioannis Sotiropoulo. Chronic pain causes Tau-mediated hippocampal pathology and memory deficits. Molecular psychiatry. 2022-09-02. PMID:36056171. |
using a peripheral (sciatic) neuropathy to model chronic pain in mice-spared nerve injury (sni) for 4 months-in wildtype as well as p301l-tau transgenic mice, we hereby demonstrate that sni triggers ad-related neuropathology characterized by tau hyperphosphorylation, accumulation, and aggregation in hippocampus followed by neuronal atrophy and memory deficits. |
2022-09-02 |
2023-08-14 |
mouse |
| Sara R Guerreiro, Marco R Guimarães, Joana M Silva, Chrysoula Dioli, Anastasia Vamvaka-Iakovou, Raquel Sousa, Patrícia Gomes, Anastasia Megalokonomou, Carlos Campos-Marques, Ana Margarida Cunha, Armando Almeida, Nuno Sousa, Hugo Leite-Almeida, Ioannis Sotiropoulo. Chronic pain causes Tau-mediated hippocampal pathology and memory deficits. Molecular psychiatry. 2022-09-02. PMID:36056171. |
interestingly, genetic ablation of tau blocks the establishment of sni-induced hippocampal morphofunctional deficits supporting the mediating role of tau in sni-evoked hippocampal pathology and memory impairment. |
2022-09-02 |
2023-08-14 |
mouse |
| Ejlal Abu-El-Rub, Ramada R Khasawneh, Fatimah A Almahasneh, Basma Milad Aloud, Hana M Zegalla. The molecular and functional changes of Neural stem cells in Alzheimer's disease: Can they be reinvigorated to conduct Neurogenesis. Current stem cell research & therapy. 2022-09-01. PMID:36045542. |
ad's previously known pathological basis is the deposition of amyloid β (aβ) aggregates and the formation of neurofibrillary tangles by tau hyperphosphorylation in the cell bodies of neurons that are located in the hippocampus, neocortex, and certain other regions of the cerebral hemispheres and limbic system. |
2022-09-01 |
2023-08-14 |
Not clear |
| Hao Liu, Zhi Yang, Chunyan Yu, Hao Dong, Shiyan Wang, Gang Wang, Denian Wan. Tau aggravates stress-induced anxiety by inhibiting adult ventral hippocampal neurogenesis in mice. Cerebral cortex (New York, N.Y. : 1991). 2022-09-01. PMID:36047921. |
tau aggravates stress-induced anxiety by inhibiting adult ventral hippocampal neurogenesis in mice. |
2022-09-01 |
2023-08-14 |
mouse |
| Hao Liu, Zhi Yang, Chunyan Yu, Hao Dong, Shiyan Wang, Gang Wang, Denian Wan. Tau aggravates stress-induced anxiety by inhibiting adult ventral hippocampal neurogenesis in mice. Cerebral cortex (New York, N.Y. : 1991). 2022-09-01. PMID:36047921. |
furthermore, glycogen synthase kinase-3β and calcium/calmodulin-dependent protein kinase ii-α activity and calcium/calmodulin-dependent protein kinase ii-β upregulation substantially promote tau phosphorylation, which disrupts the dendritic structural plasticity of granule cells in the vdg of the hippocampus, and this action is necessary and sufficient for the stress response. |
2022-09-01 |
2023-08-14 |
mouse |
| Hao Liu, Zhi Yang, Chunyan Yu, Hao Dong, Shiyan Wang, Gang Wang, Denian Wan. Tau aggravates stress-induced anxiety by inhibiting adult ventral hippocampal neurogenesis in mice. Cerebral cortex (New York, N.Y. : 1991). 2022-09-01. PMID:36047921. |
taken together, our findings reveal a novel mechanism by which tau exacerbates stress responses and anxiety-related behavior by inhibiting the proliferation and maturation of hippocampal vdg neurons, providing a potential molecular target for the treatment of anxiety-like behavior induced by stress. |
2022-09-01 |
2023-08-14 |
mouse |
| Yujun Tu, Qi Chen, Wenjia Guo, Pu Xiang, Haifeng Huang, Huizhi Fei, Lin Chen, Yang Yang, Zhe Peng, Chao Gu, Xiaodan Tan, Xia Liu, Yi Lu, Rongchun Chen, Hong Wang, Ying Luo, Junqing Yan. MiR-702-5p ameliorates diabetic encephalopathy in db/db mice by regulating 12/15-LOX. Experimental neurology. 2022-08-27. PMID:36029808. |
in vivo, diabetic mice with cognitive dysfunction and hippocampal neuronal damage had a concomitant increase in amyloid precursor protein (app), amyloid beta(aβ), tau, bax protein expressions; by contrast, bcl-2 protein expression was significantly decreased. |
2022-08-27 |
2023-08-14 |
mouse |
| Yujun Tu, Qi Chen, Wenjia Guo, Pu Xiang, Haifeng Huang, Huizhi Fei, Lin Chen, Yang Yang, Zhe Peng, Chao Gu, Xiaodan Tan, Xia Liu, Yi Lu, Rongchun Chen, Hong Wang, Ying Luo, Junqing Yan. MiR-702-5p ameliorates diabetic encephalopathy in db/db mice by regulating 12/15-LOX. Experimental neurology. 2022-08-27. PMID:36029808. |
overexpression of mir-702-5p significantly reduced the histopathological damage of the hippocampus, improved the learning and memory function of db/db mice, down-regulated 12/15-lox, app, aβ, tau, bax protein expressions significantly and up-regulated the expression of bcl-2. |
2022-08-27 |
2023-08-14 |
mouse |
| Luis A Campero-Garcia, Jose A Cantoral-Ceballos, Alejandra Martinez-Maldonado, Jose Luna-Muñoz, Miguel A Ontiveros-Torres, Andres E Gutierrez-Rodrigue. A Novel Automatic Quantification Protocol for Biomarkers of Tauopathies in the Hippocampus and Entorhinal Cortex of Post-Mortem Samples Using an Extended Semi-Siamese U-Net. Biology. vol 11. issue 8. 2022-08-26. PMID:36009757. |
however, the standard approach to exploring the phenomenon of neurodegeneration in tauopathies has not been directed at understanding the molecular mechanism that causes the aberrant polymeric and fibrillar behavior of the tau protein, which forms neurofibrillary tangles that replace neuronal populations in the hippocampal and cortical regions. |
2022-08-26 |
2023-08-14 |
human |
| Kurt Farrell, Megan A Iida, Jonathan D Cherry, Alicia Casella, Thor D Stein, Kevin F Bieniek, Jamie M Walker, Timothy E Richardson, Charles L White, Victor E Alvarez, Bertrand R Huber, Dennis W Dickson, Ricardo Insausti, Kristen Dams-O'Connor, Ann C McKee, John F Crar. Differential Vulnerability of Hippocampal Subfields in Primary Age-Related Tauopathy and Chronic Traumatic Encephalopathy. Journal of neuropathology and experimental neurology. 2022-08-25. PMID:36004533. |
in moderate to advanced cte, nfts accumulate in the hippocampus, potentially overlapping neuroanatomically with primary age-related tauopathy (part), an age-related tauopathy characterized by alzheimer disease-like tau pathology in the hippocampus devoid of amyloid plaques. |
2022-08-25 |
2023-08-14 |
human |