| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elisabeth Black, Abbey Rasch, Tyler Wimmer, Alivia Li, Amanda Araujo, Steve Cieslak, Kevin S Steed, Rajan D Adhikari, Jonathan J Wisco, Bre Anna Hutchinso. The Effects of Age, Genotype, and Diet on Hippocampal Subfield Iron Dysregulation and Alzheimer's Disease Biomarkers in an ApoE Mouse Model. The European journal of neuroscience. 2023-02-13. PMID:36775930. |
we stained for ferritin, ferroportin, hyper-phosphorylated tau, and β-amyloid proteins in the hippocampal region of apolipoprotein e2 (apoe2), apoe3, or apoe4 mice fed a control diet or a hypothesized inflammation-inducing methionine diet and euthanized at 3, 6, 9, or 12 months. |
2023-02-13 |
2023-08-14 |
mouse |
| Elisabeth Black, Abbey Rasch, Tyler Wimmer, Alivia Li, Amanda Araujo, Steve Cieslak, Kevin S Steed, Rajan D Adhikari, Jonathan J Wisco, Bre Anna Hutchinso. The Effects of Age, Genotype, and Diet on Hippocampal Subfield Iron Dysregulation and Alzheimer's Disease Biomarkers in an ApoE Mouse Model. The European journal of neuroscience. 2023-02-13. PMID:36775930. |
additionally, there were non-significant trends in each hippocampal subfield of increasing ferroportin and hyper-phosphorylated tau after 6 months of age, and decreasing β-amyloid and ferritin with age. |
2023-02-13 |
2023-08-14 |
mouse |
| Danny Baltissen, Charlotte S Bold, Lena Rehra, Marija Banićević, Justus Fricke, Jennifer Just, Susann Ludewig, Christian J Buchholz, Martin Korte, Ulrike C Mülle. APPsα rescues CDK5 and GSK3β dysregulation and restores normal spine density in Tau transgenic mice. Frontiers in cellular neuroscience. vol 17. 2023-02-13. PMID:36779015. |
immunohistochemistry revealed a dramatic increase in pathologically phosphorylated (at8 and at180) or misfolded tau species (mc1) in the hippocampus of thy-tau22 mice between 3 and 12 months of age. |
2023-02-13 |
2023-08-14 |
mouse |
| Danny Baltissen, Charlotte S Bold, Lena Rehra, Marija Banićević, Justus Fricke, Jennifer Just, Susann Ludewig, Christian J Buchholz, Martin Korte, Ulrike C Mülle. APPsα rescues CDK5 and GSK3β dysregulation and restores normal spine density in Tau transgenic mice. Frontiers in cellular neuroscience. vol 17. 2023-02-13. PMID:36779015. |
using a highly sensitive radioactive kinase assay with recombinant human tau as a substrate and immunoblotting, we demonstrate an increase in gsk3β and cdk5 activity in the hippocampus of thy-tau22 mice. |
2023-02-13 |
2023-08-14 |
mouse |
| Xiuli Zhang, Shivakumar Subbanna, Colin R O Williams, Stefanie Canals-Baker, John F Smiley, Donald A Wilson, Bhaskar C Das, Mariko Sait. Anti-inflammatory Action of BT75, a Novel RARα Agonist, in Cultured Microglia and in an Experimental Mouse Model of Alzheimer's Disease. Neurochemical research. 2023-02-13. PMID:36781685. |
western blot results showed that bt75 decreased levels of neuronal nitric oxide synthase (nnos), gfap, and phosphorylated tau, and increased levels of synaptophysin in the hippocampus of icv-stz mice. |
2023-02-13 |
2023-08-14 |
mouse |
| Yi-Ying Li, Kai-Yue Yu, Yu-Jia Cui, Zhao-Jun Wang, Hong-Yan Cai, Ji-Min Cao, Mei-Na W. Orexin-A aggravates cognitive deficits in 3xTg-AD mice by exacerbating synaptic plasticity impairment and affecting amyloid β metabolism. Neurobiology of aging. vol 124. 2023-02-09. PMID:36758468. |
the results showed that oxa aggravated memory impairments and circadian rhythm disturbance, exacerbated hippocampal ltp depression, and increased aβ and tau pathologies in 3xtg-ad mice by affecting bace1 and nep expression. |
2023-02-09 |
2023-08-14 |
mouse |
| Xiao-Hui Li, Hong-Can Zhu, Xue-Min Cui, Wang Wang, Lin Yang, Li-Bo Wang, Neng-Wei Hu, Dong-Xiao Dua. Death-associated protein kinase 1 is associated with cognitive dysfunction in major depressive disorder. Neural regeneration research. vol 18. issue 8. 2023-02-08. PMID:36751808. |
exercise and treatment with the antidepressant drug citalopram decreased dapk1 expression and tau protein phosphorylation in hippocampal tissue and improved both depressive symptoms and cognitive dysfunction. |
2023-02-08 |
2023-08-14 |
mouse |
| Ying-Ying Yang, Yan-Tao Ren, Meng-Yu Jia, Chen-Yang Bai, Xiu-Ting Liang, Hui-Ling Gao, Man-Li Zhong, Tao Wang, Chuang Gu. The human islet amyloid polypeptide reduces hippocampal tauopathy and behavioral impairments in P301S mice without inducing neurotoxicity or seeding amyloid aggregation. Experimental neurology. 2023-02-07. PMID:36750170. |
here, we found that long-term h-iapp treatment attenuated tau hyperphosphorylation levels and induced neuroinflammation and oxidative damage, prevented synaptic loss and neuronal degeneration in the hippocampus, and alleviated behavioral deficits in p301s transgenic mice (a mouse model of tauopathy). |
2023-02-07 |
2023-08-14 |
mouse |
| Amber M Tetlow, Brianna M Jackman, Mohammed M Alhadidy, Patricia Muskus, David G Morgan, Marcia N Gordo. Neural atrophy produced by AAV tau injections into hippocampus and anterior cortex of middle-aged mice. Neurobiology of aging. vol 124. 2023-02-05. PMID:36739619. |
neural atrophy produced by aav tau injections into hippocampus and anterior cortex of middle-aged mice. |
2023-02-05 |
2023-08-14 |
mouse |
| Raffaella Franciotti, Davide Nardini, Mirella Russo, Marco Onofrj, Stefano L Sens. Comparison of Machine Learning-based approaches to predict the conversion to Alzheimer's disease from Mild Cognitive Impairment. Neuroscience. 2023-02-03. PMID:36736612. |
finally, the feature selection procedure indicated that the most critical variables in the respective classes were the adas-cog-13 scale, the medial temporal lobe and hippocampus atrophy, and the ratio between phosphorylated tau and aβ42 proteins. |
2023-02-03 |
2023-08-14 |
human |
| Ling-Ling Ye, Yuan-Lu Huang, Xiao-E Cheng, Yin-Qi Shi, Zi-Ye Liu, Ying-Fen Xion. Effect of neurotropin on Alzheimer's disease-like changes and cognitive function in rats with chronic cerebral hypoperfusion. Neuroreport. 2023-01-31. PMID:36719834. |
subsequently, an elisa was applied to detect amyloid-β (aβ) 1-40 and aβ1-42 levels in rat hippocampal tissues, quantitative reverse transcription pcr assays were used to detect the mrna expression levels of brain-derived neurotrophic factor (bdnf) and trk b, and western blots were used to detect the protein expression levels of bace1, tau, p-tau, and protein kinase b (akt)/glycogen synthase kinase 3β (gsk3β) pathway-related proteins. |
2023-01-31 |
2023-08-14 |
rat |
| Ling-Ling Ye, Yuan-Lu Huang, Xiao-E Cheng, Yin-Qi Shi, Zi-Ye Liu, Ying-Fen Xion. Effect of neurotropin on Alzheimer's disease-like changes and cognitive function in rats with chronic cerebral hypoperfusion. Neuroreport. 2023-01-31. PMID:36719834. |
ntp treatment greatly ameliorated the cognitive disability, reduced aβ1-40 and aβ1-42 levels and tau phosphorylation, and upregulated bace1, trk b, and bdnf expression in the hippocampus of 2vo rats. |
2023-01-31 |
2023-08-14 |
rat |
| Ling-Ling Ye, Yuan-Lu Huang, Xiao-E Cheng, Yin-Qi Shi, Zi-Ye Liu, Ying-Fen Xion. Effect of neurotropin on Alzheimer's disease-like changes and cognitive function in rats with chronic cerebral hypoperfusion. Neuroreport. 2023-01-31. PMID:36719834. |
ntp can ameliorate cognitive disability in cch rats possibly by reducing aβ accumulation and tau phosphorylation in the hippocampus. |
2023-01-31 |
2023-08-14 |
rat |
| Miriam Zamorano, Jenolyn F Alexander, Desiree Catania, Shruti Dharmaraj, Annemieke Kavelaars, Cobi J Heijne. Nasal administration of mesenchymal stem cells prevents accelerated age-related tauopathy after chemotherapy in mice. Immunity & ageing : I & A. vol 20. issue 1. 2023-01-26. PMID:36698170. |
we showed recently that treatment of 9-month-old male mice with cisplatin causes cognitive deficits that are associated with formation of tau deposits in the hippocampus. |
2023-01-26 |
2023-08-14 |
mouse |
| Bastien Herli. Hippocampal sclerosis linked to epilepsy: clinical consequences, histopathology and evolution with aging Geriatrie et psychologie neuropsychiatrie du vieillissement. vol 20. issue 4. 2023-01-26. PMID:36700444. |
hippocampal sclerosis is associated with amyloid and tau deposits inside the hippocampus, which increases with the subjects’ age. |
2023-01-26 |
2023-08-14 |
human |
| Bastien Herli. Hippocampal sclerosis linked to epilepsy: clinical consequences, histopathology and evolution with aging Geriatrie et psychologie neuropsychiatrie du vieillissement. vol 20. issue 4. 2023-01-26. PMID:36700444. |
those deposits pattern is close to the one observed in patients with tau / amyloïd neurodegenerative diseases, which demonstrates a bilateral relationship between epilepsy, hippocampal sclerosis, and neurodegenerative diseases. |
2023-01-26 |
2023-08-14 |
human |
| Guoliang Fang, Jiexiu Zhao, Pengfei Li, Liang Li, Tao Yu, Xingya Yang, Zihong He, Ye Tia. Long-term treadmill exercise inhibits neuronal cell apoptosis and reduces tau phosphorylation in the cerebral cortex and hippocampus of aged rats. Science bulletin. vol 62. issue 11. 2023-01-20. PMID:36659268. |
long-term treadmill exercise inhibits neuronal cell apoptosis and reduces tau phosphorylation in the cerebral cortex and hippocampus of aged rats. |
2023-01-20 |
2023-08-14 |
rat |
| Gouri Patil, Shabda Kulsange, Rubina Kazi, Tejas Chirmade, Vaikhari Kale, Chandrashekhar Mote, Manoj Aswar, Santosh Koratkar, Sachin Agawane, Mahesh Kulkarn. Behavioral and Proteomic Studies Reveal Methylglyoxal Activate Pathways Associated with Alzheimer's Disease. ACS pharmacology & translational science. vol 6. issue 1. 2023-01-19. PMID:36654748. |
the hippocampal tau phosphorylation level was increased in mgo treated rats, which was reduced in the presence of aminoguanidine and telmisartan. |
2023-01-19 |
2023-08-14 |
rat |
| Nikhil Dave, Jessica M Judd, Annika Decker, Wendy Winslow, Patrick Sarette, Oscar Villarreal Espinosa, Savannah Tallino, Samantha K Bartholomew, Alina Bilal, Jessica Sandler, Ian McDonough, Joanna K Winstone, Erik A Blackwood, Christopher Glembotski, Timothy Karr, Ramon Velazque. Dietary choline intake is necessary to prevent systems-wide organ pathology and reduce Alzheimer's disease hallmarks. Aging cell. 2023-01-16. PMID:36642814. |
tissue analyses showed cardiac and liver pathology, elevated soluble and insoluble amyloid-β and thioflavin s structures, and tau hyperphosphorylation at various pathological epitopes in the hippocampus and cortex of 3xtg-ad ch- mice. |
2023-01-16 |
2023-08-14 |
mouse |
| Hai Duc Nguyen, Won Hee Jo, Ngoc Hong Minh Hoang, Min-Sun Ki. Risperidone ameliorated 1,2-Diacetylbenzene-induced cognitive impairments in mice via activating prolactin signaling pathways. International immunopharmacology. vol 115. 2023-01-15. PMID:36641890. |
risperidone alleviated dab-induced cognitive impairment in hippocampal mice, possibly by inhibiting gsk-3β, β-amyloid, cdk5, bace, and tau hyperphosphorylation. |
2023-01-15 |
2023-08-14 |
mouse |