| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Benjamin B Tournier, Christophe Snoeijs, Stergios Tsartsalis, Quentin Amossé, Ramzi Farchoukh, Eniko Kövari, Kelly Ceyzériat, Philippe Mille. The 18 kDa translocator protein is associated with microglia in the hippocampus of non-demented elderly subjects. Aging brain. vol 2. 2023-03-13. PMID:36908874. |
to determine if tspo is associated with the presence of amyloid β plaques and/or phosphorylated tau accumulation, we analyzed hippocampal sections using immunohistochemistry of 14 non-demented subjects with positive staining for aβ and/or phosphorylated tau. |
2023-03-13 |
2023-08-14 |
human |
| Emma M Coomans, Jori Tomassen, Rik Ossenkoppele, Betty M Tijms, Luigi Lorenzini, Mara Ten Kate, Lyduine E Collij, Fiona Heeman, Roos M Rikken, Sophie M van der Landen, Marijke E den Hollander, Sandeep S V Golla, Maqsood Yaqub, Albert D Windhorst, Frederik Barkhof, Philip Scheltens, Eco J C de Geus, Pieter Jelle Visser, Bart N M van Berckel, Anouk den Brabe. Genetically identical twin-pair difference models support the amyloid cascade hypothesis. Brain : a journal of neurology. 2023-03-09. PMID:36892415. |
we included 78 cognitively unimpaired identical twins with [18f]flutemetamol (amyloid-β)-pet, [18f]flortaucipir (tau)-pet, mri (hippocampal volume), and cognitive data (composite memory). |
2023-03-09 |
2023-08-14 |
Not clear |
| Emma M Coomans, Jori Tomassen, Rik Ossenkoppele, Betty M Tijms, Luigi Lorenzini, Mara Ten Kate, Lyduine E Collij, Fiona Heeman, Roos M Rikken, Sophie M van der Landen, Marijke E den Hollander, Sandeep S V Golla, Maqsood Yaqub, Albert D Windhorst, Frederik Barkhof, Philip Scheltens, Eco J C de Geus, Pieter Jelle Visser, Bart N M van Berckel, Anouk den Brabe. Genetically identical twin-pair difference models support the amyloid cascade hypothesis. Brain : a journal of neurology. 2023-03-09. PMID:36892415. |
within-pair differences in amyloid-β were strongly associated with within-pair differences in tau (β=0.68, p < 0.001), and moderately associated with within-pair differences in hippocampal volume (β=-0.37, p = 0.03) and memory functioning (β=-0.57, p < 0.001). |
2023-03-09 |
2023-08-14 |
Not clear |
| Emma M Coomans, Jori Tomassen, Rik Ossenkoppele, Betty M Tijms, Luigi Lorenzini, Mara Ten Kate, Lyduine E Collij, Fiona Heeman, Roos M Rikken, Sophie M van der Landen, Marijke E den Hollander, Sandeep S V Golla, Maqsood Yaqub, Albert D Windhorst, Frederik Barkhof, Philip Scheltens, Eco J C de Geus, Pieter Jelle Visser, Bart N M van Berckel, Anouk den Brabe. Genetically identical twin-pair difference models support the amyloid cascade hypothesis. Brain : a journal of neurology. 2023-03-09. PMID:36892415. |
within-pair differences in tau were moderately associated with within-pair differences in hippocampal volume (β=-0.53, p < 0.001) and strongly associated with within-pair differences in memory functioning (β=-0.68, p < 0.001). |
2023-03-09 |
2023-08-14 |
Not clear |
| Emma M Coomans, Jori Tomassen, Rik Ossenkoppele, Betty M Tijms, Luigi Lorenzini, Mara Ten Kate, Lyduine E Collij, Fiona Heeman, Roos M Rikken, Sophie M van der Landen, Marijke E den Hollander, Sandeep S V Golla, Maqsood Yaqub, Albert D Windhorst, Frederik Barkhof, Philip Scheltens, Eco J C de Geus, Pieter Jelle Visser, Bart N M van Berckel, Anouk den Brabe. Genetically identical twin-pair difference models support the amyloid cascade hypothesis. Brain : a journal of neurology. 2023-03-09. PMID:36892415. |
mediation analyses showed that of the total twin-difference effect of amyloid-β on memory functioning, the proportion mediated through pathways including tau and hippocampal volume was 69.9%, which was largely attributable to the pathway leading from amyloid-β to tau to memory functioning (proportion mediated: 51.6%). |
2023-03-09 |
2023-08-14 |
Not clear |
| Kayvan Khoramipour, Mohammad Abbas Bejeshk, Mohammad Amin Rajizadeh, Hamid Najafipour, Padideh Dehghan, Fattaneh Farahman. High-Intensity Interval Training Ameliorates Molecular Changes in the Hippocampus of Male Rats with the Diabetic Brain: the Role of Adiponectin. Molecular neurobiology. 2023-03-06. PMID:36877358. |
this study investigated the impact of high-intensity interval training (hiit) on diabetes-induced disturbances in ad-related factors (including amp-activated protein kinase (ampk), glycogen synthase kinase-3β (gsk3β), and tau protein) in the hippocampus, with the main focus on adiponectin signaling.in total, 28 male wistar rats at the age of 8 weeks were randomly assigned to four groups (n = 7 in each group): control (con), type 2 diabetes (t2d), hiit (ex), and type 2 diabetes + hiit (t2d + ex). |
2023-03-06 |
2023-08-14 |
rat |
| Marco Antônio De Bastiani, Bruna Bellaver, Wagner S Brum, Debora G Souza, Pamela C L Ferreira, Andreia S Rocha, Guilherme Povala, João Pedro Ferrari-Souza, Andrea L Benedet, Nicholas J Ashton, Thomas K Karikari, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto, Tharick A Pascoal, Eduardo R Zimme. Hippocampal GFAP-positive astrocyte responses to amyloid and tau pathologies. Brain, behavior, and immunity. 2023-03-06. PMID:36878332. |
hippocampal gfap-positive astrocyte responses to amyloid and tau pathologies. |
2023-03-06 |
2023-08-14 |
mouse |
| Marco Antônio De Bastiani, Bruna Bellaver, Wagner S Brum, Debora G Souza, Pamela C L Ferreira, Andreia S Rocha, Guilherme Povala, João Pedro Ferrari-Souza, Andrea L Benedet, Nicholas J Ashton, Thomas K Karikari, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto, Tharick A Pascoal, Eduardo R Zimme. Hippocampal GFAP-positive astrocyte responses to amyloid and tau pathologies. Brain, behavior, and immunity. 2023-03-06. PMID:36878332. |
here we investigated biomarker and transcriptomic associations of hippocampal gfap-positive astrocytes with aβ and tau pathologies in humans and mouse models. |
2023-03-06 |
2023-08-14 |
mouse |
| Meaghan Morris, Gabrielle I Coste, Javier Redding-Ochoa, Haidan Guo, Austin R Graves, Juan C Troncoso, Richard L Hugani. Hippocampal Synaptic Alterations Associated with Tau Pathology in Primary Age-Related Tauopathy. medRxiv : the preprint server for health sciences. 2023-03-03. PMID:36865237. |
hippocampal synaptic alterations associated with tau pathology in primary age-related tauopathy. |
2023-03-03 |
2023-08-14 |
Not clear |
| Meaghan Morris, Gabrielle I Coste, Javier Redding-Ochoa, Haidan Guo, Austin R Graves, Juan C Troncoso, Richard L Hugani. Hippocampal Synaptic Alterations Associated with Tau Pathology in Primary Age-Related Tauopathy. medRxiv : the preprint server for health sciences. 2023-03-03. PMID:36865237. |
high pathologic tau stage (braak stage) or a high burden of hippocampal tau pathology have been associated with cognitive impairment in part. |
2023-03-03 |
2023-08-14 |
Not clear |
| Meaghan Morris, Gabrielle I Coste, Javier Redding-Ochoa, Haidan Guo, Austin R Graves, Juan C Troncoso, Richard L Hugani. Hippocampal Synaptic Alterations Associated with Tau Pathology in Primary Age-Related Tauopathy. medRxiv : the preprint server for health sciences. 2023-03-03. PMID:36865237. |
in this study, we identified loss of synaptophysin puncta and intensity in the ca2 region of the hippocampus in cases of part with either a high stage (braak iv) or a high burden of neuritic tau pathology. |
2023-03-03 |
2023-08-14 |
Not clear |
| Meaghan Morris, Gabrielle I Coste, Javier Redding-Ochoa, Haidan Guo, Austin R Graves, Juan C Troncoso, Richard L Hugani. Hippocampal Synaptic Alterations Associated with Tau Pathology in Primary Age-Related Tauopathy. medRxiv : the preprint server for health sciences. 2023-03-03. PMID:36865237. |
these novel findings suggest the presence of synaptic loss in part associated with either a high hippocampal tau burden or a braak stage iv. |
2023-03-03 |
2023-08-14 |
Not clear |
| Abdel-Azim Assi, Magda M Y Farrag, Dalia M Badary, Essmat A H Allam, Mariam A Nicol. Protective effects of curcumin and Ginkgo biloba extract combination on a new model of Alzheimer's disease. Inflammopharmacology. 2023-03-01. PMID:36856916. |
this was associated with a more pronounced inhibitory effect on acetylcholinesterase (ache), caspase-3, hippocampal amyloid beta (aβ1-42), and phosphorylated tau protein (p-tau) count, and pro-inflammatory cytokines tumor necrosis factor-alpha (tnf-α) and interleukine-1beta (il-1β), as compared to the curcumin alone-treated group. |
2023-03-01 |
2023-08-14 |
rat |
| Kyle R Christensen, Benjamin Combs, Collin Richards, Tessa Grabinski, Mohammed M Alhadidy, Nicholas M Kanaa. Phosphomimetics at Ser199/Ser202/Thr205 in Tau Impairs Axonal Transport in Rat Hippocampal Neurons. Molecular neurobiology. 2023-03-01. PMID:36859689. |
phosphomimetics at ser199/ser202/thr205 in tau impairs axonal transport in rat hippocampal neurons. |
2023-03-01 |
2023-08-14 |
rat |
| Yunfang Su, Ningning Liu, Ruiqin Sun, Jinlian Ma, Zhonghua Li, Pan Wang, Huifen Ma, Yiran Sun, Junying Song, Zhenqiang Zhan. Radix Rehmanniae Praeparata (Shu Dihuang) exerts neuroprotective effects on ICV-STZ-induced Alzheimer's disease mice through modulation of INSR/IRS-1/AKT/GSK-3β signaling pathway and intestinal microbiota. Frontiers in pharmacology. vol 14. 2023-02-27. PMID:36843923. |
the pharmacological effects of rrp were evaluated by behavioral tests, brain tissue h&e staining and hippocampal tau protein phosphorylation levels. |
2023-02-27 |
2023-08-14 |
mouse |
| Yunfang Su, Ningning Liu, Ruiqin Sun, Jinlian Ma, Zhonghua Li, Pan Wang, Huifen Ma, Yiran Sun, Junying Song, Zhenqiang Zhan. Radix Rehmanniae Praeparata (Shu Dihuang) exerts neuroprotective effects on ICV-STZ-induced Alzheimer's disease mice through modulation of INSR/IRS-1/AKT/GSK-3β signaling pathway and intestinal microbiota. Frontiers in pharmacology. vol 14. 2023-02-27. PMID:36843923. |
the results showed that rrp ameliorated cognitive dysfunction and neuronal pathological changes of brain tissue in icv-stz mice, reduced tau protein hyperphosphorylation, insr, irs-1, pser473-akt/akt, and pser9-gsk-3β/gsk-3β levels in hippocampal and cortical tissues. |
2023-02-27 |
2023-08-14 |
mouse |
| Hiromitsu Tanaka, Hiroaki Matsushita, Keizo Tokuhiro, Atsushi Fukunari, Yukio And. Ingestion of Soybean Sprouts Containing a HASPIN Inhibitor Improves Condition in a Mouse Model of Alzheimer's Disease. Biology. vol 12. issue 2. 2023-02-25. PMID:36829593. |
the results showed that haspin was expressed in the hippocampus and phosphorylated tau protein, while the ingestion of soybean sprouts containing coumestrol suppressed the development of spatial cognitive dysfunction in 5xfad. |
2023-02-25 |
2023-08-14 |
mouse |
| b' Samo Ribari\\xc4\\x8. Detecting Early Cognitive Decline in Alzheimer\'s Disease with Brain Synaptic Structural and Functional Evaluation. Biomedicines. vol 11. issue 2. 2023-02-25. PMID:36830892.' |
ad dysregulation of aβ and tau metabolism progressively disrupt normal synaptic function, leading to loss of synapses, decreased hippocampal synaptic density and early hippocampal atrophy. |
2023-02-25 |
2023-08-14 |
Not clear |
| Taku Homma, Yoko Mochizuki, Shinsuke Tobisawa, Takashi Komori, Kazushi Takahash. Differential immunophenotypes of neuronal cytoplasmic inclusions in the dentate gyrus of multiple system atrophy and their association with clinicopathological features. Journal of neuropathology and experimental neurology. 2023-02-25. PMID:36840692. |
we investigated hippocampal nci pathology in 18 msa patient autopsies, focusing on phosphorylated α-synuclein (pas)- and phosphorylated tau (pt)-positive dntncis. |
2023-02-25 |
2023-08-14 |
Not clear |
| Bo Pang, Lu-Lu Zhang, Bin Li, Feng-Xian Sun, Zhi-Da Wan. The sodium glucose co-transporter 2 inhibitor ertugliflozin for Alzheimer's disease: inhibition of brain insulin signaling disruption-induced tau hyperphosphorylation. Physiology & behavior. 2023-02-22. PMID:36809844. |
importantly, we found that the hyperphosphorylation of tau in the hippocampus of stz/i.c.v rats was decreased after oral administration of ertugliflozin, which was accompanied by decreased phospho.irs-1 |
2023-02-22 |
2023-08-14 |
rat |