| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junghyung Park, Jinyoung Won, Chang-Yeop Jeon, Kyung Seob Lim, Won Seok Choi, Sung-Hyun Park, Jincheol Seo, Jiyeon Cho, Jung Bae Seong, Hyeon-Gu Yeo, Keonwoo Kim, Yu Gyeong Kim, Minji Kim, Kyung Sik Yi, Youngjeon Le. XperCT-guided Intra-cisterna Magna Injection of Streptozotocin for Establishing an Alzheimer's Disease Model Using the Cynomolgus Monkey ( Experimental neurobiology. vol 31. issue 6. 2023-01-11. PMID:36631849. |
the monkeys subjected to xperct-based stz injection via the icm route showed features of ad pathology, including markedly enhanced neuronal loss, synaptic impairment, and tau phosphorylation in the hippocampus. |
2023-01-11 |
2023-08-14 |
human |
| Arunkumar Subramanian, T Tamilanban, Abdulrhman Alsayari, Gobinath Ramachawolran, Ling Shing Wong, Mahendran Sekar, Siew Hua Gan, Vetriselvan Subramaniyan, Suresh V Chinni, Nur Najihah Izzati Mat Rani, Nagaraja Suryadevara, Shadma Waha. Trilateral association of autophagy, mTOR and Alzheimer's disease: Potential pathway in the development for Alzheimer's disease therapy. Frontiers in pharmacology. vol 13. 2023-01-09. PMID:36618946. |
alzheimer's disease (ad) is the chief cause of progressive dementia, and it is characterized by irreparable loss of cognitive abilities, forming senile plaques having amyloid beta (aβ) aggregates and neurofibrillary tangles with considerable amounts of tau in affected hippocampus and cortex regions of human brains. |
2023-01-09 |
2023-08-14 |
human |
| Young-Kook Kim, Yoon Seok Jung, Juhyun Son. Transcriptome Profile in the Mouse Brain of Hepatic Encephalopathy and Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36614117. |
alzheimer's disease (ad), the most common neurodegenerative disease, is characterized by tau hyperphosphorylation, excessive amyloid beta (aβ) accumulation, the formation of fibrillary tangles, hippocampus atrophy, and neuroinflammation. |
2023-01-08 |
2023-08-14 |
mouse |
| Zheng Liang, Xiaokang Gong, Runjia Ye, Yang Zhao, Jin Yu, Yanna Zhao, Jian Ba. Long-Term High-Fat Diet Consumption Induces Cognitive Decline Accompanied by Tau Hyper-Phosphorylation and Microglial Activation in Aging. Nutrients. vol 15. issue 1. 2023-01-08. PMID:36615907. |
compared with the nd group, the hfd-fed mice showed tau hyperphosphorylation at ps214 in the hippocampus and at ps422 and ps396 in the cortex, which was accompanied by gsk-3β activation. |
2023-01-08 |
2023-08-14 |
mouse |
| Thamires Naela Cardoso Magalhães, Raphael Fernandes Casseb, Christian Luiz Baptista Gerbelli, Luciana Ramalho Pimentel-Siva, Mateus Henrique Nogueira, Camila Vieira Ligo Teixeira, Ana Flávia Mac Knight Carletti, Thiago Junqueira Ribeiro de Rezende, Helena Passarelli Giroud Joaquim, Leda Leme Talib, Orestes Vicente Forlenza, Fernando Cendes, Marcio Luiz Figueredo Balthaza. Whole-brain DTI parameters associated with tau protein and hippocampal volume in Alzheimer's disease. Brain and behavior. 2023-01-05. PMID:36601694. |
whole-brain dti parameters associated with tau protein and hippocampal volume in alzheimer's disease. |
2023-01-05 |
2023-08-14 |
Not clear |
| Allegra Kawles, Grace Minogue, Antonia Zouridakis, Rachel Keszycki, Nathan Gill, Caren Nassif, Christina Coventry, Hui Zhang, Emily Rogalski, Margaret E Flanagan, Rudolph Castellani, Eileen H Bigio, M Marsel Mesulam, Changiz Geula, Tamar Gefe. Differential vulnerability of the dentate gyrus to tauopathies in dementias. Acta neuropathologica communications. vol 11. issue 1. 2023-01-03. PMID:36597124. |
the dentate gyrus (dg), a key hippocampal subregion in memory processing, generally resists phosphorylated tau accumulation in the amnestic dementia of the alzheimer's type due to alzheimer's disease (dat-ad), but less is known about the susceptibility of the dg to other tauopathies. |
2023-01-03 |
2023-08-14 |
human |
| Allegra Kawles, Grace Minogue, Antonia Zouridakis, Rachel Keszycki, Nathan Gill, Caren Nassif, Christina Coventry, Hui Zhang, Emily Rogalski, Margaret E Flanagan, Rudolph Castellani, Eileen H Bigio, M Marsel Mesulam, Changiz Geula, Tamar Gefe. Differential vulnerability of the dentate gyrus to tauopathies in dementias. Acta neuropathologica communications. vol 11. issue 1. 2023-01-03. PMID:36597124. |
we conclude that the dg is differentially vulnerable to pathologic tau accumulation, raising intriguing questions about the structural integrity and functional significance of hippocampal circuits in neurodegenerative dementias. |
2023-01-03 |
2023-08-14 |
human |
| Regina T Vontell, Juan Pablo de Rivero Vaccari, Xiaoyan Sun, Sakir Humayun Gultekin, Helen M Bramlett, W Dalton Dietrich, Robert W Kean. Identification of inflammasome signaling proteins in neurons and microglia in early and intermediate stages of Alzheimer's disease. Brain pathology (Zurich, Switzerland). 2022-12-29. PMID:36579934. |
we performed analysis of hippocampal thickness, β-amyloid plaques, and hyperphosphorylated tau to ascertain the cellular pathological changes that occur between low and intermediate ad pathology. |
2022-12-29 |
2023-08-14 |
Not clear |
| Yu-Xiao Wan, Guang Shi, Ling-Yan Jian, Xin-Yu Fa. Blockade of endocannabinoid system by oxytocin attenuates memory deficits in oxycodone-treated rats. Addiction biology. vol 28. issue 1. 2022-12-28. PMID:36577736. |
this finding was accompanied by elevation of pser396, pser404 in the tau, and reduction of the number of neurons, dendritic spines and synaptic density in the hippocampus. |
2022-12-28 |
2023-08-14 |
rat |
| Mariana G Fronza, Manoela Sacramento, Diego Alves, Domenico Praticò, Lucielli Savegnag. QTC-4-MeOBnE Ameliorated Depressive-Like Behavior and Memory Impairment in 3xTg Mice. Molecular neurobiology. 2022-12-25. PMID:36567360. |
among them, the reduction of amyloid beta (aβ) production mediated by changes in amyloid precursor protein metabolism and hippocampal tau phosphorylation through the inhibition of kinases. |
2022-12-25 |
2023-08-14 |
mouse |
| Hongtao Shen, Tianzhen Zhang, Yao Ji, Yu Zhang, Yongxiang Wang, Yuling Jiang, Xiongjin Chen, Qiuhao Liang, Kefeng Wu, Yunfeng Li, Xingyu Lu, Lili Cui, Bin Zhao, Yan Wan. GRK5 Deficiency in the Hippocampus Leads to Cognitive Impairment via Abnormal Microglial Alterations. Molecular neurobiology. 2022-12-16. PMID:36525154. |
here, we reported that mice with reduced grk5 in the hippocampus exhibit cognitive impairment and some alzheimer's disease (ad)-related molecular pathologies, such as significant neuronal damage and loss, enhanced tau protein phosphorylation, and increased levels of aβ peptides in the hippocampus. |
2022-12-16 |
2023-08-14 |
mouse |
| Laurel A Becket. Alzheimer's-related brain damage shows sex-specific links with risk factors. PLoS biology. vol 20. issue 12. 2022-12-14. PMID:36516115. |
alzheimer's disease is marked by brain damage from tau and amyloid aggregates, particularly to the hippocampus and the default network. |
2022-12-14 |
2023-08-14 |
Not clear |
| Vani Jangra, Jeshnu Topl. Can Alzheimer's Disease Be Secondary to Type-2 Diabetes Mellitus? Cureus. vol 14. issue 11. 2022-12-12. PMID:36505102. |
thirdly, several pathological research has also shown that beta-amyloid plaques, hyperphosphorylated tau protein, and brain shrinkage, particularly in the hippocampus, are shared brain lesions between insulin and alzheimer's disease. in light of this, type 2 diabetes mellitus may be viewed as a liability for dementia and alzheimer's disease. |
2022-12-12 |
2023-08-14 |
human |
| Chaitali Anand, Pedro D Maia, Justin Torok, Christopher Mezias, Ashish Ra. The effects of microglia on tauopathy progression can be quantified using Nexopathy in silico (Nexis) models. Scientific reports. vol 12. issue 1. 2022-12-08. PMID:36477076. |
trem2 appears to reduce tau accumulation rate while increasing its interregional spread from the hippocampal seed area, causing higher tau burden in the striatum, pallidum, and contralateral hippocampus. |
2022-12-08 |
2023-08-14 |
Not clear |
| Zhi-Yuan Lu, Chen-Yi Zhao, Guang Yang, Yu-Ting Tong, Zong-Tao Ba, Ahelijiang Reaila, Jian-Mei Yang, Ying X. [Modified Kaixin San improves memory and synaptic damage of mice with Alzheimer's disease by modulating αCaMKⅡ-PSD95 protein binding through inhibition of neuroinflammation:a study of mechanism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 22. 2022-12-06. PMID:36471948. |
novel object reco-gnition task was employed to detect the recognition memory of mice, and western blot to detect the protein levels of synapse-associated proteins in the hippocampus(hpc) of mice, such as nr1, nr2 a, nr2 b, p-αcamkⅡ, tau, and p-tau. |
2022-12-06 |
2023-08-14 |
mouse |
| Jianfeng Wu, Yi Su, Wenhui Zhu, Negar Jalili Mallak, Natasha Lepore, Eric M Reiman, Richard J Caselli, Paul M Thompson, Kewei Chen, Yalin Wan. Improved Prediction of Amyloid-β and Tau Burden Using Hippocampal Surface Multivariate Morphometry Statistics and Sparse Coding. Journal of Alzheimer's disease : JAD. 2022-12-04. PMID:36463452. |
improved prediction of amyloid-β and tau burden using hippocampal surface multivariate morphometry statistics and sparse coding. |
2022-12-04 |
2023-08-14 |
Not clear |
| Zhengtao Hu, Tomas Ondrejcak, Pengpeng Yu, Yangyang Zhang, Yin Yang, Igor Klyubin, Sean P Kennelly, Michael J Rowan, Neng-Wei H. Do tau-synaptic long-term depression interactions in the hippocampus play a pivotal role in the progression of Alzheimer's disease? Neural regeneration research. vol 18. issue 6. 2022-12-01. PMID:36453396. |
cognitive decline in alzheimer's disease correlates with the extent of tau pathology, in particular tau hyperphosphorylation that initially appears in the transentorhinal and related regions of the brain including the hippocampus. |
2022-12-01 |
2023-08-14 |
Not clear |
| Zhengtao Hu, Tomas Ondrejcak, Pengpeng Yu, Yangyang Zhang, Yin Yang, Igor Klyubin, Sean P Kennelly, Michael J Rowan, Neng-Wei H. Do tau-synaptic long-term depression interactions in the hippocampus play a pivotal role in the progression of Alzheimer's disease? Neural regeneration research. vol 18. issue 6. 2022-12-01. PMID:36453396. |
studies from our group and others demonstrate that long-term depression-inducing low-frequency stimulation triggers tau phosphorylation at different residues in the hippocampus under different experimental conditions including aging. |
2022-12-01 |
2023-08-14 |
Not clear |
| Zhengtao Hu, Tomas Ondrejcak, Pengpeng Yu, Yangyang Zhang, Yin Yang, Igor Klyubin, Sean P Kennelly, Michael J Rowan, Neng-Wei H. Do tau-synaptic long-term depression interactions in the hippocampus play a pivotal role in the progression of Alzheimer's disease? Neural regeneration research. vol 18. issue 6. 2022-12-01. PMID:36453396. |
conversely, certain forms of long-term depression at hippocampal glutamatergic synapses require endogenous tau, in particular, phosphorylation at residue ser396. |
2022-12-01 |
2023-08-14 |
Not clear |
| Wei-En Wang, Rob Chen, Robin Perry Mayrand, Malek Adjouadi, Ruogu Fang, Steven T DeKosky, Ranjan Duara, Stephen A Coombes, David E Vaillancour. Association of longitudinal cognitive decline with diffusion MRI in Gray Matter, Amyloid, and Tau deposition. Neurobiology of aging. vol 121. 2022-12-01. PMID:36455492. |
when the 3 groups were combined, increasing amyloid burden was associated with reduced extracellular free-water in the entorhinal cortex and hippocampus in those with amyloid-negative status whereas increasing tau burden was associated with increased extracellular free-water regardless of amyloid status. |
2022-12-01 |
2023-08-14 |
human |