| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alessandra Dos Santos, Fernanda Cardoso Teixeira, Daniel Schuch da Silva, Tayná Amaral Veleda, Julia Eisenhart de Mello, Karina Pereira Luduvico, Rejane Giacomelli Tavares, Francieli Moro Stefanello, Wilson Cunico Filho, Roselia Maria Spanevell. Thiazolidin-4-one prevents against memory deficits, increase in phosphorylated tau protein, oxidative damage and cholinergic dysfunction in Alzheimer disease model: comparison with donepezil drug. Brain research bulletin. 2022-11-28. PMID:36442692. |
memory, acetylcholinesterase (ache) activity, phosphorylated tau protein levels and oxidative stress were analyzed in the cerebral cortex, hippocampus, and cerebellum. |
2022-11-28 |
2023-08-14 |
rat |
| Shuai Zhao, Ziqi Fan, Xinyi Zhang, Zheyu Li, Ting Shen, Kaicheng Li, Yaping Yan, Yunfeng Yuan, Jiali Pu, Jun Tian, Zhirong Liu, Yanxing Chen, Baorong Zhan. Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2022-11-24. PMID:36422837. |
brain extracts containing tau aggregates were unilaterally injected into the hippocampus and the overlying cerebral cortex of ps19 mice. |
2022-11-24 |
2023-08-14 |
mouse |
| Daniel Ferreira, Rosaleena Mohanty, Melissa E Murray, Agneta Nordberg, Kejal Kantarci, Eric Westma. The hippocampal sparing subtype of Alzheimer's disease assessed in neuropathology and in vivo tau positron emission tomography: a systematic review. Acta neuropathologica communications. vol 10. issue 1. 2022-11-15. PMID:36376963. |
the hippocampal sparing subtype of alzheimer's disease assessed in neuropathology and in vivo tau positron emission tomography: a systematic review. |
2022-11-15 |
2023-08-14 |
human |
| Daniel Ferreira, Rosaleena Mohanty, Melissa E Murray, Agneta Nordberg, Kejal Kantarci, Eric Westma. The hippocampal sparing subtype of Alzheimer's disease assessed in neuropathology and in vivo tau positron emission tomography: a systematic review. Acta neuropathologica communications. vol 10. issue 1. 2022-11-15. PMID:36376963. |
we also implemented several methods for ad subtyping on tau pet to identify hippocampal sparing ad cases. |
2022-11-15 |
2023-08-14 |
human |
| Daniel Ferreira, Rosaleena Mohanty, Melissa E Murray, Agneta Nordberg, Kejal Kantarci, Eric Westma. The hippocampal sparing subtype of Alzheimer's disease assessed in neuropathology and in vivo tau positron emission tomography: a systematic review. Acta neuropathologica communications. vol 10. issue 1. 2022-11-15. PMID:36376963. |
in contrast, tau pet did identify ad participants with tracer retention in the association cortex while completely sparing the hippocampus. |
2022-11-15 |
2023-08-14 |
human |
| Daniel Ferreira, Rosaleena Mohanty, Melissa E Murray, Agneta Nordberg, Kejal Kantarci, Eric Westma. The hippocampal sparing subtype of Alzheimer's disease assessed in neuropathology and in vivo tau positron emission tomography: a systematic review. Acta neuropathologica communications. vol 10. issue 1. 2022-11-15. PMID:36376963. |
we conclude that tau pet can identify hippocampal sparing ad cases with nft completely sparing the hippocampus. |
2022-11-15 |
2023-08-14 |
human |
| Rocio Alfaro-Ruiz, Carolina Aguado, Alejandro Martín-Belmonte, Ana Esther Moreno-Martínez, Jesús Merchán-Rubira, Félix Hernández, Jesús Ávila, Yugo Fukazawa, Rafael Lujá. Alteration in the Synaptic and Extrasynaptic Organization of AMPA Receptors in the Hippocampus of P301S Tau Transgenic Mice. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36362317. |
alteration in the synaptic and extrasynaptic organization of ampa receptors in the hippocampus of p301s tau transgenic mice. |
2022-11-11 |
2023-08-14 |
mouse |
| Rocio Alfaro-Ruiz, Carolina Aguado, Alejandro Martín-Belmonte, Ana Esther Moreno-Martínez, Jesús Merchán-Rubira, Félix Hernández, Jesús Ávila, Yugo Fukazawa, Rafael Lujá. Alteration in the Synaptic and Extrasynaptic Organization of AMPA Receptors in the Hippocampus of P301S Tau Transgenic Mice. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36362317. |
here, we determined the impact of tau pathology on ampar expression, density, and subcellular distribution in the hippocampus of p301s mice using immunoblot, histoblot, and quantitative sds-digested freeze-fracture replica labeling (sds-frl). |
2022-11-11 |
2023-08-14 |
mouse |
| Yi Dong, Yuanjing Li, Keke Liu, Xiaolei Han, Rui Liu, Yifei Ren, Lin Cong, Qinghua Zhang, Tingting Hou, Lin Song, Shi Tang, Lin Shi, Yishan Luo, Grégoria Kalpouzos, Erika J Laukka, Bengt Winblad, Yongxiang Wang, Yifeng Du, Chengxuan Qi. Anosmia, mild cognitive impairment, and biomarkers of brain aging in older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-11-07. PMID:36341691. |
in the subsamples, we measured plasma amyloid beta (aβ)40, aβ42, total tau, and neurofilament light chain (nfl; n = 1054); and quantified hippocampal, entorhinal cortex, and white matter hyperintensity (wmh) volumes, and alzheimer's disease (ad)-signature cortical thickness (n = 917). |
2022-11-07 |
2023-08-14 |
human |
| Yi Dong, Yuanjing Li, Keke Liu, Xiaolei Han, Rui Liu, Yifei Ren, Lin Cong, Qinghua Zhang, Tingting Hou, Lin Song, Shi Tang, Lin Shi, Yishan Luo, Grégoria Kalpouzos, Erika J Laukka, Bengt Winblad, Yongxiang Wang, Yifeng Du, Chengxuan Qi. Anosmia, mild cognitive impairment, and biomarkers of brain aging in older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-11-07. PMID:36341691. |
in the subsamples, anosmia was significantly associated with higher plasma total tau and nfl concentrations, smaller hippocampal and entorhinal cortex volumes, and greater wmh volume, and marginally with lower ad-signature cortical thickness. |
2022-11-07 |
2023-08-14 |
human |
| Gabriel A Marx, Daniel G Koenigsberg, Andrew T McKenzie, Justin Kauffman, Russell W Hanson, Kristen Whitney, Maxim Signaevsky, Marcel Prastawa, Megan A Iida, Charles L White, Jamie M Walker, Timothy E Richardson, John Koll, Gerardo Fernandez, Jack Zeineh, Carlos Cordon-Cardo, John F Crary, Kurt Farrel. Artificial intelligence-derived neurofibrillary tangle burden is associated with antemortem cognitive impairment. Acta neuropathologica communications. vol 10. issue 1. 2022-11-01. PMID:36316708. |
we utilized a cnn trained to segment nfts on hippocampus sections immunohistochemically stained with antisera recognizing abnormal hyperphosphorylated tau (p-tau), which yielded metrics of regional nft counts, nft positive pixel density, as well as a novel graph-theory based metric measuring the spatial distribution of nfts. |
2022-11-01 |
2023-08-14 |
human |
| Carolyn Tallon, Benjamin J Bell, Anjali Sharma, Arindom Pal, Medhinee M Malvankar, Ajit G Thomas, Seung-Wan Yoo, Kristen R Hollinger, Kaleem Coleman, Elizabeth L Wilkinson, Sujatha Kannan, Norman J Haughey, Rangaramanujam M Kannan, Rana Rais, Barbara S Slushe. Dendrimer-Conjugated nSMase2 Inhibitor Reduces Tau Propagation in Mice. Pharmaceutics. vol 14. issue 10. 2022-10-27. PMID:36297501. |
in a mouse tau propagation model, where a mutant htau (p301l/s320f) containing adeno-associated virus was unilaterally seeded into the hippocampus, oral d-dptip (dosed 3× weekly) significantly inhibited brain nsmase2 activity and blocked the spread of ptau to the contralateral hippocampus. |
2022-10-27 |
2023-08-14 |
mouse |
| Pardeep Yadav, Yeon-Hee Lee, Hrithika Panday, Shubham Kant, Neha Bajwa, Ritika Parashar, Saurabh Kumar Jha, Niraj Kumar Jha, Parma Nand, Sang-Soo Lee, Abhimanyu Kumar Jh. Implications of Microorganisms in Alzheimer's Disease. Current issues in molecular biology. vol 44. issue 10. 2022-10-26. PMID:36286029. |
ad is manifested with hyperphosphorylated tau protein levels and amyloid beta (aβ) peptide buildup in the hippocampus and cortex regions of the brain. |
2022-10-26 |
2023-08-14 |
Not clear |
| Julia J Segura-Uribe, Paola Garcia-de la Torre, Tzayaka Castillo-Mendieta, Iván Bribiesca-Cruz, Sandra Orozco-Suárez, Marvin Soriano-Ursúa, Rodolfo Pinto-Almazán, Claudia Fuentes-Venado, Christian Guerra-Araiz. Tibolone Improves Memory and Decreases the Content of Amyloid-β Peptides and Tau Protein in the Hippocampus of a Mice Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2022-10-24. PMID:36278346. |
tibolone improves memory and decreases the content of amyloid-β peptides and tau protein in the hippocampus of a mice model of alzheimer's disease. |
2022-10-24 |
2023-08-14 |
mouse |
| Ankur Kumar, Bhupender Nehra, Dilpreet Singh, Dileep Kuma, Pooja A Chawl. Recent advances in the development of nitrogen-containing heterocyclic Anti-Alzheimer's agents. Current topics in medicinal chemistry. 2022-10-24. PMID:36278462. |
alzheimer's disease is usually triggered by numerous associated factors, including depleted amount of acetylcholine (ach), excessive aggregation of β-amyloid peptide (aβ), tau hyperphosphorylation with neurofibrillary tangle formation as well as deposition of feeble plaques in a specific portion of the brain (hippocampus and cortex). |
2022-10-24 |
2023-08-14 |
Not clear |
| Ramón Martínez-Mármol, Christopher Small, Anmin Jiang, Tishila Palliyaguru, Tristan P Wallis, Rachel S Gormal, Jean-Baptiste Sibarita, Jürgen Götz, Frédéric A Meunie. Fyn nanoclustering requires switching to an open conformation and is enhanced by FTLD-Tau biomolecular condensates. Molecular psychiatry. 2022-10-18. PMID:36258016. |
expression of p301l mutant tau promotes aberrant trapping of fyn in nanoclusters within hippocampal dendrites by an unknown mechanism. |
2022-10-18 |
2023-08-14 |
Not clear |
| Jianping Tang, Yanjun Li, Xu Liu, Guangxia Yu, Fuli Zheng, Zhenkun Guo, Yating Zhang, Wenya Shao, Siying Wu, Huangyuan L. Cobalt induces neurodegenerative damages through impairing autophagic flux by activating hypoxia-inducible factor-1α triggered ROS overproduction. The Science of the total environment. 2022-10-15. PMID:36243078. |
we first reveal cobalt as an environmental toxicant to severely induce β amyloid (aβ) deposition, tau hyperphosphorylation, and dysregulated autophagy in the hippocampus and cortex of mice. |
2022-10-15 |
2023-08-14 |
mouse |
| Yueh-Ting Tsai, Shung-Te Kao, Chin-Yi Chen. Medicinal Herbs and Their Derived Ingredients Protect against Cognitive Decline in In Vivo Models of Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232612. |
therefore, mhdis listed in this review protect against aβ-induced cognitive decline by inhibiting aβ accumulation, oxidative stress, tau hyperphosphorylation, inflammation, synaptic damage, and neuronal apoptosis in the cortex and hippocampus during the early and late ad phases. |
2022-10-14 |
2023-08-14 |
Not clear |
| Mychael V Lourenco, Guilherme B de Freitas, Ícaro Raony, Sergio T Ferreira, Fernanda G De Felic. Irisin stimulates protective signaling pathways in rat hippocampal neurons. Frontiers in cellular neuroscience. vol 16. 2022-10-03. PMID:36187295. |
finally, analysis of rna sequencing (rnaseq) datasets shows a trend of reduction of hippocampal fndc5 mrna with aging and tau pathology in humans. |
2022-10-03 |
2023-08-14 |
mouse |
| Dongli Meng, Mengzhe Yang, Lilin Hu, Tonglin Liu, Huiliang Zhang, Xuying Sun, Xiaochuan Wang, Yu Chen, Yu Jin, Rong Li. Rifaximin protects against circadian rhythm disruption-induced cognitive impairment through preventing gut barrier damage and neuroinflammation. Journal of neurochemistry. 2022-10-03. PMID:36189686. |
furthermore, the impairment in hippocampal neurogenesis, tau hyperphosphorylation and loss in synaptic proteins in crd mice is also reversed by rifaximin. |
2022-10-03 |
2023-08-14 |
mouse |