| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kelly L Krass, Veronica Colinayo, Anatole Ghazalpour, Harry V Vinters, Aldons J Lusis, Thomas A Drak. Genetic loci contributing to age-related hippocampal lesions in mice. Neurobiology of disease. vol 13. issue 2. 2003-08-08. PMID:12828934. |
these lesions may represent a useful model for investigating dysregulation of tau protein in the hippocampus. |
2003-08-08 |
2023-08-12 |
mouse |
| Mariko Kobayashi, Koichi Ishiguro, Yuko Katoh-Fukui, Minesuke Yokoyama, Shinobu C Fujit. Phosphorylation state of tau in the hippocampus of apolipoprotein E4 and E3 knock-in mice. Neuroreport. vol 14. issue 5. 2003-07-23. PMID:12692466. |
phosphorylation state of tau in the hippocampus of apolipoprotein e4 and e3 knock-in mice. |
2003-07-23 |
2023-08-12 |
mouse |
| Jennifer Bendiske, Ben A Bah. Lysosomal activation is a compensatory response against protein accumulation and associated synaptopathogenesis--an approach for slowing Alzheimer disease? Journal of neuropathology and experimental neurology. vol 62. issue 5. 2003-07-09. PMID:12769185. |
in the hippocampal slice model, tau deposits and amyloidogenic fragments induced by the lysosomal inhibitor chloroquine were accompanied by disrupted microtubule integrity and by corresponding declines in postsynaptic glutamate receptors and the presynaptic marker synaptophysin. |
2003-07-09 |
2023-08-12 |
Not clear |
| Peter Kasa, Henrietta Papp, Janos Zombori, Peter Mayer, Frederic Checle. C-terminal fragments of amyloid-beta peptide cause cholinergic axonal degeneration by a toxic effect rather than by physical injury in the nondemented human brain. Neurochemical research. vol 28. issue 3-4. 2003-06-18. PMID:12675137. |
in this study, acetylcholinesterase histochemical, and abeta and tau immunohistochemical double-staining were performed in nondemented elderly human hippocampal and entorhinal brain samples, to demonstrate the presence of dystrophic neurites caused by the c-terminal or n-terminal fragments of abeta. |
2003-06-18 |
2023-08-12 |
human |
| Fu-Chun Hsu, Robert Waldeck, Donald S Faber, Sheryl S Smit. Neurosteroid effects on GABAergic synaptic plasticity in hippocampus. Journal of neurophysiology. vol 89. issue 4. 2003-05-29. PMID:12612040. |
this change in subunit composition was accompanied by altered pharmacology and an increase in general excitability associated with acceleration of the decay time constant (tau) for gaba-gated current of pyramidal cells acutely isolated from ca1 hippocampus similar to what we have reported following withdrawal from the steroid after chronic long-term administration. |
2003-05-29 |
2023-08-12 |
rat |
| Othman Ghribi, Mary M Herman, John Savor. Lithium inhibits Abeta-induced stress in endoplasmic reticulum of rabbit hippocampus but does not prevent oxidative damage and tau phosphorylation. Journal of neuroscience research. vol 71. issue 6. 2003-05-07. PMID:12605412. |
lithium inhibits abeta-induced stress in endoplasmic reticulum of rabbit hippocampus but does not prevent oxidative damage and tau phosphorylation. |
2003-05-07 |
2023-08-12 |
rabbit |
| T L Wallace, C V Vorhees, F P Zemlan, G A Gudelsk. Methamphetamine enhances the cleavage of the cytoskeletal protein tau in the rat brain. Neuroscience. vol 116. issue 4. 2003-04-30. PMID:12617947. |
cleaved tau concentrations also were significantly elevated in the dorsal hippocampus and, to a lesser extent, in the prefrontal cortex of methamphetamine-treated rats. |
2003-04-30 |
2023-08-12 |
rat |
| Yong-Mei Zhao, Jin-Jing Pei, Zhi-Juan Ji, Zhi-Wei Zhao, Yu-Ying Qian, Shu-Li Shen. Effect of amyloid precursor protein 17mer peptide on microtubule structure and tau protein hyperphosphorylation in hippocampal neurons of experimental diabetic mice. Neuroreport. vol 14. issue 1. 2003-04-25. PMID:12544832. |
effect of amyloid precursor protein 17mer peptide on microtubule structure and tau protein hyperphosphorylation in hippocampal neurons of experimental diabetic mice. |
2003-04-25 |
2023-08-12 |
mouse |
| Yong-Mei Zhao, Jin-Jing Pei, Zhi-Juan Ji, Zhi-Wei Zhao, Yu-Ying Qian, Shu-Li Shen. Effect of amyloid precursor protein 17mer peptide on microtubule structure and tau protein hyperphosphorylation in hippocampal neurons of experimental diabetic mice. Neuroreport. vol 14. issue 1. 2003-04-25. PMID:12544832. |
the objective of this study was to investigate whether microtubular structure changes and tau protein hyperphosphorylation exist in hippocampal neurons of experimental diabetic mice, and to study the effect of amyloid precursor protein 17mer peptide. |
2003-04-25 |
2023-08-12 |
mouse |
| Yong-Mei Zhao, Jin-Jing Pei, Zhi-Juan Ji, Zhi-Wei Zhao, Yu-Ying Qian, Shu-Li Shen. Effect of amyloid precursor protein 17mer peptide on microtubule structure and tau protein hyperphosphorylation in hippocampal neurons of experimental diabetic mice. Neuroreport. vol 14. issue 1. 2003-04-25. PMID:12544832. |
the results showed that the microtubules of hippocampal neurons of diabetic mice manifested prominent signs of fragmentation and dissolution, tau protein is hyperphosphorylated at ser 199/thr 202 sites, enzymes related to the phosphorylation and dephosphorylation of tau protein were diminished. |
2003-04-25 |
2023-08-12 |
mouse |
| Yoshitaka Tatebayashi, Moon H Lee, Liang Li, Khalid Iqbal, Inge Grundke-Iqba. The dentate gyrus neurogenesis: a therapeutic target for Alzheimer's disease. Acta neuropathologica. vol 105. issue 3. 2003-04-23. PMID:12557008. |
in hippocampal progenitor cells from adult rats, fibroblast growth factor-2 (fgf-2) dose-dependently decreased microtubule-associated protein 2 and increased tau levels, indicating an fgf-2-induced dendrite to axon polarity shift. |
2003-04-23 |
2023-08-12 |
human |
| I Ferrer, P Pastor, M J Rey, E Muñoz, B Puig, E Pastor, R Oliva, E Tolos. Tau phosphorylation and kinase activation in familial tauopathy linked to deln296 mutation. Neuropathology and applied neurobiology. vol 29. issue 1. 2003-04-23. PMID:12581337. |
hyper-phosphorylated tau accumulated in neurones with neurofibrillary tangles and in neurones with pretangles in the substantia nigra, locus ceruleus, peri-aqueductal grey matter, reticular formation, motor nuclei of the brainstem, and thalamus, amygdala and hippocampus. |
2003-04-23 |
2023-08-12 |
Not clear |
| I Ferrer, M Barrachina, M Tolnay, M J Rey, N Vidal, M Carmona, R Blanco, B Pui. Phosphorylated protein kinases associated with neuronal and glial tau deposits in argyrophilic grain disease. Brain pathology (Zurich, Switzerland). vol 13. issue 1. 2003-03-31. PMID:12580546. |
hyperphosphorylated tau accumulated in grains and pre-tangles in the hippocampus, dentate gyrus, entorhinal and trans-entorhinal cortices, and amygdala in all cases. |
2003-03-31 |
2023-08-12 |
Not clear |
| Kuai Yu, Shao-Yu Ge, Di-Yun Rua. Fe2+ decreases the taurine-induced Cl- current in acutely dissociated rat hippocampal neurons. Brain research. vol 960. issue 1-2. 2003-03-28. PMID:12505654. |
these results indicate that fe(2+) decreases i(tau) in acutely dissociated rat hippocampal neurons and the inhibition of glycine receptors by fe(2+) might be one possible approach through which fe(2+) induces seizures. |
2003-03-28 |
2023-08-12 |
rat |
| D A Cottrell, G M Borthwick, M A Johnson, P G Ince, D M Turnbul. The role of cytochrome c oxidase deficient hippocampal neurones in Alzheimer's disease. Neuropathology and applied neurobiology. vol 28. issue 5. 2003-03-12. PMID:12366820. |
cox-deficient, succinate dehydrogenase-positive hippocampal neurones indicative of high mtdna mutation load do not appear to be prone to apoptosis or to directly participate in the over production of tau or beta-amyloid. |
2003-03-12 |
2023-08-12 |
Not clear |
| W-H Zheng, S Bastianetto, F Mennicken, W Ma, S Ka. Amyloid beta peptide induces tau phosphorylation and loss of cholinergic neurons in rat primary septal cultures. Neuroscience. vol 115. issue 1. 2003-02-05. PMID:12401334. |
the neuropathological features associated with alzheimer's disease (ad) brain include the presence of extracellular neuritic plaques composed of amyloid beta protein (abeta), intracellular neurofibrillary tangles containing phosphorylated tau protein and the loss of basal forebrain cholinergic neurons which innervate regions such as the hippocampus and the cortex. |
2003-02-05 |
2023-08-12 |
rat |
| Jochen Brich, Feng-Shiun Shie, Brian W Howell, Renhua Li, Katalin Tus, Edward K Wakeland, Lee-Way Jin, Marc Mumby, Gary Churchill, Joachim Herz, Jonathan A Coope. Genetic modulation of tau phosphorylation in the mouse. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 1. 2003-01-27. PMID:12514215. |
tau hyperphosphorylation correlates with early death in susceptible mouse strains, and it occurs in the neurons of the hippocampus and dentate gyrus. |
2003-01-27 |
2023-08-12 |
mouse |
| I Ferre. Differential expression of phosphorylated translation initiation factor 2 alpha in Alzheimer's disease and Creutzfeldt-Jakob's disease. Neuropathology and applied neurobiology. vol 28. issue 6. 2003-01-23. PMID:12445160. |
phosphorylated tif 2 alpha is restricted to neurones with abnormal tau deposition, but only approximately 80% of neurones with nfts in the hippocampus and 60% in the isocortex colocalize phosphorylated tif 2 alpha, thus indicating that not all neurones with nfts over-express phosphorylated tif 2 alpha. |
2003-01-23 |
2023-08-12 |
human |
| Félix Hernández, José Borrell, Carmen Guaza, Jesús Avila, José J Luca. Spatial learning deficit in transgenic mice that conditionally over-express GSK-3beta in the brain but do not form tau filaments. Journal of neurochemistry. vol 83. issue 6. 2003-01-16. PMID:12472906. |
we found a significant increase in gsk-3 activity in the hippocampus of tet/gsk-3beta mice whereas no tau fibrils could be found even in very old mice. |
2003-01-16 |
2023-08-12 |
mouse |
| b' Petri Kerokoski, Tiina Suuronen, Antero Salminen, Hilkka Soininen, Tuula Pirttil\\xc3\\xa. Cleavage of the cyclin-dependent kinase 5 activator p35 to p25 does not induce tau hyperphosphorylation. Biochemical and biophysical research communications. vol 298. issue 5. 2003-01-15. PMID:12419309.' |
to test this hypothesis, we induced calpain-mediated p35 cleavage in rat hippocampal neuronal cultures and studied the relationship between p25 production, cdk5 activity, and tau phosphorylation. |
2003-01-15 |
2023-08-12 |
rat |