| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hillel Grossma. Does diabetes protect or provoke Alzheimer's disease? Insights into the pathobiology and future treatment of Alzheimer's disease. CNS spectrums. vol 8. issue 11. 2004-02-23. PMID:14702004. |
insulin dysregulation may contribute to ad pathology through several mechanisms including decreased cortical glucose utilization particularly in the hippocampus and entorhinal cortex; increased oxidative stress through the formation of advanced glycation end-products; increased tau phosphorylation and neurofibrillary tangle formation; increased b-amyloid aggregation through inhibition of insulin-degrading enzyme. |
2004-02-23 |
2023-08-12 |
Not clear |
| Othman Ghribi, Patcharin Prammonjago, Mary M Herman, Natalie K Spaulding, John Savor. Abeta(1-42)-induced JNK and ERK activation in rabbit hippocampus is differentially regulated by lithium but is not involved in the phosphorylation of tau. Brain research. Molecular brain research. vol 119. issue 2. 2004-02-20. PMID:14625087. |
abeta(1-42)-induced jnk and erk activation in rabbit hippocampus is differentially regulated by lithium but is not involved in the phosphorylation of tau. |
2004-02-20 |
2023-08-12 |
rabbit |
| Grazyna Niewiadomska, Marta Baksalerska-Pazer. Age-dependent changes in axonal transport and cellular distribution of Tau 1 in the rat basal forebrain neurons. Neuroreport. vol 14. issue 13. 2004-01-14. PMID:14512841. |
we also characterized the distribution of tau 1 in cellular compartments of bf and hippocampal neurons. |
2004-01-14 |
2023-08-12 |
rat |
| Xiang-You Hu, Song Qin, Ya-Ping Lu, Rivka Ravid, Dick F Swaab, Jiang-Ning Zho. Decreased estrogen receptor-alpha expression in hippocampal neurons in relation to hyperphosphorylated tau in Alzheimer patients. Acta neuropathologica. vol 106. issue 3. 2004-01-09. PMID:12819990. |
decreased estrogen receptor-alpha expression in hippocampal neurons in relation to hyperphosphorylated tau in alzheimer patients. |
2004-01-09 |
2023-08-12 |
Not clear |
| Alexei R Koudinov, Natalia V Koudinov. Cholesterol, synaptic function and Alzheimer's disease. Pharmacopsychiatry. vol 36 Suppl 2. 2003-12-10. PMID:14574623. |
from additional immunofluorescent analysis of the slices, we could demonstrate that the cholesterol imbalance also caused neurodegeneration of hippocampal neural cell processes and the appearance of tau protein pathology in the mossy fibers. |
2003-12-10 |
2023-08-12 |
rat |
| Kun Zou, Daesung Kim, Atsuko Kakio, Kyunghee Byun, Jian-Sheng Gong, Jaewoo Kim, Myeungju Kim, Naoya Sawamura, Sei-ichi Nishimoto, Katsumi Matsuzaki, Bonghee Lee, Katsuhiko Yanagisawa, Makoto Michikaw. Amyloid beta-protein (Abeta)1-40 protects neurons from damage induced by Abeta1-42 in culture and in rat brain. Journal of neurochemistry. vol 87. issue 3. 2003-11-24. PMID:14535944. |
abeta1-42 injection into the rat entorhinal cortex (ec) caused the hyperphosphorylation of tau on both sides of ec and hippocampus and increased the number of glial fibrillary acidic protein (gfap)-positive astrocytes in the ipsilateral ec, which were prevented by the concurrent injection of abeta1-40. |
2003-11-24 |
2023-08-12 |
rat |
| Zhiming Suo, Min Wu, Bruce A Citron, Robert E Palazzo, Barry W Festof. Rapid tau aggregation and delayed hippocampal neuronal death induced by persistent thrombin signaling. The Journal of biological chemistry. vol 278. issue 39. 2003-11-17. PMID:12821672. |
rapid tau aggregation and delayed hippocampal neuronal death induced by persistent thrombin signaling. |
2003-11-17 |
2023-08-12 |
Not clear |
| Zhiming Suo, Min Wu, Bruce A Citron, Robert E Palazzo, Barry W Festof. Rapid tau aggregation and delayed hippocampal neuronal death induced by persistent thrombin signaling. The Journal of biological chemistry. vol 278. issue 39. 2003-11-17. PMID:12821672. |
here we report that nanomolar thrombin induced rapid tau hyperphosphorylation and aggregation in murine hippocampal neurons via protease-activated receptors, which was followed by delayed synaptophysin reduction and apoptotic neuronal death. |
2003-11-17 |
2023-08-12 |
Not clear |
| Hoau-Yan Wang, Weiwei Li, Nancy J Benedetti, Daniel H S Le. Alpha 7 nicotinic acetylcholine receptors mediate beta-amyloid peptide-induced tau protein phosphorylation. The Journal of biological chemistry. vol 278. issue 34. 2003-10-29. PMID:12801934. |
we show that a beta 42 elicited rapid and reversible tau protein phosphorylation on three proline-directed sites (ser-202, thr-181, and thr-231) in systems enriched in alpha 7 nicotinic acetylcholine receptors (alpha 7nachr) including serum-deprived human sk-n-mc neuroblastoma cells and hippocampal synaptosomes. |
2003-10-29 |
2023-08-12 |
human |
| Faith M Harris, Walter J Brecht, Qin Xu, Ina Tesseur, Lisa Kekonius, Tony Wyss-Coray, Jo Dee Fish, Eliezer Masliah, Paul C Hopkins, Kimberly Scearce-Levie, Karl H Weisgraber, Lennart Mucke, Robert W Mahley, Yadong Huan. Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 19. 2003-10-29. PMID:12939405. |
the cortex and hippocampus of these mice displayed ad-like neurodegenerative alterations, including abnormally phosphorylated tau (p-tau) and gallyas silver-positive neurons that contained cytosolic straight filaments with diameters of 15-20 nm, resembling preneurofibrillary tangles. |
2003-10-29 |
2023-08-12 |
mouse |
| M A Kurt, D C Davies, M Kidd, K Duff, D R Howlet. Hyperphosphorylated tau and paired helical filament-like structures in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes. Neurobiology of disease. vol 14. issue 1. 2003-10-29. PMID:13678670. |
lm immunocytochemistry revealed cerebral abeta deposits to be present from 8 weeks of age, whereas hyperphosphorylated tau was not detected until 24 weeks of age, when it appeared as punctate deposits in close association with the abeta deposits in the cortex and hippocampus. |
2003-10-29 |
2023-08-12 |
mouse |
| E Head, I T Lott, P R Hof, C Bouras, J H Su, R Kim, R Haier, C W Cotma. Parallel compensatory and pathological events associated with tau pathology in middle aged individuals with Down syndrome. Journal of neuropathology and experimental neurology. vol 62. issue 9. 2003-10-28. PMID:14533781. |
immunohistochemistry and confocal microscopy studies in the hippocampus from 15 individuals ranging in age from 5 months to 67 years compared markers of normal and abnormal tau accumulation (phosphorylated tau [at8, mc-1], tau-1, n-terminal tau) with the extent and location of neuronal growth marker immunoreactivity (bdnf, gap-43, map-2). |
2003-10-28 |
2023-08-12 |
Not clear |
| Thomas Arendt, Jens Stieler, Arjen M Strijkstra, Roelof A Hut, Jan Rüdiger, Eddy A Van der Zee, Tibor Harkany, Max Holzer, Wolfgang Härti. Reversible paired helical filament-like phosphorylation of tau is an adaptive process associated with neuronal plasticity in hibernating animals. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 18. 2003-09-09. PMID:12904458. |
distribution of phf-like tau followed a consistent pattern, being most intense in the entorhinal cortex, hippocampus, and isocortical areas. |
2003-09-09 |
2023-08-12 |
Not clear |
| Markus Schubert, Derek P Brazil, Deborah J Burks, Jake A Kushner, Jing Ye, Carrie L Flint, Janet Farhang-Fallah, Pieter Dikkes, Xavier M Warot, Carlos Rio, Gabriel Corfas, Morris F Whit. Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 18. 2003-09-09. PMID:12904469. |
second, neurofibrillary tangles containing phosphorylated tau accumulated in the hippocampus of old irs2 knock-out mice, suggesting that irs2 signaling is neuroprotective. |
2003-09-09 |
2023-08-12 |
mouse |
| A González-Quevedo, F Obregón, M Urbina, T Roussó, L Lim. Effects of taurine deficiency and chronic methanol administration on rat retina, optic nerve and brain amino acids and monoamines. Nutritional neuroscience. vol 6. issue 4. 2003-09-03. PMID:12887142. |
beta-ala administration reduced taurine (tau) levels in plasma, hippocampus and posterior cortex, but not in retina and optic nerve. |
2003-09-03 |
2023-08-12 |
rat |
| A González-Quevedo, F Obregón, M Urbina, T Roussó, L Lim. Effects of taurine deficiency and chronic methanol administration on rat retina, optic nerve and brain amino acids and monoamines. Nutritional neuroscience. vol 6. issue 4. 2003-09-03. PMID:12887142. |
on the other hand, in the hippocampus, asp metabolism could be affected by tau depletion with beta-ala. |
2003-09-03 |
2023-08-12 |
rat |
| José Tomás Egaña, Cristian Zambrano, Marco Tulio Nuñez, Christian Gonzalez-Billault, Ricardo B Maccion. Iron-induced oxidative stress modify tau phosphorylation patterns in hippocampal cell cultures. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 16. issue 1. 2003-08-20. PMID:12572681. |
iron-induced oxidative stress modify tau phosphorylation patterns in hippocampal cell cultures. |
2003-08-20 |
2023-08-12 |
Not clear |
| José Tomás Egaña, Cristian Zambrano, Marco Tulio Nuñez, Christian Gonzalez-Billault, Ricardo B Maccion. Iron-induced oxidative stress modify tau phosphorylation patterns in hippocampal cell cultures. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 16. issue 1. 2003-08-20. PMID:12572681. |
in the current paper we have shown that iron induces an imbalance in the function of cdk5/p25 system of hippocampal neurons, resulting in a marked decrease in tau phosphorylation at the typical alzheimer's epitopes. |
2003-08-20 |
2023-08-12 |
Not clear |
| Michael D Devou. Functional brain imaging in the dementias: role in early detection, differential diagnosis, and longitudinal studies. European journal of nuclear medicine and molecular imaging. vol 29. issue 12. 2003-08-15. PMID:12458405. |
even greater predictive ability for progression to ad is obtained by combining measures of perfusion or metabolism with risk factors, tau protein levels, hippocampal n-acetyl aspartate concentrations, or hippocampal volume measures. |
2003-08-15 |
2023-08-12 |
human |
| Kelly L Krass, Veronica Colinayo, Anatole Ghazalpour, Harry V Vinters, Aldons J Lusis, Thomas A Drak. Genetic loci contributing to age-related hippocampal lesions in mice. Neurobiology of disease. vol 13. issue 2. 2003-08-08. PMID:12828934. |
c57bl/6j mice develop genetically determined age-related hippocampal granular deposits that have some similarities to lesions seen in the brains of human patients with tau protein related neurodegenerative disorders ("tauopathies"). |
2003-08-08 |
2023-08-12 |
mouse |