| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R B Maccioni, J P Muñoz, L Barbeit. The molecular bases of Alzheimer's disease and other neurodegenerative disorders. Archives of medical research. vol 32. issue 5. 2001-12-04. PMID:11578751. |
experiments with hippocampal cells in culture have indicated a relationship between fibrillary amyloid and the cascade of molecular signals that trigger tau hyperphosphorylations. |
2001-12-04 |
2023-08-12 |
human |
| E Planel, K Yasutake, S C Fujita, K Ishigur. Inhibition of protein phosphatase 2A overrides tau protein kinase I/glycogen synthase kinase 3 beta and cyclin-dependent kinase 5 inhibition and results in tau hyperphosphorylation in the hippocampus of starved mouse. The Journal of biological chemistry. vol 276. issue 36. 2001-10-11. PMID:11441005. |
inhibition of protein phosphatase 2a overrides tau protein kinase i/glycogen synthase kinase 3 beta and cyclin-dependent kinase 5 inhibition and results in tau hyperphosphorylation in the hippocampus of starved mouse. |
2001-10-11 |
2023-08-12 |
mouse |
| M J Ramirez, K E Heslop, P T Francis, M Rattra. Expression of amyloid precursor protein, tau and presenilin RNAs in rat hippocampus following deafferentation lesions. Brain research. vol 907. issue 1-2. 2001-10-04. PMID:11430905. |
expression of amyloid precursor protein, tau and presenilin rnas in rat hippocampus following deafferentation lesions. |
2001-10-04 |
2023-08-12 |
human |
| M J Ramirez, K E Heslop, P T Francis, M Rattra. Expression of amyloid precursor protein, tau and presenilin RNAs in rat hippocampus following deafferentation lesions. Brain research. vol 907. issue 1-2. 2001-10-04. PMID:11430905. |
tau mrna level in hippocampus was unchanged after lesions. |
2001-10-04 |
2023-08-12 |
human |
| M J Ramirez, K E Heslop, P T Francis, M Rattra. Expression of amyloid precursor protein, tau and presenilin RNAs in rat hippocampus following deafferentation lesions. Brain research. vol 907. issue 1-2. 2001-10-04. PMID:11430905. |
our results support the hypothesis that amyloid precursor protein expression in hippocampal neurons is differentially affected by glutamatergic and cholinergic afferent input, and that presenilin-1, but not tau, may be subject to the same type of control in vivo. |
2001-10-04 |
2023-08-12 |
human |
| A Takashima, M Murayama, K Yasutake, H Takahashi, M Yokoyama, K Ishigur. Involvement of cyclin dependent kinase5 activator p25 on tau phosphorylation in mouse brain. Neuroscience letters. vol 306. issue 1-2. 2001-08-16. PMID:11403952. |
exposure to ca ionophore (a23187) at 10(-6) m induced p25 accumulation in rat primary hippocampal neurons, causing neuronal death without showing hyperphosphorylation of tau. |
2001-08-16 |
2023-08-12 |
mouse |
| M Yamada, Y Itoh, N Sodeyama, N Suematsu, E Otomo, M Matsushita, H Mizusaw. Senile dementia of the neurofibrillary tangle type: a comparison with Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 12. issue 2. 2001-07-12. PMID:11173884. |
to elucidate the pathogenesis of sd-nft in comparison with alzheimer's disease (ad), we investigated the hippocampal lesions and analyzed the tau gene. |
2001-07-12 |
2023-08-12 |
human |
| H N Dawson, A Ferreira, M V Eyster, N Ghoshal, L I Binder, M P Vite. Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice. Journal of cell science. vol 114. issue Pt 6. 2001-07-05. PMID:11228161. |
inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice. |
2001-07-05 |
2023-08-12 |
mouse |
| H N Dawson, A Ferreira, M V Eyster, N Ghoshal, L I Binder, M P Vite. Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice. Journal of cell science. vol 114. issue Pt 6. 2001-07-05. PMID:11228161. |
in contrast to a previously reported tau knockout mouse, embryonic hippocampal cultures from tau deficient mice show a significant delay in maturation as measured by axonal and neuritic extensions. |
2001-07-05 |
2023-08-12 |
mouse |
| R K Ellerkmann, V Riazanski, C E Elger, B W Urban, H Bec. Slow recovery from inactivation regulates the availability of voltage-dependent Na(+) channels in hippocampal granule cells, hilar neurons and basket cells. The Journal of physiology. vol 532. issue Pt 2. 2001-06-14. PMID:11306658. |
in isolated hippocampal dentate granule cells (dgcs), recovery from this inactivation was biexponential, with time constants for the two phases of slow inactivation tau(slow,1) and tau(slow,2) ranging from 1 to 10 s and 20 to 50 s, respectively. |
2001-06-14 |
2023-08-12 |
human |
| A K Mudher, B Yee, A D Smith, V H Perr. Deafferentation of the hippocampus results in the induction of AT8 positive 'granules' in the rat. Neuroscience letters. vol 301. issue 1. 2001-06-07. PMID:11239703. |
to investigate what effect deafferentation of the hippocampus has on the phosphorylation state of tau, we lesioned the entorhinal cortex in rats and looked for hyperphosphorylated tau in the hippocampus at various days post lesioning. |
2001-06-07 |
2023-08-12 |
rat |
| C X Gong, T Lidsky, J Wegiel, I Grundke-Iqbal, K Iqba. Metabolically active rat brain slices as a model to study the regulation of protein phosphorylation in mammalian brain. Brain research. Brain research protocols. vol 6. issue 3. 2001-05-24. PMID:11223412. |
selective inhibition of protein phosphatase 2a in these rat brain slices by the treatment with okadaic acid induced hyperphosphorylation of tau at many abnormal sites seen in alzheimer's disease brain and the accumulation of hyperphosphorylated tau in pyramidal neurons of the cortex and hippocampus. |
2001-05-24 |
2023-08-12 |
human |
| V Vogelsberg-Ragaglia, T Schuck, J Q Trojanowski, V M Le. PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus. Experimental neurology. vol 168. issue 2. 2001-05-10. PMID:11259128. |
since abnormal tau phosphorylation may play a role in neurofibrillary tangle (nft) formation in aging and alzheimer's disease (ad), we probed the distribution and abundance of protein phosphatase 2a (pp2a) catalytic (calpha) and regulatory (pr55alpha and gamma, pr61varepsilon and delta) subunit mrna in control and ad hippocampus using in situ hybridization. |
2001-05-10 |
2023-08-12 |
Not clear |
| H Kumanogoh, S Miyata, Y Sokawa, S Maekaw. Biochemical and morphological analysis on the localization of Rac1 in neurons. Neuroscience research. vol 39. issue 2. 2001-05-03. PMID:11223464. |
double immunostaining of cultured hippocampal neurons with antibodies to rac1 and map-2, or rac1 and tau, showed punctate distribution of rac1 in axons as well as in dendrites. |
2001-05-03 |
2023-08-12 |
rat |
| R B Maccioni, C Otth, I I Concha, J P Muño. The protein kinase Cdk5. Structural aspects, roles in neurogenesis and involvement in Alzheimer's pathology. European journal of biochemistry. vol 268. issue 6. 2001-05-03. PMID:11248668. |
cdk5 inhibitors protect hippocampal neurons against both tau anomalous phosphorylations and neuronal death. |
2001-05-03 |
2023-08-12 |
human |
| J J Lucas, F Hernández, P Gómez-Ramos, M A Morán, R Hen, J Avil. Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice. The EMBO journal. vol 20. issue 1-2. 2001-04-12. PMID:11226152. |
these mice show decreased levels of nuclear beta-catenin and hyperphosphorylation of tau in hippocampal neurons, the latter resulting in pretangle-like somatodendritic localization of tau. |
2001-04-12 |
2023-08-12 |
mouse |
| T Miyasaka, M Morishima-Kawashima, R Ravid, P Heutink, J C van Swieten, K Nagashima, Y Ihar. Molecular analysis of mutant and wild-type tau deposited in the brain affected by the FTDP-17 R406W mutation. The American journal of pathology. vol 158. issue 2. 2001-04-05. PMID:11159174. |
consistent with this, wild-type and mutant tau colocalized in neurofibrillary tangles in the frontal cortex and hippocampus of the r406w brain. |
2001-04-05 |
2023-08-12 |
Not clear |
| T Ishihara, B Zhang, M Higuchi, Y Yoshiyama, J Q Trojanowski, V M Le. Age-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic mice. The American journal of pathology. vol 158. issue 2. 2001-04-05. PMID:11159192. |
these tg mice develop congophilic tau inclusions in several brain regions including the hippocampus, amygdala, and entorhinal cortex. |
2001-04-05 |
2023-08-12 |
mouse |
| b' P Kerokoski, T Suuronen, A Salminen, H Soininen, T Pirttil\\xc3\\xa. The levels of cdk5 and p35 proteins and tau phosphorylation are reduced during neuronal apoptosis. Biochemical and biophysical research communications. vol 280. issue 4. 2001-03-29. PMID:11162625.' |
we studied the expression of the protein levels of cdk5 and the neuron-specific cdk5 activator p35 as well as cdk5 activity and tau phosphorylation during apoptosis in rat hippocampal neuronal cultures. |
2001-03-29 |
2023-08-12 |
rat |
| N Durany, R Ravid, P Riederer, F F Cruz-Sánche. Increased frequency of the alpha-1-antichymotrypsin T allele in cerebral amyloid angiopathy. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 20. issue 3. 2001-03-22. PMID:11132933. |
representative brain areas (cerebral cortex, hippocampus, putamen, white matter, and gyrus cinguli) from all cases were studied using classical histologic staining techniques (hematoxylin-eosin (he), mallory's thrichromic or alkaline congo red stain), and immunohistochemistry for tau and beta-amyloid proteins. |
2001-03-22 |
2023-08-12 |
Not clear |