| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S M Rosso, W Kamphorst, R Ravid, J C van Swiete. Coexistent tau and amyloid pathology in hereditary frontotemporal dementia with tau mutations. Annals of the New York Academy of Sciences. vol 920. 2001-02-08. PMID:11193139. |
pathological changes consist of accumulation of hyperphosphorylated tau protein in frontal and temporal cortex, hippocampus, and some subcortical nuclei. |
2001-02-08 |
2023-08-12 |
Not clear |
| C L Weaver, M Espinoza, Y Kress, P Davie. Conformational change as one of the earliest alterations of tau in Alzheimer's disease. Neurobiology of aging. vol 21. issue 5. 2001-01-18. PMID:11016541. |
we have assessed the temporal and spatial occurrence of the tau conformation recognized by mc1, and found its appearance in hippocampal neurons vulnerable to neurofibrillary tangle (nft) formation in braak stage i and ii cases. |
2001-01-18 |
2023-08-12 |
Not clear |
| M Z Smith, Z Nagy, L Barnetson, E M King, M M Esir. Coexisting pathologies in the brain: influence of vascular disease and Parkinson's disease on Alzheimer's pathology in the hippocampus. Acta neuropathologica. vol 100. issue 1. 2000-12-07. PMID:10912925. |
in this study we analyse the hippocampal expression patterns of hyperphosphorylated tau, paired helical filament (phf)-related protein, beta-amyloid and synaptophysin in a group of alzheimer's disease (ad) sufferers with and without additional pathology. |
2000-12-07 |
2023-08-12 |
Not clear |
| M Z Smith, Z Nagy, L Barnetson, E M King, M M Esir. Coexisting pathologies in the brain: influence of vascular disease and Parkinson's disease on Alzheimer's pathology in the hippocampus. Acta neuropathologica. vol 100. issue 1. 2000-12-07. PMID:10912925. |
compared to cases with only ad-type pathology we found that the presence of additional vascular disease augmented the accumulation of hyperphosphorylated tau in the ca1 region of the hippocampus without affecting phf formation in cases with mild ad changes and reduced the extent of phf formation in the ca2/3 and ca4 regions of the hippocampus in cases with severe ad pathology. |
2000-12-07 |
2023-08-12 |
Not clear |
| M Kashihara, S Miyata, H Kumanogoh, N Funatsu, W Matsunaga, T Kiyohara, Y Sokawa, S Maekaw. Changes in the localization of NAP-22, a calmodulin binding membrane protein, during the development of neuronal polarity. Neuroscience research. vol 37. issue 4. 2000-09-15. PMID:10958980. |
throughout the developmental stages of hippocampal neurons, the localization change of nap-22 was quite similar to that of tau, an axonal marker protein, but not to that of microtubule-associated protein-2 (map-2), a dendritic marker protein. |
2000-09-15 |
2023-08-12 |
Not clear |
| K A Kékesi, N Szilágyi, G Nyitrai, A Dobolyi, N Skuban, J Kardo. Persistent depolarization and Glu uptake inhibition operate distinct osmoregulatory mechanisms in the mammalian brain. Neurochemistry international. vol 37. issue 2-3. 2000-08-14. PMID:10812202. |
the results showed that (1) extracellular [gln] was low whereas [glu] and [tau] were high during infusion of nmda (0.5-1.0 mm) or high-k(+) (80 mm) in the hippocampus and ventrobasal thalamus, (2) hippocampal extracellular [glu], [gln] and [tau] were increased in response to the glu uptake inhibitor, l-trans-pyrrolidine-2, 4-dicarboxilic acid (tpdc, 0.5-3.0 mm), in a concentration-dependent manner, (3) high-k(+)-induced increase of extracellular [glu] was partially blocked by the addition of 10 mm cocl(2) with the high-k(+) dialysate in the hippocampus. |
2000-08-14 |
2023-08-12 |
rat |
| S Capsoni, G Ugolini, A Comparini, F Ruberti, N Berardi, A Cattane. Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 12. 2000-07-13. PMID:10841577. |
in this paper, we analyze the phenotype of aged anti-ngf transgenic mice and demonstrate that these mice acquire an age-dependent neurodegenerative pathology including amyloid plaques, insoluble and hyperphosphorylated tau, and neurofibrillary tangles in cortical and hippocampal neurons. |
2000-07-13 |
2023-08-12 |
mouse |
| C B Chambers, E M Sigurdsson, M J Hejna, S A Lorens, J M Lee, N A Mum. Amyloid-beta injection in rat amygdala alters tau protein but not mRNA expression. Experimental neurology. vol 162. issue 1. 2000-04-18. PMID:10716896. |
to determine whether these alterations were due to changes in the expression of tau, we measured tau protein expression by western blotting and tau mrna isoform expression by the reverse transcription-polymerase chain reaction in the amygdala, hippocampus, and cerebellum following a unilateral injection of abeta(25-35) or vehicle into the amygdala. |
2000-04-18 |
2023-08-12 |
human |
| X Bi, T S Haque, J Zhou, A G Skillman, B Lin, C E Lee, I D Kuntz, J A Ellman, G Lync. Novel cathepsin D inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus. Journal of neurochemistry. vol 74. issue 4. 2000-04-11. PMID:10737603. |
novel cathepsin d inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus. |
2000-04-11 |
2023-08-12 |
human |
| X Bi, T S Haque, J Zhou, A G Skillman, B Lin, C E Lee, I D Kuntz, J A Ellman, G Lync. Novel cathepsin D inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus. Journal of neurochemistry. vol 74. issue 4. 2000-04-11. PMID:10737603. |
partial lysosomal dysfunction was induced in cultured hippocampal slices with a selective inhibitor of cathepsins b and l. this led within 48 h to hyperphosphorylated tau protein fragments recognized by antibodies against human tangles. |
2000-04-11 |
2023-08-12 |
human |
| C X Gong, T Lidsky, J Wegiel, L Zuck, I Grundke-Iqbal, K Iqba. Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease. The Journal of biological chemistry. vol 275. issue 8. 2000-03-30. PMID:10681533. |
immunocytochemical staining revealed hyperphosphorylated tau accumulation in pyramidal neurons in cornu ammonis and in neocortical neurons. |
2000-03-30 |
2023-08-12 |
rat |
| M Herrmann, S Golombowski, K Kräuchi, P Frey, C Mourton-Gilles, C Hulette, C Rosenberg, F Müller-Spahn, C Hoc. ELISA-quantitation of phosphorylated tau protein in the Alzheimer's disease brain. European neurology. vol 42. issue 4. 2000-01-27. PMID:10567816. |
we demonstrated significant elevations of phosphorylated tau levels in the frontal and parietal cortex as well as in the hippocampus of ad patients as compared to the nondemented controls. |
2000-01-27 |
2023-08-12 |
human |
| M Rapoport, A Ferreir. PD98059 prevents neurite degeneration induced by fibrillar beta-amyloid in mature hippocampal neurons. Journal of neurochemistry. vol 74. issue 1. 2000-01-18. PMID:10617113. |
we have previously shown that the addition of fibrillar beta-amyloid (abeta) to mature hippocampal neurons results in progressive neuritic degeneration accompanied by the enhanced phosphorylation of adult tau isoforms. |
2000-01-18 |
2023-08-12 |
Not clear |
| M Yanagisawa, E Planel, K Ishiguro, S C Fujit. Starvation induces tau hyperphosphorylation in mouse brain: implications for Alzheimer's disease. FEBS letters. vol 461. issue 3. 1999-12-28. PMID:10567721. |
food deprivation of mice for 1 to 3 days progressively enhanced tau hyperphosphorylation in the hippocampus, to a lesser extent in the cerebral cortex, but the effect was least in the cerebellum, in correspondence with the regional selectivity of tauopathy in alzheimer's disease. |
1999-12-28 |
2023-08-12 |
mouse |
| J C van Swieten, M Stevens, S M Rosso, P Rizzu, M Joosse, I de Koning, W Kamphorst, R Ravid, M G Spillantini, Niermeijer, P Heutin. Phenotypic variation in hereditary frontotemporal dementia with tau mutations. Annals of neurology. vol 46. issue 4. 1999-12-03. PMID:10514099. |
the p301l brain contained many pretangles in the frontal and temporal cortex, and the dentate gyrus of hippocampus, showing three tau bands (64, 68, and 72 kd) of extracted tau from the frontal cortex. |
1999-12-03 |
2023-08-12 |
Not clear |
| J C van Swieten, M Stevens, S M Rosso, P Rizzu, M Joosse, I de Koning, W Kamphorst, R Ravid, M G Spillantini, Niermeijer, P Heutin. Phenotypic variation in hereditary frontotemporal dementia with tau mutations. Annals of neurology. vol 46. issue 4. 1999-12-03. PMID:10514099. |
the presence of many neurofibrillary tangles, many diffuse and classic neuritic plaques in the temporal and parietal cortex, and the hippocampus of the same p301l brain correlated with the presence of four sarkosyl-insoluble (60, 64, 68, and 72 kd) tau bands. |
1999-12-03 |
2023-08-12 |
Not clear |
| M Takahashi, K Yasutake, K Tomizaw. Lithium inhibits neurite growth and tau protein kinase I/glycogen synthase kinase-3beta-dependent phosphorylation of juvenile tau in cultured hippocampal neurons. Journal of neurochemistry. vol 73. issue 5. 1999-11-05. PMID:10537067. |
lithium inhibits neurite growth and tau protein kinase i/glycogen synthase kinase-3beta-dependent phosphorylation of juvenile tau in cultured hippocampal neurons. |
1999-11-05 |
2023-08-12 |
rat |
| N Ghoshal, J F Smiley, A J DeMaggio, M F Hoekstra, E J Cochran, L I Binder, J Kure. A new molecular link between the fibrillar and granulovacuolar lesions of Alzheimer's disease. The American journal of pathology. vol 155. issue 4. 1999-11-04. PMID:10514399. |
markers of end stage disease include fibrillar lesions, which accumulate hyperphosphorylated tau protein polymerized into filaments, and granulovacuolar lesions, which appear primarily within the hippocampus. |
1999-11-04 |
2023-08-12 |
Not clear |
| L Chen, L Baum, H K Ng, L Y Chan, C P Pan. Apolipoprotein E genotype and its pathological correlation in Chinese Alzheimer's disease with late onset. Human pathology. vol 30. issue 10. 1999-11-02. PMID:10534164. |
hippocampus (including entorhinal cortex), amygdala, superior temporal lobe, middle frontal gyrus, and inferior parietal lobule of the brains of ad and poss were examined with beta amyloid (a beta) immunostaining, and the same regions plus medial occipital lobe were examined with tau immunostaining. |
1999-11-02 |
2023-08-12 |
human |
| b' P M Mattila, J O Rinne, H Helenius, M R\\xc3\\xb6ytt\\xc3\\xa. Neuritic degeneration in the hippocampus and amygdala in Parkinson\'s disease in relation to Alzheimer pathology. Acta neuropathologica. vol 98. issue 2. 1999-09-09. PMID:10442555.' |
samples from amygdala, hippocampus, entorhinal cortex (erc) and cortical gyri were examined for alzheimer-type (ad) changes and lewy bodies (lbs) using antibodies against ubiquitin and tau. |
1999-09-09 |
2023-08-12 |
Not clear |