| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Victoria Zhukareva, David Mann, Stuart Pickering-Brown, Kunihiro Uryu, Theresa Shuck, Keyur Shah, Murray Grossman, Bruce L Miller, Christine M Hulette, Stuart C Feinstein, John Q Trojanowski, Virginia M-Y Le. Sporadic Pick's disease: a tauopathy characterized by a spectrum of pathological tau isoforms in gray and white matter. Annals of neurology. vol 51. issue 6. 2002-08-09. PMID:12112079. |
therefore, pick's disease is characterized by an accumulations of pick bodies in the hippocampal region and cortex as well as the presence of three and four microtubule-binding repeat tau pathology in both cortical gray and white matter that distinguish this tauopathy from other neurodegenerative disorders. |
2002-08-09 |
2023-08-12 |
Not clear |
| R Sinigaglia-Coimbra, E A Cavalheiro, C G Coimbr. Postischemic hyperthermia induces Alzheimer-like pathology in the rat brain. Acta neuropathologica. vol 103. issue 5. 2002-06-21. PMID:11935259. |
associated immunohistochemical findings after 2 or 6 months of recovery included: (1) complement activation (membrane attack complex formation); (2) generalized overexpression of ubiquitin in surviving forebrain neurons; (3) persistent activation of macrophages; (4) presence of gemistocytic astrocytes in the hippocampus; (5) maturation of amyloid plaques (identified by immunohistochemistry using anti-human beta-a4 primary antibody) in cerebral cortex; and (6) intracellular deposits identified by anti-human hyperphosphorylated tau protein antibodies. |
2002-06-21 |
2023-08-12 |
human |
| Mark Rapoport, Hana N Dawson, Lester I Binder, Michael P Vitek, Adriana Ferreir. Tau is essential to beta -amyloid-induced neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 9. 2002-06-11. PMID:11959919. |
cultured hippocampal neurons obtained from wild-type, tau knockout, and human tau transgenic mice were treated with fibrillar abeta. |
2002-06-11 |
2023-08-12 |
mouse |
| Eizo Iseki, Noriko Takayama, Wami Marui, Kenji Uéda, Kenji Kosak. Relationship in the formation process between neurofibrillary tangles and Lewy bodies in the hippocampus of dementia with Lewy bodies brains. Journal of the neurological sciences. vol 195. issue 1. 2002-05-07. PMID:11867079. |
using tau immunohistochemistry and alpha-synuclein immunohistochemistry, we quantitatively investigated the most frequent sites and the formation process of neurofibrillary tangles (nft) and lewy bodies (lb) in the hippocampus from 20 patients with dementia with lewy bodies (dlb). |
2002-05-07 |
2023-08-12 |
Not clear |
| H C Baxter, W-G Liu, J L Forster, A Aitken, J R Frase. Immunolocalisation of 14-3-3 isoforms in normal and scrapie-infected murine brain. Neuroscience. vol 109. issue 1. 2002-04-11. PMID:11784696. |
the tau isoform was found only in the hippocampus and medulla, and the epsilon isoform was found throughout grey matter of the cns. |
2002-04-11 |
2023-08-12 |
Not clear |
| C González-Billault, M Engelke, E M Jiménez-Mateos, F Wandosell, A Cáceres, J Avil. Participation of structural microtubule-associated proteins (MAPs) in the development of neuronal polarity. Journal of neuroscience research. vol 67. issue 6. 2002-04-09. PMID:11891784. |
in this report we have characterized the effect of the combined suppression of map1b and tau, and map1b and map2 on neuronal polarization in cultured hippocampal cells grown on a laminin-containing substrate. |
2002-04-09 |
2023-08-12 |
mouse |
| Steven M Singer, Gina M Zainelli, Maryam A Norlund, John M Lee, Nancy A Mum. Transglutaminase bonds in neurofibrillary tangles and paired helical filament tau early in Alzheimer's disease. Neurochemistry international. vol 40. issue 1. 2002-03-06. PMID:11738469. |
in control cases with nft present in the entorhinal cortex and hippocampus, indicative of braak and braak stage ii, epsilon(gamma-glutamyl)lysine bonds were present in phf tau in parietal and frontal cortex, despite the lack of microscopically detectable nft or senile plaques in these cortical regions. |
2002-03-06 |
2023-08-12 |
Not clear |
| I K Takeuchi, Y K Takeuch. Transient accumulation of Gallyas-Braak-positive and phosphorylated tau-immunopositive substances in neuronal lipofuscin granules in the amygdala, hippocampus and entorhinal cortex of rats during long-term chloroquine intoxication. Acta neuropathologica. vol 102. issue 2. 2002-02-25. PMID:11563636. |
long-term chloroquine (cq) intoxication of normal and groggy mutant rats resulted in transient accumulation of gallyas-braak (g-b) -positive and phosphorylated tau (at8) -immunopositive substances in neuronal lipofuscin granules in the amygdala, hippocampus and entorhinal cortex. |
2002-02-25 |
2023-08-12 |
rat |
| Kentaro Tanemura, Miyuki Murayama, Takumi Akagi, Tsutomu Hashikawa, Takashi Tominaga, Michinori Ichikawa, Haruyasu Yamaguchi, Akihiko Takashim. Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 1. 2002-02-04. PMID:11756496. |
v337m tg mice revealed tau aggregations in the hippocampus, which fulfills the histological criteria for nfts in human neurodegenerative diseases. |
2002-02-04 |
2023-08-12 |
mouse |
| R B Maccioni, J P Muñoz, L Barbeit. The molecular bases of Alzheimer's disease and other neurodegenerative disorders. Archives of medical research. vol 32. issue 5. 2001-12-04. PMID:11578751. |
experiments with hippocampal cells in culture have indicated a relationship between fibrillary amyloid and the cascade of molecular signals that trigger tau hyperphosphorylations. |
2001-12-04 |
2023-08-12 |
human |
| E Planel, K Yasutake, S C Fujita, K Ishigur. Inhibition of protein phosphatase 2A overrides tau protein kinase I/glycogen synthase kinase 3 beta and cyclin-dependent kinase 5 inhibition and results in tau hyperphosphorylation in the hippocampus of starved mouse. The Journal of biological chemistry. vol 276. issue 36. 2001-10-11. PMID:11441005. |
inhibition of protein phosphatase 2a overrides tau protein kinase i/glycogen synthase kinase 3 beta and cyclin-dependent kinase 5 inhibition and results in tau hyperphosphorylation in the hippocampus of starved mouse. |
2001-10-11 |
2023-08-12 |
mouse |
| M J Ramirez, K E Heslop, P T Francis, M Rattra. Expression of amyloid precursor protein, tau and presenilin RNAs in rat hippocampus following deafferentation lesions. Brain research. vol 907. issue 1-2. 2001-10-04. PMID:11430905. |
expression of amyloid precursor protein, tau and presenilin rnas in rat hippocampus following deafferentation lesions. |
2001-10-04 |
2023-08-12 |
human |
| M J Ramirez, K E Heslop, P T Francis, M Rattra. Expression of amyloid precursor protein, tau and presenilin RNAs in rat hippocampus following deafferentation lesions. Brain research. vol 907. issue 1-2. 2001-10-04. PMID:11430905. |
tau mrna level in hippocampus was unchanged after lesions. |
2001-10-04 |
2023-08-12 |
human |
| M J Ramirez, K E Heslop, P T Francis, M Rattra. Expression of amyloid precursor protein, tau and presenilin RNAs in rat hippocampus following deafferentation lesions. Brain research. vol 907. issue 1-2. 2001-10-04. PMID:11430905. |
our results support the hypothesis that amyloid precursor protein expression in hippocampal neurons is differentially affected by glutamatergic and cholinergic afferent input, and that presenilin-1, but not tau, may be subject to the same type of control in vivo. |
2001-10-04 |
2023-08-12 |
human |
| A Takashima, M Murayama, K Yasutake, H Takahashi, M Yokoyama, K Ishigur. Involvement of cyclin dependent kinase5 activator p25 on tau phosphorylation in mouse brain. Neuroscience letters. vol 306. issue 1-2. 2001-08-16. PMID:11403952. |
exposure to ca ionophore (a23187) at 10(-6) m induced p25 accumulation in rat primary hippocampal neurons, causing neuronal death without showing hyperphosphorylation of tau. |
2001-08-16 |
2023-08-12 |
mouse |
| M Yamada, Y Itoh, N Sodeyama, N Suematsu, E Otomo, M Matsushita, H Mizusaw. Senile dementia of the neurofibrillary tangle type: a comparison with Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 12. issue 2. 2001-07-12. PMID:11173884. |
to elucidate the pathogenesis of sd-nft in comparison with alzheimer's disease (ad), we investigated the hippocampal lesions and analyzed the tau gene. |
2001-07-12 |
2023-08-12 |
human |
| H N Dawson, A Ferreira, M V Eyster, N Ghoshal, L I Binder, M P Vite. Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice. Journal of cell science. vol 114. issue Pt 6. 2001-07-05. PMID:11228161. |
inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice. |
2001-07-05 |
2023-08-12 |
mouse |
| H N Dawson, A Ferreira, M V Eyster, N Ghoshal, L I Binder, M P Vite. Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice. Journal of cell science. vol 114. issue Pt 6. 2001-07-05. PMID:11228161. |
in contrast to a previously reported tau knockout mouse, embryonic hippocampal cultures from tau deficient mice show a significant delay in maturation as measured by axonal and neuritic extensions. |
2001-07-05 |
2023-08-12 |
mouse |
| R K Ellerkmann, V Riazanski, C E Elger, B W Urban, H Bec. Slow recovery from inactivation regulates the availability of voltage-dependent Na(+) channels in hippocampal granule cells, hilar neurons and basket cells. The Journal of physiology. vol 532. issue Pt 2. 2001-06-14. PMID:11306658. |
in isolated hippocampal dentate granule cells (dgcs), recovery from this inactivation was biexponential, with time constants for the two phases of slow inactivation tau(slow,1) and tau(slow,2) ranging from 1 to 10 s and 20 to 50 s, respectively. |
2001-06-14 |
2023-08-12 |
human |
| A K Mudher, B Yee, A D Smith, V H Perr. Deafferentation of the hippocampus results in the induction of AT8 positive 'granules' in the rat. Neuroscience letters. vol 301. issue 1. 2001-06-07. PMID:11239703. |
to investigate what effect deafferentation of the hippocampus has on the phosphorylation state of tau, we lesioned the entorhinal cortex in rats and looked for hyperphosphorylated tau in the hippocampus at various days post lesioning. |
2001-06-07 |
2023-08-12 |
rat |