| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Ghoshal, J F Smiley, A J DeMaggio, M F Hoekstra, E J Cochran, L I Binder, J Kure. A new molecular link between the fibrillar and granulovacuolar lesions of Alzheimer's disease. The American journal of pathology. vol 155. issue 4. 1999-11-04. PMID:10514399. |
markers of end stage disease include fibrillar lesions, which accumulate hyperphosphorylated tau protein polymerized into filaments, and granulovacuolar lesions, which appear primarily within the hippocampus. |
1999-11-04 |
2023-08-12 |
Not clear |
| L Chen, L Baum, H K Ng, L Y Chan, C P Pan. Apolipoprotein E genotype and its pathological correlation in Chinese Alzheimer's disease with late onset. Human pathology. vol 30. issue 10. 1999-11-02. PMID:10534164. |
hippocampus (including entorhinal cortex), amygdala, superior temporal lobe, middle frontal gyrus, and inferior parietal lobule of the brains of ad and poss were examined with beta amyloid (a beta) immunostaining, and the same regions plus medial occipital lobe were examined with tau immunostaining. |
1999-11-02 |
2023-08-12 |
human |
| b' P M Mattila, J O Rinne, H Helenius, M R\\xc3\\xb6ytt\\xc3\\xa. Neuritic degeneration in the hippocampus and amygdala in Parkinson\'s disease in relation to Alzheimer pathology. Acta neuropathologica. vol 98. issue 2. 1999-09-09. PMID:10442555.' |
samples from amygdala, hippocampus, entorhinal cortex (erc) and cortical gyri were examined for alzheimer-type (ad) changes and lewy bodies (lbs) using antibodies against ubiquitin and tau. |
1999-09-09 |
2023-08-12 |
Not clear |
| X Wei, Y Zhang, J Zho. Alzheimer's disease-related gene expression in the brain of senescence accelerated mouse. Neuroscience letters. vol 268. issue 3. 1999-09-01. PMID:10406024. |
the levels of alzheimer's disease (ad)-related genes, including beta-amyloid precursor protein(app), presenilin-1 (ps-1), ps-2, apoe, tau, c-fos, neural cell adhesion molecular 180 (ncam-180), tgf-beta 1, il-1 alpha/beta, il-6, tnf-alpha/beta, alpha-2-macroglobulin (alpha 2m), class ii major histocompatibility antigen la (mhcii la), bcl-2 alpha, glucocorticoid receptor-alpha (gr alpha) and mineralocorticoid receptor (mr) mrnas were determined by reverse transcription polymerase chain reaction (rt-pcr) in the hippocampus and cerebral cortex of senescence accelerated mouse (sam). |
1999-09-01 |
2023-08-12 |
mouse |
| C M Hulette, M A Pericak-Vance, A D Roses, D E Schmechel, L H Yamaoka, P C Gaskell, K A Welsh-Bohmer, R A Crowther, M G Spillantin. Neuropathological features of frontotemporal dementia and parkinsonism linked to chromosome 17q21-22 (FTDP-17): Duke Family 1684. Journal of neuropathology and experimental neurology. vol 58. issue 8. 1999-08-30. PMID:10446810. |
sarkosyl-insoluble tau extracted from the hippocampus and cortex migrated as 2 major bands at 64 and 68 kilodaltons and a minor band at 72 kilodaltons, which after alkaline phosphatase treatment appeared to contain mainly tau isoforms with 4 repeats. |
1999-08-30 |
2023-08-12 |
Not clear |
| S V Nayak, P Rondé, A D Spier, S C Lummis, R A Nichol. Calcium changes induced by presynaptic 5-hydroxytryptamine-3 serotonin receptors on isolated terminals from various regions of the rat brain. Neuroscience. vol 91. issue 1. 1999-08-02. PMID:10336063. |
in particular, m-chlorophenyl biguanide-induced changes were notably slower in synaptosomes from the amygdala (rise time constant, tau = 25 s), when compared to responses in synaptosomes from other regions (striatum, tau = 12 s; hippocampus, tau= 9.6 s; cerebellum, tau = 7 s). |
1999-08-02 |
2023-08-12 |
rat |
| B Eppler, T A Patterson, W Zhou, W J Millard, R Dawso. Kainic acid (KA)-induced seizures in Sprague-Dawley rats and the effect of dietary taurine (TAU) supplementation or deficiency. Amino acids. vol 16. issue 2. 1999-07-23. PMID:10319185. |
tau supplementation significantly increased serum and hippocampal tau levels, but not tau content in temporal cortex or striatum. |
1999-07-23 |
2023-08-12 |
rat |
| Z Nagy, M M Esiri, M LeGris, P M Matthew. Mitochondrial enzyme expression in the hippocampus in relation to Alzheimer-type pathology. Acta neuropathologica. vol 97. issue 4. 1999-07-20. PMID:10208273. |
levels of cox iv but not of cox i were related to the amount of hyperphosphorylated tau accumulated in the same hippocampal region but not to the amount of amyloid deposited in sporadic ad. |
1999-07-20 |
2023-08-12 |
Not clear |
| Z Nagy, M M Esiri, M LeGris, P M Matthew. Mitochondrial enzyme expression in the hippocampus in relation to Alzheimer-type pathology. Acta neuropathologica. vol 97. issue 4. 1999-07-20. PMID:10208273. |
however, in these cases levels of enzyme expression were correlated to the amount of amyloid accumulation but not the amount of hyperphosphorylated tau in the hippocampus. |
1999-07-20 |
2023-08-12 |
Not clear |
| Y Tatebayashi, K Iqbal, I Grundke-Iqba. Dynamic regulation of expression and phosphorylation of tau by fibroblast growth factor-2 in neural progenitor cells from adult rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 13. 1999-07-15. PMID:10377336. |
dynamic regulation of expression and phosphorylation of tau by fibroblast growth factor-2 in neural progenitor cells from adult rat hippocampus. |
1999-07-15 |
2023-08-12 |
rat |
| Y Tatebayashi, K Iqbal, I Grundke-Iqba. Dynamic regulation of expression and phosphorylation of tau by fibroblast growth factor-2 in neural progenitor cells from adult rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 13. 1999-07-15. PMID:10377336. |
we have found that neural progenitor cells from adult rat hippocampus express adult isoforms of tau and that the expression and the phosphorylation of tau are regulated by fibroblast growth factor-2 (fgf-2). |
1999-07-15 |
2023-08-12 |
rat |
| Y Tatebayashi, K Iqbal, I Grundke-Iqba. Dynamic regulation of expression and phosphorylation of tau by fibroblast growth factor-2 in neural progenitor cells from adult rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 13. 1999-07-15. PMID:10377336. |
these results demonstrate that proliferating adult rat hippocampal progenitor cells express adult isoforms of tau stably and that fgf-2 upregulates the expression and, by upregulating gsk-3 activity, the phosphorylation of tau. |
1999-07-15 |
2023-08-12 |
rat |
| D A Shackelford, R Y Ye. Dephosphorylation of tau during transient forebrain ischemia in the rat. Molecular and chemical neuropathology. vol 34. issue 2-3. 1999-06-21. PMID:10327411. |
in this study, tau was rapidly dephosphorylated during ischemia in the hippocampus, neocortex, and striatum. |
1999-06-21 |
2023-08-12 |
rat |
| T Revesz, J L Holton, B Doshi, B H Anderton, F Scaravilli, G T Plan. Cytoskeletal pathology in familial cerebral amyloid angiopathy (British type) with non-neuritic amyloid plaque formation. Acta neuropathologica. vol 97. issue 2. 1999-05-18. PMID:9928828. |
sections from the hippocampus and cerebellum of three cases from three unrelated families were stained with silver impregnation methods and antibodies to antigens including tau, neurofilaments, ubiquitin and glial fibrillary acidic protein. |
1999-05-18 |
2023-08-12 |
Not clear |
| T Revesz, J L Holton, B Doshi, B H Anderton, F Scaravilli, G T Plan. Cytoskeletal pathology in familial cerebral amyloid angiopathy (British type) with non-neuritic amyloid plaque formation. Acta neuropathologica. vol 97. issue 2. 1999-05-18. PMID:9928828. |
all hippocampal subregions contained large numbers of nfts and neuropil threads (nt), which were stained with both phosphorylation-dependent and phosphorylation-independent tau antibodies and ultrastructurally were found to be composed of paired helical filaments (phfs). |
1999-05-18 |
2023-08-12 |
Not clear |
| M Hüll, J Eistetter, B L Fiebich, J Baue. Glutamate but not interleukin-6 influences the phosphorylation of tau in primary rat hippocampal neurons. Neuroscience letters. vol 261. issue 1-2. 1999-05-06. PMID:10081920. |
glutamate but not interleukin-6 influences the phosphorylation of tau in primary rat hippocampal neurons. |
1999-05-06 |
2023-08-12 |
rat |
| M Hüll, J Eistetter, B L Fiebich, J Baue. Glutamate but not interleukin-6 influences the phosphorylation of tau in primary rat hippocampal neurons. Neuroscience letters. vol 261. issue 1-2. 1999-05-06. PMID:10081920. |
we investigated the influence of glutamate and il-6 on tau phosphorylation in cultured primary rat hippocampal neurons. |
1999-05-06 |
2023-08-12 |
rat |
| G Rammes, D Swandulla, P Spielmanns, C G Parson. Interactions of GYKI 52466 and NBQX with cyclothiazide at AMPA receptors: experiments with outside-out patches and EPSCs in hippocampal neurones. Neuropharmacology. vol 37. issue 10-11. 1999-03-04. PMID:9849667. |
in outside-out patches from cultured hippocampal neurones, glutamate (1 mm) applied for 1 ms evoked currents which rose rapidly (tau(on) 451 +/- 31 micros) to a peak and then deactivated with slower kinetics (1.95 +/- 0.13 ms). |
1999-03-04 |
2023-08-12 |
Not clear |
| H P Horikawa, H Naw. Turnover rates of the AMPA-type glutamate receptor GluR1 measured by transient gene expression. Journal of neuroscience methods. vol 84. issue 1-2. 1999-01-26. PMID:9821649. |
decay of the receptor protein was monitored by western blotting probed by an anti-tag antibody: tau 1/2 was 52 h in hippocampal neurons, similar to that in pc12. |
1999-01-26 |
2023-08-12 |
rat |
| A Takashima, T Honda, K Yasutake, G Michel, O Murayama, M Murayama, K Ishiguro, H Yamaguch. Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons. Neuroscience research. vol 31. issue 4. 1999-01-05. PMID:9809590. |
activation of tau protein kinase i/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons. |
1999-01-05 |
2023-08-12 |
human |