| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi-Gang Che. Specific tau phosphorylation sites in hippocampus correlate with impairment of step-down inhibitory avoidance task in rats. Behavioural brain research. vol 158. issue 2. 2005-04-19. PMID:15698894. |
specific tau phosphorylation sites in hippocampus correlate with impairment of step-down inhibitory avoidance task in rats. |
2005-04-19 |
2023-08-12 |
rat |
| Yi-Gang Che. Specific tau phosphorylation sites in hippocampus correlate with impairment of step-down inhibitory avoidance task in rats. Behavioural brain research. vol 158. issue 2. 2005-04-19. PMID:15698894. |
it was found that among rats that developed the impairment in memory retention in step-down inhibitory avoidance task, tau protein in their hippocampus was hyperphosohorylated at thr231/ser235 (m4) sites of tau, and the significantly increased expression of pp-1 and the decreased one of pp-2b were also determined by western blot and/or immunohistochemistry. |
2005-04-19 |
2023-08-12 |
rat |
| Su Jeon Shin, Sung-Eun Lee, Jung Hyun Boo, Mihyang Kim, Young-Dae Yoon, Su-il Kim, Inhee Mook-Jun. Profiling proteins related to amyloid deposited brain of Tg2576 mice. Proteomics. vol 4. issue 11. 2005-04-13. PMID:15378736. |
alzheimer's disease (ad) is an age-related neurodegenerative disorder that is characterized by the extracellular deposition of beta-amyloid and intracellular hyperphosphorylation of tau in the cortex and hippocampus of the brain. |
2005-04-13 |
2023-08-12 |
mouse |
| Thor D Stein, Nicholas J Anders, Charles DeCarli, Sic L Chan, Mark P Mattson, Jeffrey A Johnso. Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 35. 2005-04-05. PMID:15342738. |
neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (app) in appsw mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis. |
2005-04-05 |
2023-08-12 |
mouse |
| Thor D Stein, Nicholas J Anders, Charles DeCarli, Sic L Chan, Mark P Mattson, Jeffrey A Johnso. Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 35. 2005-04-05. PMID:15342738. |
here, we show that sappalpha increases the expression levels of several neuroprotective genes and protects organotypic hippocampal cultures from abeta-induced tau phosphorylation and neuronal death. |
2005-04-05 |
2023-08-12 |
mouse |
| Thor D Stein, Nicholas J Anders, Charles DeCarli, Sic L Chan, Mark P Mattson, Jeffrey A Johnso. Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 35. 2005-04-05. PMID:15342738. |
chronic infusion of an antibody against transthyretin into the hippocampus of mice overexpressing app with the swedish mutation (app(sw)) leads to increased abeta, tau phosphorylation, and neuronal loss and apoptosis within the ca1 neuronal field. |
2005-04-05 |
2023-08-12 |
mouse |
| Masaki Ikeda, Mikio Shoji, Toshitaka Kawarai, Takeshi Kawarabayashi, Etsuro Matsubara, Tetsuro Murakami, Atsushi Sasaki, Yasushi Tomidokoro, Yasushi Ikarashi, Hisashi Kuribara, Koichi Ishiguro, Masato Hasegawa, Shu-Hui Yen, M Azhar Chishti, Yasuo Harigaya, Koji Abe, Koichi Okamoto, Peter St George-Hyslop, David Westawa. Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice. The American journal of pathology. vol 166. issue 2. 2005-03-29. PMID:15681835. |
the tgtaur406w 21807 line showed tau accumulation beginning in the hippocampus and amygdala at 6 months of age, which subsequently spread to the cortices and subcortical areas. |
2005-03-29 |
2023-08-12 |
mouse |
| Luguang Luo, Edward G Stop. Thyrotropin releasing hormone inhibits tau phosphorylation by dual signaling pathways in hippocampal neurons. Journal of Alzheimer's disease : JAD. vol 6. issue 5. 2005-03-21. PMID:15505375. |
thyrotropin releasing hormone inhibits tau phosphorylation by dual signaling pathways in hippocampal neurons. |
2005-03-21 |
2023-08-12 |
rat |
| Luguang Luo, Edward G Stop. Thyrotropin releasing hormone inhibits tau phosphorylation by dual signaling pathways in hippocampal neurons. Journal of Alzheimer's disease : JAD. vol 6. issue 5. 2005-03-21. PMID:15505375. |
depletion of thyrotropin releasing hormone (trh) gene expression resulted in augmented tau and glycosynthetase kinase-3beta (gsk-3beta), in contrast, trh administration resulted in decreases of 75% in gsk-3beta and 90% in tau phosphorylation in cultured rat hippocampal neurons. |
2005-03-21 |
2023-08-12 |
rat |
| Yue-Ju Wang, Gui-Hai Chen, Xiang-You Hu, Ya-Ping Lu, Jiang-Ning Zhou, Rong-Yu Li. The expression of calcium/calmodulin-dependent protein kinase II-alpha in the hippocampus of patients with Alzheimer's disease and its links with AD-related pathology. Brain research. vol 1031. issue 1. 2005-03-18. PMID:15621017. |
since calcium/calmodulin-dependent protein kinase ii-alpha (camkii-alpha), one of the most abundant kinases in the brain, is involved in the phosphorylation of tau and amyloid precursor protein (app), we examined the expression of camkii-alpha and its relationships with the neuropathology in the hippocampus of ad patients using immunohistochemistry and double-labeling immunofluorescence methods. |
2005-03-18 |
2023-08-12 |
Not clear |
| T Estefanía Saez, Mariana Pehar, Marcelo Vargas, Luis Barbeito, Ricardo B Maccion. Astrocytic nitric oxide triggers tau hyperphosphorylation in hippocampal neurons. In vivo (Athens, Greece). vol 18. issue 3. 2005-03-07. PMID:15341183. |
astrocytic nitric oxide triggers tau hyperphosphorylation in hippocampal neurons. |
2005-03-07 |
2023-08-12 |
rat |
| T Estefanía Saez, Mariana Pehar, Marcelo Vargas, Luis Barbeito, Ricardo B Maccion. Astrocytic nitric oxide triggers tau hyperphosphorylation in hippocampal neurons. In vivo (Athens, Greece). vol 18. issue 3. 2005-03-07. PMID:15341183. |
remarkably, hippocampal neurons co-cultured with astrocytes, previously stimulated with abeta, displayed hyperphosphorylation of the microtubule-associated protein tau. |
2005-03-07 |
2023-08-12 |
rat |
| V Echeverria, A Ducatenzeiler, E Dowd, J Jänne, S M Grant, M Szyf, F Wandosell, J Avila, H Grimm, S B Dunnett, T Hartmann, L Alhonen, A C Cuell. Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons. Neuroscience. vol 129. issue 3. 2005-03-07. PMID:15541880. |
altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons. |
2005-03-07 |
2023-08-12 |
rat |
| V Echeverria, A Ducatenzeiler, E Dowd, J Jänne, S M Grant, M Szyf, F Wandosell, J Avila, H Grimm, S B Dunnett, T Hartmann, L Alhonen, A C Cuell. Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons. Neuroscience. vol 129. issue 3. 2005-03-07. PMID:15541880. |
in these rats, the presence of intraneuronal abeta is sufficient to provoke up-regulation of the phosphorylated form of extracellular-regulated kinase (erk) 2 and its enzymatic activity in the hippocampus while no changes were observed in the activity or phosphorylation status of other putative tau kinases such as p38, glycogen synthase kinase 3, and cycline-dependent kinase 5. |
2005-03-07 |
2023-08-12 |
rat |
| Xiaomei Liao, Yingchun Zhang, Yipeng Wang, Jianzhi Wan. The effect of cdk-5 overexpression on tau phosphorylation and spatial memory of rat. Science in China. Series C, Life sciences. vol 47. issue 3. 2005-03-04. PMID:15524282. |
we demonstrated that 24 h after transfection into rat hippocampus, cdk-5 was overexpressed and induced a reduced staining with antibody tau-1 and an enhanced staining with antibodies 12e8 and phf-1, suggesting hyperphosphorylation of tau at ser199/202, ser262/356 and ser396/404 sites. |
2005-03-04 |
2023-08-12 |
rat |
| Satyabrata Kar, Stephen P M Slowikowski, David Westaway, Howard T J Moun. Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease. Journal of psychiatry & neuroscience : JPN. vol 29. issue 6. 2005-02-23. PMID:15644984. |
the brain of an individual with alzheimer's disease exhibits extracellular plaques of aggregated beta-amyloid protein (abeta), intracellular neurofibrillary tangles that contain hyperphosphorylated tau protein and a profound loss of basal forebrain cholinergic neurons that innervate the hippocampus and the neocortex. |
2005-02-23 |
2023-08-12 |
Not clear |
| Baolin Li, John Ryder, Yuan Su, Steven A Moore, Feng Liu, Patricia Solenberg, Kellie Brune, Niles Fox, Binhui Ni, Rugao Liu, Yan Zho. Overexpression of GSK3betaS9A resulted in tau hyperphosphorylation and morphology reminiscent of pretangle-like neurons in the brain of PDGSK3beta transgenic mice. Transgenic research. vol 13. issue 4. 2005-02-22. PMID:15517997. |
by analyzing the offspring from several transgenic mouse lines, including lines other than 3083 and 3107, it was found that overexpressed constitutively active human gsk3betas9a resulted in hyperphosphorylation of tau and morphology reminiscent of pretangle-like neurons in cortex and hippocampus. |
2005-02-22 |
2023-08-12 |
mouse |
| Li Sun, XiaoChuang Wang, Shengyuan Liu, Quan Wang, JianZhi Wang, Malika Bennecib, Cheng-Xin Gong, Amitabha Sengupta, Inge Grundke-Iqbal, Khalid Iqba. Bilateral injection of isoproterenol into hippocampus induces Alzheimer-like hyperphosphorylation of tau and spatial memory deficit in rat. FEBS letters. vol 579. issue 1. 2005-02-17. PMID:15620722. |
bilateral injection of isoproterenol into hippocampus induces alzheimer-like hyperphosphorylation of tau and spatial memory deficit in rat. |
2005-02-17 |
2023-08-12 |
rat |
| Li Sun, XiaoChuang Wang, Shengyuan Liu, Quan Wang, JianZhi Wang, Malika Bennecib, Cheng-Xin Gong, Amitabha Sengupta, Inge Grundke-Iqbal, Khalid Iqba. Bilateral injection of isoproterenol into hippocampus induces Alzheimer-like hyperphosphorylation of tau and spatial memory deficit in rat. FEBS letters. vol 579. issue 1. 2005-02-17. PMID:15620722. |
here, we show that injection of isoproterenol, an activator of camp-dependent kinase (pka), into rat hippocampus bilaterally results in the activation of pka, calcium/calmodulin-dependent kinase ii and cyclin-dependent kinase-5, inhibition of protein phosphatase-2a, hyperphosphorylation of tau at several alzheimer-like epitopes and a disturbance of spatial memory retention 48 h after the drug injection. |
2005-02-17 |
2023-08-12 |
rat |
| Shagufta Ahmad, Leslie J Fowler, Peter S Whitto. Effects of acute and chronic lamotrigine treatment on basal and stimulated extracellular amino acids in the hippocampus of freely moving rats. Brain research. vol 1029. issue 1. 2005-02-14. PMID:15533314. |
in the present study, we have investigated the effects of acute and chronic (up to 21 days) treatment with ltg on basal and either veratridine- or kcl-stimulated release of aspartate (asp), glu, taurine (tau) and gaba in the hippocampus of freely moving rats using microdialysis. |
2005-02-14 |
2023-08-12 |
rat |