| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dan-Ling Wang, Zhi-Qun Ling, Fu-Yuan Cao, Ling-Qiang Zhu, Jian-Zhi Wan. Melatonin attenuates isoproterenol-induced protein kinase A overactivation and tau hyperphosphorylation in rat brain. Journal of pineal research. vol 37. issue 1. 2005-02-10. PMID:15230863. |
in the present study, isoproterenol (iso) was injected bilaterally into hippocampus of rat brain; iso is a specific pka activator and it induces tau hyperphosphorylation. |
2005-02-10 |
2023-08-12 |
rat |
| Dan-Ling Wang, Zhi-Qun Ling, Fu-Yuan Cao, Ling-Qiang Zhu, Jian-Zhi Wan. Melatonin attenuates isoproterenol-induced protein kinase A overactivation and tau hyperphosphorylation in rat brain. Journal of pineal research. vol 37. issue 1. 2005-02-10. PMID:15230863. |
we found that hippocampal injection of iso (0.02 microm) induced pka overactivation and tau hyperphosphorylation at both paired helical filament (phf)-1 and tau-1 sites. |
2005-02-10 |
2023-08-12 |
rat |
| Markus Tolnay, Florence Clavaguer. Argyrophilic grain disease: a late-onset dementia with distinctive features among tauopathies. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 24. issue 4. 2005-02-10. PMID:15641585. |
agd changes consist of the microtubule-associated protein tau in an abnormally and hyperphosphorylated state and are mainly found in limbic regions, for example, in the hippocampus, the entorhinal and transentorhinal cortices and the amygdala. |
2005-02-10 |
2023-08-12 |
Not clear |
| Octavio Mercado-Gómez, Patricia Ferrera, Clorinda Aria. Histopathologic changes induced by the microtubule-stabilizing agent Taxol in the rat hippocampus in vivo. Journal of neuroscience research. vol 78. issue 4. 2005-02-03. PMID:15449327. |
we studied the effects of taxol on neuronal morphology and viability as well as changes in microtubule-associated proteins map2 and tau in rat hippocampus. |
2005-02-03 |
2023-08-12 |
rat |
| Octavio Mercado-Gómez, Patricia Ferrera, Clorinda Aria. Histopathologic changes induced by the microtubule-stabilizing agent Taxol in the rat hippocampus in vivo. Journal of neuroscience research. vol 78. issue 4. 2005-02-03. PMID:15449327. |
interestingly paired helical filament (phf)-1 immunoreactivity, which is associated with a phosphorylated epitope of tau proteins, was induced in the damaged hippocampus. |
2005-02-03 |
2023-08-12 |
rat |
| D C Paviour, A J Lees, K A Josephs, T Ozawa, M Ganguly, C Strand, A Godbolt, R S Howard, T Revesz, J L Holto. Frontotemporal lobar degeneration with ubiquitin-only-immunoreactive neuronal changes: broadening the clinical picture to include progressive supranuclear palsy. Brain : a journal of neurology. vol 127. issue Pt 11. 2005-01-18. PMID:15459024. |
the ftld with ubiquitin-only-immunoreactive neuronal changes (ftld-u) subtype is pathologically characterized by ubiquitin-positive, tau and alpha-synuclein-negative neuronal cytoplasmic inclusions in the frontotemporal cortex and hippocampal dentate fascia. |
2005-01-18 |
2023-08-12 |
Not clear |
| Andrea Reyna-Neyra, Clorinda Arias, Patricia Ferrera, Sumiko Morimoto, Ignacio Camacho-Arroy. Changes in the content and distribution of microtubule associated protein 2 in the hippocampus of the rat during the estrous cycle. Journal of neurobiology. vol 60. issue 4. 2004-12-02. PMID:15307151. |
because this process implicates changes in neuronal cytoskeleton organization, we analyzed the content of microtubule associated protein 2 (map2) and tau in the hippocampus and the frontal cortex of the rat by western blot, as well as the hippocampal distribution of map2 during the estrous cycle by immunohistochemistry. |
2004-12-02 |
2023-08-12 |
rat |
| Andrea Reyna-Neyra, Clorinda Arias, Patricia Ferrera, Sumiko Morimoto, Ignacio Camacho-Arroy. Changes in the content and distribution of microtubule associated protein 2 in the hippocampus of the rat during the estrous cycle. Journal of neurobiology. vol 60. issue 4. 2004-12-02. PMID:15307151. |
in contrast, the content of tau did not vary during the estrous cycle in either the hippocampus or the frontal cortex. |
2004-12-02 |
2023-08-12 |
rat |
| Gytis Baranauska. Cell-type-specific splicing of KChIP4 mRNA correlates with slower kinetics of A-type current. The European journal of neuroscience. vol 20. issue 2. 2004-09-30. PMID:15233748. |
for example, in globus pallidus (gp) and basal forebrain (bf) neurons in rats, a-type current possesses a slowly inactivating (tau > 80 ms) component of inactivation that is absent in the currents obtained from striatal cholinergic interneurons (stri) and hippocampal area ca1 pyramidal neurons (hip). |
2004-09-30 |
2023-08-12 |
rat |
| Cristian A Zambrano, José T Egaña, Marco T Núñez, Ricardo B Maccioni, Christian González-Billaul. Oxidative stress promotes tau dephosphorylation in neuronal cells: the roles of cdk5 and PP1. Free radical biology & medicine. vol 36. issue 11. 2004-08-19. PMID:15135175. |
by using phospho-specific antibodies, we analyzed the changes in tau phosphorylation patterns after treatment of rat hippocampal and shsy5y human neuroblastoma cells with h2o2. |
2004-08-19 |
2023-08-12 |
human |
| Gary W Arendash, Jada Lewis, Ralph E Leighty, Eileen McGowan, Jennifer R Cracchiolo, Mike Hutton, Marcos F Garci. Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain. Brain research. vol 1012. issue 1-2. 2004-08-17. PMID:15158158. |
moreover, correlation analyses involving tau mice alone revealed linkage between poorer cognitive performance in all three water maze tasks and the number of neurofibrillary tangle (nft)-containing neurons in neocortex and hippocampus. |
2004-08-17 |
2023-08-12 |
mouse |
| Bin Zhang, Makoto Higuchi, Yasumasa Yoshiyama, Takeshi Ishihara, Mark S Forman, Dan Martinez, Sonali Joyce, John Q Trojanowski, Virginia M-Y Le. Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 19. 2004-08-13. PMID:15140937. |
rw but not hwt tau tg mice developed an age-dependent accumulation of insoluble filamentous tau aggregates in neuronal perikarya of the cerebral cortex, hippocampus, cerebellum, and spinal cord. |
2004-08-13 |
2023-08-12 |
mouse |
| Alejandra R Alvarez, Juan A Godoy, Karin Mullendorff, Gonzalo H Olivares, Miguel Bronfman, Nibaldo C Inestros. Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons. Experimental cell research. vol 297. issue 1. 2004-08-12. PMID:15194435. |
we report herein that the wnt-3a ligand was indeed able to overcome toxic effects induced by abeta in hippocampal neurons, including a neuronal impairment on cell survival, an increase in glycogen synthase kinase-3beta (gsk-3beta) and tau phosphorylation, a decrease in cytoplasmic beta-catenin and a decrease in the expression of the wnt target gene engrailed-1. |
2004-08-12 |
2023-08-12 |
rat |
| Liang Li, Amitabha Sengupta, Niloufar Haque, Inge Grundke-Iqbal, Khalid Iqba. Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration. FEBS letters. vol 566. issue 1-3. 2004-07-16. PMID:15147906. |
here we show that memantine inhibits and reverses the pp-2a inhibition-induced abnormal hyperphosphorylation and accumulation of tau in organotypic culture of rat hippocampal slices. |
2004-07-16 |
2023-08-12 |
rat |
| Kelsi L Anderson, Adriana Ferreir. alpha1 Integrin activation: a link between beta-amyloid deposition and neuronal death in aging hippocampal neurons. Journal of neuroscience research. vol 75. issue 5. 2004-07-13. PMID:14991844. |
we have shown previously that fibrillar abeta induced sustained activation of the mitogen-activated protein kinase (mapk) followed by hyperphosphorylation of tau proteins in aging hippocampal neurons. |
2004-07-13 |
2023-08-12 |
Not clear |
| P Cardona-Gomez, M Perez, J Avila, L M Garcia-Segura, F Wandosel. Estradiol inhibits GSK3 and regulates interaction of estrogen receptors, GSK3, and beta-catenin in the hippocampus. Molecular and cellular neurosciences. vol 25. issue 3. 2004-05-26. PMID:15033165. |
the present data show that estradiol, in vivo, induces a transient activation of gsk3 in the adult female rat hippocampus, followed by a more sustained inhibition, as inferred from phosphorylation levels of tau. |
2004-05-26 |
2023-08-12 |
rat |
| Rodrigo A Quintanilla, Daniel I Orellana, Christian González-Billault, Ricardo B Maccion. Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway. Experimental cell research. vol 295. issue 1. 2004-05-26. PMID:15051507. |
in the present study, we describe the effect of the administration at physiologic doses of one of these cytokines, il-6, to hippocampal neurons, on the protein kinase pathways as well as on the tau phosphorylation patterns. |
2004-05-26 |
2023-08-12 |
Not clear |
| F F Cruz-Sánchez, N Durany, J Thome, P Riederer, D Zambó. Correlation between Apolipoprotein-E polymorphism and Alzheimer's disease pathology. Journal of Alzheimer's disease : JAD. vol 2. issue 3-4. 2004-05-05. PMID:12214086. |
representative cerebral regions (cortex, gyrus cinguli, putamen, hippocampus, white matter) from 28 ad cases, 7 svdd and 38 non-neurological controls were studied using classical histological techniques and immunohistochemistry for tau protein and amyloid-beta. |
2004-05-05 |
2023-08-12 |
Not clear |
| Salvatore Oddo, Antonella Caccamo, Masashi Kitazawa, Bertrand P Tseng, Frank M LaFerl. Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease. Neurobiology of aging. vol 24. issue 8. 2004-03-11. PMID:14643377. |
we find that abeta deposits initiate in the cortex and progress to the hippocampus with aging, whereas tau pathology is first apparent in the hippocampus and then progresses to the cortex. |
2004-03-11 |
2023-08-12 |
mouse |
| Ronald L Klein, Wen-Lang Lin, Dennis W Dickson, Jada Lewis, Michael Hutton, Karen Duff, Edwin M Meyer, Michael A Kin. Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau. The American journal of pathology. vol 164. issue 1. 2004-02-27. PMID:14695347. |
tau gene transfer to the hippocampal region of amyloid-depositing transgenic mice produced pretangles and threads, as well as intensely tau-immunoreactive neurites in amyloid plaques. |
2004-02-27 |
2023-08-12 |
mouse |