| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| María Cecilia Scorza, Anna Castañé, Analía Bortolozzi, Francesc Artiga. Clozapine does not require 5-HT1A receptors to block the locomotor hyperactivity induced by MK-801 Clz and MK-801 in KO1A mice. Neuropharmacology. vol 59. issue 1-2. 2010-10-20. PMID:20412811. |
to examine whether 5-ht(1a) receptors are involved in the therapeutic action of clozapine (clz) on positive symptoms, here we examined the ability of clz to antagonize the behavioural syndrome induced by the non-competitive n-methyl-d-aspartate receptor antagonist, mk-801 in wild-type (wt) and 5-ht(1a)-receptor knockout (ko(1a)) mice. |
2010-10-20 |
2023-08-12 |
mouse |
| Helen N Panas, Laurie J Lynch, Eric J Vallender, Zhihua Xie, Guo-Lin Chen, Spencer K Lynn, Thomas S Scanlan, Gregory M Mille. Normal thermoregulatory responses to 3-iodothyronamine, trace amines and amphetamine-like psychostimulants in trace amine associated receptor 1 knockout mice. Journal of neuroscience research. vol 88. issue 9. 2010-09-16. PMID:20155805. |
t1am inhibition of 10 nm [(3)h]dopamine uptake (ic(50): wt, 1.4 + or - 0.5 microm; ko, 1.2 + or - 0.4 microm) or 50 nm [(3)h]serotonin uptake (ic(50): wt, 4.5 + or - 0.6 microm; ko, 4.7 + or - 1.1 microm) in wt and ko synaptosomes was also highly similar. |
2010-09-16 |
2023-08-12 |
mouse |
| Yuta Ishizuka, Hiroshi Abe, Akito Tanoue, Hiroshi Kannan, Yasushi Ishid. Involvement of vasopressin V1b receptor in anti-anxiety action of SSRI and SNRI in mice. Neuroscience research. vol 66. issue 3. 2010-06-07. PMID:19914307. |
to examine whether the interaction of the v1br and serotonin in the central nervous system controls anxiety-related behavior, we investigated the effects of acute and chronic treatment with a selective serotonin reuptake inhibitor (ssri) and with a serotonin noradrenalin reuptake inhibitor (snri) on v1br knockout (ko) mice and on v1br antagonist (ssr149415)-treated mice. |
2010-06-07 |
2023-08-12 |
mouse |
| Christiaan H Vinkers, Ronald S Oosting, Meg J V van Bogaert, Berend Olivier, Lucianne Groenin. Early-life blockade of 5-HT(1A) receptors alters adult anxiety behavior and benzodiazepine sensitivity. Biological psychiatry. vol 67. issue 4. 2010-04-14. PMID:19811773. |
an increased anxiety phenotype in 5-ht(1a) receptor ko mice (1ako) mice has been ascribed to 5-ht(1a) receptor absence during the early postnatal period. |
2010-04-14 |
2023-08-12 |
mouse |
| Jason Peter Twohig, Malcolm I Roberts, Nuria Gavalda, Emma L Rees-Taylor, Albert Giralt, Debbie Adams, Simon P Brooks, Melanie J Bull, Claudia J Calder, Simone Cuff, Audrey A Yong, Jordi Alberch, Alun Davies, Stephen B Dunnett, Aviva M Tolkovsky, Eddie C Y Wan. Age-dependent maintenance of motor control and corticostriatal innervation by death receptor 3. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 10. 2010-04-09. PMID:20220013. |
dr3(ko) mice progressively developed behavioral defects characterized by altered gait, dyskinesia, and hyperactivity, which were associated with elevated dopamine and lower serotonin levels in the striatum. |
2010-04-09 |
2023-08-12 |
mouse |
| Ryan T Strachan, Noah Sciaky, Mark R Cronan, Wesley K Kroeze, Bryan L Rot. Genetic deletion of p90 ribosomal S6 kinase 2 alters patterns of 5-hydroxytryptamine 2A serotonin receptor functional selectivity. Molecular pharmacology. vol 77. issue 3. 2010-03-19. PMID:19933401. |
to test this hypothesis, we evaluated a chemically diverse set of 5-ht(2a) agonists at three readouts of 5-ht(2a) receptor activation in both wild-type (wt) and rsk2 knock-out (ko) mouse embryonic fibroblasts (mefs). |
2010-03-19 |
2023-08-12 |
mouse |
| Ryan T Strachan, Noah Sciaky, Mark R Cronan, Wesley K Kroeze, Bryan L Rot. Genetic deletion of p90 ribosomal S6 kinase 2 alters patterns of 5-hydroxytryptamine 2A serotonin receptor functional selectivity. Molecular pharmacology. vol 77. issue 3. 2010-03-19. PMID:19933401. |
here we report that 5-ht(2a) receptor agonist efficacies were significantly and variably augmented in rsk2 ko mefs compared with wt mefs. |
2010-03-19 |
2023-08-12 |
mouse |
| Lin Li, Nigel Whittle, Stefanie Klug, Wei-Qiang Chen, Nicolas Singewald, Miklos Toth, Gert Lube. Serotonin(1A)-receptor-dependent signaling proteins in mouse hippocampus. Neuropharmacology. vol 57. issue 5-6. 2009-12-04. PMID:19607848. |
the serotonin(1a) receptor (5-ht(1a) r) knock-out mouse (ko) is a widely used animal model for anxiety and cognitive function and regulation of signaling cascades by this receptor has been reported. |
2009-12-04 |
2023-08-12 |
mouse |
| Lin Li, Nigel Whittle, Stefanie Klug, Wei-Qiang Chen, Nicolas Singewald, Miklos Toth, Gert Lube. Serotonin(1A)-receptor-dependent signaling proteins in mouse hippocampus. Neuropharmacology. vol 57. issue 5-6. 2009-12-04. PMID:19607848. |
hippocampal proteins from wild type and 5-ht(1a) r ko mice were extracted, run on two-dimensional gel electrophoresis, proteins were identified by maldi and nano-esi-lc-ms/ms and sps were quantified by specific software. |
2009-12-04 |
2023-08-12 |
mouse |
| F S Hall, X-F Li, J Randall-Thompson, I Sora, D L Murphy, K-P Lesch, M Caron, G R Uh. Cocaine-conditioned locomotion in dopamine transporter, norepinephrine transporter and 5-HT transporter knockout mice. Neuroscience. vol 162. issue 4. 2009-11-10. PMID:19482066. |
the behavioral effects of cocaine are affected by gene knockout (ko) of the dopamine transporter (dat), the serotonin transporter (sert) and the norepinephrine transporter (net). |
2009-11-10 |
2023-08-12 |
mouse |
| Ichiro Sora, Bingjin Li, Setsu Fumushima, Asami Fukui, Yosefu Arime, Yoshiyuki Kasahara, Hiroaki Tomita, Kazutaka Iked. Monoamine transporter as a target molecule for psychostimulants. International review of neurobiology. vol 85. 2009-09-10. PMID:19607959. |
the effects of map in dat or serotonin transporter (sert) single knockout (ko) mice and dat/sert double ko mice suggested that dat and sert are key molecules for hyperthermia and neuronal toxicity of map. |
2009-09-10 |
2023-08-12 |
mouse |
| Adam L Halberstadt, Iris van der Heijden, Michael A Ruderman, Victoria B Risbrough, Jay A Gingrich, Mark A Geyer, Susan B Powel. 5-HT(2A) and 5-HT(2C) receptors exert opposing effects on locomotor activity in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 8. 2009-09-02. PMID:19322172. |
the increase in locomotor activity induced by 1.0 mg/kg doi was absent in 5-ht(2a) receptor ko mice, suggesting the involvement of 5-ht(2a) receptors. |
2009-09-02 |
2023-08-12 |
mouse |
| Adam L Halberstadt, Iris van der Heijden, Michael A Ruderman, Victoria B Risbrough, Jay A Gingrich, Mark A Geyer, Susan B Powel. 5-HT(2A) and 5-HT(2C) receptors exert opposing effects on locomotor activity in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 8. 2009-09-02. PMID:19322172. |
the reduction in locomotor activity produced by 10 mg/kg doi was potentiated in 5-ht(2a) ko mice and attenuated by pretreatment with the selective 5-ht(2c/2b) antagonist ser-082. |
2009-09-02 |
2023-08-12 |
mouse |
| Adam L Halberstadt, Iris van der Heijden, Michael A Ruderman, Victoria B Risbrough, Jay A Gingrich, Mark A Geyer, Susan B Powel. 5-HT(2A) and 5-HT(2C) receptors exert opposing effects on locomotor activity in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 8. 2009-09-02. PMID:19322172. |
these data indicate that the decrease in locomotor activity induced by 10 mg/kg doi is mediated by 5-ht(2c) receptors, an interpretation that is supported by the finding that the selective 5-ht(2c) agonist way 161,503 produces reductions in the locomotor activity that are potentiated in 5ht(2a) ko mice. |
2009-09-02 |
2023-08-12 |
mouse |
| Min-Tsai Liu, Yung-Hui Kuan, Jingwen Wang, René Hen, Michael D Gersho. 5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 31. 2009-08-21. PMID:19657021. |
the relative number of enteric neurons in wild-type (wt) mice and those lacking 5-ht(4) receptors [knock-out (ko)] was found to be similar at birth; however, the abundance of ens neurons increased during the first 4 months after birth in wt but not ko littermates. |
2009-08-21 |
2023-08-12 |
mouse |
| Min-Tsai Liu, Yung-Hui Kuan, Jingwen Wang, René Hen, Michael D Gersho. 5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 31. 2009-08-21. PMID:19657021. |
in vivo, in wt but not ko mice, 5-ht(4) agonists induced bromodeoxyuridine incorporation into cells that expressed markers of neurons (huc/d, doublecortin), neural precursors (sox10, nestin, phox2b), or stem cells (musashi-1). |
2009-08-21 |
2023-08-12 |
mouse |
| Jonathan Savitz, Irwin Lucki, Wayne C Drevet. 5-HT(1A) receptor function in major depressive disorder. Progress in neurobiology. vol 88. issue 1. 2009-08-18. PMID:19428959. |
5-ht(1a) receptor knockout (ko) mice display increased anxiety-related behavior, which, unlike in their wild-type counterparts, cannot be rescued with antidepressant drug (ad) treatment. |
2009-08-18 |
2023-08-12 |
mouse |
| Alain M Gardier, Bruno P Guiard, Jean-Philippe Guilloux, Christelle Repérant, François Coudoré, Denis J Davi. Interest of using genetically manipulated mice as models of depression to evaluate antidepressant drugs activity: a review. Fundamental & clinical pharmacology. vol 23. issue 1. 2009-06-01. PMID:19267769. |
the present review will thus focus on ko mice lacking g protein-coupled monoaminergic receptors (e.g; 5-ht1b, 5-ht1a, and 5-ht4 receptors) and the 5-ht serotonin transporter, which is the main target of antidepressant drugs (or strategies). |
2009-06-01 |
2023-08-12 |
mouse |
| Atsushi Sanbe, Yoshio Tanaka, Yoko Fujiwara, Noriko Miyauchi, Reiko Mizutani, Junji Yamauchi, Susanna Cotecchia, Katsuo Koike, Gozoh Tsujimoto, Akito Tanou. Enhanced vascular contractility in alpha1-adrenergic receptor-deficient mice. Life sciences. vol 84. issue 21-22. 2009-05-28. PMID:19249315. |
presently, we characterized vascular contractility against other vasoconstrictors, such as potassium, prostaglandin f2alpha (pgf(2alpha)) and 5-hydroxytryptamine (5-ht), in alpha1a-ar, alpha1b-ar, and alpha1d-ar triple knockout (alpha1-ar triple ko) mice. |
2009-05-28 |
2023-08-12 |
mouse |
| Olivier Lairez, Denis Calise, Pascale Bianchi, Catherine Ordener, Odile Spreux-Varoquaux, Céline Guilbeau-Frugier, Ghislaine Escourrou, Isabelle Seif, Jérôme Roncalli, Nathalie Pizzinat, Michel Galinier, Angelo Parini, Jeanne Mialet-Pere. Genetic deletion of MAO-A promotes serotonin-dependent ventricular hypertrophy by pressure overload. Journal of molecular and cellular cardiology. vol 46. issue 4. 2009-05-06. PMID:19162038. |
at baseline, mao-a deletion was associated with an increase in whole blood 5-ht (39.4+/-1.9 microm vs. 24.0+/-0.9 microm in ko and wt mice, respectively). |
2009-05-06 |
2023-08-12 |
mouse |