| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Fujiwara, T Kofuji, K Akagaw. Dysfunction of the hypothalamic-pituitary-adrenal axis in STX1A knockout mice. Journal of neuroendocrinology. vol 23. issue 12. 2012-03-30. PMID:21910766. |
previously, we reported that stx1a null mutant (stx1a ko) mice unexpectedly showed normal glutamatergic and gabaergic fast synaptic transmission but exhibited disturbances in monoaminergic transmission, such as serotonin, 5-hydroxytryptamine (5-ht), which may induce attenuation of latent inhibition. |
2012-03-30 |
2023-08-12 |
mouse |
| T Fujiwara, T Kofuji, K Akagaw. Dysfunction of the hypothalamic-pituitary-adrenal axis in STX1A knockout mice. Journal of neuroendocrinology. vol 23. issue 12. 2012-03-30. PMID:21910766. |
furthermore, an in vivo microdialysis study revealed that the elevation of extracellular 5-ht in the hypothalamus, which was induced by the selective serotonin reuptake inhibitor, fluoxetine, was significantly reduced in stx1a ko mice compared to wt mice. |
2012-03-30 |
2023-08-12 |
mouse |
| T Fujiwara, T Kofuji, K Akagaw. Dysfunction of the hypothalamic-pituitary-adrenal axis in STX1A knockout mice. Journal of neuroendocrinology. vol 23. issue 12. 2012-03-30. PMID:21910766. |
5-ht elevation in the hypothalamus, which was induced by acute restraint stress, was also reduced in stx1a ko mice. |
2012-03-30 |
2023-08-12 |
mouse |
| C Wakabayashi, Y Kiyama, H Kunugi, T Manabe, Y Iwakur. Age-dependent regulation of depression-like behaviors through modulation of adrenergic receptor α₁A subtype expression revealed by the analysis of interleukin-1 receptor antagonist knockout mice. Neuroscience. vol 192. 2012-01-18. PMID:21722710. |
although the contents of 5-ht, norepinephrine (ne), and dopamine (da), which are known to be associated with major symptoms of psychiatric disorders, were not significantly different in the hippocampus or cerebral cortex between il-1ra ko and their wild-type (wt) littermate mice, the mrna expression level of the arα(1a) subtype was significantly changed in the cerebral cortex. |
2012-01-18 |
2023-08-12 |
mouse |
| Junlin Zhang, Ryan D Darling, Ian A Paul, Kimberly L Simpson, Kevin Chen, Jean C Shih, Rick C S Li. Altered expression of tyrosine hydroxylase in the locus coeruleus noradrenergic system in citalopram neonatally exposed rats and monoamine oxidase a knock out mice. Anatomical record (Hoboken, N.J. : 2007). vol 294. issue 10. 2012-01-17. PMID:21901841. |
we have noted the following novel findings: (1) neonatal exposure to the selective serotonin reuptake inhibitor (ssri) ctm enhanced ne th immunoreactive fibers throughout the entire neocortex, and a few of them appeared to be hypertrophic; (2) slightly enhanced ne cortical th immunoreactive fibers were also noted in mao a ko mice, and many of them revealed varicosities compared with the rather smooth ne cortical th immunoreactive fibers in wild-type (wt) mice; (3) lc dendrites of mao a ko mice exhibited beaded morphology compared with the smooth lc dendrites in wt mice. |
2012-01-17 |
2023-08-12 |
mouse |
| Christiaan H Vinkers, Lucianne Groenink, Tommy Pattij, Berend Olivier, J Adriaan Bouwknech. 5-HT(1A) receptor sensitivity in 5-HT(1B) receptor KO mice is unaffected by chronic fluvoxamine treatment. European journal of pharmacology. vol 667. issue 1-3. 2011-12-27. PMID:21723276. |
5-ht(1a) receptor sensitivity in 5-ht(1b) receptor ko mice is unaffected by chronic fluvoxamine treatment. |
2011-12-27 |
2023-08-12 |
mouse |
| Rachel A Hill, Simon S Murray, Paul G Halley, Michele D Binder, Sally J Martin, Maarten van den Buus. Brain-derived neurotrophic factor expression is increased in the hippocampus of 5-HT(2C) receptor knockout mice. Hippocampus. vol 21. issue 4. 2011-09-28. PMID:20087884. |
therefore, in this study we investigated bdnf expression in 5-ht(2c) receptor knockout mice (5-ht(2c) ko). |
2011-09-28 |
2023-08-12 |
mouse |
| Rachel A Hill, Simon S Murray, Paul G Halley, Michele D Binder, Sally J Martin, Maarten van den Buus. Brain-derived neurotrophic factor expression is increased in the hippocampus of 5-HT(2C) receptor knockout mice. Hippocampus. vol 21. issue 4. 2011-09-28. PMID:20087884. |
western blot analysis demonstrated a significant 2.2-fold increase in the expression of the mature form of bdnf in 5-ht(2c) ko mice when compared with wild-type controls (wt) in the hippocampus (p = 0.008), but not frontal cortex or striatum. |
2011-09-28 |
2023-08-12 |
mouse |
| Rachel A Hill, Simon S Murray, Paul G Halley, Michele D Binder, Sally J Martin, Maarten van den Buus. Brain-derived neurotrophic factor expression is increased in the hippocampus of 5-HT(2C) receptor knockout mice. Hippocampus. vol 21. issue 4. 2011-09-28. PMID:20087884. |
no differences in the expression of the pro-bdnf isoform were found, and the ratio of mature/pro bdnf was significantly increased in 5-ht(2c) ko (p = 0.003). |
2011-09-28 |
2023-08-12 |
mouse |
| Rachel A Hill, Simon S Murray, Paul G Halley, Michele D Binder, Sally J Martin, Maarten van den Buus. Brain-derived neurotrophic factor expression is increased in the hippocampus of 5-HT(2C) receptor knockout mice. Hippocampus. vol 21. issue 4. 2011-09-28. PMID:20087884. |
hence, increased mature bdnf levels in 5-ht(2c) ko hippocampus are most likely due to increased extracellular cleavage rates of pro-bdnf to its mature form. |
2011-09-28 |
2023-08-12 |
mouse |
| Rachel A Hill, Simon S Murray, Paul G Halley, Michele D Binder, Sally J Martin, Maarten van den Buus. Brain-derived neurotrophic factor expression is increased in the hippocampus of 5-HT(2C) receptor knockout mice. Hippocampus. vol 21. issue 4. 2011-09-28. PMID:20087884. |
with repeated training in a 10-day win-shift radial arm maze task, 5-ht(2c) ko and wt showed similar decreases of the number of working memory and reference memory errors. |
2011-09-28 |
2023-08-12 |
mouse |
| Rachel A Hill, Simon S Murray, Paul G Halley, Michele D Binder, Sally J Martin, Maarten van den Buus. Brain-derived neurotrophic factor expression is increased in the hippocampus of 5-HT(2C) receptor knockout mice. Hippocampus. vol 21. issue 4. 2011-09-28. PMID:20087884. |
5-ht(2c) ko showed modest locomotor hyperactivity but no differences in tests for anxiety, sensorimotor gating, or depressive-like behaviors; however, in the tail suspension test 5-ht(2c) ko showed significantly reduced climbing (p < 0.05). |
2011-09-28 |
2023-08-12 |
mouse |
| Rachel A Hill, Simon S Murray, Paul G Halley, Michele D Binder, Sally J Martin, Maarten van den Buus. Brain-derived neurotrophic factor expression is increased in the hippocampus of 5-HT(2C) receptor knockout mice. Hippocampus. vol 21. issue 4. 2011-09-28. PMID:20087884. |
despite this marked increase, 5-ht(2c) ko show only subtle behavioral changes. |
2011-09-28 |
2023-08-12 |
mouse |
| Robert Patrick Davis, A Elizabeth Linder, Stephanie W Watt. Lack of the serotonin transporter (SERT) reduces the ability of 5-hydroxytryptamine to lower blood pressure. Naunyn-Schmiedeberg's archives of pharmacology. vol 383. issue 5. 2011-09-02. PMID:21448568. |
5-ht (25 μg/kg/min; s.c.) was infused for 7 days to male and female, sert wild-type (wt) and sert knockout (ko) rats. |
2011-09-02 |
2023-08-12 |
rat |
| Robert Patrick Davis, A Elizabeth Linder, Stephanie W Watt. Lack of the serotonin transporter (SERT) reduces the ability of 5-hydroxytryptamine to lower blood pressure. Naunyn-Schmiedeberg's archives of pharmacology. vol 383. issue 5. 2011-09-02. PMID:21448568. |
5-ht produced a significantly greater fall in map (at the nadir) in the male sert wt rat (-20 ± 1 mmhg) compared to the male sert ko rat (-10 ± 2 mmhg). |
2011-09-02 |
2023-08-12 |
rat |
| Robert Patrick Davis, A Elizabeth Linder, Stephanie W Watt. Lack of the serotonin transporter (SERT) reduces the ability of 5-hydroxytryptamine to lower blood pressure. Naunyn-Schmiedeberg's archives of pharmacology. vol 383. issue 5. 2011-09-02. PMID:21448568. |
similarly, 5-ht also produced a significantly greater fall in map (at the nadir) in the female sert wt rat (-19 ± 1 mmhg) compared to the female sert ko rat (-15 ± 0.4 mmhg). |
2011-09-02 |
2023-08-12 |
rat |
| Soichiro Ide, Shunsuke Fujiwara, Masayuki Fujiwara, Ichiro Sora, Kazutaka Ikeda, Masabumi Minami, George R Uhl, Kumatoshi Ishihar. Antidepressant-like effect of venlafaxine is abolished in μ-opioid receptor-knockout mice. Journal of pharmacological sciences. vol 114. issue 1. 2011-08-11. PMID:20703010. |
we investigated the role of μ-opioid receptors (mops) in the effects of venlafaxine, a serotonin and norepinephrine reuptake inhibitor, in the forced swim test using mop-knockout (ko) mice. |
2011-08-11 |
2023-08-12 |
mouse |
| Antonio Ortega-Alvaro, Auxiliadora Aracil-Fernández, María S García-Gutiérrez, Francisco Navarrete, Jorge Manzanare. Deletion of CB2 cannabinoid receptor induces schizophrenia-related behaviors in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 7. 2011-08-10. PMID:21430651. |
cb(2)ko mice presented increased d(2)r and α(2c)r gene expressions in the prefrontal cortex (pfc) and locus coeruleus (lc), decreased 5-ht(2c)r gene expression in the dorsal raphe (dr), and 5-ht(2a)r gene expression in the pfc. |
2011-08-10 |
2023-08-12 |
mouse |
| Antonio Ortega-Alvaro, Auxiliadora Aracil-Fernández, María S García-Gutiérrez, Francisco Navarrete, Jorge Manzanare. Deletion of CB2 cannabinoid receptor induces schizophrenia-related behaviors in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 7. 2011-08-10. PMID:21430651. |
in cb(2)ko, the gene expression of d(2)r in the pfc, of α(2c)r in the lc, and of 5-ht(2c)r and 5-ht(2a)r in pfc was reduced; 5-ht(2c)r and 5-ht(2a)r gene expressions in dr were increased after treatment with risperidone. |
2011-08-10 |
2023-08-12 |
mouse |
| D Hoyle, G Juhasz, E Aso, D Chase, J del Rio, V Fabre, M Hamon, L Lanfumey, K-P Lesch, R Maldonado, M-A Serra, T Sharp, R Tordera, C Toro, J F W Deaki. Shared changes in gene expression in frontal cortex of four genetically modified mouse models of depression. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 21. issue 1. 2011-07-20. PMID:21030216. |
altered 5ht function was modelled using the 5-ht transporter knock out mouse, impaired glucocorticoid receptor (gr) function using an antisense-induced knock down mouse, disrupted glutamate function using a heterozygous ko of the vesicular glutamate transporter 1 gene, and impaired cannabinoid signalling using the cannabinoid 1 receptor ko mouse. |
2011-07-20 |
2023-08-12 |
mouse |