| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiang Lu, Suguru Komenoi, Takako Usuki, Daisuke Takahashi, Fumio Sakan. Abnormalities of the serotonergic system in diacylglycerol kinase δ-deficient mouse brain. Biochemical and biophysical research communications. vol 497. issue 4. 2018-04-10. PMID:29486157. |
we previously reported that brain-specific diacylglycerol kinase (dgk) δ-knockout (ko) mice showed obsessive-compulsive disorder (ocd)-like behaviors, which were alleviated by a serotonin (5-ht) transporter (sert) inhibitor. |
2018-04-10 |
2023-08-13 |
mouse |
| Tomoyuki Tashiro, Yuki Murakami, Akihiro Mouri, Yukio Imamura, Toshitaka Nabeshima, Yasuko Yamamoto, Kuniaki Sait. Kynurenine 3-monooxygenase is implicated in antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions. Behavioural brain research. vol 317. 2017-11-29. PMID:27693848. |
higher contents of trp metabolites such as kynurenine (kyn), kynurenic acid (ka), anthranilic acid (aa), and 3-hydroxykynurenine (3-hk) in the serum and hippocampus and decreased serotonin turnover and higher content of normetanephrine (nm) in the hippocampus were observed in the kmo ko mice. |
2017-11-29 |
2023-08-13 |
mouse |
| Coedy Hadden, Tariq Fahmi, Anthonya Cooper, Alena V Savenka, Vladimir V Lupashin, Drucilla J Roberts, Luc Maroteaux, Sylvie Hauguel-de Mouzon, Fusun Kili. Serotonin transporter protects the placental cells against apoptosis in caspase 3-independent pathway. Journal of cellular physiology. vol 232. issue 12. 2017-10-02. PMID:28109119. |
using placentas dissected from 18d gestational sert-knock out (ko), peripheral 5-ht (tph1)-ko, and wild-type (wt) mice, we explored the role of 5-ht and sert in placental functions in detail. |
2017-10-02 |
2023-08-13 |
mouse |
| Viktória Kormos, László Gáspár, László Á Kovács, József Farkas, Tamás Gaszner, Valér Csernus, András Balogh, Hitoshi Hashimoto, Dóra Reglődi, Zsuzsanna Helyes, Balázs Gaszne. Reduced response to chronic mild stress in PACAP mutant mice is associated with blunted FosB expression in limbic forebrain and brainstem centers. Neuroscience. vol 330. 2017-07-11. PMID:27282087. |
although cvms did not induce fosb in 5ht-dr neurons, pacap ko mice had increased 5ht cell counts and 5ht content. |
2017-07-11 |
2023-08-13 |
mouse |
| Tomohisa Mori, Naoki Uzawa, Yoshiyuki Iwase, Daiki Masukawa, Mahardian Rahmadi, Shigeto Hirayama, Mayuna Hokazono, Kimio Higashiyama, Seiji Shioda, Tsutomu Suzuk. Narcolepsy-like sleep disturbance in orexin knockout mice are normalized by the 5-HT1A receptor agonist 8-OH-DPAT. Psychopharmacology. vol 233. issue 12. 2017-02-14. PMID:27068481. |
orexin knockout (ko) mice exhibit a phenotype that is similar to human narcolepsy, and monoamine-related compounds, such as psychostimulants and 5-ht uptake inhibitors, have been used for the treatment of narcoleptic disorders. |
2017-02-14 |
2023-08-13 |
mouse |
| Daisaku Yoshihara, Noriko Fujiwara, Nobue Kitanaka, Junichi Kitanaka, Haruhiko Sakiyama, Hironobu Eguchi, Motohiko Takemura, Keiichiro Suzuk. The absence of the SOD1 gene causes abnormal monoaminergic neurotransmission and motivational impairment-like behavior in mice. Free radical research. vol 50. issue 11. 2017-02-09. PMID:27629432. |
high levels of dopamine transporter protein and an acceleration of serotonin turnover were also detected in the cerebrums of the sod1 ko mice. |
2017-02-09 |
2023-08-13 |
mouse |
| Alexander V Kulikov, Valeria S Korostina, Elizabeth A Kulikova, Dariya V Fursenko, Andrey E Akulov, Mikhail P Moshkin, Egor B Prokhortchou. Knockout Zbtb33 gene results in an increased locomotion, exploration and pre-pulse inhibition in mice. Behavioural brain research. vol 297. 2016-09-15. PMID:26454239. |
norepinephrine concentration was reduced in the hypothalami and hippocampi in ko mice, while the levels of serotonin, dopamine, their metabolites as well as mrna of the gene coding brain-derived neurotrophic factor were not altered in the brain of ko mice compared to wt mice. |
2016-09-15 |
2023-08-13 |
mouse |
| Jimena Laporta, Francisco Peñagaricano, Laura L Hernande. Transcriptomic Analysis of the Mouse Mammary Gland Reveals New Insights for the Role of Serotonin in Lactation. PloS one. vol 10. issue 10. 2016-06-27. PMID:26470019. |
therefore, we used tph1 deficient dams (ko; serotonin deficient, n = 4) and compared them to wild-type (wt; n = 4) and rescue (rc; ko + 100 mg/kg 5-hydroxytryptophan injected daily, n = 4) dams. |
2016-06-27 |
2023-08-13 |
mouse |
| Cristina Viaggi, Claudio Gerace, Carla Pardini, Giovanni U Corsini, Francesca Vaglin. Serotonin abnormalities in Engrailed-2 knockout mice: New insight relevant for a model of Autism Spectrum Disorder. Neurochemistry international. vol 87. 2016-05-24. PMID:26002543. |
the 5-ht content of cerebellar cortex was significantly reduced at 1 month old but significantly high when the ko mice reached 3 months of age. |
2016-05-24 |
2023-08-13 |
mouse |
| Jenny Schneiders, Franziska Fuchs, Jelena Damm, Christiane Herden, Rüdiger Gerstberger, Denis Melo Soares, Joachim Roth, Christoph Rumme. The transcription factor nuclear factor interleukin 6 mediates pro- and anti-inflammatory responses during LPS-induced systemic inflammation in mice. Brain, behavior, and immunity. vol 48. 2016-04-13. PMID:25813145. |
hypothalamic-pituitary-adrenal-axis-activity of ko was intact, but tryptophan-metabolizing enzymes were shifted to enhanced serotonin production and reuptake. |
2016-04-13 |
2023-08-13 |
mouse |
| Jenny Schneiders, Franziska Fuchs, Jelena Damm, Christiane Herden, Rüdiger Gerstberger, Denis Melo Soares, Joachim Roth, Christoph Rumme. The transcription factor nuclear factor interleukin 6 mediates pro- and anti-inflammatory responses during LPS-induced systemic inflammation in mice. Brain, behavior, and immunity. vol 48. 2016-04-13. PMID:25813145. |
moreover, reduced locomotor activity observed in ko might be due to altered tryptophan metabolism and serotonin reuptake suggesting some role for nf-il6 as therapeutic target for depressive disorders. |
2016-04-13 |
2023-08-13 |
mouse |
| Barbara Schreier, Mirja Hünerberg, Sindy Rabe, Sigrid Mildenberger, Daniel Bethmann, Christian Heise, Maria Sibilia, Stefan Offermanns, Michael Gekl. Consequences of postnatal vascular smooth muscle EGFR deletion on acute angiotensin II action. Clinical science (London, England : 1979). vol 130. issue 1. 2016-02-29. PMID:26438881. |
by contrast, we observed no difference in force development during application of serotonin, kcl, endothelin-1 or endothelin-1-induced pressure load in ko animals. |
2016-02-29 |
2023-08-13 |
mouse |
| Scott D Gleason, Akihiko Kato, Hai H Bui, Linda K Thompson, Sabrina N Valli, Patrick V Stutz, Ming-Shang Kuo, Julie F Falcone, Wesley H Anderson, Xia Li, Jeffrey M Witki. Inquiries into the Biological Significance of Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8 Through Investigations of TARP γ-8 Null Mice§. CNS & neurological disorders drug targets. vol 14. issue 5. 2016-02-16. PMID:25921737. |
ko mice displayed decreased turnover of dopamine and increased histamine turnover in multiple brain areas in contrast, serotonin and its metabolites were not significantly affected by deletion of the γ-8 protein. |
2016-02-16 |
2023-08-13 |
mouse |
| Frank Scott Hall, Ichiro Sora, René Hen, George R Uh. Serotonin/dopamine interactions in a hyperactive mouse: reduced serotonin receptor 1B activity reverses effects of dopamine transporter knockout. PloS one. vol 9. issue 12. 2016-02-04. PMID:25514162. |
these results have led to suggestions that dat ko mice may model features of attention deficit hyperactivity disorder (adhd) and that these drugs may act upon serotonin (5-ht) systems to produce these unusual locomotor decreasing effects. |
2016-02-04 |
2023-08-13 |
mouse |
| Frank Scott Hall, Ichiro Sora, René Hen, George R Uh. Serotonin/dopamine interactions in a hyperactive mouse: reduced serotonin receptor 1B activity reverses effects of dopamine transporter knockout. PloS one. vol 9. issue 12. 2016-02-04. PMID:25514162. |
these findings of complementation of the locomotor effects of dat ko by reducing 5-ht1b receptor activity underscore roles for interactions between specific 5-ht receptors and dopamine (da) systems in basal and cocaine-stimulated locomotion and support evaluation of 5-ht1b antagonists as potential, non-stimulant adhd therapeutics. |
2016-02-04 |
2023-08-13 |
mouse |
| Chang-Myung Oh, Jun Namkung, Younghoon Go, Ko Eun Shong, Kyuho Kim, Hyeongseok Kim, Bo-Yoon Park, Ho Won Lee, Yong Hyun Jeon, Junghan Song, Minho Shong, Vijay K Yadav, Gerard Karsenty, Shingo Kajimura, In-Kyu Lee, Sangkyu Park, Hail Ki. Regulation of systemic energy homeostasis by serotonin in adipose tissues. Nature communications. vol 6. 2016-01-08. PMID:25864946. |
mice with inducible tph1 ko in adipose tissues exhibit a similar phenotype as mice in which 5-ht synthesis is inhibited pharmacologically, suggesting 5-ht has localized effects on adipose tissues. |
2016-01-08 |
2023-08-13 |
mouse |
| Chisato Wakabayashi, Tadahiro Numakawa, Haruki Odaka, Yoshiko Ooshima, Yuji Kiyama, Toshiya Manabe, Hiroshi Kunugi, Yoichiro Iwakur. IL-1 receptor-antagonist (IL-1Ra) knockout mice show anxiety-like behavior by aging. Neuroscience letters. vol 599. 2015-10-16. PMID:26002078. |
analysis of monoamine concentration in the hippocampus revealed that tryptophan, the serotonin metabolite 5-hydroxyindole acetic acid (5-hiaa), and the dopamine metabolite homovanillic acid (hva) were significantly increased in 20-week-old il-1ra ko mice compared to littermate wt mice. |
2015-10-16 |
2023-08-13 |
mouse |
| Moe Igari, Hao-Wei Shen, Yoko Hagino, Setsu Fukushima, Yoshiyuki Kasahara, Klaus-Peter Lesch, Dennis L Murphy, Frank Scott Hall, George R Uhl, Kazutaka Ikeda, Nobuo Yaegashi, Ichiro Sor. Attenuated methamphetamine-induced locomotor sensitization in serotonin transporter knockout mice is restored by serotonin 1B receptor antagonist treatment. Behavioural pharmacology. vol 26. issue 1-2. 2015-09-03. PMID:25485646. |
the present experiments examined serotonergic roles in meth-induced locomotor sensitization by assessing: (a) the effect of serotonin transporter (sert; slc6a4) knockout (ko) on meth-induced locomotor sensitization; (b) extracellular monoamine levels in meth-treated animals as determined by in-vivo microdialysis; and (c) effects of serotonin (5-ht) receptor antagonists on meth-induced behavioral sensitization, with focus on effects of the 5-ht1b receptor antagonist sb 216641 and a comparison with the 5-ht2 receptor antagonist ketanserin. |
2015-09-03 |
2023-08-13 |
mouse |
| Robert Brommage, Jeff Liu, Deon Doree, Wangsheng Yu, David R Powell, Qi Melissa Yan. Adult Tph2 knockout mice without brain serotonin have moderately elevated spine trabecular bone but moderately low cortical bone thickness. BoneKEy reports. vol 4. 2015-08-03. PMID:26229596. |
disruption of serotonin synthesis in neurons and the periphery by knockout (ko) of mouse genes for tryptophan hydroxylases (peripheral tph1 and neuronal tph2) has been claimed to decrease (tph2 ko) and increase (tph1 ko) bone mass. |
2015-08-03 |
2023-08-13 |
mouse |
| Liyan Ren, Xuanchen Qian, Lijing Zhai, Miao Sun, Zhigang Miao, Jizhen Li, Xingshun X. Loss of Ahi1 impairs neurotransmitter release and causes depressive behaviors in mice. PloS one. vol 9. issue 4. 2015-06-09. PMID:24691070. |
in ahi1 ko mice, neurotransmitters including serotonin and dopamine were significantly decreased in different brain regions. |
2015-06-09 |
2023-08-13 |
mouse |