| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jonah J Scott-McKean, Galen R Wenger, Laurence H Tecott, Alberto C S Cost. 5-HT(1A) Receptor Null Mutant Mice Responding Under a Differential-Reinforcement-of-Low-Rate 72-Second Schedule of Reinforcement. The open neuropsychopharmacology journal. vol 1. 2021-10-20. PMID:20352018. |
we have analyzed the actions of the specific serotonin reuptake inhibitor (ssri) fluoxetine and the tricyclic agent desipramine (dmi) on wild-type and 5-hydroxytryptamine 1a receptor-null mutant (5-ht(1a)r ko) mice. |
2021-10-20 |
2023-08-12 |
mouse |
| Jonah J Scott-McKean, Galen R Wenger, Laurence H Tecott, Alberto C S Cost. 5-HT(1A) Receptor Null Mutant Mice Responding Under a Differential-Reinforcement-of-Low-Rate 72-Second Schedule of Reinforcement. The open neuropsychopharmacology journal. vol 1. 2021-10-20. PMID:20352018. |
in agreement with the literature on rats, we found that fluoxetine produced an acute antidepressant-like effect in 5-ht(1a)r ko mice but not in wild-type (wt) mice. |
2021-10-20 |
2023-08-12 |
mouse |
| Jonah J Scott-McKean, Galen R Wenger, Laurence H Tecott, Alberto C S Cost. 5-HT(1A) Receptor Null Mutant Mice Responding Under a Differential-Reinforcement-of-Low-Rate 72-Second Schedule of Reinforcement. The open neuropsychopharmacology journal. vol 1. 2021-10-20. PMID:20352018. |
additionally, an antidepressant-like effect was observed when dmi was administered to both 5-ht(1a)r ko and wt mice. |
2021-10-20 |
2023-08-12 |
mouse |
| Joana D'Arc Campeiro, João V Nani, Gabriela G Monte, Priscila G C Almeida, Marcelo A Mori, Mirian A F Hayash. Regulation of monoamine levels by typical and atypical antipsychotics in Caenorhabditis elegans mutant for nuclear distribution element genes. Neurochemistry international. vol 147. 2021-09-07. PMID:33872680. |
dopamine, serotonin and octopamine levels were significantly lower in homozygous loss-of-function mutant worms ko for nud genes compared with wild-type (wt) c. elegans at baseline. |
2021-09-07 |
2023-08-13 |
mouse |
| Lara Costa, Alessandra Tempio, Enza Lacivita, Marcello Leopoldo, Lucia Cirann. Serotonin 5-HT7 receptors require cyclin-dependent kinase 5 to rescue hippocampal synaptic plasticity in a mouse model of Fragile X Syndrome. The European journal of neuroscience. 2021-08-18. PMID:33949019. |
we have previously demonstrated that activation of serotonin 5-ht7 receptors reverses mglur-ltd in the hippocampus of wild-type and fmr1 ko mice, thus correcting a synaptic dysfunction typically observed in this disease model. |
2021-08-18 |
2023-08-13 |
mouse |
| Erica Seigneur, Jie Wang, Jinye Dai, Jai Polepalli, Thomas C Südho. Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors. Molecular psychiatry. 2021-06-23. PMID:34158618. |
here, we report that constitutive cbln2 ko mice, but not cbln1 ko mice, display robust compulsive behaviors, including stereotypic pattern running, marble burying, explosive jumping, and excessive nest building, and exhibit decreased brain serotonin levels. |
2021-06-23 |
2023-08-13 |
mouse |
| Erica Seigneur, Jie Wang, Jinye Dai, Jai Polepalli, Thomas C Südho. Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors. Molecular psychiatry. 2021-06-23. PMID:34158618. |
strikingly, treatment of cbln2 ko mice with the serotonin precursor 5-hydroxytryptophan or the serotonin reuptake-inhibitor fluoxetine alleviated compulsive behaviors. |
2021-06-23 |
2023-08-13 |
mouse |
| Chao Ciu-Gwok Guo, Tao He, Joanes Grandjean, Judith Homber. Knockout serotonin transporter in rats moderates outcome and stimulus generalization. Translational psychiatry. vol 11. issue 1. 2021-06-18. PMID:33414390. |
testing generalization in serotonin transporter (5-htt) knockout (ko) rats, an animal model showing depression/anxiety-like behaviors and drug addiction-like behaviors, could therefore provide more insights into this framework. |
2021-06-18 |
2023-08-13 |
human |
| Carey Wilson, Jake Rogers, Feng Chen, Shanshan Li, Paul A Adlard, Anthony J Hannan, Thibault Renoi. Exercise ameliorates aberrant synaptic plasticity without enhancing adult-born cell survival in the hippocampus of serotonin transporter knockout mice. Brain structure & function. vol 226. issue 6. 2021-06-15. PMID:34052925. |
here, we investigate hippocampal adult-born cell survival and synaptic plasticity (long-term potentiation, ltp, and long-term depression, ltd) in serotonin transporter (5-htt) knockout (ko) mice. |
2021-06-15 |
2023-08-13 |
mouse |
| Colm M P O'Tuathaigh, Lieve Desbonnet, Christina Payne, Emilie Petit, Rachel Cox, Samim Loftus, Gerard Clarke, John F Cryan, Orna Tighe, Steve Wilson, Brian P Kirby, Timothy G Dinan, John L Waddingto. Ethologically based behavioural and neurochemical characterisation of mice with isoform-specific loss of dysbindin-1A in the context of schizophrenia. Neuroscience letters. vol 736. 2021-05-13. PMID:32615248. |
dys-1a ko demonstrated lower levels of 5-ht in ratio to its metabolite 5-hiaa in the prefrontal cortex. |
2021-05-13 |
2023-08-13 |
mouse |
| Colm M P O'Tuathaigh, Lieve Desbonnet, Christina Payne, Emilie Petit, Rachel Cox, Samim Loftus, Gerard Clarke, John F Cryan, Orna Tighe, Steve Wilson, Brian P Kirby, Timothy G Dinan, John L Waddingto. Ethologically based behavioural and neurochemical characterisation of mice with isoform-specific loss of dysbindin-1A in the context of schizophrenia. Neuroscience letters. vol 736. 2021-05-13. PMID:32615248. |
these studies elaborate the behavioural and neurochemical phenotype of dys-1a ko mice, revealing subtle genotype-related differences in non-social and social exploratory behaviours and habituation of exploration in a novel environment, as well as changes in 5-ht activity in brain areas related to schizophrenia. |
2021-05-13 |
2023-08-13 |
mouse |
| Claudia Fuchs, Laura Gennaccaro, Elisa Ren, Giuseppe Galvani, Stefania Trazzi, Giorgio Medici, Manuela Loi, Erin Conway, Orrin Devinsky, Roberto Rimondini, Elisabetta Cian. Pharmacotherapy with sertraline rescues brain development and behavior in a mouse model of CDKL5 deficiency disorder. Neuropharmacology. vol 167. 2021-04-23. PMID:31469994. |
here we show a dysregulation of hippocampal and cortical serotonergic (5-ht) receptor expression in heterozygous cdkl5 knockout (ko) female mice, suggesting that impaired 5-ht neurotransmission contributes to cdd. |
2021-04-23 |
2023-08-13 |
mouse |
| Claudia Fuchs, Laura Gennaccaro, Elisa Ren, Giuseppe Galvani, Stefania Trazzi, Giorgio Medici, Manuela Loi, Erin Conway, Orrin Devinsky, Roberto Rimondini, Elisabetta Cian. Pharmacotherapy with sertraline rescues brain development and behavior in a mouse model of CDKL5 deficiency disorder. Neuropharmacology. vol 167. 2021-04-23. PMID:31469994. |
we demonstrate that targeting impaired 5-ht signaling via the selective serotonin reuptake inhibitor (ssri) sertraline rescues cdd-related neurodevelopmental and behavioral defects in heterozygous cdkl5 ko female mice. |
2021-04-23 |
2023-08-13 |
mouse |
| Danielle M Giangrasso, Teri M Furlong, Kristen A Keef. Characterization of striatum-mediated behavior and neurochemistry in the DJ-1 knock-out rat model of Parkinson's disease. Neurobiology of disease. vol 134. 2021-01-13. PMID:31734455. |
we therefore assessed a variety of striatally-mediated behavioral tasks, as well as the integrity of dopamine and serotonin systems, in male dj-1 ko rats and wild-type (wt) controls at 4, 6, and 8 months of age. |
2021-01-13 |
2023-08-13 |
rat |
| Danielle M Giangrasso, Teri M Furlong, Kristen A Keef. Characterization of striatum-mediated behavior and neurochemistry in the DJ-1 knock-out rat model of Parkinson's disease. Neurobiology of disease. vol 134. 2021-01-13. PMID:31734455. |
lastly, serotonin transporter binding was increased in the medial and orbitofrontal cortices of 4-month old dj-1 ko rats. |
2021-01-13 |
2023-08-13 |
rat |
| Amy G Aslamkhan, Qiuwei Xu, Amy Loughlin, Heather Vu, Stephen Pacchione, Bhavana Bhatt, Ivy Garfinkel, Tara Grady Styring, Lisa LaFranco-Scheuch, Kara Pearson, Spencer Reynolds, Nianyu Li, Heather Zhou, J Richard Miller, Nicolas Solban, Alan Bass, Warren E Glaa. Characterization of indoleamine-2,3-dioxygenase 1, tryptophan-2,3-dioxygenase, and Ido1/Tdo2 knockout mice. Toxicology and applied pharmacology. vol 406. 2021-01-11. PMID:32871117. |
metabolism of trp to serotonin and its metabolites resulted in an increase in 5-hydroxyindole-3-acetic acid in the tdo2 and dual ko mice. |
2021-01-11 |
2023-08-13 |
mouse |
| Ioannis Mantas, Yunting Yang, Clotilde Mannoury-la-Cour, Mark J Millan, Xiaoqun Zhang, Per Svenningsso. Genetic deletion of GPR88 enhances the locomotor response to L-DOPA in experimental parkinsonism while counteracting the induction of dyskinesia. Neuropharmacology. vol 162. 2021-01-06. PMID:31666199. |
in accordance with a role for serotonin neurons in lid development, wt but not gpr88 ko striata exhibited 5-hydroxytryptamine displacement upon repeated l-dopa treatment. |
2021-01-06 |
2023-08-13 |
mouse |
| Francisco J Pavón, Antonia Serrano, David G Stouffer, Ilham Polis, Marisa Roberto, Benjamin F Cravatt, Rémi Martin-Fardon, Fernando Rodríguez de Fonseca, Loren H Parson. Ethanol-induced alterations in endocannabinoids and relevant neurotransmitters in the nucleus accumbens of fatty acid amide hydrolase knockout mice. Addiction biology. vol 24. issue 6. 2020-10-28. PMID:30421483. |
whereas (r)etoh-treated mice showed higher baseline dopamine and serotonin levels than etoh-naive mice in wt mice, these differences were attenuated in faah ko mice. |
2020-10-28 |
2023-08-13 |
mouse |
| Stefano Cinque, Francesca Zoratto, Anna Poleggi, Damiana Leo, Luca Cerniglia, Silvia Cimino, Renata Tambelli, Enrico Alleva, Raul R Gainetdinov, Giovanni Laviola, Walter Adrian. Behavioral Phenotyping of Dopamine Transporter Knockout Rats: Compulsive Traits, Motor Stereotypies, and Anhedonia. Frontiers in psychiatry. vol 9. 2020-10-01. PMID:29520239. |
finally, we measured the levels of tyrosine hydroxylase, dopamine receptor 2 (d2), serotonin transporter, and taar1 mrna transcripts in samples of ventral striatum, finding no significant differences between wt and ko genotypes. |
2020-10-01 |
2023-08-13 |
mouse |
| Gloria Blázquez, Anna Castañé, Ana Saavedra, Mercè Masana, Jordi Alberch, Esther Pérez-Navarr. Social Memory and Social Patterns Alterations in the Absence of STriatal-Enriched Protein Tyrosine Phosphatase. Frontiers in behavioral neuroscience. vol 12. 2020-10-01. PMID:30760987. |
moreover, the extracellular levels of dopamine (da), but not serotonin (5-ht), were increased in the dorsal striatum of step ko mice. |
2020-10-01 |
2023-08-13 |
mouse |