| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liyan Ren, Xuanchen Qian, Lijing Zhai, Miao Sun, Zhigang Miao, Jizhen Li, Xingshun X. Loss of Ahi1 impairs neurotransmitter release and causes depressive behaviors in mice. PloS one. vol 9. issue 4. 2015-06-09. PMID:24691070. |
the antidepressant imipramine attenuated depressive behaviors and partially restored brain serotonin level in ahi1 ko mice. |
2015-06-09 |
2023-08-13 |
mouse |
| Kuldip D Dave, Shehan De Silva, Niketa P Sheth, Sylvie Ramboz, Melissa J Beck, Changyu Quang, Robert C Switzer, Syed O Ahmad, Susan M Sunkin, Dan Walker, Xiaoxia Cui, Daniel A Fisher, Aaron M McCoy, Kevin Gamber, Xiaodong Ding, Matthew S Goldberg, Stanley A Benkovic, Meredith Haupt, Marco A S Baptista, Brian K Fiske, Todd B Sherer, Mark A Frasie. Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease. Neurobiology of disease. vol 70. 2015-04-21. PMID:24969022. |
thepink1 ko and dj-1 ko rats also showed a two to three fold increase in striatal dopamine and serotonin content at 8 months of age. |
2015-04-21 |
2023-08-13 |
rat |
| Lara Costa, Lara M Sardone, Enza Lacivita, Marcello Leopoldo, Lucia Cirann. Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome. Frontiers in behavioral neuroscience. vol 9. 2015-03-27. PMID:25814945. |
novel agonists for serotonin 5-ht7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and fmr1 ko mice, a model of fragile x syndrome. |
2015-03-27 |
2023-08-13 |
mouse |
| Kyuho Kim, Chang-Myung Oh, Mica Ohara-Imaizumi, Sangkyu Park, Jun Namkung, Vijay K Yadav, Natalia A Tamarina, Michael W Roe, Louis H Philipson, Gerard Karsenty, Shinya Nagamatsu, Michael S German, Hail Ki. Functional role of serotonin in insulin secretion in a diet-induced insulin-resistant state. Endocrinology. vol 156. issue 2. 2015-03-24. PMID:25426873. |
gsis was impaired in islets isolated from hfd-fed htr3a ko and tph1 βko mice, and 5-ht treatment improved insulin secretion from tph1 βko islets but not from htr3a ko islets. |
2015-03-24 |
2023-08-13 |
mouse |
| Sean C Godar, Marco Bortolato, M Paola Castelli, Alberto Casti, Angelo Casu, Kevin Chen, M Grazia Ennas, Simone Tambaro, Jean C Shi. The aggression and behavioral abnormalities associated with monoamine oxidase A deficiency are rescued by acute inhibition of serotonin reuptake. Journal of psychiatric research. vol 56. 2015-02-19. PMID:24882701. |
both mao-a mutant lines displayed significant reductions in 5-htt expression across the prefrontal cortex, amygdala and striatum, as quantified by immunohistochemical detection; however, the down-regulation of 5-htt in mao-a(neo) mice was more pervasive and widespread than in their ko counterparts, possibly indicating a greater ability of the hypomorphic line to enact compensatory mechanisms with respect to 5-ht homeostasis. |
2015-02-19 |
2023-08-13 |
mouse |
| Christine Saunders, Michael Siuta, Sabrina D Robertson, Adeola R Davis, Jennifer Sauer, Heinrich J G Matthies, Paul J Gresch, David Airey, Craig W Lindsley, John A Schetz, Kevin D Niswender, Jeremy M Veenstra-Vanderweele, Aurelio Gall. Neuronal ablation of p-Akt at Ser473 leads to altered 5-HT1A/2A receptor function. Neurochemistry international. vol 73. 2015-02-02. PMID:24090638. |
to explore how impairment in akt function regulates 5-ht homeostasis, we used a brain-specific rictor knockout (ko) mouse model of impaired neuronal phosphorylation of akt at ser473. |
2015-02-02 |
2023-08-12 |
mouse |
| Sylvia Montañez, Jaclyn L Munn, W Anthony Owens, Rebecca E Horton, Lynette C Daw. 5-HT1B receptor modulation of the serotonin transporter in vivo: studies using KO mice. Neurochemistry international. vol 73. 2015-02-02. PMID:24246466. |
5-ht1b receptor modulation of the serotonin transporter in vivo: studies using ko mice. |
2015-02-02 |
2023-08-12 |
mouse |
| Noé Dumas, Marcelle Moulin-Sallanon, Nathalie Ginovart, Benjamin B Tournier, Peggy Suzanne, Thomas Cailly, Frédéric Fabis, Sylvain Rault, Yves Charnay, Philippe Mille. Small-animal single-photon emission computed tomographic imaging of the brain serotoninergic systems in wild-type and mdr1a knockout rats. Molecular imaging. vol 13. 2014-11-04. PMID:24622810. |
thus, we compared the performances of 123i-p-mppi, 123i-r91150, 123i-sb207710, and 123i-adam radioligands, for imaging of their respective targets (5-hydroxytryptamine [5-ht]1a, 5-ht2a, 5-ht4, and serotonin transporter [sert]), in wt and mdr1a knockout (ko) rats. |
2014-11-04 |
2023-08-12 |
rat |
| Sasha Dimitrova-Nakov, Anne Baudry, Yassine Harichane, Corinne Collet, Arnaud Marchadier, Odile Kellermann, Michel Goldber. Deletion of serotonin 2B receptor provokes structural alterations of mouse dental tissues. Calcified tissue international. vol 94. issue 3. 2014-09-30. PMID:24170303. |
as the serotonin 2b receptor (5ht2br) regulates sert functionality and capacity to recognize sris, we investigated the potential role of 5ht2br on dental tissues by exploiting 5ht2br knockout (ko) mice. |
2014-09-30 |
2023-08-12 |
mouse |
| Marco Bortolato, Sean C Godar, Simone Tambaro, Felix G Li, Paola Devoto, Marcelo P Coba, Kevin Chen, Jean C Shi. Early postnatal inhibition of serotonin synthesis results in long-term reductions of perseverative behaviors, but not aggression, in MAO A-deficient mice. Neuropharmacology. vol 75. 2014-08-19. PMID:23871843. |
we previously showed that the elevation in brain 5-ht levels in mao-a knockout (ko) mice is particularly marked during the first two weeks of postnatal life. |
2014-08-19 |
2023-08-12 |
mouse |
| Marco Bortolato, Sean C Godar, Simone Tambaro, Felix G Li, Paola Devoto, Marcelo P Coba, Kevin Chen, Jean C Shi. Early postnatal inhibition of serotonin synthesis results in long-term reductions of perseverative behaviors, but not aggression, in MAO A-deficient mice. Neuropharmacology. vol 75. 2014-08-19. PMID:23871843. |
building on this finding, we hypothesized that the reduction of 5-ht levels during these early stages may lead to enduring attenuations of the aggression and other behavioral aberrances observed in mao-a ko mice. |
2014-08-19 |
2023-08-12 |
mouse |
| Marco Bortolato, Sean C Godar, Simone Tambaro, Felix G Li, Paola Devoto, Marcelo P Coba, Kevin Chen, Jean C Shi. Early postnatal inhibition of serotonin synthesis results in long-term reductions of perseverative behaviors, but not aggression, in MAO A-deficient mice. Neuropharmacology. vol 75. 2014-08-19. PMID:23871843. |
to test this possibility, mao-a ko mice were treated with daily injections of a 5-ht synthesis blocker, the tryptophan hydroxylase inhibitor p-chloro-phenylalanine (pcpa, 300 mg/kg/day, ip), from postnatal day 1 through 7. |
2014-08-19 |
2023-08-12 |
mouse |
| Marco Bortolato, Sean C Godar, Simone Tambaro, Felix G Li, Paola Devoto, Marcelo P Coba, Kevin Chen, Jean C Shi. Early postnatal inhibition of serotonin synthesis results in long-term reductions of perseverative behaviors, but not aggression, in MAO A-deficient mice. Neuropharmacology. vol 75. 2014-08-19. PMID:23871843. |
as expected, this regimen significantly reduced 5-ht forebrain levels in mao-a ko pups. |
2014-08-19 |
2023-08-12 |
mouse |
| Richard J Lamb, Jonathan W Pinkston, Lynette C Daw. Ethanol effects on multiple fixed-interval, fixed-ratio responding in mice with deletions of the serotonin transporter gene. Behavioural pharmacology. vol 25. issue 1. 2014-08-11. PMID:24247279. |
serotonin transporter knockout (ko) mice self-administer less ethanol than either heterozygous or wild-type mice; however, the mechanistic basis for this difference remains unclear. |
2014-08-11 |
2023-08-12 |
mouse |
| Richard J Lamb, Jonathan W Pinkston, Lynette C Daw. Ethanol effects on multiple fixed-interval, fixed-ratio responding in mice with deletions of the serotonin transporter gene. Behavioural pharmacology. vol 25. issue 1. 2014-08-11. PMID:24247279. |
the decreased level of ethanol self-administration in serotonin transporter ko mice is not explained by an increased sensitivity to the response-decreasing effects of ethanol in ko mice, as sensitivity to the response-decreasing effects of ethanol was similar in the ko, heterozygous, and wild-type mice. |
2014-08-11 |
2023-08-12 |
mouse |
| M A Fox, M G Panessiti, P R Moya, T J Tolliver, K Chen, J C Shih, D L Murph. Mutations in monoamine oxidase (MAO) genes in mice lead to hypersensitivity to serotonin-enhancing drugs: implications for drug side effects in humans. The pharmacogenomics journal. vol 13. issue 6. 2014-07-14. PMID:22964922. |
maoa/b-knockout (ko) mice displayed baseline serotonin syndrome behaviors, and these behavioral responses were highly exaggerated following 5-htp or tramadol versus baseline and wild-type (wt) littermates. |
2014-07-14 |
2023-08-12 |
mouse |
| Marko Uutela, Jesse Lindholm, Tomi Rantamäki, Juzoh Umemori, Kerri Hunter, Vootele Võikar, Maija L Castré. Distinctive behavioral and cellular responses to fluoxetine in the mouse model for Fragile X syndrome. Frontiers in cellular neuroscience. vol 8. 2014-06-06. PMID:24904293. |
the postnatal mrna expression of serotonin transporter (sert) was reduced in the thalamic nuclei of fmr1 ko mice during the time of transient innervation of somatosensory neurons suggesting that developmental changes of sert expression were involved in the differential cellular and behavioral responses to fluoxetine in wild-type and fmr1 mice. |
2014-06-06 |
2023-08-13 |
mouse |
| Cara L Wellman, Marguerite Camp, V Morgan Jones, Kathryn P MacPherson, Jessica Ihne, Paul Fitzgerald, Mouna Maroun, Emily Drabant, Ryan Bogdan, Ahmad R Hariri, Andrew Holme. Convergent effects of mouse Pet-1 deletion and human PET-1 variation on amygdala fear and threat processing. Experimental neurology. vol 250. 2014-01-30. PMID:24100022. |
constitutive pet-1 knockout (ko) causes major loss of serotonin neurons and forebrain serotonin availability, and behavioral abnormalities. |
2014-01-30 |
2023-08-12 |
mouse |
| Alessia Luoni, Sjoerd Hulsken, Greta Cazzaniga, Giorgio Racagni, Judith R Homberg, Marco A Riv. Behavioural and neuroplastic properties of chronic lurasidone treatment in serotonin transporter knockout rats. The international journal of neuropsychopharmacology. vol 16. issue 6. 2014-01-15. PMID:23164505. |
the aim of this study was thus to establish the ability of lurasidone, a novel sga characterized by a multi-receptor signature, to modulate behavioural and molecular defects associated with a genetic model of impaired emotional control, namely serotonin transporter knockout (sert ko) rats. |
2014-01-15 |
2023-08-12 |
rat |
| Marco Bortolato, Sean C Godar, Loai Alzghoul, Junlin Zhang, Ryan D Darling, Kimberly L Simpson, Valentina Bini, Kevin Chen, Cara L Wellman, Rick C S Lin, Jean C Shi. Monoamine oxidase A and A/B knockout mice display autistic-like features. The international journal of neuropsychopharmacology. vol 16. issue 4. 2013-12-27. PMID:22850464. |
maoa and a/b knockout (ko) mice display high 5-ht levels, particularly during early developmental stages. |
2013-12-27 |
2023-08-12 |
mouse |