| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Charles A Hoeffer, Helen Wong, Peter Cain, Josien Levenga, Kiriana K Cowansage, Yoon Choi, Camille Davy, Neil Majmundar, D Randy McMillan, Beverly A Rothermel, Eric Klan. Regulator of calcineurin 1 modulates expression of innate anxiety and anxiogenic responses to selective serotonin reuptake inhibitor treatment. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 43. 2013-12-23. PMID:24155299. |
finally, we found that rcan1 ko mice lacked the early anxiogenic response to the selective serotonin reuptake inhibitor (ssri) fluoxetine and had improved latency for its therapeutic anxiolytic effects. |
2013-12-23 |
2023-08-12 |
mouse |
| Naozumi Araragi, Klaus-Peter Lesc. Serotonin (5-HT) in the regulation of depression-related emotionality: insight from 5-HT transporter and tryptophan hydroxylase-2 knockout mouse models. Current drug targets. vol 14. issue 5. 2013-10-29. PMID:23547810. |
moreover, the recent advent of knockout (ko) mice for tryptophan hydroxylase 2 (tph2 ko), which lacks the rate-limiting enzyme for 5-ht synthesis in the brain, has further provided insight to the brain serotonergic system and its role in emotion dysregulation. |
2013-10-29 |
2023-08-12 |
mouse |
| Rebecca E Horton, Deana M Apple, W Anthony Owens, Nicole L Baganz, Sonia Cano, Nathan C Mitchell, Melissa Vitela, Georgianna G Gould, Wouter Koek, Lynette C Daw. Decynium-22 enhances SSRI-induced antidepressant-like effects in mice: uncovering novel targets to treat depression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 25. 2013-08-30. PMID:23785165. |
this antidepressant-like activity of d-22 was attenuated in oct3 ko mice, whereas the effect of d-22 to inhibit 5-ht clearance in the ca3 region of hippocampus persisted. |
2013-08-30 |
2023-08-12 |
mouse |
| Caitlin E McOmish, Alena Lira, James B Hanks, Jay A Gingric. Clozapine-induced locomotor suppression is mediated by 5-HT2A receptors in the forebrain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 13. 2013-08-26. PMID:22871913. |
wild-type (wt) and 5-ht(2a) knockout (ko) mice treated with haloperidol, clozapine, and risperidone were assessed for locomotor activity and catalepsy. |
2013-08-26 |
2023-08-12 |
mouse |
| Caitlin E McOmish, Alena Lira, James B Hanks, Jay A Gingric. Clozapine-induced locomotor suppression is mediated by 5-HT2A receptors in the forebrain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 13. 2013-08-26. PMID:22871913. |
interestingly, 5-ht(2a) ko mice were cataleptic following haloperidol and risperidone, but did not respond to clozapine's locomotor-suppressing effects. |
2013-08-26 |
2023-08-12 |
mouse |
| Karlene T Barrett, Hannah C Kinney, Aihua Li, J Andrew Daubenspeck, James C Leiter, Eugene E Natti. Subtle alterations in breathing and heart rate control in the 5-HT1A receptor knockout mouse in early postnatal development. Journal of applied physiology (Bethesda, Md. : 1985). vol 113. issue 10. 2013-04-29. PMID:22936722. |
in conscious wild type (wt) and 5-ht(1a) receptor knockout (ko) mice, we measured resting ventilation (ve), oxygen consumption (vo(2)), heart rate (hr), breathing and hr variability, and the hypercapnic ventilatory response (hcvr) at postnatal day 5 (p5), day 15 (p15), and day 25 (p25). |
2013-04-29 |
2023-08-12 |
mouse |
| Karlene T Barrett, Hannah C Kinney, Aihua Li, J Andrew Daubenspeck, James C Leiter, Eugene E Natti. Subtle alterations in breathing and heart rate control in the 5-HT1A receptor knockout mouse in early postnatal development. Journal of applied physiology (Bethesda, Md. : 1985). vol 113. issue 10. 2013-04-29. PMID:22936722. |
we conclude that 5-ht(1a) ko mice have a critical period of potential vulnerability at p5 when pups hypoventilate and have a slower respiratory frequency and hr with enhanced variability of both, suggesting abnormal maturation of cardiorespiratory control. |
2013-04-29 |
2023-08-12 |
mouse |
| Daniel W Nuno, Sarah K England, Kathryn G Lampin. RhoA localization with caveolin-1 regulates vascular contractions to serotonin. American journal of physiology. Regulatory, integrative and comparative physiology. vol 303. issue 9. 2013-03-29. PMID:22955057. |
to test this hypothesis, we measured aortic contractions in response to serotonin in wild-type (wt) and cav-1-deficient mice (cav-1 ko). |
2013-03-29 |
2023-08-12 |
mouse |
| Daniel W Nuno, Sarah K England, Kathryn G Lampin. RhoA localization with caveolin-1 regulates vascular contractions to serotonin. American journal of physiology. Regulatory, integrative and comparative physiology. vol 303. issue 9. 2013-03-29. PMID:22955057. |
rhoa-dependent contractions in response to serotonin were markedly augmented in arteries from cav-1 ko mice despite a modest reduction in rhoa expression compared with wt. |
2013-03-29 |
2023-08-12 |
mouse |
| Osamu Uchiumi, Yoshiyuki Kasahara, Asami Fukui, F Scott Hall, George R Uhl, Ichiro Sor. Serotonergic involvement in the amelioration of behavioral abnormalities in dopamine transporter knockout mice by nicotine. Neuropharmacology. vol 64. 2013-02-11. PMID:22809709. |
we report nicotine-induced normalization of effects on locomotion and prepulse inhibition of acoustic startle (ppi) in dat ko mice that require intact serotonin 5-ht1a systems. |
2013-02-11 |
2023-08-12 |
mouse |
| Colm M P O'Tuathaigh, Gerard Clarke, Jeremy Walsh, Lieve Desbonnet, Emilie Petit, Claire O'Leary, Orna Tighe, Niamh Clarke, Maria Karayiorgou, Joseph A Gogos, Ted G Dinan, John F Cryan, John L Waddingto. Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes. The international journal of neuropsychopharmacology. vol 15. issue 9. 2013-01-17. PMID:22074909. |
in this paper we compared the effect of chronic adolescent exposure to the cannabinoid win 55212 on sensorimotor gating, behaviours related to the negative symptoms of schizophrenia, anxiety- and stress-related behaviours, as well as ex-vivo brain dopamine and serotonin levels, in comt ko vs. wild-type (wt) mice. |
2013-01-17 |
2023-08-12 |
mouse |
| Raina D Pang, Daniel P Holschneider, Joseph D Mille. Circadian rhythmicity in serotonin transporter knockout mice. Life sciences. vol 91. issue 11-12. 2012-12-10. PMID:22884802. |
serotonin transporter knockout (5-htt ko) mice exhibit elevated basal extracellular serotonin, increased depressive-like behaviors and increased rapid eye movement sleep. |
2012-12-10 |
2023-08-12 |
mouse |
| Marco Bortolato, Sean C Godar, Miriam Melis, Alessio Soggiu, Paola Roncada, Angelo Casu, Giovanna Flore, Kevin Chen, Roberto Frau, Andrea Urbani, M Paola Castelli, Paola Devoto, Jean C Shi. NMDARs mediate the role of monoamine oxidase A in pathological aggression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 25. 2012-08-30. PMID:22723698. |
in comparison with wt male mice, mao a ko counterparts exhibited increases in 5-ht and ne levels across all brain regions, but no difference in glutamate concentrations and nmdar binding. |
2012-08-30 |
2023-08-12 |
mouse |
| Marco Bortolato, Kevin Chen, Sean C Godar, Gao Chen, Weihua Wu, Igor Rebrin, Mollee R Farrell, Anna L Scott, Cara L Wellman, Jean C Shi. Social deficits and perseverative behaviors, but not overt aggression, in MAO-A hypomorphic mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 13. 2012-08-14. PMID:21832987. |
in the prefrontal cortex and amygdala, mao-a(neo) mice showed low, yet detectable, mao-a catalytic activity, as well as 5-ht levels equivalent to wt littermates; conversely, the hippocampus and midbrain of mao-a(neo) mice featured a neurochemical profile akin to mao-a-knockout (ko) mice, with undetectable mao-a activity and high 5-ht concentrations. |
2012-08-14 |
2023-08-12 |
mouse |
| Jorge E Ortega, Jason Katner, Richard Davis, Mark Wade, Laura Nisenbaum, George G Nomikos, Kjell A Svensson, Kenneth W Perr. Modulation of neurotransmitter release in orexin/hypocretin-2 receptor knockout mice: a microdialysis study. Journal of neuroscience research. vol 90. issue 3. 2012-07-19. PMID:22038504. |
after kcl perfusion, significantly higher increases in ne, 5-ht, and da release were found in ko compared with wt mice. |
2012-07-19 |
2023-08-12 |
mouse |
| Yassine Harichane, Sasha Dimitrova-Nakov, Arnaud Marchadier, Corinne Collet, Anne Baudry, Catherine Vidal, Agnès Kamoun-Goldrat, Odile Kellermann, Michel Goldber. Enamel alterations in serotonin 2B receptor knockout mice. European journal of oral sciences. vol 119 Suppl 1. 2012-06-18. PMID:22243244. |
the role of the serotonin 2b receptor (5-ht(2b) r) in enamel formation and mineralization was explored in adult 5ht(2b) r knockout (ko) mice compared with wild-type (wt) mice. |
2012-06-18 |
2023-08-12 |
mouse |
| Yassine Harichane, Sasha Dimitrova-Nakov, Arnaud Marchadier, Corinne Collet, Anne Baudry, Catherine Vidal, Agnès Kamoun-Goldrat, Odile Kellermann, Michel Goldber. Enamel alterations in serotonin 2B receptor knockout mice. European journal of oral sciences. vol 119 Suppl 1. 2012-06-18. PMID:22243244. |
structural modifications, thinner enamel crystallites, and porosities observed in ko mice indicate that the 5-ht(2b) r-mediated signaling pathways as part of the enamel formation process. |
2012-06-18 |
2023-08-12 |
mouse |
| Yassine Harichane, Sasha Dimitrova-Nakov, Arnaud Marchadier, Corinne Collet, Anne Baudry, Catherine Vidal, Agnès Kamoun-Goldrat, Odile Kellermann, Michel Goldber. Enamel alterations in serotonin 2B receptor knockout mice. European journal of oral sciences. vol 119 Suppl 1. 2012-06-18. PMID:22243244. |
defects observed in the mineralization and structure of enamel in ko mice highlight that the 5-ht(2b) r interferes with the mechanisms directing amelogenesis. |
2012-06-18 |
2023-08-12 |
mouse |
| Vincent Fournet, Annie Schweitzer, Caroline Chevarin, Jean-Christophe Deloulme, Michel Hamon, Bruno Giros, Annie Andrieux, Marie-Pascale Martre. The deletion of STOP/MAP6 protein in mice triggers highly altered mood and impaired cognitive performances. Journal of neurochemistry. vol 121. issue 1. 2012-05-03. PMID:22146001. |
in stop knockout (ko) compared with wild-type mice, serotonin (5-ht) markers are found to be markedly accumulated in the raphe nuclei and, in contrast, deeply depleted in all serotonergic projection areas. |
2012-05-03 |
2023-08-12 |
mouse |
| Vincent Fournet, Annie Schweitzer, Caroline Chevarin, Jean-Christophe Deloulme, Michel Hamon, Bruno Giros, Annie Andrieux, Marie-Pascale Martre. The deletion of STOP/MAP6 protein in mice triggers highly altered mood and impaired cognitive performances. Journal of neurochemistry. vol 121. issue 1. 2012-05-03. PMID:22146001. |
we also showed that stop ko mice exhibited regional imbalance of the norepinephrine tone as observed for 5-ht. |
2012-05-03 |
2023-08-12 |
mouse |