| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ze Li, Hai-Yuan Yang, Ying Wang, Man-Ling Zhang, Xiao-Rui Liu, Qiang Xiong, Li-Ning Zhang, Yong Jin, Li-Sha Mou, Yan Liu, Rong-Feng Li, Yi Rao, Yi-Fan Da. Generation of tryptophan hydroxylase 2 gene knockout pigs by CRISPR/Cas9-mediated gene targeting. Journal of biomedical research. vol 31. issue 5. 2020-09-29. PMID:28866660. |
thesetph2 ko pigs are valuable large-animal models for studies of 5-ht deficiency induced behavior abnomality. |
2020-09-29 |
2023-08-13 |
Not clear |
| Tatyana Budylin, Sara R Guariglia, Leah I Duran, Brandon M Behring, Zarya Shaikh, Lorenz S Neuwirth, Probal Banerje. Ultrasonic vocalization sex differences in 5-HT Behavioural brain research. vol 373. 2020-09-14. PMID:31288061. |
the present study assessed the developmental-behavioral milestones (dbms) and their relationship with later life anxiety-like behaviors by comparing postnatal ultrasonic vocalizations (usvs) with open field (of), elevated plus maze (epm), and light/dark (ld) anxiety test outcomes using the serotonin 1a receptor knockout (ko) mouse model of anxiety. |
2020-09-14 |
2023-08-13 |
mouse |
| Xunwei Wu, Jun Huang, Cong Shen, Yeling Liu, Shengjie He, Junquan Sun, Bolan Y. NRF2 deficiency increases obesity susceptibility in a mouse menopausal model. PloS one. vol 15. issue 2. 2020-04-30. PMID:32045430. |
in addition, the level of 5-ht was significantly reduced (p<0.05) in the ko mice after ovariectomy. |
2020-04-30 |
2023-08-13 |
mouse |
| Deborah G A Peeters, Sietse F de Boer, Anneke Terneusen, Adrian Newman-Tancredi, Mark A Varney, Robbert-Jan Verkes, Judith R Homber. Enhanced aggressive phenotype of Tph2 knockout rats is associated with diminished 5-HT Neuropharmacology. vol 153. 2020-03-03. PMID:31078489. |
the present study showed that tryptophan hydroxylase 2 (tph2) knockout (ko) rats, which exhibit profoundly diminished extracellular serotonin levels, display increased aggressiveness compared to their tph2 wildtype (wt) counterparts. |
2020-03-03 |
2023-08-13 |
rat |
| Nadine El-Ayache, James J Galliga. 5-HT American journal of physiology. Gastrointestinal and liver physiology. vol 316. issue 1. 2019-11-19. PMID:30359082. |
female serotonin transporter (sert)-gene knockout (ko) rats exhibit hypersensitivity to colorectal balloon distention (crd) that mimics colonic hypersensitivity occurring in female ibs patients. |
2019-11-19 |
2023-08-13 |
rat |
| Jean C Shi. Monoamine oxidase isoenzymes: genes, functions and targets for behavior and cancer therapy. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 11. 2019-11-04. PMID:30259128. |
mao a ko mice exhibited autistic-like behaviors which could be prevented by reducing serotonin levels at an early developmental age (p1-p7) providing potential therapy. |
2019-11-04 |
2023-08-13 |
mouse |
| Francisco J Pavon, Antonia Serrano, Nimish Sidhpura, Ilham Polis, David Stouffer, Fernando Rodriguez de Fonseca, Benjamin F Cravatt, Rémi Martin-Fardon, Loren H Parson. Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens. Addiction biology. vol 23. issue 2. 2019-09-17. PMID:28660730. |
we conducted a microdialysis study to characterize nicotine-induced changes in da and serotonin (5-ht) levels in the nac of faah knockout (ko) mice using a conditioned place preference-like paradigm with three nicotine doses (0.1, 1 and 10 mg/kg, s.c.). |
2019-09-17 |
2023-08-13 |
mouse |
| Francisco J Pavon, Antonia Serrano, Nimish Sidhpura, Ilham Polis, David Stouffer, Fernando Rodriguez de Fonseca, Benjamin F Cravatt, Rémi Martin-Fardon, Loren H Parson. Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens. Addiction biology. vol 23. issue 2. 2019-09-17. PMID:28660730. |
furthermore, faah ko mice displayed a moderate enhancement of the effect of low-dose nicotine on nac 5-ht release (p < 0.05), with no differences between the genotypes at higher doses. |
2019-09-17 |
2023-08-13 |
mouse |
| Francisco J Pavon, Antonia Serrano, Nimish Sidhpura, Ilham Polis, David Stouffer, Fernando Rodriguez de Fonseca, Benjamin F Cravatt, Rémi Martin-Fardon, Loren H Parson. Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens. Addiction biology. vol 23. issue 2. 2019-09-17. PMID:28660730. |
similar to faah ko mice, pf-3845-pretreated mice displayed a moderate enhancement of the effect of low-dose nicotine on nac 5-ht release (p < 0.01). |
2019-09-17 |
2023-08-13 |
mouse |
| Tao-Fang Xi, Dan-Ni Li, Yu-Yian Li, Ying Qin, Hai-Hong Wang, Ning-Ning Song, Qiong Zhang, Yu-Qiang Ding, Xuan-Zheng Shi, Dong-Ping Xi. Central 5-hydroxytryptamine (5-HT) mediates colonic motility by hypothalamus oxytocin-colonic oxytocin receptor pathway. Biochemical and biophysical research communications. vol 508. issue 3. 2019-09-17. PMID:30545636. |
in this study, we used central 5-ht knockout (ko) mice to investigate whether brain-derived 5-ht mediates colonic motility, and if so, whether it involves oxytocin (ot) production in the hypothalamus and ot receptor in the colon. |
2019-09-17 |
2023-08-13 |
mouse |
| Alexander D Vincent, Xuan-Yu Wang, Sean P Parsons, Waliul I Khan, Jan D Huizing. Abnormal absorptive colonic motor activity in germ-free mice is rectified by butyrate, an effect possibly mediated by mucosal serotonin. American journal of physiology. Gastrointestinal and liver physiology. vol 315. issue 5. 2019-08-16. PMID:30095295. |
motility was then assessed in tryptophan hydroxylase-1 (tph1) knockout (ko) mice, devoid of mucosal 5-ht, with phosphate buffer, butyrate, or propionate intraluminal perfusion. |
2019-08-16 |
2023-08-13 |
mouse |
| Tatiana Bregman, Christina Nona, Julien Volle, Mustansir Diwan, Roger Raymond, Paul J Fletcher, José N Nobrega, Clement Haman. Deep brain stimulation induces antidepressant-like effects in serotonin transporter knockout mice. Brain stimulation. vol 11. issue 2. 2019-01-28. PMID:29174865. |
ssris have limited efficacy when given to sert knockout (ko) mice, or patients with mutations in the serotonin transporter promoter gene (5-httlpr). |
2019-01-28 |
2023-08-13 |
mouse |
| Jesse Wood, Zoe LaPalombara, Susanne E Ahmar. Monoamine abnormalities in the SAPAP3 knockout model of obsessive-compulsive disorder-related behaviour. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 373. issue 1742. 2019-01-02. PMID:29352023. |
these data provide evidence of monoaminergic dysregulation in a translational model of ocd symptoms and are consistent with aberrant cortical and striatal serotonin and dopamine release/metabolism in sapap-3 ko mice. |
2019-01-02 |
2023-08-13 |
mouse |
| Fumihiro Matsui, Patrick Hecht, Kanji Yoshimoto, Yoshihisa Watanabe, Masafumi Morimoto, Kevin Fritsche, Matthew Will, David Beversdor. DHA Mitigates Autistic Behaviors Accompanied by Dopaminergic Change in a Gene/Prenatal Stress Mouse Model. Neuroscience. vol 371. 2018-11-09. PMID:29288796. |
we previously reported that prenatal stress exposure in stress-susceptible heterozygous serotonin transporter (sert) ko pregnant dams in a mouse model resulted in autism-like behavior in the offspring (sert/s mice). |
2018-11-09 |
2023-08-13 |
mouse |
| Jingyao Zhang, Ruixia Cui, Yang Feng, Weiman Gao, Jianbin Bi, Zeyu Li, Chang Li. Serotonin Exhibits Accelerated Bleomycin-Induced Pulmonary Fibrosis through TPH1 Knockout Mouse Experiments. Mediators of inflammation. vol 2018. 2018-10-01. PMID:29849496. |
the aim of this study was to investigate the role of 5-ht in bleomycin- (blm-) induced pulmonary fibrosis through wild-type c57bl/6 (wt) and tph1 knockout (ko) mouse experiments. |
2018-10-01 |
2023-08-13 |
mouse |
| Travis C Jackson, Shawn E Kotermanski, Patrick M Kochane. Whole-transcriptome microarray analysis reveals regulation of Rab4 by RBM5 in neurons. Neuroscience. vol 361. 2018-06-14. PMID:28818525. |
also, elevated rab4a levels in ko neurons were associated with decreased membrane levels of oligomeric serotonin transporters (sert). |
2018-06-14 |
2023-08-13 |
rat |
| Ji-Chun Zhang, Wei Yao, Qian Ren, Chun Yang, Chao Dong, Min Ma, Jin Wu, Kenji Hashimot. Depression-like phenotype by deletion of α7 nicotinic acetylcholine receptor: Role of BDNF-TrkB in nucleus accumbens. Scientific reports. vol 6. 2018-05-14. PMID:27821848. |
systemic administration of the trkb antagonist ana-12, but not the trkb agonist 7,8-dihydroxyflavone and the selective serotonin reuptake inhibitor fluoxetine, showed a rapid antidepressant effect in ko mice by normalizing increased synaptogenesis in the nac. |
2018-05-14 |
2023-08-13 |
mouse |
| Kevin Chen, Abbey Kardys, Yibu Chen, Stephen Flink, Boris Tabakoff, Jean C Shi. Altered gene expression in early postnatal monoamine oxidase A knockout mice. Brain research. vol 1669. 2018-04-12. PMID:28535982. |
we reported previously that monoamine oxidase (mao) a knockout (ko) mice show increased serotonin (5-hydroxytryptamine, 5-ht) levels and autistic-like behaviors characterized by repetitive behaviors, and anti-social behaviors. |
2018-04-12 |
2023-08-13 |
mouse |
| Kevin Chen, Abbey Kardys, Yibu Chen, Stephen Flink, Boris Tabakoff, Jean C Shi. Altered gene expression in early postnatal monoamine oxidase A knockout mice. Brain research. vol 1669. 2018-04-12. PMID:28535982. |
we showed that administration of the serotonin synthesis inhibitor para-chlorophenylalanine (pcpa) from post-natal day 1 (p1) through 7 (p7) in mao a ko mice reduced the serotonin level to normal and reverses the repetitive behavior. |
2018-04-12 |
2023-08-13 |
mouse |
| Kevin Chen, Abbey Kardys, Yibu Chen, Stephen Flink, Boris Tabakoff, Jean C Shi. Altered gene expression in early postnatal monoamine oxidase A knockout mice. Brain research. vol 1669. 2018-04-12. PMID:28535982. |
this result suggests that modulation of these genes by the increased serotonin may lead to neurodevelopmental alteration in mao a ko mice and results in autistic-like behaviors. |
2018-04-12 |
2023-08-13 |
mouse |