| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A M Gardier, B Gruwez, A C Trillat, C Jacquot, R Hen, M Bouri. Interaction between 5-HT(1A) and 5-HT(1B) receptors: effects of 8-OH-DPAT-induced hypothermia in 5-HT(1B) receptor knockout mice. European journal of pharmacology. vol 421. issue 3. 2001-09-06. PMID:11516433. |
we found a higher efficacy of 8-oh-dpat-induced hypothermia in 5-ht(1b) -/- ko compared to wild-type mice suggesting that an adaptive thermoregulatory process involving the functional activity of somatodendritic 5-ht(1a) receptors is altered in mutant mice lacking 5-ht(1b) receptors. |
2001-09-06 |
2023-08-12 |
mouse |
| J A Bouwknecht, T H Hijzen, J van der Gugten, R A Maes, R Hen, B Olivie. Absence of 5-HT(1B) receptors is associated with impaired impulse control in male 5-HT(1B) knockout mice. Biological psychiatry. vol 49. issue 7. 2001-07-05. PMID:11297712. |
this was studied here in mice lacking 5-ht(1b) receptors (5-ht(1b) ko). |
2001-07-05 |
2023-08-12 |
mouse |
| A Ravary, A Muzerelle, M Darmon, D L Murphy, R Moessner, K P Lesch, P Gaspa. Abnormal trafficking and subcellular localization of an N-terminally truncated serotonin transporter protein. The European journal of neuroscience. vol 13. issue 7. 2001-06-21. PMID:11298795. |
we report here that a truncated 5-htt protein is produced in the neurons of the raphe, in serotonin transporter (5-htt) knockout (ko) mice. |
2001-06-21 |
2023-08-12 |
mouse |
| A Ravary, A Muzerelle, M Darmon, D L Murphy, R Moessner, K P Lesch, P Gaspa. Abnormal trafficking and subcellular localization of an N-terminally truncated serotonin transporter protein. The European journal of neuroscience. vol 13. issue 7. 2001-06-21. PMID:11298795. |
this protein is not functional as there is no high-affinity serotonin uptake in 5-htt ko mice, in adults or during development. |
2001-06-21 |
2023-08-12 |
mouse |
| A Ravary, A Muzerelle, M Darmon, D L Murphy, R Moessner, K P Lesch, P Gaspa. Abnormal trafficking and subcellular localization of an N-terminally truncated serotonin transporter protein. The European journal of neuroscience. vol 13. issue 7. 2001-06-21. PMID:11298795. |
this study therefore validates the 5-htt ko model despite the occurrence of an incomplete translation, and brings novel information on the in vivo 5-ht uptake and cellular processing of an abnormal 5-htt protein. |
2001-06-21 |
2023-08-12 |
mouse |
| Z Sarnyai, E L Sibille, C Pavlides, R J Fenster, B S McEwen, M Tot. Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin(1A) receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 26. 2001-02-15. PMID:11121072. |
to test whether a deficit in 5-ht(1a) receptors impairs hippocampus-related functions, we studied hippocampal-dependent learning and memory, synaptic plasticity in the hippocampus, and limbic neuronal excitability in 5-ht(1a)-knockout (ko) mice. |
2001-02-15 |
2023-08-12 |
mouse |
| C Gross, L Santarelli, D Brunner, X Zhuang, R He. Altered fear circuits in 5-HT(1A) receptor KO mice. Biological psychiatry. vol 48. issue 12. 2001-02-08. PMID:11137057. |
altered fear circuits in 5-ht(1a) receptor ko mice. |
2001-02-08 |
2023-08-12 |
mouse |
| C Gross, L Santarelli, D Brunner, X Zhuang, R He. Altered fear circuits in 5-HT(1A) receptor KO mice. Biological psychiatry. vol 48. issue 12. 2001-02-08. PMID:11137057. |
mice with a genetic deletion of the serotonin 1a receptor (5-ht(1a)r knockout [ko]) have been shown to be more fearful in a number of behavioral conflict tests, confirming the important role of this receptor in modulating anxiety. |
2001-02-08 |
2023-08-12 |
mouse |
| C Gross, L Santarelli, D Brunner, X Zhuang, R He. Altered fear circuits in 5-HT(1A) receptor KO mice. Biological psychiatry. vol 48. issue 12. 2001-02-08. PMID:11137057. |
factor analysis of the behavior of wt and 5-ht(1a)r ko mice in the open field test shows that locomotion and anxiety measures segregate independently, supporting the idea that the anxious behavior of the ko mice is not the result of altered locomotion. |
2001-02-08 |
2023-08-12 |
mouse |
| C Gross, L Santarelli, D Brunner, X Zhuang, R He. Altered fear circuits in 5-HT(1A) receptor KO mice. Biological psychiatry. vol 48. issue 12. 2001-02-08. PMID:11137057. |
the dual function of the 5-ht(1a)r as both a presynaptic autoreceptor, negatively regulating serotonin activity, and a postsynaptic heteroreceptor, inhibiting the activity of nonserotonergic neurons in forebrain structures, has complicated interpretation of the anxious phenotype of these ko mice. |
2001-02-08 |
2023-08-12 |
mouse |
| C López-Rubalcava, R Hen, S L Cru. Anxiolytic-like actions of toluene in the burying behavior and plus-maze tests: differences in sensitivity between 5-HT(1B) knockout and wild-type mice. Behavioural brain research. vol 115. issue 1. 2000-10-24. PMID:10996411. |
this paper compares the anxiolytic-like actions of toluene in two anxiety paradigms, the burying behavior and plus-maze tests, in 5-ht(1b) knockout (ko) and 129/sv-ter wild-type (wt) mice. |
2000-10-24 |
2023-08-12 |
mouse |
| C López-Rubalcava, R Hen, S L Cru. Anxiolytic-like actions of toluene in the burying behavior and plus-maze tests: differences in sensitivity between 5-HT(1B) knockout and wild-type mice. Behavioural brain research. vol 115. issue 1. 2000-10-24. PMID:10996411. |
our results suggest that 5-ht(1b) ko mice are more sensitive to those of toluene's actions related to anxiety, but not to those related with motor coordination or nociception. |
2000-10-24 |
2023-08-12 |
mouse |
| J C Shih, K Che. MAO-A and -B gene knock-out mice exhibit distinctly different behavior. Neurobiology (Budapest, Hungary). vol 7. issue 2. 2000-01-04. PMID:10591056. |
mao-a ko mice have elevated brain levels of 5-ht, ne and da and manifest aggressive behavior similar to men with a deletion of mao-a. |
2000-01-04 |
2023-08-12 |
mouse |
| J C Shih, K Chen, M J Rid. Role of MAO A and B in neurotransmitter metabolism and behavior. Polish journal of pharmacology. vol 51. issue 1. 1999-10-21. PMID:10389141. |
mao a ko mice have elevated brain levels of 5-ht, ne and da and manifest aggressive behavior similar to men with a deletion of mao a. |
1999-10-21 |
2023-08-12 |
mouse |
| A C Trillat, I Malagié, M Bourin, C Jacquot, R Hen, A M Gardie. [Homozygote mice deficient in serotonin 5-HT1B receptor and antidepressant effect of selective serotonin reuptake inhibitors]. Comptes rendus des seances de la Societe de biologie et de ses filiales. vol 192. issue 6. 1999-05-03. PMID:10101609. |
using microdialysis in awake 129/sv mice, we show that the absence of the 5-ht1b receptor in mutant mice (ko 1b -/-) potentiated the effect of paroxetine on extracellular 5-ht levels in the ventral hippocampus, but not in the frontal cortex compared to wild-type mice (wt). |
1999-05-03 |
2023-08-12 |
mouse |