| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Scott Hall, Ichiro Sora, Jana Drgonova, Xiao-Fei Li, Michelle Goeb, George R Uh. Molecular mechanisms underlying the rewarding effects of cocaine. Annals of the New York Academy of Sciences. vol 1025. 2005-02-18. PMID:15542699. |
our initial approach to this problem was to combine dat ko mice with serotonin transporter (sert) ko mice to make combined dat/sert ko mice. |
2005-02-18 |
2023-08-12 |
mouse |
| Yossef Itzhak, Karen L Anderson, Syed F Al. Differential response of nNOS knockout mice to MDMA ("ecstasy")- and methamphetamine-induced psychomotor sensitization and neurotoxicity. Annals of the New York Academy of Sciences. vol 1025. 2005-02-18. PMID:15542708. |
for the neurochemical studies, a high dose of mdma caused marked depletion of 5-ht in several brain regions of both wt and ko mice, suggesting that the absence of the nnos gene did not afford protection against mdma-induced depletion of 5-ht. |
2005-02-18 |
2023-08-12 |
mouse |
| Yossef Itzhak, Karen L Anderson, Syed F Al. Differential response of nNOS knockout mice to MDMA ("ecstasy")- and methamphetamine-induced psychomotor sensitization and neurotoxicity. Annals of the New York Academy of Sciences. vol 1025. 2005-02-18. PMID:15542708. |
the differential response of nnos ko mice to the behavioral and neurotoxic effects of mdma and meth suggests that the nnos gene is required for the expression and persistence of da-mediated effects of meth and mdma, while 5-ht-mediated effects of mdma (induction of sensitization and 5-ht depletion) are not dependent on nnos. |
2005-02-18 |
2023-08-12 |
mouse |
| Hao-Wei Shen, Yoko Hagino, Hideaki Kobayashi, Keiko Shinohara-Tanaka, Kazutaka Ikeda, Hideko Yamamoto, Toshifumi Yamamoto, Klaus-Peter Lesch, Dennis L Murphy, F Scott Hall, George R Uhl, Ichiro Sor. Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 10. 2004-11-22. PMID:15226739. |
cocaine conditioned place preference (cpp) is intact in dopamine transporter (dat) knockout (ko) mice and enhanced in serotonin transporter (sert) ko mice. |
2004-11-22 |
2023-08-12 |
mouse |
| Kevin Chen, Daniel P Holschneider, Weihua Wu, Igor Rebrin, Jean C Shi. A spontaneous point mutation produces monoamine oxidase A/B knock-out mice with greatly elevated monoamines and anxiety-like behavior. The Journal of biological chemistry. vol 279. issue 38. 2004-10-25. PMID:15272015. |
brain levels of serotonin, norepinephrine, dopamine, and phenylethylamine increased, and serotonin metabolite 5-hydroxyindoleacetic acid levels decreased, to a much greater degree than in either mao a or b single ko mice. |
2004-10-25 |
2023-08-12 |
mouse |
| Lotte De Groote, Berend Olivier, Herman G M Westenber. Role of 5-HT1B receptors in the regulation of extracellular serotonin and dopamine in the dorsal striatum of mice. European journal of pharmacology. vol 476. issue 1-2. 2004-08-06. PMID:12969751. |
local administration by reversed microdialysis of the selective 5-ht reuptake inhibitor, fluvoxamine (0.1-10 microm), concentration dependently increased 5-ht to the same extent in wildtype and in 5-ht1b knockout (ko) mice. |
2004-08-06 |
2023-08-12 |
mouse |
| Lotte De Groote, Berend Olivier, Herman G M Westenber. Role of 5-HT1B receptors in the regulation of extracellular serotonin and dopamine in the dorsal striatum of mice. European journal of pharmacology. vol 476. issue 1-2. 2004-08-06. PMID:12969751. |
the 5-ht1b receptor agonist, 1,4-dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-5h-pyrrolo[3,2-b]pyridin-5-one (cp-93,129), reduced 5-ht levels in the wildtype, but not in 5-ht1b ko mice. |
2004-08-06 |
2023-08-12 |
mouse |
| Michelle D Lee, Elizabeth M Somerville, Guy A Kennett, Colin T Dourish, Peter G Clifto. Tonic regulation of satiety by 5-HT receptors in the mouse: converging evidence from behavioural and c-fos immunoreactivity studies? The European journal of neuroscience. vol 19. issue 11. 2004-08-02. PMID:15182309. |
earlier studies have shown that 5-ht(1b)-knockout (ko) mice eat more and are heavier than wild-type (wt) controls and that the selective 5-ht(1b) receptor agonist cp-94,253 reduces food intake in food-deprived mice. |
2004-08-02 |
2023-08-12 |
mouse |
| G Campbell Teskey, Kathleen S Radford, Isabelle Seif, Richard H Dyc. MAO(A) knockout mice are more susceptible to seizures but show reduced epileptogenesis. Epilepsy research. vol 59. issue 1. 2004-07-23. PMID:15135164. |
we conclude that the high levels of neuroactive amines in the mao(a) ko mice reorganize the brain to make the mice more susceptible to seizures but the remaining high levels of serotonin and norepinephrine likely inhibit epileptogenesis. |
2004-07-23 |
2023-08-12 |
mouse |
| M Hamo. [Introduction. Physiological and physiopathological roles of serotonin: recent data from KO mice]. Journal de la Societe de biologie. vol 198. issue 1. 2004-07-19. PMID:15146949. |
physiological and physiopathological roles of serotonin: recent data from ko mice]. |
2004-07-19 |
2023-08-12 |
mouse |
| Patricia Gaspa. [Genetic models to understand how serotonin acts during development]. Journal de la Societe de biologie. vol 198. issue 1. 2004-07-19. PMID:15146951. |
mice with an excess or a severe reduction of 5-ht during development, such as the maoa and the vmat2 ko mice, show abnormalities that concern late stages of development: alterations in axon branching, dendritic remodeling and developmental cell death. |
2004-07-19 |
2023-08-12 |
mouse |
| Alasdair M Barr, Virginia Lehmann-Masten, Martin Paulus, Raul R Gainetdinov, Marc G Caron, Mark A Geye. The selective serotonin-2A receptor antagonist M100907 reverses behavioral deficits in dopamine transporter knockout mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 2. 2004-04-27. PMID:14603268. |
as novel treatment strategies for these disorders have focused on the serotonin (5-ht) 2a receptor, we determined the capacity of the highly selective 5-ht(2a) receptor antagonist m100907 to reverse behavioral deficits in dat knockout (ko) mice. |
2004-04-27 |
2023-08-12 |
mouse |
| Jean Chen Shi. Cloning, after cloning, knock-out mice, and physiological functions of MAO A and B. Neurotoxicology. vol 25. issue 1-2. 2004-04-01. PMID:14697877. |
mao a ko mice showed increased levels of serotonin (5-ht), norepinephrine (ne), dopamine (da) whereas mao b ko mice showed increased phenylethylamine (pea) levels only. |
2004-04-01 |
2023-08-12 |
mouse |
| Jennifer M Chou-Green, Todd D Holscher, Mary F Dallman, Susan F Akan. Compulsive behavior in the 5-HT2C receptor knockout mouse. Physiology & behavior. vol 78. issue 4-5. 2004-01-16. PMID:12782219. |
we hypothesized that 5-ht(2c) receptor knockout (ko) mice may display compulsive-like behavior. |
2004-01-16 |
2023-08-12 |
mouse |
| Jennifer M Chou-Green, Todd D Holscher, Mary F Dallman, Susan F Akan. Compulsive behavior in the 5-HT2C receptor knockout mouse. Physiology & behavior. vol 78. issue 4-5. 2004-01-16. PMID:12782219. |
this paper describes characterization of several distinct, highly organized behaviors in mice lacking functional 5-ht(2c) receptors, which supports a compulsive-like syndrome.compulsive-like behavior was assessed in male 5-ht(2c) receptor ko and wildtype (wt) mice. |
2004-01-16 |
2023-08-12 |
mouse |
| Jennifer M Chou-Green, Todd D Holscher, Mary F Dallman, Susan F Akan. Compulsive behavior in the 5-HT2C receptor knockout mouse. Physiology & behavior. vol 78. issue 4-5. 2004-01-16. PMID:12782219. |
5-ht(2c) receptor ko mice chewed more clay, produced a distinct pattern of "neat" chewing of plastic screens and exhibited reduced habituation of head dipping activity compared to wt mice. |
2004-01-16 |
2023-08-12 |
mouse |
| Berend Olivier, Theo Zethof, Tommy Pattij, Meg van Boogaert, Ruud van Oorschot, Christina Leahy, Ronald Oosting, Arjan Bouwknecht, Jan Veening, Jan van der Gugten, Lucianne Groenin. Stress-induced hyperthermia and anxiety: pharmacological validation. European journal of pharmacology. vol 463. issue 1-3. 2003-11-12. PMID:12600705. |
the procedure was applied in various genetically modified mice [5-ht(1a) and 5-ht(1b) receptor knockout (ko) mice and corticotropin-releasing hormone overexpressing (crh-oe) mice] to study phenotypic influences of the various mutations on aspects of anxiety. |
2003-11-12 |
2023-08-12 |
mouse |
| Jennifer M Chou-Green, Todd D Holscher, Mary F Dallman, Susan F Akan. Repeated stress in young and old 5-HT(2C) receptor knockout mice. Physiology & behavior. vol 79. issue 2. 2003-10-29. PMID:12834793. |
serotonin (5-ht)(2c) receptor null mutant (knockout, ko) mice develop hyperphagia and midlife obesity. |
2003-10-29 |
2023-08-12 |
mouse |
| Jennifer M Chou-Green, Todd D Holscher, Mary F Dallman, Susan F Akan. Repeated stress in young and old 5-HT(2C) receptor knockout mice. Physiology & behavior. vol 79. issue 2. 2003-10-29. PMID:12834793. |
to test this, we examined the effect of two intensities of repeated stress on food intake and body weight in 5-ht(2c) receptor ko and wild-type (wt) mice. |
2003-10-29 |
2023-08-12 |
mouse |
| Jennifer M Chou-Green, Todd D Holscher, Mary F Dallman, Susan F Akan. Repeated stress in young and old 5-HT(2C) receptor knockout mice. Physiology & behavior. vol 79. issue 2. 2003-10-29. PMID:12834793. |
together, these findings indicate that 5-ht(2c) receptor ko mice are hyperresponsive to repeated stress and this effect is influenced by stressor intensity and initial metabolic state of the mouse. |
2003-10-29 |
2023-08-12 |
mouse |