| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D R Deng, S Djalali, M Höltje, G Grosse, T Stroh, I Voigt, H Kusserow, F Theuring, G Ahnert-Hilger, H Hörtnag. Embryonic and postnatal development of the serotonergic raphe system and its target regions in 5-HT1A receptor deletion or overexpressing mouse mutants. Neuroscience. vol 147. issue 2. 2007-09-18. PMID:17543467. |
tissue levels of 5-ht and of its main metabolite 5-hydroxyindoleacetic acid as well as 5-ht turnover were considerably higher in brains of oe mice and slightly elevated in ko mice in comparison with the wt, starting at e16.5 through p15.5. |
2007-09-18 |
2023-08-12 |
mouse |
| Jeffrey M Witkin, Melvyn Baez, Jianliang Yu, Matthew E Barton, Harlan E Shanno. Constitutive deletion of the serotonin-7 (5-HT(7)) receptor decreases electrical and chemical seizure thresholds. Epilepsy research. vol 75. issue 1. 2007-08-15. PMID:17485199. |
in the present study, the potential involvement of 5-ht(7) receptors in epilepsy and other seizure disorders was assessed by comparing the seizures produced by three types of electrical stimulation and three chemical convulsants in 5-ht(7) receptor-deficient (knockout, ko) mice to those seizures observed in wild-type (wt) mice. |
2007-08-15 |
2023-08-12 |
mouse |
| Jeffrey M Witkin, Melvyn Baez, Jianliang Yu, Matthew E Barton, Harlan E Shanno. Constitutive deletion of the serotonin-7 (5-HT(7)) receptor decreases electrical and chemical seizure thresholds. Epilepsy research. vol 75. issue 1. 2007-08-15. PMID:17485199. |
ptz was more potent in inducing seizures in 5-ht(7) ko mice than in wild-type mice. |
2007-08-15 |
2023-08-12 |
mouse |
| Jeffrey M Witkin, Melvyn Baez, Jianliang Yu, Matthew E Barton, Harlan E Shanno. Constitutive deletion of the serotonin-7 (5-HT(7)) receptor decreases electrical and chemical seizure thresholds. Epilepsy research. vol 75. issue 1. 2007-08-15. PMID:17485199. |
likewise, cocaine was more potent in inducing seizures in 5-ht(7) ko than in wt mice; moreover, death resulted from cocaine administration in 5-ht(7) ko mice but not in wt mice. |
2007-08-15 |
2023-08-12 |
mouse |
| C Altamura, M L Dell'Acqua, R Moessner, D L Murphy, K P Lesch, Antonio M Persic. Altered neocortical cell density and layer thickness in serotonin transporter knockout mice: a quantitation study. Cerebral cortex (New York, N.Y. : 1991). vol 17. issue 6. 2007-07-03. PMID:16905592. |
to further characterize 5-ht's contributions to neocortical development, we assessed the thickness and neuronal cell density of various cerebral cortical areas in serotonin transporter (5-htt) knockout (ko) mice, characterized by elevated extracellular 5-ht levels. |
2007-07-03 |
2023-08-12 |
mouse |
| Grégory Conductier, Nicole Dusticier, Guillaume Lucas, Francine Côté, Guy Debonnel, Annie Daszuta, Aline Dumuis, André Nieoullon, René Hen, Joël Bockaert, Valérie Compa. Adaptive changes in serotonin neurons of the raphe nuclei in 5-HT(4) receptor knock-out mouse. The European journal of neuroscience. vol 24. issue 4. 2007-03-06. PMID:16930432. |
based on recent evidence that stress-induced anorexia may involve 5-ht(4)receptors (5-ht(4)r), we measured various aspects of 5-ht function in 5-ht(4)r knock-out (ko) mice. |
2007-03-06 |
2023-08-12 |
mouse |
| Grégory Conductier, Nicole Dusticier, Guillaume Lucas, Francine Côté, Guy Debonnel, Annie Daszuta, Aline Dumuis, André Nieoullon, René Hen, Joël Bockaert, Valérie Compa. Adaptive changes in serotonin neurons of the raphe nuclei in 5-HT(4) receptor knock-out mouse. The European journal of neuroscience. vol 24. issue 4. 2007-03-06. PMID:16930432. |
when compared to dorsal raphe nucleus (drn) 5-ht neurons from wild-type mice, those from 5-ht(4)r ko mice exhibited reduced spontaneous electrical activity. |
2007-03-06 |
2023-08-12 |
mouse |
| Grégory Conductier, Nicole Dusticier, Guillaume Lucas, Francine Côté, Guy Debonnel, Annie Daszuta, Aline Dumuis, André Nieoullon, René Hen, Joël Bockaert, Valérie Compa. Adaptive changes in serotonin neurons of the raphe nuclei in 5-HT(4) receptor knock-out mouse. The European journal of neuroscience. vol 24. issue 4. 2007-03-06. PMID:16930432. |
cumulative, systemic doses of the 5-ht uptake blocker citalopram, that reduced 5-ht cell firing by 30% in wild-type animals, completely inhibited 5-ht neuron firing in the ko mice. |
2007-03-06 |
2023-08-12 |
mouse |
| Grégory Conductier, Nicole Dusticier, Guillaume Lucas, Francine Côté, Guy Debonnel, Annie Daszuta, Aline Dumuis, André Nieoullon, René Hen, Joël Bockaert, Valérie Compa. Adaptive changes in serotonin neurons of the raphe nuclei in 5-HT(4) receptor knock-out mouse. The European journal of neuroscience. vol 24. issue 4. 2007-03-06. PMID:16930432. |
other changes in drn of the ko mice included increases in the levels of 5-ht plasma membrane transporter sites and mrna, as well as a decrease in the density of 5-ht(1a)r sites without any change in 5-ht(1a) mrna content. |
2007-03-06 |
2023-08-12 |
mouse |
| Léa Stankovski, Chantal Alvarez, Tanja Ouimet, Tania Vitalis, Khalid H El-Hachimi, David Price, Evan Deneris, Patricia Gaspar, Olivier Case. Developmental cell death is enhanced in the cerebral cortex of mice lacking the brain vesicular monoamine transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 6. 2007-03-06. PMID:17287506. |
we report that genetic depletion of serotonin, dopamine, and norepinephrine in mice lacking the vesicular monoamine transporter (vmat2 ko mice) causes an increase in cell death in the superficial layers of the cingulate and retrosplenial cortices during early postnatal life (postnatal days 0-4). |
2007-03-06 |
2023-08-12 |
mouse |
| Léa Stankovski, Chantal Alvarez, Tanja Ouimet, Tania Vitalis, Khalid H El-Hachimi, David Price, Evan Deneris, Patricia Gaspar, Olivier Case. Developmental cell death is enhanced in the cerebral cortex of mice lacking the brain vesicular monoamine transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 6. 2007-03-06. PMID:17287506. |
however, when monoamine oxidase type a was invalidated in the vmat2 ko background (vmat2-maoa dko mice), increases in 5-ht levels coincided with a reduction of cell death and a normalization of bcl-x(l) expression. |
2007-03-06 |
2023-08-12 |
mouse |
| Wolfgang Kummer, Silke Wiegand, Sibel Akinci, Alfred H Schinkel, Jürgen Wess, Hermann Koepsell, Rainer Viktor Haberberger, Katrin Susanne Lip. Role of acetylcholine and muscarinic receptors in serotonin-induced bronchoconstriction in the mouse. Journal of molecular neuroscience : MN. vol 30. issue 1-2. 2007-02-23. PMID:17192631. |
we tested this hypothesis in a well-established model of videomorphometric analysis of bronchial diameter in precision-cut murine lung slices utilizing epithelium removal to assess the role of the epithelium, oct mouse knockout (ko) strains to assess the role of oct isoforms, and muscarinic receptor m2/m3 double-ko mice to assess the cholinergic component of 5-ht induced bronchoconstriction, as bronchi of this strain are entirely unresponsive to cholinergic stimulation(struckmann et al., 2003). |
2007-02-23 |
2023-08-12 |
mouse |
| Kevin Chen, Olivier Cases, Igor Rebrin, Weihua Wu, Timothy K Gallaher, Isabelle Seif, Jean Chen Shi. Forebrain-specific expression of monoamine oxidase A reduces neurotransmitter levels, restores the brain structure, and rescues aggressive behavior in monoamine oxidase A-deficient mice. The Journal of biological chemistry. vol 282. issue 1. 2007-02-08. PMID:17090537. |
also, compared with mao a ko mice, lower levels of 5-ht, norepinephrine, and da and higher levels of mao a metabolite 5-hydroxyindoleacetic acid were found in the forebrain regions but not in the cerebellum of the transgenic mice. |
2007-02-08 |
2023-08-12 |
mouse |
| C L Wellman, A Izquierdo, J E Garrett, K P Martin, J Carroll, R Millstein, K-P Lesch, D L Murphy, A Holme. Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 3. 2007-02-06. PMID:17234600. |
pyramidal neurons in bla had normal dendritic morphology but significantly greater spine density in 5-ht ko mice compared with wt mice. |
2007-02-06 |
2023-08-12 |
mouse |
| Yukio Takamatsu, Hideko Yamamoto, Yasukazu Ogai, Yoko Hagino, Athina Markou, Kazutaka Iked. Fluoxetine as a potential pharmacotherapy for methamphetamine dependence: studies in mice. Annals of the New York Academy of Sciences. vol 1074. 2007-01-10. PMID:17105925. |
interestingly, the rewarding effects of cocaine are retained in dopamine transporter (dat) knockout (ko) mice, while serotonin transporter (sert) and dat double ko mice do not exhibit conditioned place preference (cpp) to cocaine. |
2007-01-10 |
2023-08-12 |
mouse |
| Motoyasu Yamashita, Setsu Fukushima, Hao-wei Shen, F Scott Hall, George R Uhl, Yohtaro Numachi, Hideaki Kobayashi, Ichiro Sor. Norepinephrine transporter blockade can normalize the prepulse inhibition deficits found in dopamine transporter knockout mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 10. 2006-11-01. PMID:16407898. |
the 'paradoxical' effects of cocaine and methylphenidate in dat ko mice are thus likely to be mediated, at least in part by the ability of these drugs to block net, although serotonin systems may also have some role. |
2006-11-01 |
2023-08-12 |
mouse |
| Susanne Rutz, Céline Riegert, Anna Katharina Rothmaier, Marie-Christine Buhot, Jean-Christophe Cassel, Rolf Jackisc. Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice. Brain research bulletin. vol 70. issue 1. 2006-09-05. PMID:16750486. |
improved memory performance described in 5-ht1b-knockout (ko) mice might thus be due to a weaker 5-ht1b-mediated inhibitory influence of 5-ht on hippocampal ach release. |
2006-09-05 |
2023-08-12 |
mouse |
| Susanne Rutz, Céline Riegert, Anna Katharina Rothmaier, Marie-Christine Buhot, Jean-Christophe Cassel, Rolf Jackisc. Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice. Brain research bulletin. vol 70. issue 1. 2006-09-05. PMID:16750486. |
the selective delay-dependent impairment of working memory observed in these ko mice suggests, however, that cortical regions also participate in task performance, possibly via indirect influences of 5-ht on ach release. |
2006-09-05 |
2023-08-12 |
mouse |
| Susanne Rutz, Céline Riegert, Anna Katharina Rothmaier, Marie-Christine Buhot, Jean-Christophe Cassel, Rolf Jackisc. Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice. Brain research bulletin. vol 70. issue 1. 2006-09-05. PMID:16750486. |
to provide neuropharmacological support for these hypotheses we measured evoked ach and 5-ht release in hippocampal and cortical slices of wild-type (wt) and 5-ht1b ko mice. |
2006-09-05 |
2023-08-12 |
mouse |
| Susanne Rutz, Céline Riegert, Anna Katharina Rothmaier, Marie-Christine Buhot, Jean-Christophe Cassel, Rolf Jackisc. Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice. Brain research bulletin. vol 70. issue 1. 2006-09-05. PMID:16750486. |
in hippocampus and cortex, 5-ht1b agonists decreased and antagonists increased 5-ht release in wt, but not in 5-ht1b ko mice. |
2006-09-05 |
2023-08-12 |
mouse |