| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A M Gardier, D J David, G Jego, C Przybylski, C Jacquot, S Durier, B Gruwez, E Douvier, P Beauverie, N Poisson, R Hen, M Bouri. Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807420. |
the role of serotonin (5-ht)1b receptors in the mechanism of action of selective serotonin re-uptake inhibitors (ssri) was studied by using intracerebral in vivo microdialysis in conscious, freely moving wild-type and 5-ht1b receptor knockout (ko 5-ht1b) mice in order to compare the effects of chronic administration of paroxetine via osmotic minipumps (1 mg per kg per day for 14 days) on extracellular 5-ht levels ([5-ht]ext) in the medial prefrontal cortex and ventral hippocampus. |
2003-08-26 |
2023-08-12 |
mouse |
| A M Gardier, D J David, G Jego, C Przybylski, C Jacquot, S Durier, B Gruwez, E Douvier, P Beauverie, N Poisson, R Hen, M Bouri. Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807420. |
by using the zero net flux method of quantitative microdialysis in the medial prefrontal cortex and ventral hippocampus of wild-type and ko 5-ht1b mice, we found that basal [5-ht]ext and the extraction fraction of 5-ht were similar in the medial prefrontal cortex and ventral hippocampus of both genotypes, suggesting that no compensatory response to the constitutive deletion of the 5-ht1b receptor involving changes in 5-ht uptake capacity occurred in vivo. |
2003-08-26 |
2023-08-12 |
mouse |
| Sylvia Montañez, W Anthony Owens, Georgianna G Gould, Dennis L Murphy, Lynette C Daw. Exaggerated effect of fluvoxamine in heterozygote serotonin transporter knockout mice. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807440. |
clearance rates for serotonin (5-ht) in heterozygote (+/-) and homozygote (-/-) serotonin transporter (5-htt) knockout (ko) mice have not been determined in vivo. |
2003-08-26 |
2023-08-12 |
mouse |
| Sylvia Montañez, W Anthony Owens, Georgianna G Gould, Dennis L Murphy, Lynette C Daw. Exaggerated effect of fluvoxamine in heterozygote serotonin transporter knockout mice. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807440. |
compared with wild-type mice, the maximal rate of 5-ht clearance from extracellular fluid (ecf) was decreased in heterozygotes and more markedly so in ko mice. |
2003-08-26 |
2023-08-12 |
mouse |
| Sylvia Montañez, W Anthony Owens, Georgianna G Gould, Dennis L Murphy, Lynette C Daw. Exaggerated effect of fluvoxamine in heterozygote serotonin transporter knockout mice. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807440. |
heterozygote mice were more sensitive to the 5-ht uptake inhibitor, fluvoxamine, resulting in longer clearance times for 5-ht than in wild-type mice; as expected, the ko mice were completely unresponsive to fluvoxamine. |
2003-08-26 |
2023-08-12 |
mouse |
| Jason M Cuellar, Steven L Jinks, Christopher T Simons, E Carsten. Deletion of the preprotachykinin A gene in mice does not reduce scratching behavior elicited by intradermal serotonin. Neuroscience letters. vol 339. issue 1. 2003-05-19. PMID:12618303. |
to assess a possible role of the neuropeptide, substance p (sp), in the central neurotransmission of itch, we investigated itch-related scratching behavior elicited by intradermal injection of serotonin (5-ht; 0.03-0.3%) in normal mice (wildtype, wt) and knockout mice (ko) with deletion of the preprotachykinin a gene. |
2003-05-19 |
2023-08-12 |
mouse |
| Gabriela Rodríguez-Manzo, Carolina López-Rubalcava, Rene Hen, Alonso Fernández-Guast. Participation of 5-HT(1B) receptors in the inhibitory actions of serotonin on masculine sexual behaviour of mice: pharmacological analysis in 5-HT(1B) receptor knockout mice. British journal of pharmacology. vol 136. issue 8. 2003-04-28. PMID:12163345. |
1 the role of the 5-hydroxytryptamine(1b) (5-ht(1b)) receptor subtype in masculine sexual behaviour in mice was analysed in both 5-ht(1b) receptor knockout (ko(1b)) and wild-type (wt) animals. |
2003-04-28 |
2023-08-12 |
mouse |
| Gabriela Rodríguez-Manzo, Carolina López-Rubalcava, Rene Hen, Alonso Fernández-Guast. Participation of 5-HT(1B) receptors in the inhibitory actions of serotonin on masculine sexual behaviour of mice: pharmacological analysis in 5-HT(1B) receptor knockout mice. British journal of pharmacology. vol 136. issue 8. 2003-04-28. PMID:12163345. |
in addition, the diminished sensitivity to serotonergic stimulation exhibited by ko(1b) mice suggests the occurrence of compensatory changes as a consequence of the absence of the 5-ht(1b) receptor subtype. |
2003-04-28 |
2023-08-12 |
mouse |
| M Wolff, M Savova, G Malleret, R Hen, L Segu, M-C Buho. Serotonin 1B knockout mice exhibit a task-dependent selective learning facilitation. Neuroscience letters. vol 338. issue 1. 2003-04-10. PMID:12565126. |
serotonin 1b knockout (ko) mice exhibit better spatial reference memory performance in the morris water maze than their wild type (wt) controls. |
2003-04-10 |
2023-08-12 |
mouse |
| Tommy Pattij, Lucianne Groenink, Theo H Hijzen, Ronald S Oosting, Robert A A Maes, Jan van der Gugten, Berend Olivie. Autonomic changes associated with enhanced anxiety in 5-HT(1A) receptor knockout mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 3. 2002-11-15. PMID:12225695. |
5-ht(1a) receptor knockout (ko) mice have been described as more anxious in various anxiety paradigms. |
2002-11-15 |
2023-08-12 |
mouse |
| Tommy Pattij, Lucianne Groenink, Theo H Hijzen, Ronald S Oosting, Robert A A Maes, Jan van der Gugten, Berend Olivie. Autonomic changes associated with enhanced anxiety in 5-HT(1A) receptor knockout mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 3. 2002-11-15. PMID:12225695. |
furthermore, the 5-ht(1a) receptor agonist flesinoxan dose-dependently antagonized sih and stress-induced tachycardia in wt, but not in ko, mice. |
2002-11-15 |
2023-08-12 |
mouse |
| Tommy Pattij, Lucianne Groenink, Theo H Hijzen, Ronald S Oosting, Robert A A Maes, Jan van der Gugten, Berend Olivie. Autonomic changes associated with enhanced anxiety in 5-HT(1A) receptor knockout mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 3. 2002-11-15. PMID:12225695. |
the present findings show that 5-ht(1a) receptor ko mice display a more "anxious-like" phenotype not only at a behavioral, but also at autonomic levels. |
2002-11-15 |
2023-08-12 |
mouse |
| A R Ase, J Sénécal, T A Reader, R Hen, L Descarrie. Decreased G-protein coupling of serotonin 5-HT(1A) receptors in the brain of 5-HT(1B) knockout mouse. Neuropharmacology. vol 42. issue 7. 2002-09-17. PMID:12069904. |
to further characterize mutual adaptations of these two receptor subtypes in the absence of one of them, activation of g-protein coupling by agonist was measured and compared to wild-type (wt) in 5-ht(1a) and 5-ht(1b) homozygous knockout (ko) mice. |
2002-09-17 |
2023-08-12 |
mouse |
| Catarina A Owesson, Sarah E Hopwood, Luis F Callado, Isabelle Seif, Daniel P McLaughlin, Jonathan A Stamfor. Altered presynaptic function in monoaminergic neurons of monoamine oxidase-A knockout mice. The European journal of neuroscience. vol 15. issue 9. 2002-07-26. PMID:12028362. |
monoamine oxidase-a knockout (mao-a ko) mice have elevated brain serotonin (5-ht) and noradrenaline (na) levels, and one would therefore anticipate increased monoamine release and compensatory changes in other aspects of presynaptic monoamine function. |
2002-07-26 |
2023-08-12 |
mouse |
| Catarina A Owesson, Sarah E Hopwood, Luis F Callado, Isabelle Seif, Daniel P McLaughlin, Jonathan A Stamfor. Altered presynaptic function in monoaminergic neurons of monoamine oxidase-A knockout mice. The European journal of neuroscience. vol 15. issue 9. 2002-07-26. PMID:12028362. |
in drn, peak 5-ht efflux on stimulation (99 pulses, 100 hz) was greater (p < 0.01) in mao-a ko (262 +/- 44 nm) than c3h mice (157 +/- 16 nm). |
2002-07-26 |
2023-08-12 |
mouse |
| Catarina A Owesson, Sarah E Hopwood, Luis F Callado, Isabelle Seif, Daniel P McLaughlin, Jonathan A Stamfor. Altered presynaptic function in monoaminergic neurons of monoamine oxidase-A knockout mice. The European journal of neuroscience. vol 15. issue 9. 2002-07-26. PMID:12028362. |
moreover, 5-ht uptake t(1/2) was longer (p < 0.05) in mao-a ko than in c3h mice (8.8 +/- 1.1 s cf. |
2002-07-26 |
2023-08-12 |
mouse |
| Catarina A Owesson, Sarah E Hopwood, Luis F Callado, Isabelle Seif, Daniel P McLaughlin, Jonathan A Stamfor. Altered presynaptic function in monoaminergic neurons of monoamine oxidase-A knockout mice. The European journal of neuroscience. vol 15. issue 9. 2002-07-26. PMID:12028362. |
serotonin transporter binding was also lower in both the drn and lc of mao-a ko mice. |
2002-07-26 |
2023-08-12 |
mouse |
| Catarina A Owesson, Sarah E Hopwood, Luis F Callado, Isabelle Seif, Daniel P McLaughlin, Jonathan A Stamfor. Altered presynaptic function in monoaminergic neurons of monoamine oxidase-A knockout mice. The European journal of neuroscience. vol 15. issue 9. 2002-07-26. PMID:12028362. |
the 5-ht(1a) agonist 8-oh-dpat (1 microm) decreased 5-ht efflux more in c3h than in mao-a ko mice (38.3% inhibition cf. |
2002-07-26 |
2023-08-12 |
mouse |
| J Adriaan Bouwknecht, Theo H Hijzen, Jan van der Gugten, Robert A A Maes, René Hen, Berend Olivie. 5-HT(1B) receptor knockout mice show no adaptive changes in 5-HT(1A) receptor function as measured telemetrically on body temperature and heart rate responses. Brain research bulletin. vol 57. issue 1. 2002-04-16. PMID:11827741. |
the present study focuses on putative adaptive changes in the 5-ht(1a) receptor system in mice that lack 5-ht(1b) receptors (5-ht(1b) ko). |
2002-04-16 |
2023-08-12 |
mouse |
| J Adriaan Bouwknecht, Theo H Hijzen, Jan van der Gugten, Robert A A Maes, René Hen, Berend Olivie. 5-HT(1B) receptor knockout mice show no adaptive changes in 5-HT(1A) receptor function as measured telemetrically on body temperature and heart rate responses. Brain research bulletin. vol 57. issue 1. 2002-04-16. PMID:11827741. |
the effects of 5-ht(1a) receptor activation by flesinoxan (0.1-3.0 mg/kg s.c.) were determined telemetrically on body temperature and heart rate in 5-ht(1b) ko and wild-type (wt) mice. |
2002-04-16 |
2023-08-12 |
mouse |