| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Susanne Rutz, Céline Riegert, Anna Katharina Rothmaier, Marie-Christine Buhot, Jean-Christophe Cassel, Rolf Jackisc. Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice. Brain research bulletin. vol 70. issue 1. 2006-09-05. PMID:16750486. |
in 5-ht1b ko mice, 5-ht release was enhanced in both structures, while ach release (in nci) was reduced. |
2006-09-05 |
2023-08-12 |
mouse |
| Susanne Rutz, Céline Riegert, Anna Katharina Rothmaier, Marie-Christine Buhot, Jean-Christophe Cassel, Rolf Jackisc. Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice. Brain research bulletin. vol 70. issue 1. 2006-09-05. PMID:16750486. |
our data (i) confirm the absence of autoinhibition of 5-ht release in 5-ht1b-ko mice, (ii) demonstrate a reduced release of ach, and the absence of 5-ht1b-receptor-mediated inhibition of ach release, in the hippocampus and cortex of 5-ht1b-ko mice, and (iii) are compatible with an indirect role of cortical ach in the working memory impairment observed in these ko mice. |
2006-09-05 |
2023-08-12 |
mouse |
| Lucas Salomon, Christophe Lanteri, Jacques Glowinski, Jean-Pol Tassi. Behavioral sensitization to amphetamine results from an uncoupling between noradrenergic and serotonergic neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 19. 2006-07-19. PMID:16648258. |
third, knockout mice for alpha1b-adrenergic (alpha1b-ar ko) or 5-ht(2a) (5-ht(2a)-r ko) receptor, respectively, exhibit a behavioral and biochemical hyperreactivity to the acute injection of p-chloroamphetamine (alpha1b-ar ko; 5-ht levels) and d-amphetamine (5-ht(2a)-r ko; ne levels). |
2006-07-19 |
2023-08-12 |
mouse |
| Jeanne Lanoir, Gerard Hilaire, Isabelle Sei. Reduced density of functional 5-HT1A receptors in the brain, medulla and spinal cord of monoamine oxidase-A knockout mouse neonates. The Journal of comparative neurology. vol 495. issue 5. 2006-06-26. PMID:16498683. |
abnormally high brain 5-ht levels in monoamine oxidase-a knockout (mao-a ko) mouse neonates raise the question of whether the distribution and density of the 5-ht1a receptors (5-ht1ar) expressed in the brain by postnatal day p7 are affected and, if so, whether the 5-ht1a autoreceptors in the dorsal raphe are modified in the same way as the postsynaptic 5-ht1ar present in raphe target structures. |
2006-06-26 |
2023-08-12 |
mouse |
| Jeanne Lanoir, Gerard Hilaire, Isabelle Sei. Reduced density of functional 5-HT1A receptors in the brain, medulla and spinal cord of monoamine oxidase-A knockout mouse neonates. The Journal of comparative neurology. vol 495. issue 5. 2006-06-26. PMID:16498683. |
data are discussed with reference to the ectopic 5-ht uptake and accumulation reported to occur during the first 10 postnatal days in wild-type and mao-a ko mice. |
2006-06-26 |
2023-08-12 |
mouse |
| Jeanne Lanoir, Gerard Hilaire, Isabelle Sei. Reduced density of functional 5-HT1A receptors in the brain, medulla and spinal cord of monoamine oxidase-A knockout mouse neonates. The Journal of comparative neurology. vol 495. issue 5. 2006-06-26. PMID:16498683. |
as previously suggested to explain the raphe autoreceptor loss in 2-month-old mao-a ko mice, the overall 5-ht1ar down-regulation in mutant pups probably results from extracellular 5-ht excess in both raphe and target structures. |
2006-06-26 |
2023-08-12 |
mouse |
| Kristen C Klemenhagen, Joshua A Gordon, Denis J David, René Hen, Cornelius T Gros. Increased fear response to contextual cues in mice lacking the 5-HT1A receptor. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 1. 2006-05-12. PMID:15920501. |
serotonin 1a receptor knockout (5-ht1ar ko) mice exhibit increased behavioral inhibition in conflict tests. |
2006-05-12 |
2023-08-12 |
mouse |
| Alain Gardie. [Mechanism of action of antidepressant drugs: importance of genetically modified mice in the pharmacological in vivo approach]. Therapie. vol 60. issue 5. 2006-03-28. PMID:16433012. |
important information on ssris has been obtained by applying this technique to genetically modified animals, such as constitutive knockout (ko) mice lacking 5-ht1b receptors (5-ht1b ko) generated by homologous recombination: we compared the effects of a combined treatment on extracellular/intrasynaptic levels of serotonin in various nerve terminals area in wild-type control and ko mice. |
2006-03-28 |
2023-08-12 |
mouse |
| Alain Gardie. [Mechanism of action of antidepressant drugs: importance of genetically modified mice in the pharmacological in vivo approach]. Therapie. vol 60. issue 5. 2006-03-28. PMID:16433012. |
in collaborative work we found that genetic (r-nk1 ko mice) or pharmacological (gr205171) blockade of r-nk1 is associated with several changes: the increase in cortical 5-ht outflow caused by systemic injection of paroxetine was 4- to 6-fold higher in freely moving r-nk1 ko mice than in wild-type controls. |
2006-03-28 |
2023-08-12 |
mouse |
| H H Hofstetter, R Mössner, K P Lesch, R A Linker, K V Toyka, R Gol. Absence of reuptake of serotonin influences susceptibility to clinical autoimmune disease and neuroantigen-specific interferon-gamma production in mouse EAE. Clinical and experimental immunology. vol 142. issue 1. 2005-12-20. PMID:16178854. |
we studied eae in knockout (ko) mice lacking the 5-ht transporter (5-htt) on a c57.bl/6 background, in comparison with wild-type c57.bl/6 animals. |
2005-12-20 |
2023-08-12 |
mouse |
| Daniel G Smith, Eleni T Tzavara, Janice Shaw, Susan Luecke, Mark Wade, Richard Davis, Craig Salhoff, George G Nomikos, Donald R Gehler. Mesolimbic dopamine super-sensitivity in melanin-concentrating hormone-1 receptor-deficient mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 4. 2005-08-31. PMID:15673672. |
we tested whether dopamine, norepinephrine, and serotonin function is dysregulated in mch1r ko and wild-type (wt) mice. |
2005-08-31 |
2023-08-12 |
mouse |
| Daniel G Smith, Eleni T Tzavara, Janice Shaw, Susan Luecke, Mark Wade, Richard Davis, Craig Salhoff, George G Nomikos, Donald R Gehler. Mesolimbic dopamine super-sensitivity in melanin-concentrating hormone-1 receptor-deficient mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 4. 2005-08-31. PMID:15673672. |
norepinephrine transporter (net) binding was significantly elevated within the nac shell and globus pallidus of ko mice, whereas serotonin transporter binding was decreased in the nac shell. |
2005-08-31 |
2023-08-12 |
mouse |
| Jeffrey Sprouse, Xingfang Li, Jeffrey Stock, John McNeish, Linda Reynold. Circadian rhythm phenotype of 5-HT7 receptor knockout mice: 5-HT and 8-OH-DPAT-induced phase advances of SCN neuronal firing. Journal of biological rhythms. vol 20. issue 2. 2005-07-28. PMID:15834109. |
coapplication of 8-oh-dpat with way-100,635 (10 microm), a highly selective 5-ht(1a) antagonist, significantly reduced the phase advance, both in experiments with wt and ko mice, suggesting the greater importance of this serotonin sub-type independent of genetic modification. |
2005-07-28 |
2023-08-12 |
mouse |
| Jeffrey Sprouse, Xingfang Li, Jeffrey Stock, John McNeish, Linda Reynold. Circadian rhythm phenotype of 5-HT7 receptor knockout mice: 5-HT and 8-OH-DPAT-induced phase advances of SCN neuronal firing. Journal of biological rhythms. vol 20. issue 2. 2005-07-28. PMID:15834109. |
5-ht itself (0.5 +/-m, 10 min) at zt6 also yielded phase advances that were indistinguishable in slices prepared from wt and ko mice (1.8 +/- 0.4 h and 2.1 +/- 0.2 h, respectively) and that were also sensitive to way-100,635. |
2005-07-28 |
2023-08-12 |
mouse |
| Jeffrey Sprouse, Xingfang Li, Jeffrey Stock, John McNeish, Linda Reynold. Circadian rhythm phenotype of 5-HT7 receptor knockout mice: 5-HT and 8-OH-DPAT-induced phase advances of SCN neuronal firing. Journal of biological rhythms. vol 20. issue 2. 2005-07-28. PMID:15834109. |
unlike the pattern with 8-oh-dpat, however, 5-ht-induced phase advances, in both wt and ko mice, were blocked by ritanserin, in this paradigm useful as a 5-ht(5a/7) antagonist (in addition to its more typical role as a 5-ht2a/2c antagonist). |
2005-07-28 |
2023-08-12 |
mouse |
| Jeffrey Sprouse, Xingfang Li, Jeffrey Stock, John McNeish, Linda Reynold. Circadian rhythm phenotype of 5-HT7 receptor knockout mice: 5-HT and 8-OH-DPAT-induced phase advances of SCN neuronal firing. Journal of biological rhythms. vol 20. issue 2. 2005-07-28. PMID:15834109. |
serotonin antagonists when administered alone were without effect in slices from wt mice but produced significant phase shifts when administered to those from ko animals. |
2005-07-28 |
2023-08-12 |
mouse |
| Mathieu Wolff, Pierre Costet, Cornelius Gross, René Hen, Louis Segu, Marie-Christine Buho. Age-dependent effects of serotonin-1A receptor gene deletion in spatial learning abilities in mice. Brain research. Molecular brain research. vol 130. issue 1-2. 2005-03-30. PMID:15519675. |
to investigate whether the effects of 5-ht via 5-ht1a receptors on learning are age-sensitive, we evaluated the performance of young-adult (3 months old) and aged (22 months old) 5-ht1a knockout (ko) mice and their homologous wild types (wt) in the hippocampal-dependent spatial reference memory version of the morris water maze. |
2005-03-30 |
2023-08-12 |
mouse |
| Michelle D Lee, Elizabeth M Somerville, Guy A Kennett, Colin T Dourish, Peter G Clifto. Reduced hypophagic effects of d-fenfluramine and the 5-HT2C receptor agonist mCPP in 5-HT1B receptor knockout mice. Psychopharmacology. vol 176. issue 1. 2005-03-29. PMID:15138762. |
in addition we measured 5-ht(2c/a) receptor binding in 5-ht1b ko and wild-type (wt) mice and examined the effects of 5-ht1b receptor antagonists on d-fenfluramine-induced hypophagia in wt mice. |
2005-03-29 |
2023-08-12 |
mouse |
| Matthew S Chang, Lisa M Ariah, Alexander Marks, Efrain C Azmiti. Chronic gliosis induced by loss of S-100B: knockout mice have enhanced GFAP-immunoreactivity but blunted response to a serotonin challenge. Brain research. vol 1031. issue 1. 2005-03-18. PMID:15621007. |
to compare the response of gfap-ir cells to 5-ht in s-100b ko (-/-) and wt (cd-1) mice, we injected animals with para-chloroamphetamine (pca) over 2 days (5 and 10 mg/ml). |
2005-03-18 |
2023-08-12 |
mouse |
| Matthew S Chang, Lisa M Ariah, Alexander Marks, Efrain C Azmiti. Chronic gliosis induced by loss of S-100B: knockout mice have enhanced GFAP-immunoreactivity but blunted response to a serotonin challenge. Brain research. vol 1031. issue 1. 2005-03-18. PMID:15621007. |
these results are consistent with the hypothesis that 5-ht may modulate glial morphology by inducing a release of intracellular s-100b, and this pathway is inoperable in the s-100b ko (-/-). |
2005-03-18 |
2023-08-12 |
mouse |