| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Adriaan Bouwknecht, Theo H Hijzen, Jan van der Gugten, Robert A A Maes, René Hen, Berend Olivie. 5-HT(1B) receptor knockout mice show no adaptive changes in 5-HT(1A) receptor function as measured telemetrically on body temperature and heart rate responses. Brain research bulletin. vol 57. issue 1. 2002-04-16. PMID:11827741. |
5-ht(1b) ko mice showed no shift in 5-ht(1a) receptor sensitivity compared to wt mice. |
2002-04-16 |
2023-08-12 |
mouse |
| J Adriaan Bouwknecht, Theo H Hijzen, Jan van der Gugten, Robert A A Maes, René Hen, Berend Olivie. 5-HT(1B) receptor knockout mice show no adaptive changes in 5-HT(1A) receptor function as measured telemetrically on body temperature and heart rate responses. Brain research bulletin. vol 57. issue 1. 2002-04-16. PMID:11827741. |
this study found no indications for adaptive changes in presynaptic 5-ht(1a) receptor function in 5-ht(1b) ko mice as measured telemetrically on body temperature and heart rate responses. |
2002-04-16 |
2023-08-12 |
mouse |
| Claire-Marie Vacher, Philippe Frétier, Christophe Créminon, André Calas, Hélène Hardin-Pouze. Activation by serotonin and noradrenaline of vasopressin and oxytocin expression in the mouse paraventricular and supraoptic nuclei. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 5. 2002-03-22. PMID:11880481. |
to test this hypothesis, we used the tg8 transgenic mice ko for the monoamine oxidase-a gene, which present high levels of noradrenaline and serotonin in the brain. |
2002-03-22 |
2023-08-12 |
mouse |
| B Olivier, T Pattij, S J Wood, R Oosting, Z Sarnyai, M Tot. The 5-HT(1A) receptor knockout mouse and anxiety. Behavioural pharmacology. vol 12. issue 6-7. 2002-03-20. PMID:11742137. |
the recent production, in three independent research groups, of 5-ht(1a) receptor knockout (r ko) mice in three different genetic backgrounds (c57bl/6j, 129/sv, swiss-webster) led to the intriguing finding that all mice, independent from the genetic background strain from which the null mutants were made, showed an "anxious" phenotype compared to corresponding wild-type mice. |
2002-03-20 |
2023-08-12 |
mouse |
| B Olivier, T Pattij, S J Wood, R Oosting, Z Sarnyai, M Tot. The 5-HT(1A) receptor knockout mouse and anxiety. Behavioural pharmacology. vol 12. issue 6-7. 2002-03-20. PMID:11742137. |
the 5-ht(1a) r ko made in the swiss-webster background displays disturbances in the gaba(a)-benzodiazepine (bz) receptor system in the brain, including downregulation of gaba(a) alpha1 and alpha2 subunits in the amygdala. |
2002-03-20 |
2023-08-12 |
mouse |
| B Olivier, T Pattij, S J Wood, R Oosting, Z Sarnyai, M Tot. The 5-HT(1A) receptor knockout mouse and anxiety. Behavioural pharmacology. vol 12. issue 6-7. 2002-03-20. PMID:11742137. |
in contrast, the gaba(a)-bz receptor system seems to function normally in the 5-ht(1a) r ko in the 129/sv background suggesting that changes in the gaba(a)-bz receptor system may not be a prerequisite for anxiety but rather could have a modifying effect on this phenotype. |
2002-03-20 |
2023-08-12 |
mouse |
| J A Bouwknecht, J van der Gugten, T H Hijzen, R A Maes, R Hen, B Olivie. Male and female 5-HT(1B) receptor knockout mice have higher body weights than wildtypes. Physiology & behavior. vol 74. issue 4-5. 2002-03-07. PMID:11790410. |
because the absence of 5-ht(1b) receptors may cause changes in this regulation, body weight was measured in male and female 5-ht(1b) receptor knockout (5-ht(1b) ko) and wildtype (wt) mice from weaning until the age of 30 weeks. |
2002-03-07 |
2023-08-12 |
mouse |
| J A Bouwknecht, J van der Gugten, T H Hijzen, R A Maes, R Hen, B Olivie. Male and female 5-HT(1B) receptor knockout mice have higher body weights than wildtypes. Physiology & behavior. vol 74. issue 4-5. 2002-03-07. PMID:11790410. |
in both genders, 5-ht(1b) ko mice had a higher body weight than wt mice (17% and 9%, respectively). |
2002-03-07 |
2023-08-12 |
mouse |
| J A Bouwknecht, J van der Gugten, T H Hijzen, R A Maes, R Hen, B Olivie. Male and female 5-HT(1B) receptor knockout mice have higher body weights than wildtypes. Physiology & behavior. vol 74. issue 4-5. 2002-03-07. PMID:11790410. |
5-ht(1b) ko males drank strikingly more water. |
2002-03-07 |
2023-08-12 |
mouse |
| J A Bouwknecht, J van der Gugten, T H Hijzen, R A Maes, R Hen, B Olivie. Male and female 5-HT(1B) receptor knockout mice have higher body weights than wildtypes. Physiology & behavior. vol 74. issue 4-5. 2002-03-07. PMID:11790410. |
plasma leptin levels and most organ weights did not differ between genotypes, indicating that higher body weight in 5-ht(1b) ko mice is not related to obesity. |
2002-03-07 |
2023-08-12 |
mouse |
| J A Bouwknecht, J van der Gugten, T H Hijzen, R A Maes, R Hen, B Olivie. Male and female 5-HT(1B) receptor knockout mice have higher body weights than wildtypes. Physiology & behavior. vol 74. issue 4-5. 2002-03-07. PMID:11790410. |
kidneys were smaller in females, but larger in 5-ht(1b) ko mice, while lungs showed opposite effects. |
2002-03-07 |
2023-08-12 |
mouse |
| J A Bouwknecht, J van der Gugten, T H Hijzen, R A Maes, R Hen, B Olivie. Male and female 5-HT(1B) receptor knockout mice have higher body weights than wildtypes. Physiology & behavior. vol 74. issue 4-5. 2002-03-07. PMID:11790410. |
spleen and testes were smaller in 5-ht(1b) ko mice. |
2002-03-07 |
2023-08-12 |
mouse |
| J A Bouwknecht, J van der Gugten, T H Hijzen, R A Maes, R Hen, B Olivie. Male and female 5-HT(1B) receptor knockout mice have higher body weights than wildtypes. Physiology & behavior. vol 74. issue 4-5. 2002-03-07. PMID:11790410. |
although 5-ht(1b) ko males are more aggressive, testosterone levels were not different from wt mice. |
2002-03-07 |
2023-08-12 |
mouse |
| K A Miczek, S C Maxson, E W Fish, S Faccidom. Aggressive behavioral phenotypes in mice. Behavioural brain research. vol 125. issue 1-2. 2002-01-22. PMID:11682108. |
a potentially common mechanism may be some components of the serotonin system, since alterations in 5-ht neurotransmission have been found in several of the ko mice that display unusual aggressive behavior. |
2002-01-22 |
2023-08-12 |
mouse |
| M He, E Sibille, D Benjamin, M Toth, T Shippenber. Differential effects of 5-HT1A receptor deletion upon basal and fluoxetine-evoked 5-HT concentrations as revealed by in vivo microdialysis. Brain research. vol 902. issue 1. 2001-09-20. PMID:11376590. |
basal and fluoxetine-evoked extracellular concentrations of 5-ht were quantified in the striatum, a projection area of dorsal raphe neurons (drn), of wild-type (wt) and 5-ht1a receptor knock out (ko) mice. |
2001-09-20 |
2023-08-12 |
mouse |
| M He, E Sibille, D Benjamin, M Toth, T Shippenber. Differential effects of 5-HT1A receptor deletion upon basal and fluoxetine-evoked 5-HT concentrations as revealed by in vivo microdialysis. Brain research. vol 902. issue 1. 2001-09-20. PMID:11376590. |
basal 5-ht concentrations did not differ in wt and ko mice. |
2001-09-20 |
2023-08-12 |
mouse |
| M He, E Sibille, D Benjamin, M Toth, T Shippenber. Differential effects of 5-HT1A receptor deletion upon basal and fluoxetine-evoked 5-HT concentrations as revealed by in vivo microdialysis. Brain research. vol 902. issue 1. 2001-09-20. PMID:11376590. |
the enhanced response to fluoxetine in ko mice is consistent with pharmacological studies and suggests that adaptive mechanisms that occur in response to 5-ht1a receptor deletion are insufficient to oppose increases in 5-ht concentrations produced by acute inhibition of the 5-ht transporter. |
2001-09-20 |
2023-08-12 |
mouse |
| A M Persico, E Mengual, R Moessner, F S Hall, R S Revay, I Sora, J Arellano, J DeFelipe, J M Gimenez-Amaya, M Conciatori, R Marino, A Baldi, S Cabib, T Pascucci, G R Uhl, D L Murphy, K P Lesch, F Keller, S F Hal. Barrel pattern formation requires serotonin uptake by thalamocortical afferents, and not vesicular monoamine release. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 17. 2001-09-20. PMID:11517274. |
5-htt knock-out (ko) mice reveal a nearly complete absence of 5-ht in the cerebral cortex by immunohistochemistry, and of barrels, both at p7 and adulthood. |
2001-09-20 |
2023-08-12 |
mouse |
| A M Persico, E Mengual, R Moessner, F S Hall, R S Revay, I Sora, J Arellano, J DeFelipe, J M Gimenez-Amaya, M Conciatori, R Marino, A Baldi, S Cabib, T Pascucci, G R Uhl, D L Murphy, K P Lesch, F Keller, S F Hal. Barrel pattern formation requires serotonin uptake by thalamocortical afferents, and not vesicular monoamine release. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 17. 2001-09-20. PMID:11517274. |
vmat2 ko mice, completely lacking activity-dependent vesicular release of monoamines including 5-ht, also show a complete lack of 5-ht in the cortex but display largely normal barrel fields, despite sometimes markedly reduced postnatal growth. |
2001-09-20 |
2023-08-12 |
mouse |
| A M Gardier, B Gruwez, A C Trillat, C Jacquot, R Hen, M Bouri. Interaction between 5-HT(1A) and 5-HT(1B) receptors: effects of 8-OH-DPAT-induced hypothermia in 5-HT(1B) receptor knockout mice. European journal of pharmacology. vol 421. issue 3. 2001-09-06. PMID:11516433. |
to test for adaptive compensatory changes that may have occurred in the functional activity of somatodendritic 5-ht(1a) receptors during the development of constitutive "knockout" mice lacking the 5-ht(1b) receptor subtype (5-ht(1b) -/- ko), we assayed for decrease in body temperature induced by an acute subcutaneous injection of the 5-ht(1a) receptor agonist, 8-hydroxy 2(di-n-propyl(amino)tetralin (8-oh-dpat), either alone or in the presence of a selective 5-ht(1a) receptor antagonist, n-[4-(2-methoxyphenyl)-1-piperazinyl]-n-(2-pyridinyl) cyclo-hexanecarboxamide (way 100635). |
2001-09-06 |
2023-08-12 |
mouse |