| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Olivier Lairez, Denis Calise, Pascale Bianchi, Catherine Ordener, Odile Spreux-Varoquaux, Céline Guilbeau-Frugier, Ghislaine Escourrou, Isabelle Seif, Jérôme Roncalli, Nathalie Pizzinat, Michel Galinier, Angelo Parini, Jeanne Mialet-Pere. Genetic deletion of MAO-A promotes serotonin-dependent ventricular hypertrophy by pressure overload. Journal of molecular and cellular cardiology. vol 46. issue 4. 2009-05-06. PMID:19162038. |
cardiac 5-ht(2a), but not 5-ht(2b) receptors were overexpressed in mao-a ko mice, as demonstrated by real-time pcr and western-blot experiments. |
2009-05-06 |
2023-08-12 |
mouse |
| Olivier Lairez, Denis Calise, Pascale Bianchi, Catherine Ordener, Odile Spreux-Varoquaux, Céline Guilbeau-Frugier, Ghislaine Escourrou, Isabelle Seif, Jérôme Roncalli, Nathalie Pizzinat, Michel Galinier, Angelo Parini, Jeanne Mialet-Pere. Genetic deletion of MAO-A promotes serotonin-dependent ventricular hypertrophy by pressure overload. Journal of molecular and cellular cardiology. vol 46. issue 4. 2009-05-06. PMID:19162038. |
exacerbation of hypertrophy in ko mice was associated with increased amounts of 5-ht in the heart. |
2009-05-06 |
2023-08-12 |
mouse |
| Olivier Lairez, Denis Calise, Pascale Bianchi, Catherine Ordener, Odile Spreux-Varoquaux, Céline Guilbeau-Frugier, Ghislaine Escourrou, Isabelle Seif, Jérôme Roncalli, Nathalie Pizzinat, Michel Galinier, Angelo Parini, Jeanne Mialet-Pere. Genetic deletion of MAO-A promotes serotonin-dependent ventricular hypertrophy by pressure overload. Journal of molecular and cellular cardiology. vol 46. issue 4. 2009-05-06. PMID:19162038. |
in order to determine the role of 5-ht and 5-ht(2a) receptors in ventricular remodeling in mao-a ko mice, we administered the 5-ht(2a) receptor antagonists ketanserin (1 mg/kg/day) or m100907 (0.1 mg/kg/day) during 4 weeks of aortic banding. |
2009-05-06 |
2023-08-12 |
mouse |
| Alain M Gardie. Mutant mouse models and antidepressant drug research: focus on serotonin and brain-derived neurotrophic factor. Behavioural pharmacology. vol 20. issue 1. 2009-03-03. PMID:19179848. |
constitutive ko, tissue specific, or inducible ko mice targeting both 5-ht and brain-derived neurotrophic factor systems may potentially make an important contribution to knowledge of the pathophysiology and treatment of depression. |
2009-03-03 |
2023-08-12 |
mouse |
| Lori Asaria. Loss of cholecystokinin and glucagon-like peptide-1-induced satiation in mice lacking serotonin 2C receptors. American journal of physiology. Regulatory, integrative and comparative physiology. vol 296. issue 1. 2009-02-06. PMID:19005016. |
to investigate the role of serotonin 2c receptors (2cr), which are expressed only in the central nervous system, in the satiating actions of the gut peptides cck and glucagon-like peptide 1 (glp-1), we examined 1) the effect of null mutations of serotonin 2cr (2cr ko) on the eating-inhibitory potencies of dark-onset intraperitoneal injections of 0.9, 1.7, or 3.5 nmol/kg (1, 2, or 4 microg/kg) cck and 100, 200, and 400 nmol/kg (33, 66, or 132 microg/kg) glp-1, and 2) the effects of intraperitoneal injections of 1.7 nmol//kg cck and 100 nmol/kg glp-1 on neuronal activation in the brain, as measured by c-fos expression. |
2009-02-06 |
2023-08-12 |
mouse |
| Katerina V Savelieva, Shulei Zhao, Vladimir M Pogorelov, Indrani Rajan, Qi Yang, Emily Cullinan, Thomas H Lanthor. Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants. PloS one. vol 3. issue 10. 2008-12-18. PMID:18923670. |
the behavioral effects observed in the tph2 ko and dko mice strongly confirm the role of 5-ht and its synthetic enzymes in the etiology and treatment of affective disorders. |
2008-12-18 |
2023-08-12 |
mouse |
| Olaf Schulte-Herbrüggen, Heide Hörtnagl, Gerald Ponath, Matthias Rothermundt, Rainer Hellwe. Distinct regulation of brain-derived neurotrophic factor and noradrenaline in S100B knockout mice. Neuroscience letters. vol 442. issue 2. 2008-12-12. PMID:18638525. |
therefore we investigated levels of serotonin (5-ht) and its metabolite 5-hydroxyindoleacetic acid (5-hiaa), noradrenaline (na), dopamine (da), brain-derived neurotrophic factor (bdnf) and nerve growth factor (ngf) in the hippocampus, frontal cortex and residual neocortex in s100b knock out (s100b ko) mice compared to wildtype controls. |
2008-12-12 |
2023-08-12 |
mouse |
| Susan F Akan. Feeding and stress interact through the serotonin 2C receptor in developing mice. Physiology & behavior. vol 94. issue 4. 2008-09-04. PMID:18495184. |
the phenotype of the serotonin 2c receptor null (ko) mouse is adult-onset hyperphagia, depressed metabolic rate, and disruption in satiety, with a progression to midlife obesity. |
2008-09-04 |
2023-08-12 |
mouse |
| M Gardani, S M Biell. The effects of photic and nonphotic stimuli in the 5-HT7 receptor knockout mouse. Neuroscience. vol 152. issue 1. 2008-08-05. PMID:18065150. |
finally, as the 5-ht7 receptor has been associated with the modulation of nonphotic resetting in vitro, we examined the response of the 5-ht7 ko mice to systemic administration of a 5-ht(1a/7) agonist. |
2008-08-05 |
2023-08-12 |
mouse |
| A Elizabeth Linder, Jessica Diaz, Wei Ni, Theo Szasz, Robert Burnett, Stephanie W Watt. Vascular reactivity, 5-HT uptake, and blood pressure in the serotonin transporter knockout rat. American journal of physiology. Heart and circulatory physiology. vol 294. issue 4. 2008-05-29. PMID:18263707. |
a sert knockout (ko) rat is a useful model to test the hypothesis that sert is the primary mechanism for arterial 5-ht uptake and to investigate the impact of sert removal on blood pressure. |
2008-05-29 |
2023-08-12 |
rat |
| A Elizabeth Linder, Jessica Diaz, Wei Ni, Theo Szasz, Robert Burnett, Stephanie W Watt. Vascular reactivity, 5-HT uptake, and blood pressure in the serotonin transporter knockout rat. American journal of physiology. Heart and circulatory physiology. vol 294. issue 4. 2008-05-29. PMID:18263707. |
wild-type (wt) and ko rats were used to measure 5-ht content (plasma, raphe, aorta, carotid, and mesenteric artery), aortic isometric contraction, and blood pressure. |
2008-05-29 |
2023-08-12 |
rat |
| A Elizabeth Linder, Jessica Diaz, Wei Ni, Theo Szasz, Robert Burnett, Stephanie W Watt. Vascular reactivity, 5-HT uptake, and blood pressure in the serotonin transporter knockout rat. American journal of physiology. Heart and circulatory physiology. vol 294. issue 4. 2008-05-29. PMID:18263707. |
hplc supported the lack of circulating 5-ht in plasma (ng/ml plasma, wt, 310 +/- 96; and ko, 1.0 +/- 0.5; p < 0.05). |
2008-05-29 |
2023-08-12 |
rat |
| A Elizabeth Linder, Jessica Diaz, Wei Ni, Theo Szasz, Robert Burnett, Stephanie W Watt. Vascular reactivity, 5-HT uptake, and blood pressure in the serotonin transporter knockout rat. American journal of physiology. Heart and circulatory physiology. vol 294. issue 4. 2008-05-29. PMID:18263707. |
in contrast, the potency of 5-ht was increased in the aorta from ko rats compared with wt rats [-log ec(50) (m); wt, 5.71 +/- 0.08; and ko, 6.7 +/- 0.18] and maximum contraction was reduced [%phenylephrine (10 mum) contraction, wt, 113 +/- 6%; and ko, 52 +/- 12%]. |
2008-05-29 |
2023-08-12 |
rat |
| A Elizabeth Linder, Jessica Diaz, Wei Ni, Theo Szasz, Robert Burnett, Stephanie W Watt. Vascular reactivity, 5-HT uptake, and blood pressure in the serotonin transporter knockout rat. American journal of physiology. Heart and circulatory physiology. vol 294. issue 4. 2008-05-29. PMID:18263707. |
5-ht uptake was reduced but not abolished in arteries of the ko compared with the wt rats. |
2008-05-29 |
2023-08-12 |
rat |
| Yohtaro Numachi, Arihisa Ohara, Motoyasu Yamashita, Setsu Fukushima, Hideaki Kobayashi, Harumi Hata, Hidekazu Watanabe, F Scott Hall, Klaus-Peter Lesch, Dennis L Murphy, George R Uhl, Ichiro Sor. Methamphetamine-induced hyperthermia and lethal toxicity: role of the dopamine and serotonin transporters. European journal of pharmacology. vol 572. issue 2-3. 2008-01-14. PMID:17673199. |
we examined the hyperthermic and lethal toxic effects of methamphetamine in dopamine transporter (dat) and/or serotonin transporter (sert) knockout (ko) mice. |
2008-01-14 |
2023-08-12 |
mouse |
| E Sibille, J Su, S Leman, A M Le Guisquet, Y Ibarguen-Vargas, J Joeyen-Waldorf, C Glorioso, G C Tseng, M Pezzone, R Hen, C Belzun. Lack of serotonin1B receptor expression leads to age-related motor dysfunction, early onset of brain molecular aging and reduced longevity. Molecular psychiatry. vol 12. issue 11. 2008-01-09. PMID:17420766. |
we show that the lack of 5-ht(1b)r (htr1b(ko) mice) induced an early age-related motor decline and resulted in decreased longevity. |
2008-01-09 |
2023-08-12 |
mouse |
| José Manuel Trigo, Thibault Renoir, Laurence Lanfumey, Michel Hamon, Klaus-Peter Lesch, Patricia Robledo, Rafael Maldonad. 3,4-methylenedioxymethamphetamine self-administration is abolished in serotonin transporter knockout mice. Biological psychiatry. vol 62. issue 6. 2008-01-02. PMID:17306775. |
the aim of the present study was to determine the contribution of the serotonin transporter (sert) in mdma self-administration behavior by using knockout (ko) mice deficient in sert. |
2008-01-02 |
2023-08-12 |
mouse |
| Katelijne O De Swert, Romain A Lefebvre, Romain A Pauwels, Guy F Joo. Role of the tachykinin NK(1) receptor in mediating contraction to 5-hydroxytryptamine and antigen in the mouse trachea. Pulmonary pharmacology & therapeutics. vol 20. issue 5. 2007-12-27. PMID:16919985. |
we evaluated the role of the tachykinin nk(1) receptor in the contractile response of isolated trachea from tachykinin nk(1) receptor wild type (wt) and knockout (ko) mice, to the antigen ovalbumin and the contractile agonist serotonin (5-hydroxytryptamine). |
2007-12-27 |
2023-08-12 |
mouse |
| L K Heisler, L Zhou, P Bajwa, J Hsu, L H Tecot. Serotonin 5-HT(2C) receptors regulate anxiety-like behavior. Genes, brain, and behavior. vol 6. issue 5. 2007-09-19. PMID:17451451. |
here, we report that the 5-ht(2c) receptor (5-ht(2c)r) subtype is critically involved in regulating behaviors characteristic of anxiety using male 5-ht(2c)r knockout (ko) mice. |
2007-09-19 |
2023-08-12 |
mouse |
| L K Heisler, L Zhou, P Bajwa, J Hsu, L H Tecot. Serotonin 5-HT(2C) receptors regulate anxiety-like behavior. Genes, brain, and behavior. vol 6. issue 5. 2007-09-19. PMID:17451451. |
specific neural substrates underlying the 5-ht(2c)r ko anxiolytic phenotype were investigated, and we report that 5-ht(2c)r ko mice display a selective blunting of extended amygdala corticotropin-releasing hormone neuronal activation in response to anxiety stimuli. |
2007-09-19 |
2023-08-12 |
mouse |