| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Véronique Fabre, Renaud Massart, Adeline Rachalski, Katie Jennings, Andrew Brass, Trevor Sharp, Klaus-Peter Lesch, Laurence Lanfumey, Michel Hamo. Differential gene expression in mutant mice overexpressing or deficient in the serotonin transporter: a focus on urocortin 1. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 21. issue 1. 2011-07-20. PMID:21075611. |
transcriptome analyses were performed in the anterior raphe area of mutant mice deficient in the serotonin transporter (5-htt ko) or overexpressing this protein (5-htt tg), which exhibit opposite changes in anxiety-related behavior. |
2011-07-20 |
2023-08-12 |
mouse |
| Neil Dawson, Linda Ferrington, Klaus-Peter Lesch, Paul A T Kell. Cerebral metabolic responses to 5-HT2A/C receptor activation in mice with genetically modified serotonin transporter (SERT) expression. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 21. issue 1. 2011-07-20. PMID:21093224. |
here we characterise the cerebral metabolic response to 5-ht(2a/c) receptor activation in two transgenic mouse models of altered sert function, sert knock-out (sert ko) and hsert over-expressing (hsert oe) mice, to test the hypothesis that genetically mediated variability in sert expression alters 5-ht(2a/c) function. |
2011-07-20 |
2023-08-12 |
mouse |
| Neil Dawson, Linda Ferrington, Klaus-Peter Lesch, Paul A T Kell. Cerebral metabolic responses to 5-HT2A/C receptor activation in mice with genetically modified serotonin transporter (SERT) expression. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 21. issue 1. 2011-07-20. PMID:21093224. |
we found that a constitutive increase in sert expression (hsert oe) enhanced, whereas a constitutive decrease in sert expression (sert ko) attenuated, 5-ht(2a/c) function. |
2011-07-20 |
2023-08-12 |
mouse |
| Mei Huang, Jin Dai, Herbert Y Meltze. 5-HT(2A) and 5-HT(2C) receptor stimulation are differentially involved in the cortical dopamine efflux-Studied in 5-HT(2A) and 5-HT(2C) genetic mutant mice. European journal of pharmacology. vol 652. issue 1-3. 2011-04-18. PMID:21118683. |
in the 5-ht(2a) mice, the preferential 5-ht(2a) receptor agonist doi (2.5mg/kg, s.c.) induced a slight but significant increase in cortical dopamine efflux only in the wild type (wt) mice; mk-212 (2.5mg/kg) reduced dopamine efflux in both wt and receptor knockout (ko) mice; moreover, mcpp, 2.5mg/kg, had no effect in either types. |
2011-04-18 |
2023-08-12 |
mouse |
| Mei Huang, Jin Dai, Herbert Y Meltze. 5-HT(2A) and 5-HT(2C) receptor stimulation are differentially involved in the cortical dopamine efflux-Studied in 5-HT(2A) and 5-HT(2C) genetic mutant mice. European journal of pharmacology. vol 652. issue 1-3. 2011-04-18. PMID:21118683. |
in 5-ht(2c) mice, doi increased dopamine efflux in both types; while mk-212 decreased dopamine efflux in the wt, but not the receptor ko mice. |
2011-04-18 |
2023-08-12 |
mouse |
| Analía Bortolozzi, Mercè Masana, Llorenç Díaz-Mataix, Roser Cortés, María Cecilia Scorza, Jay A Gingrich, Miklos Toth, Francesc Artiga. Dopamine release induced by atypical antipsychotics in prefrontal cortex requires 5-HT(1A) receptors but not 5-HT(2A) receptors. The international journal of neuropsychopharmacology. vol 13. issue 10. 2011-03-18. PMID:20158933. |
here we tested this hypothesis by examining the dependence of the apd-induced da release in medial pfc (mpfc) on each receptor by using in-vivo microdialysis in wild-type (wt) and 5-ht(1a)r and 5-ht(2a)r knockout (ko) mice. |
2011-03-18 |
2023-08-12 |
mouse |
| Analía Bortolozzi, Mercè Masana, Llorenç Díaz-Mataix, Roser Cortés, María Cecilia Scorza, Jay A Gingrich, Miklos Toth, Francesc Artiga. Dopamine release induced by atypical antipsychotics in prefrontal cortex requires 5-HT(1A) receptors but not 5-HT(2A) receptors. The international journal of neuropsychopharmacology. vol 13. issue 10. 2011-03-18. PMID:20158933. |
local apds (clozapine, olanzapine, risperidone) administered by reverse dialysis induced a dose-dependent increase in mpfc da output equally in wt and 5-ht(2a)r ko mice whereas the da increase was absent in 5-ht(1a)r ko mice. |
2011-03-18 |
2023-08-12 |
mouse |
| A Lockridge, J Su, L L Yua. Abnormal 5-HT modulation of stress behaviors in the Kv4.2 knockout mouse. Neuroscience. vol 170. issue 4. 2011-01-18. PMID:20801198. |
kv4.2 knockout (ko) mice, generated in the 129svev background, demonstrated elevated immobility and a loss of swimming, as well as antidepressant resistance to the selective 5-ht reuptake inhibitor fluoxetine (flx). |
2011-01-18 |
2023-08-12 |
mouse |
| A Lockridge, J Su, L L Yua. Abnormal 5-HT modulation of stress behaviors in the Kv4.2 knockout mouse. Neuroscience. vol 170. issue 4. 2011-01-18. PMID:20801198. |
based on our findings, we hypothesize that kv4.2 ko mice may have an exaggerated 5-ht response to stress leading to a premature desensitization of postsynaptic receptors and a loss of continued behavior modulation. |
2011-01-18 |
2023-08-12 |
mouse |
| Vincent Fournet, Marion Jany, Véronique Fabre, Farah Chali, Didier Orsal, Annie Schweitzer, Annie Andrieux, Fany Messanvi, Bruno Giros, Michel Hamon, Laurence Lanfumey, Jean-Christophe Deloulme, Marie-Pascale Martre. The deletion of the microtubule-associated STOP protein affects the serotonergic mouse brain network. Journal of neurochemistry. vol 115. issue 6. 2011-01-04. PMID:20969568. |
preliminary data showed decreased brain serotonin (5-ht) tissue levels in stop ko mice. |
2011-01-04 |
2023-08-12 |
mouse |
| Vincent Fournet, Marion Jany, Véronique Fabre, Farah Chali, Didier Orsal, Annie Schweitzer, Annie Andrieux, Fany Messanvi, Bruno Giros, Michel Hamon, Laurence Lanfumey, Jean-Christophe Deloulme, Marie-Pascale Martre. The deletion of the microtubule-associated STOP protein affects the serotonergic mouse brain network. Journal of neurochemistry. vol 115. issue 6. 2011-01-04. PMID:20969568. |
as literature data demonstrate various interactions between microtubule-associated proteins and 5-ht, we characterized some features of the serotonergic neurotransmission in stop ko mice. |
2011-01-04 |
2023-08-12 |
mouse |
| Vincent Fournet, Marion Jany, Véronique Fabre, Farah Chali, Didier Orsal, Annie Schweitzer, Annie Andrieux, Fany Messanvi, Bruno Giros, Michel Hamon, Laurence Lanfumey, Jean-Christophe Deloulme, Marie-Pascale Martre. The deletion of the microtubule-associated STOP protein affects the serotonergic mouse brain network. Journal of neurochemistry. vol 115. issue 6. 2011-01-04. PMID:20969568. |
conversely, in projection areas, stop ko mice exhibited lower 5-ht levels and in vivo synthesis rate, associated with severe decreases in 5-ht transporter densities, possibly related to reduced serotonergic terminals. |
2011-01-04 |
2023-08-12 |
mouse |
| Vincent Fournet, Marion Jany, Véronique Fabre, Farah Chali, Didier Orsal, Annie Schweitzer, Annie Andrieux, Fany Messanvi, Bruno Giros, Michel Hamon, Laurence Lanfumey, Jean-Christophe Deloulme, Marie-Pascale Martre. The deletion of the microtubule-associated STOP protein affects the serotonergic mouse brain network. Journal of neurochemistry. vol 115. issue 6. 2011-01-04. PMID:20969568. |
finally, stop ko mice exhibited a reduced anxiety- and, probably, an increased helpness-status, that could be because of the strong imbalance of the serotonin neurotransmission between somas and terminals. |
2011-01-04 |
2023-08-12 |
mouse |
| Claudia Kriegebaum, Ning-Ning Song, Lise Gutknecht, Ying Huang, Angelika Schmitt, Andreas Reif, Yu-Qiang Ding, Klaus-Peter Lesc. Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life. Neurochemistry international. vol 57. issue 5. 2010-12-22. PMID:20599453. |
raphe neurons of a brain-specific constitutive tph2 ko were completely devoid of tph2-positive neurons and, consequently, 5-ht in the brain, and also displayed no compensatory up-regulation of tph1 expression. |
2010-12-22 |
2023-08-12 |
mouse |
| Katie Ann Jennings, Klaus-Peter Lesch, Trevor Sharp, Stephanie Jane Crag. Non-linear relationship between 5-HT transporter gene expression and frequency sensitivity of 5-HT signals. Journal of neurochemistry. vol 115. issue 4. 2010-11-23. PMID:20854367. |
stimulus-evoked [5-ht](o) was detected using fast-scan cyclic voltammetry at carbon-fibre microelectrodes in the substantia nigra in brain slices from 5-htt knockout (ko) and 5-htt over-expressing (oe) mice. |
2010-11-23 |
2023-08-12 |
mouse |
| Katie Ann Jennings, Klaus-Peter Lesch, Trevor Sharp, Stephanie Jane Crag. Non-linear relationship between 5-HT transporter gene expression and frequency sensitivity of 5-HT signals. Journal of neurochemistry. vol 115. issue 4. 2010-11-23. PMID:20854367. |
compared with wild-type (wt) controls, evoked [5-ht](o) was greater in ko and less in oe mice. |
2010-11-23 |
2023-08-12 |
mouse |
| Katie Ann Jennings, Klaus-Peter Lesch, Trevor Sharp, Stephanie Jane Crag. Non-linear relationship between 5-HT transporter gene expression and frequency sensitivity of 5-HT signals. Journal of neurochemistry. vol 115. issue 4. 2010-11-23. PMID:20854367. |
in wt controls, evoked [5-ht](o) was frequency-sensitive; however, in both ko and oe mice, evoked [5-ht](o) showed a striking loss of frequency sensitivity. |
2010-11-23 |
2023-08-12 |
mouse |
| Xiaowei Zhang, Elaine L Bearer, Benoit Boulat, F Scott Hall, George R Uhl, Russell E Jacob. Altered neurocircuitry in the dopamine transporter knockout mouse brain. PloS one. vol 5. issue 7. 2010-10-28. PMID:20634895. |
this is in contradistinction to the state of this circuitry in serotonin transporter ko mice where we observed more robust connectivity in more posterior brain regions using methods identical to those employed here. |
2010-10-28 |
2023-08-12 |
mouse |
| N Uçeyler, M Schütt, F Palm, C Vogel, M Meier, A Schmitt, K-P Lesch, R Mössner, C Somme. Lack of the serotonin transporter in mice reduces locomotor activity and leads to gender-dependent late onset obesity. International journal of obesity (2005). vol 34. issue 4. 2010-10-27. PMID:20084070. |
mice deficient of the serotonin transporter (5-htt ko) mice have a reduced brain serotonin content and develop late-onset obesity. |
2010-10-27 |
2023-08-12 |
mouse |
| Eugene Oh, Takashi Maejima, Chen Liu, Evan Deneris, Stefan Herlitz. Substitution of 5-HT1A receptor signaling by a light-activated G protein-coupled receptor. The Journal of biological chemistry. vol 285. issue 40. 2010-10-26. PMID:20643652. |
finally, rh-ct(5-ht1a) is able to rescue 5-ht(1a) signaling of 5-ht(1a) ko mice in cultured neurons and in slices of the dorsal raphe showing that rh-ct(5-ht1a) is able to functionally compensate for native 5-ht(1a). |
2010-10-26 |
2023-08-12 |
mouse |