| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christine Deisl, Manuel Anderegg, Giuseppe Albano, Benjamin P Lüscher, David Cerny, Rodrigo Soria, Elisa Bouillet, Stefano Rimoldi, Urs Scherrer, Daniel G Fuste. Loss of Sodium/Hydrogen Exchanger NHA2 Exacerbates Obesity- and Aging-Induced Glucose Intolerance in Mice. PloS one. vol 11. issue 9. 2019-11-20. PMID:27685945. |
in contrast, aging was characterized by a gradual increase of nha2 expression in islets, paralleled by an increasing difference in insulin secretion between wt and nha2 ko islets. |
2019-11-20 |
2023-08-13 |
mouse |
| Masashi Satoh, Kazuya Iwabuch. Role of Natural Killer T Cells in the Development of Obesity and Insulin Resistance: Insights From Recent Progress. Frontiers in immunology. vol 9. 2019-11-20. PMID:29942311. |
in this mini-review, we discuss these points considering recent findings from our laboratory and others as well as the role of nkt cells in the development of obesity and insulin resistance based on data obtained from studies on conditional cd1d1 ko and new jα18 ko mice generated through gene editing. |
2019-11-20 |
2023-08-13 |
mouse |
| Andrea Tura, Giovanni Pacini, Yuchiro Yamada, Yutaka Seino, Bo Ahré. Glucagon and insulin secretion, insulin clearance, and fasting glucose in GIP receptor and GLP-1 receptor knockout mice. American journal of physiology. Regulatory, integrative and comparative physiology. vol 316. issue 1. 2019-11-19. PMID:30462524. |
it is not known whether gip receptor and glp-1 receptor knockout (ko) mice have perturbations in glucagon secretion or insulin clearance, and studies on impact on fasting glycemia have previously been inconsistent in these mice. |
2019-11-19 |
2023-08-13 |
mouse |
| Andrea Tura, Giovanni Pacini, Yuchiro Yamada, Yutaka Seino, Bo Ahré. Glucagon and insulin secretion, insulin clearance, and fasting glucose in GIP receptor and GLP-1 receptor knockout mice. American journal of physiology. Regulatory, integrative and comparative physiology. vol 316. issue 1. 2019-11-19. PMID:30462524. |
we therefore studied glucagon secretion after oral whey protein (60 mg) and intravenous arginine (6.25 mg), insulin clearance after intravenous glucose (0.35 g/kg) and fasting glucose, insulin, and glucagon levels after standardized 5-h fasting in female gip receptor and glp-1 receptor ko mice and their wild-type (wt) littermates. |
2019-11-19 |
2023-08-13 |
mouse |
| Andrea Tura, Giovanni Pacini, Yuchiro Yamada, Yutaka Seino, Bo Ahré. Glucagon and insulin secretion, insulin clearance, and fasting glucose in GIP receptor and GLP-1 receptor knockout mice. American journal of physiology. Regulatory, integrative and comparative physiology. vol 316. issue 1. 2019-11-19. PMID:30462524. |
furthermore, the intravenous glucose test revealed normal insulin clearance in both gip receptor and glp-1 receptor ko mice, whereas β-cell glucose sensitivity was enhanced in gip receptor ko mice and reduced in glp-1 receptor ko mice. |
2019-11-19 |
2023-08-13 |
mouse |
| Peiyao Liu, Poshiuan Hsieh, Huitsu Lin, Tejung Liu, Hsuehling Wu, Chengcheung Chen, Yingchuan Che. Grail is involved in adipocyte differentiation and diet-induced obesity. Cell death & disease. vol 9. issue 5. 2019-11-08. PMID:29743578. |
hfd-fed grail ko mice had improved glucose and insulin tolerance. |
2019-11-08 |
2023-08-13 |
mouse |
| Hye-Na Cha, Soyoung Park, Yongwook Dan, Jae-Ryong Kim, So-Young Par. Peroxiredoxin2 Deficiency Aggravates Aging-Induced Insulin Resistance and Declines Muscle Strength. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 74. issue 2. 2019-11-01. PMID:29733327. |
this study examined the role of peroxiredoxin2 (prx2) in aging-induced insulin resistance and reduction in skeletal muscle function in young (2-month-old) and old (24-month-old) prx2 knockout (ko) and wild-type mice. |
2019-11-01 |
2023-08-13 |
mouse |
| Hye-Na Cha, Soyoung Park, Yongwook Dan, Jae-Ryong Kim, So-Young Par. Peroxiredoxin2 Deficiency Aggravates Aging-Induced Insulin Resistance and Declines Muscle Strength. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 74. issue 2. 2019-11-01. PMID:29733327. |
plasma insulin levels increased with aging in prx2 ko mice but not in wild-type mice. |
2019-11-01 |
2023-08-13 |
mouse |
| Hye-Na Cha, Soyoung Park, Yongwook Dan, Jae-Ryong Kim, So-Young Par. Peroxiredoxin2 Deficiency Aggravates Aging-Induced Insulin Resistance and Declines Muscle Strength. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 74. issue 2. 2019-11-01. PMID:29733327. |
insulin sensitivity in the whole-body and skeletal muscle as assessed with the hyperinsulinemic-euglycemic clamp was lower in prx2 ko mice than in wild-type mice in the old group but was not significantly different between the two genotypes in the young group. |
2019-11-01 |
2023-08-13 |
mouse |
| Misa Nakamura, Sachiko Nomura, Tadashi Yamakawa, Ryohei Kono, Akihiro Maeno, Takashi Ozaki, Akitoshi Ito, Toyonobu Uzawa, Hirotoshi Utsunomiya, Kennichi Kakud. Endogenous calcitonin regulates lipid and glucose metabolism in diet-induced obesity mice. Scientific reports. vol 8. issue 1. 2019-10-31. PMID:30451912. |
furthermore, ct ko mice exhibited significantly decreased fat contents in the liver, lipid droplets in adipose tissues, serum glucose, and lipid levels, and significantly increased insulin sensitivity and serum adiponectin levels. |
2019-10-31 |
2023-08-13 |
mouse |
| Steffen H Raun, Mona Ali, Rasmus Kjøbsted, Lisbeth L V Møller, Morten A Federspiel, Erik A Richter, Thomas E Jensen, Lykke Sylo. Rac1 muscle knockout exacerbates the detrimental effect of high-fat diet on insulin-stimulated muscle glucose uptake independently of Akt. The Journal of physiology. vol 596. issue 12. 2019-10-22. PMID:29749029. |
muscle rac1 ko protects against hfd-induced insulin resistance in fat tissue indicating tissue cross-talk. |
2019-10-22 |
2023-08-13 |
mouse |
| Vanessa R Lee, Kevin J Barr, John J Kelly, Danielle Johnston, Cody F C Brown, Kevin P Robb, Samar Sayedyahossein, Kenneth Huang, Robert Gros, Lauren E Flynn, Silvia Penuel. Pannexin 1 regulates adipose stromal cell differentiation and fat accumulation. Scientific reports. vol 8. issue 1. 2019-10-22. PMID:30385873. |
despite having higher fat content, panx1 ko mice on a high fat diet exhibited no differences in weight gain and blood markers of obesity as compared to wt controls, except for an increase in glucose and insulin levels. |
2019-10-22 |
2023-08-13 |
mouse |
| Boyang Zhang, Masanori Nakata, Jun Nakae, Wataru Ogawa, Toshihiko Yad. Central insulin action induces activation of paraventricular oxytocin neurons to release oxytocin into circulation. Scientific reports. vol 8. issue 1. 2019-10-08. PMID:29991705. |
we generated the mice deficient of 3-phosphoinositide-dependent protein kinase-1 (pdk1), a major signaling molecule particularly for insulin, specifically in oxytocin neurons (oxy pdk1 ko). |
2019-10-08 |
2023-08-13 |
mouse |
| Chun-Ling Dai, Jin-Hua Gu, Fei Liu, Khalid Iqbal, Cheng-Xin Gon. Neuronal O-GlcNAc transferase regulates appetite, body weight, and peripheral insulin resistance. Neurobiology of aging. vol 70. 2019-09-27. PMID:29944994. |
here, we report that the camkiiα promoter-dependent neuronal knockout (ko) of ogt in adult mice led to short-term overeating, body weight gain, and peripheral insulin resistance. |
2019-09-27 |
2023-08-13 |
mouse |
| Chun-Ling Dai, Jin-Hua Gu, Fei Liu, Khalid Iqbal, Cheng-Xin Gon. Neuronal O-GlcNAc transferase regulates appetite, body weight, and peripheral insulin resistance. Neurobiology of aging. vol 70. 2019-09-27. PMID:29944994. |
the neuronal ogt ko exacerbated obesity and insulin resistance induced by high-fat diet. |
2019-09-27 |
2023-08-13 |
mouse |
| Chun-Ling Dai, Jin-Hua Gu, Fei Liu, Khalid Iqbal, Cheng-Xin Gon. Neuronal O-GlcNAc transferase regulates appetite, body weight, and peripheral insulin resistance. Neurobiology of aging. vol 70. 2019-09-27. PMID:29944994. |
surprisingly, the peripheral insulin resistance induced by neuronal ogt ko was reversed at its own 2-3 months after ogt ko, and the mice even showed increased insulin sensitivity several months later. |
2019-09-27 |
2023-08-13 |
mouse |
| Daorong Feng, Dulguun Amgalan, Rajat Singh, Jianwen Wei, Jennifer Wen, Tszki Peter Wei, Timothy E McGraw, Richard N Kitsis, Jeffrey E Pessi. SNAP23 regulates BAX-dependent adipocyte programmed cell death independently of canonical macroautophagy. The Journal of clinical investigation. vol 128. issue 9. 2019-09-24. PMID:30102258. |
surprisingly, we observed that adipocyte-specific ko of snap23 in mice resulted in a temporal development of severe generalized lipodystrophy associated with adipose tissue inflammation, insulin resistance, hyperglycemia, liver steatosis, and early death. |
2019-09-24 |
2023-08-13 |
mouse |
| Huimin Zhang, Rufeng Xue, Shasha Zhu, Sicheng Fu, Zuolong Chen, Rongbin Zhou, Zhigang Tian, Li Ba. M2-specific reduction of CD1d switches NKT cell-mediated immune responses and triggers metaflammation in adipose tissue. Cellular & molecular immunology. vol 15. issue 5. 2019-09-13. PMID:28392574. |
with cd1d conditional knockout (ko) mice, we further demonstrated that natural killer t (nkt) cell activation by m2 macrophages inhibited metaflammation and insulin resistance by promoting th2 responses and m2 polarization in visceral adipose tissues of obese mice, whereas nkt cell activation by m1 macrophages exacerbated metaflammation and insulin resistance by promoting th1 responses and inhibiting m2 polarization. |
2019-09-13 |
2023-08-13 |
mouse |
| Hong He, Katie Holl, Sarah DeBehnke, Chay Teng Yeo, Polly Hansen, Abraham K Gebre, Sandra Leone-Kabler, Margarida Ruas, John S Parks, John Parrington, Leah C Solberg Wood. Tpcn2 knockout mice have improved insulin sensitivity and are protected against high-fat diet-induced weight gain. Physiological genomics. vol 50. issue 8. 2019-08-26. PMID:29750602. |
despite the protection against diet-induced weight gain, however, tpcn2 ko mice are not protected against hf-diet-induced changes in glucose or insulin area under the curve during glucose tolerance tests in female mice, while hf diet has no significant effect on glucose tolerance in the male mice, regardless of genotype. |
2019-08-26 |
2023-08-13 |
mouse |
| Hong He, Katie Holl, Sarah DeBehnke, Chay Teng Yeo, Polly Hansen, Abraham K Gebre, Sandra Leone-Kabler, Margarida Ruas, John S Parks, John Parrington, Leah C Solberg Wood. Tpcn2 knockout mice have improved insulin sensitivity and are protected against high-fat diet-induced weight gain. Physiological genomics. vol 50. issue 8. 2019-08-26. PMID:29750602. |
glucose disappearance during an insulin tolerance test is augmented in male ko mice, consistent with our previous findings suggesting enhanced insulin sensitivity in these mice. |
2019-08-26 |
2023-08-13 |
mouse |