| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christelle Douillet, Madelyn C Huang, R Jesse Saunders, Ellen N Dover, Chongben Zhang, Miroslav Stýbl. Knockout of arsenic (+3 oxidation state) methyltransferase is associated with adverse metabolic phenotype in mice: the role of sex and arsenic exposure. Archives of toxicology. vol 91. issue 7. 2018-03-26. PMID:27847981. |
these data suggest that as3mt ko is associated with an adverse metabolic phenotype that is characterized by obesity and insulin resistance, and that the extent of the impairment depends on sex and exposure to ias, including exposure to ias from mouse diet. |
2018-03-26 |
2023-08-13 |
mouse |
| Cong Yao, Xiong Guo, Wan-Xia Yao, Chun Zhan. Cereblon (CRBN) deletion reverses streptozotocin induced diabetic osteoporosis in mice. Biochemical and biophysical research communications. vol 496. issue 3. 2018-02-22. PMID:29353038. |
however, crbn knockout (ko) reduced blood glucose the levels and attenuated insulin resistance. |
2018-02-22 |
2023-08-13 |
mouse |
| Dries Bauters, Pierre Bedossa, Henri Roger Lijnen, Bianca Hemmeryck. Functional role of ADAMTS5 in adiposity and metabolic health. PloS one. vol 13. issue 1. 2018-02-21. PMID:29293679. |
insulin sensitivity was improved in the adamts5-j ko mice, and they were protected against non-alcoholic steatohepatitis in the dio model (as the adamts5-p mice). |
2018-02-21 |
2023-08-13 |
mouse |
| Lijun Li, Marcus Byrd, Kwame Doh, Patrice D Dixon, Hwal Lee, Swasti Tiwari, Carolyn M Ecelbarge. Absence of renal enlargement in fructose-fed proximal-tubule-select insulin receptor (IR), insulin-like-growth factor receptor (IGF1R) double knockout mice. Physiological reports. vol 4. issue 23. 2018-02-01. PMID:27923977. |
to test whether insulin and/or igf1 signaling in the pt is involved in renal structural/functional responses to dietary fructose, we bred mice with dual knockout (ko) of the insulin receptor (ir) and the igf1 receptor (igf1r) in pt by cre-lox recombination, using a γ-glutamyl transferase promoter. |
2018-02-01 |
2023-08-13 |
mouse |
| Louise Mannerås-Holm, Milena Schönke, Joseph T Brozinick, Laurène Vetterli, Hai-Hoang Bui, Philip Sanders, Emmani B M Nascimento, Marie Björnholm, Alexander V Chibalin, Juleen R Zierat. Diacylglycerol kinase ε deficiency preserves glucose tolerance and modulates lipid metabolism in obese mice. Journal of lipid research. vol 58. issue 5. 2017-12-22. PMID:28246337. |
although skeletal muscle insulin sensitivity was unaltered, whole-body respiratory exchange ratio was reduced, and abundance of mitochondrial markers was increased, indicating a greater reliance on fat oxidation and intracellular lipid metabolism in dgkε ko mice. |
2017-12-22 |
2023-08-13 |
mouse |
| Louise Mannerås-Holm, Milena Schönke, Joseph T Brozinick, Laurène Vetterli, Hai-Hoang Bui, Philip Sanders, Emmani B M Nascimento, Marie Björnholm, Alexander V Chibalin, Juleen R Zierat. Diacylglycerol kinase ε deficiency preserves glucose tolerance and modulates lipid metabolism in obese mice. Journal of lipid research. vol 58. issue 5. 2017-12-22. PMID:28246337. |
thus, the increased intracellular lipids in skeletal muscle from dgkε ko mice may undergo rapid turnover because of increased mitochondrial function and lipid oxidation, rather than storage, which in turn may preserve insulin sensitivity. |
2017-12-22 |
2023-08-13 |
mouse |
| Tetsuya Kouno, Nobuteru Akiyama, Kumiko Fujieda, Isamu Nanchi, Tomohiko Okuda, Takanori Iwasaki, Shogo Oka, Hideo Yukiok. Reduced intake of carbohydrate prevents the development of obesity and impaired glucose metabolism in ghrelin O-acyltransferase knockout mice. Peptides. vol 86. 2017-12-19. PMID:27816752. |
when fed a diet rich in maltodextrin, starch and fat for 12 weeks, goat ko mice showed less food intake and weight gain, as well as improved glucose tolerance and insulin sensitivity than wt mice. |
2017-12-19 |
2023-08-13 |
mouse |
| Amber D Lockridge, Daniel C Baumann, Brian Akhaphong, Alleah Abrenica, Robert F Miller, Emilyn U Alejandr. Serine racemase is expressed in islets and contributes to the regulation of glucose homeostasis. Islets. vol 8. issue 6. 2017-11-03. PMID:27880078. |
mice with whole body deletion of srr (srr ko) show improved glucose tolerance through enhanced insulin secretory capacity, possibly through srr-mediated alterations in islet nmdar expression and function. |
2017-11-03 |
2023-08-13 |
mouse |
| Amber D Lockridge, Daniel C Baumann, Brian Akhaphong, Alleah Abrenica, Robert F Miller, Emilyn U Alejandr. Serine racemase is expressed in islets and contributes to the regulation of glucose homeostasis. Islets. vol 8. issue 6. 2017-11-03. PMID:27880078. |
srr expression in neonatal and embryonic islets, and adult deficits in srr ko pancreas weight and islet insulin content, point toward a potential role for srr in pancreatic development. |
2017-11-03 |
2023-08-13 |
mouse |
| Xiaolin Chen, Lili Huang, Hwee Y Tan, Hongzhuo Li, Ying Wan, Michael Cowley, Johannes D Veldhuis, Chen Che. Deficient melanocortin-4 receptor causes abnormal reproductive neuroendocrine profile in female mice. Reproduction (Cambridge, England). vol 153. issue 3. 2017-10-30. PMID:28003536. |
mc4r ko mice were hyperphagic, obese, hyperglycemic, hyperinsulinemic and demonstrated insulin resistance and hepatic steatosis. |
2017-10-30 |
2023-08-13 |
mouse |
| Sun-O Ka, In Hyuk Bang, Eun Ju Bae, Byung-Hyun Par. Hepatocyte-specific sirtuin 6 deletion predisposes to nonalcoholic steatohepatitis by up-regulation of Bach1, an Nrf2 repressor. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 31. issue 9. 2017-10-13. PMID:28536120. |
hfhf-fed ko mice had increased hepatic steatosis and inflammation and aggravated glucose intolerance and insulin resistance compared with wild-type mice. |
2017-10-13 |
2023-08-13 |
mouse |
| Anna Veprik, Dana Laufer, Sara Weiss, Nir Rubins, Michael D Walke. GPR41 modulates insulin secretion and gene expression in pancreatic β-cells and modifies metabolic homeostasis in fed and fasting states. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 30. issue 11. 2017-09-21. PMID:27550964. |
gpr41 gain of function [gpr41-overexpressing transgenic (41 tg) model] and gpr41 loss of function [gpr41-knockout (ko 41) model] resulted in complementary changes in glucose tolerance, without significant effects on insulin sensitivity. |
2017-09-21 |
2023-08-13 |
mouse |
| Anna Veprik, Dana Laufer, Sara Weiss, Nir Rubins, Michael D Walke. GPR41 modulates insulin secretion and gene expression in pancreatic β-cells and modifies metabolic homeostasis in fed and fasting states. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 30. issue 11. 2017-09-21. PMID:27550964. |
ko 41 mice showed fasting hypoglycemia, which was consistent with increased basal and glucose-induced insulin secretion by islets in vitro mirroring this, 41 tg islets showed impaired glucose responsiveness in vitro microarray analysis of islets from 41 tg mice indicated significant alterations in gene expression patterns; several of the altered genes were chosen for further analysis and were also observed to change upon incubation of islets and cultured β-cells with scfas in a gpr41-dependent manner. |
2017-09-21 |
2023-08-13 |
mouse |
| Mariko Sugiyama, Ryoichi Banno, Akira Mizoguchi, Takashi Tominaga, Taku Tsunekawa, Takeshi Onoue, Daisuke Hagiwara, Yoshihiro Ito, Yoshiaki Morishita, Shintaro Iwama, Motomitsu Goto, Hidetaka Suga, Hiroshi Arim. PTP1B deficiency improves hypothalamic insulin sensitivity resulting in the attenuation of AgRP mRNA expression under high-fat diet conditions. Biochemical and biophysical research communications. vol 488. issue 1. 2017-09-21. PMID:28479249. |
in the present study, we investigated the role of ptp1b in hypothalamic insulin signaling using ptp1b deficient (ko) mice in vivo and ex vivo. |
2017-09-21 |
2023-08-13 |
mouse |
| Mariko Sugiyama, Ryoichi Banno, Akira Mizoguchi, Takashi Tominaga, Taku Tsunekawa, Takeshi Onoue, Daisuke Hagiwara, Yoshihiro Ito, Yoshiaki Morishita, Shintaro Iwama, Motomitsu Goto, Hidetaka Suga, Hiroshi Arim. PTP1B deficiency improves hypothalamic insulin sensitivity resulting in the attenuation of AgRP mRNA expression under high-fat diet conditions. Biochemical and biophysical research communications. vol 488. issue 1. 2017-09-21. PMID:28479249. |
for the in vivo study, hypothalamic insulin resistance induced by a high-fat diet (hfd) improved in ko mice compared to wild-type (wt) mice. |
2017-09-21 |
2023-08-13 |
mouse |
| Mariko Sugiyama, Ryoichi Banno, Akira Mizoguchi, Takashi Tominaga, Taku Tsunekawa, Takeshi Onoue, Daisuke Hagiwara, Yoshihiro Ito, Yoshiaki Morishita, Shintaro Iwama, Motomitsu Goto, Hidetaka Suga, Hiroshi Arim. PTP1B deficiency improves hypothalamic insulin sensitivity resulting in the attenuation of AgRP mRNA expression under high-fat diet conditions. Biochemical and biophysical research communications. vol 488. issue 1. 2017-09-21. PMID:28479249. |
in an ex vivo study using hypothalamic organotypic cultures, insulin treatment significantly increased the phosphorylation of both irβ and akt in the hypothalamus of ko mice compared to wt mice, and also significantly decreased agrp mrna expression levels in ko mice. |
2017-09-21 |
2023-08-13 |
mouse |
| Mariko Sugiyama, Ryoichi Banno, Akira Mizoguchi, Takashi Tominaga, Taku Tsunekawa, Takeshi Onoue, Daisuke Hagiwara, Yoshihiro Ito, Yoshiaki Morishita, Shintaro Iwama, Motomitsu Goto, Hidetaka Suga, Hiroshi Arim. PTP1B deficiency improves hypothalamic insulin sensitivity resulting in the attenuation of AgRP mRNA expression under high-fat diet conditions. Biochemical and biophysical research communications. vol 488. issue 1. 2017-09-21. PMID:28479249. |
while incubation with inhibitors of phosphatidylinositol-3 kinase (pi3k) had no effect on basal levels of akt phosphorylation, these suppressed insulin induction of akt phosphorylation to almost basal levels in wt and ko mice. |
2017-09-21 |
2023-08-13 |
mouse |
| Mariko Sugiyama, Ryoichi Banno, Akira Mizoguchi, Takashi Tominaga, Taku Tsunekawa, Takeshi Onoue, Daisuke Hagiwara, Yoshihiro Ito, Yoshiaki Morishita, Shintaro Iwama, Motomitsu Goto, Hidetaka Suga, Hiroshi Arim. PTP1B deficiency improves hypothalamic insulin sensitivity resulting in the attenuation of AgRP mRNA expression under high-fat diet conditions. Biochemical and biophysical research communications. vol 488. issue 1. 2017-09-21. PMID:28479249. |
the inhibition of the pi3k-akt pathway blocked the downregulation of agrp mrna expression in ko mice treated with insulin. |
2017-09-21 |
2023-08-13 |
mouse |
| Andrew C Shin, Nika Filatova, Claudia Lindtner, Tiffany Chi, Seta Degann, Douglas Oberlin, Christoph Buettne. Insulin Receptor Signaling in POMC, but Not AgRP, Neurons Controls Adipose Tissue Insulin Action. Diabetes. vol 66. issue 6. 2017-08-22. PMID:28385803. |
mice lacking the insulin receptor in agrp neurons (agrp ir ko) exhibited impaired hepatic insulin action because the ability of insulin to suppress hepatic glucose production (hgp) was reduced, but the ability of insulin to suppress lipolysis was unaltered. |
2017-08-22 |
2023-08-13 |
mouse |
| Andrew C Shin, Nika Filatova, Claudia Lindtner, Tiffany Chi, Seta Degann, Douglas Oberlin, Christoph Buettne. Insulin Receptor Signaling in POMC, but Not AgRP, Neurons Controls Adipose Tissue Insulin Action. Diabetes. vol 66. issue 6. 2017-08-22. PMID:28385803. |
to the contrary, in pomc ir ko mice, insulin lowered hgp but failed to suppress adipose tissue lipolysis. |
2017-08-22 |
2023-08-13 |
mouse |