| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weiwei An, Zhuzhen Zhang, Liyong Zeng, Ying Yang, Xueliang Zhu, Jiarui W. Cyclin Y Is Involved in the Regulation of Adipogenesis and Lipid Production. PloS one. vol 10. issue 7. 2016-04-19. PMID:26161966. |
furthermore, both hepatocytes and hepg2 cells that were depleted of ccny were insensitive to insulin stimulation, consistent with the significant inhibition of insulin sensitivity in the liver of the ccny ko mice, but no significant changes in wat and muscle, indicating that ccny is involved in regulating the hepatic insulin signaling pathway. |
2016-04-19 |
2023-08-13 |
mouse |
| Jinghong Wang, Zheng Pan, Helene Baribault, Danny Chui, Caroline Gundel, Murielle Vénian. GPR21 KO mice demonstrate no resistance to high fat diet induced obesity or improved glucose tolerance. F1000Research. vol 5. 2016-04-15. PMID:27081476. |
gpr21 ko mice generated with gpr21 ko es cells obtained from deltagen showed improved glucose tolerance and insulin sensitivity when fed a high fat diet. |
2016-04-15 |
2023-08-13 |
mouse |
| Heather L Armata, Sally Chamberland, Lauren Watts, Hwi Jin Ko, Yongjin Lee, Dae Young Jung, Jason K Kim, Hayla K Slus. Deficiency of the tumor promoter gene wip1 induces insulin resistance. Molecular endocrinology (Baltimore, Md.). vol 29. issue 1. 2016-03-24. PMID:25379953. |
initial characterization of insulin signaling in wip1 knockout (wip1(ko)) murine embryo fibroblasts demonstrated reduced insulin-mediated ak mouse transforming activation. |
2016-03-24 |
2023-08-13 |
mouse |
| Heather L Armata, Sally Chamberland, Lauren Watts, Hwi Jin Ko, Yongjin Lee, Dae Young Jung, Jason K Kim, Hayla K Slus. Deficiency of the tumor promoter gene wip1 induces insulin resistance. Molecular endocrinology (Baltimore, Md.). vol 29. issue 1. 2016-03-24. PMID:25379953. |
wip1(ko) mice exhibited glucose intolerance and insulin intolerance on a lfd and hfd. |
2016-03-24 |
2023-08-13 |
mouse |
| Heather L Armata, Sally Chamberland, Lauren Watts, Hwi Jin Ko, Yongjin Lee, Dae Young Jung, Jason K Kim, Hayla K Slus. Deficiency of the tumor promoter gene wip1 induces insulin resistance. Molecular endocrinology (Baltimore, Md.). vol 29. issue 1. 2016-03-24. PMID:25379953. |
wip1(ko) mice on a lfd develop hepatic insulin resistance, whereas this is not observed in hfd-fed mice. |
2016-03-24 |
2023-08-13 |
mouse |
| Heather L Armata, Sally Chamberland, Lauren Watts, Hwi Jin Ko, Yongjin Lee, Dae Young Jung, Jason K Kim, Hayla K Slus. Deficiency of the tumor promoter gene wip1 induces insulin resistance. Molecular endocrinology (Baltimore, Md.). vol 29. issue 1. 2016-03-24. PMID:25379953. |
we propose that this increased inflammation triggers insulin resistance in wip1(ko) mice on lfd and hfd. |
2016-03-24 |
2023-08-13 |
mouse |
| David J Herren, David J Herre, J Blake Norman, Ruchi Anderson, Michel L Tremblay, Anne-Cecile Huby, Eric J Belin de Chantemèl. Deletion of Protein Tyrosine Phosphatase 1B (PTP1B) Enhances Endothelial Cyclooxygenase 2 Expression and Protects Mice from Type 1 Diabetes-Induced Endothelial Dysfunction. PloS one. vol 10. issue 5. 2016-02-23. PMID:25974252. |
after 28 days of t1dm, ko mice exhibited a similar reduction in body weight and plasma insulin levels and a comparable increase in glycemia (wt: 384 ± 20 vs. ko: 432 ± 29 mg/dl), cholesterol and triglycerides, as wt mice. |
2016-02-23 |
2023-08-13 |
mouse |
| Cristal M Hill, Oge Arum, Ravneet K Boparai, Feiya Wang, Yimin Fang, Liou Y Sun, Michal M Masternak, Andrzej Bartk. Female PAPP-A knockout mice are resistant to metabolic dysfunction induced by high-fat/high-sucrose feeding at middle age. Age (Dordrecht, Netherlands). vol 37. issue 3. 2016-01-13. PMID:25953669. |
papp-a ko mice fed hfhs diet for 10 weeks were more glucose tolerant and had enhanced insulin sensitivity compared to normal mice fed hfhs diet. |
2016-01-13 |
2023-08-13 |
mouse |
| Bilun Ke, Zhiyun Zhao, Xin Ye, Zhanguo Gao, Vincent Manganiello, Bin Wu, Jianping Y. Inactivation of NF-κB p65 (RelA) in Liver Improves Insulin Sensitivity and Inhibits cAMP/PKA Pathway. Diabetes. vol 64. issue 10. 2016-01-04. PMID:26038580. |
to test nf-κb in the control of hepatic insulin sensitivity, we inactivated nf-κb in the livers of c57bl/6 mice through deletion of the p65 gene, which was achieved by crossing floxed-p65 and alb-cre mice to generate l-p65-knockout (ko) mice. |
2016-01-04 |
2023-08-13 |
mouse |
| M Ramdas, C Harel, M Armoni, E Karniel. AHNAK KO mice are protected from diet-induced obesity but are glucose intolerant. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 47. issue 4. 2015-12-15. PMID:25153686. |
however, ko mice exhibited higher fasting glucose levels, impaired glucose tolerance, and diminished serum insulin levels on either diet. |
2015-12-15 |
2023-08-13 |
mouse |
| M Ramdas, C Harel, M Armoni, E Karniel. AHNAK KO mice are protected from diet-induced obesity but are glucose intolerant. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 47. issue 4. 2015-12-15. PMID:25153686. |
concomitantly, ko mice on hfd displayed defects in insulin signaling, as evident from reduced akt phosphorylation and decreased cellular glucose transporter (glut4) levels. |
2015-12-15 |
2023-08-13 |
mouse |
| M Ramdas, C Harel, M Armoni, E Karniel. AHNAK KO mice are protected from diet-induced obesity but are glucose intolerant. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 47. issue 4. 2015-12-15. PMID:25153686. |
taken together, these data demonstrate that (a) ahnak is involved in glucose homeostasis and weight balance (b) under normal feeding ko mice are insulin sensitive yet insulin deficient; and (c) ahnak deletion protects against hfd-induced obesity, but not against hfd-induced insulin resistance and glucose intolerance in vivo. |
2015-12-15 |
2023-08-13 |
mouse |
| Yuriko Mishima, Yo Shinoda, Tetsushi Sadakata, Masami Kojima, Shigeharu Wakana, Teiichi Furuich. Lack of stress responses to long-term effects of corticosterone in Caps2 knockout mice. Scientific reports. vol 5. 2015-12-09. PMID:25754523. |
caps2 knockout (ko) mice exhibit decreased body weight, reduced glucose-induced insulin release, and abnormal psychiatric behaviors. |
2015-12-09 |
2023-08-13 |
mouse |
| Yuriko Mishima, Yo Shinoda, Tetsushi Sadakata, Masami Kojima, Shigeharu Wakana, Teiichi Furuich. Lack of stress responses to long-term effects of corticosterone in Caps2 knockout mice. Scientific reports. vol 5. 2015-12-09. PMID:25754523. |
we chronically administered the stress hormone corticosterone (cort), which induces anxiety/depressive-like behavior and normally increases plasma insulin levels, via the drinking water for 10 weeks, and we examined the stress response in ko mice. |
2015-12-09 |
2023-08-13 |
mouse |
| Yuriko Mishima, Yo Shinoda, Tetsushi Sadakata, Masami Kojima, Shigeharu Wakana, Teiichi Furuich. Lack of stress responses to long-term effects of corticosterone in Caps2 knockout mice. Scientific reports. vol 5. 2015-12-09. PMID:25754523. |
moreover, serum insulin and leptin levels were increased in cort-treated wt mice, but not in ko mice. |
2015-12-09 |
2023-08-13 |
mouse |
| Eric R Prossnitz, Helen J Hathawa. What have we learned about GPER function in physiology and disease from knockout mice? The Journal of steroid biochemistry and molecular biology. vol 153. 2015-12-07. PMID:26189910. |
however, the study of gper ko mice over the last six years has revealed that gper deficiency results in multiple physiological alterations including obesity, cardiovascular dysfunction, insulin resistance and glucose intolerance. |
2015-12-07 |
2023-08-13 |
mouse |
| W Y So, Q Cheng, A Xu, K S L Lam, P S Leun. Loss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in mice. Cell death & disease. vol 6. 2015-11-30. PMID:25811804. |
furthermore, distorted islet morphology and impaired gsis were observed in ko mice, suggestive of islet dysfunction, whereas the enhanced insulin expression and impaired gsis in fgf21-ko mouse islets could be reversed by blockade of gh signaling. |
2015-11-30 |
2023-08-13 |
mouse |
| João Paulo G Camporez, Mohamed Asrih, Dongyan Zhang, Mario Kahn, Varman T Samuel, Michael J Jurczak, François R Jornayva. Hepatic insulin resistance and increased hepatic glucose production in mice lacking Fgf21. The Journal of endocrinology. vol 226. issue 3. 2015-11-20. PMID:26203166. |
to address the role of fgf21 in hepatic insulin resistance, we assessed insulin action in fgf21 whole-body knock-out (fgf21 ko) male mice and their littermate wt controls fed a kd. |
2015-11-20 |
2023-08-13 |
mouse |
| João Paulo G Camporez, Mohamed Asrih, Dongyan Zhang, Mario Kahn, Varman T Samuel, Michael J Jurczak, François R Jornayva. Hepatic insulin resistance and increased hepatic glucose production in mice lacking Fgf21. The Journal of endocrinology. vol 226. issue 3. 2015-11-20. PMID:26203166. |
here, we report that fgf21 ko mice have hepatic insulin resistance and increased hepatic glucose production associated with an increase in plasma glucagon levels. |
2015-11-20 |
2023-08-13 |
mouse |
| Louise Lantier, Ashley S Williams, Ian M Williams, Karen K Yang, Deanna P Bracy, Mickael Goelzer, Freyja D James, David Gius, David H Wasserma. SIRT3 Is Crucial for Maintaining Skeletal Muscle Insulin Action and Protects Against Severe Insulin Resistance in High-Fat-Fed Mice. Diabetes. vol 64. issue 9. 2015-11-17. PMID:25948682. |
insulin action was not impaired in the lean sirt3 ko mice. |
2015-11-17 |
2023-08-13 |
mouse |