| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Veronica Bellisario, Alessandra Berry, Sara Capoccia, Carla Raggi, Pamela Panetta, Igor Branchi, Giovanni Piccaro, Marco Giorgio, Pier G Pelicci, Francesca Cirull. Gender-dependent resiliency to stressful and metabolic challenges following prenatal exposure to high-fat diet in the p66(Shc-/-) mouse. Frontiers in behavioral neuroscience. vol 8. 2014-09-09. PMID:25202246. |
ko mice were overall characterized by metabolic resiliency, showing a blunted change in glycemia levels in response to glucose or insulin challenges. |
2014-09-09 |
2023-08-13 |
mouse |
| Ben Zhou, Yi Zhang, Fang Zhang, Yulei Xia, Jun Liu, Rui Huang, Yuangao Wang, Yanan Hu, Jingxia Wu, Changgui Dai, Hui Wang, Yanyang Tu, Xiaozhong Peng, Yiqian Wang, Qiwei Zha. CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1. Hepatology (Baltimore, Md.). vol 59. issue 6. 2014-08-08. PMID:24442997. |
moreover, circadian change of insulin sensitivity is impaired in clock mutant, liver-specific bmal1 knockout (ko) or sirt1 ko mice, and clock and bmal1 are required for hepatic circadian expression of sirt1. |
2014-08-08 |
2023-08-12 |
mouse |
| Min Jung Kwon, Tae-Jin Ju, Jung-Yoon Heo, Yong-Woon Kim, Jong-Yeon Kim, Kyu-Chang Won, Jae-Ryong Kim, Young Kyung Bae, In-Sun Park, Bon-Hong Min, In-Kyu Lee, So-Young Par. Deficiency of clusterin exacerbates high-fat diet-induced insulin resistance in male mice. Endocrinology. vol 155. issue 6. 2014-06-30. PMID:24684302. |
the present study examined the role of clusterin in insulin resistance in high fat-fed wild-type and clusterin knockout (ko) mice. |
2014-06-30 |
2023-08-12 |
mouse |
| Min Jung Kwon, Tae-Jin Ju, Jung-Yoon Heo, Yong-Woon Kim, Jong-Yeon Kim, Kyu-Chang Won, Jae-Ryong Kim, Young Kyung Bae, In-Sun Park, Bon-Hong Min, In-Kyu Lee, So-Young Par. Deficiency of clusterin exacerbates high-fat diet-induced insulin resistance in male mice. Endocrinology. vol 155. issue 6. 2014-06-30. PMID:24684302. |
in an ip glucose tolerance test, the area under the curve for glucose was not different, whereas the area under the curve for insulin was higher in clusterin ko mice. |
2014-06-30 |
2023-08-12 |
mouse |
| Min Jung Kwon, Tae-Jin Ju, Jung-Yoon Heo, Yong-Woon Kim, Jong-Yeon Kim, Kyu-Chang Won, Jae-Ryong Kim, Young Kyung Bae, In-Sun Park, Bon-Hong Min, In-Kyu Lee, So-Young Par. Deficiency of clusterin exacerbates high-fat diet-induced insulin resistance in male mice. Endocrinology. vol 155. issue 6. 2014-06-30. PMID:24684302. |
in a hyperinsulinemic-euglycemic clamp, the clamp insulin levels were higher in clusterin ko mice after the high-fat diet. |
2014-06-30 |
2023-08-12 |
mouse |
| Min Jung Kwon, Tae-Jin Ju, Jung-Yoon Heo, Yong-Woon Kim, Jong-Yeon Kim, Kyu-Chang Won, Jae-Ryong Kim, Young Kyung Bae, In-Sun Park, Bon-Hong Min, In-Kyu Lee, So-Young Par. Deficiency of clusterin exacerbates high-fat diet-induced insulin resistance in male mice. Endocrinology. vol 155. issue 6. 2014-06-30. PMID:24684302. |
after adjusting for the clamp insulin levels, the glucose infusion rate, suppression of hepatic glucose production, and glucose uptake were lower in clusterin ko mice in the high fat-fed group. |
2014-06-30 |
2023-08-12 |
mouse |
| Min Jung Kwon, Tae-Jin Ju, Jung-Yoon Heo, Yong-Woon Kim, Jong-Yeon Kim, Kyu-Chang Won, Jae-Ryong Kim, Young Kyung Bae, In-Sun Park, Bon-Hong Min, In-Kyu Lee, So-Young Par. Deficiency of clusterin exacerbates high-fat diet-induced insulin resistance in male mice. Endocrinology. vol 155. issue 6. 2014-06-30. PMID:24684302. |
akt phosphorylation by insulin was reduced in the hepatocytes of clusterin ko mice. |
2014-06-30 |
2023-08-12 |
mouse |
| Tan Hooi Min Grahn, Rajween Kaur, Jun Yin, Martina Schweiger, Vishva Mitra Sharma, Mi-Jeong Lee, Yasuo Ido, Cynthia M Smas, Rudolf Zechner, Achim Lass, Vishwajeet Pur. Fat-specific protein 27 (FSP27) interacts with adipose triglyceride lipase (ATGL) to regulate lipolysis and insulin sensitivity in human adipocytes. The Journal of biological chemistry. vol 289. issue 17. 2014-06-25. PMID:24627478. |
in embryonic fibroblasts derived from atgl ko mice, exogenous free fatty acids did not affect insulin sensitivity. |
2014-06-25 |
2023-08-12 |
mouse |
| Ho-Seong Ki. Role of insulin-like growth factor binding protein-3 in glucose and lipid metabolism. Annals of pediatric endocrinology & metabolism. vol 18. issue 1. 2014-06-24. PMID:24904844. |
igfbp-3 knockout (ko) mice exhibited normal insulin level and glucose response after glucose challenge. |
2014-06-24 |
2023-08-13 |
mouse |
| Ho-Seong Ki. Role of insulin-like growth factor binding protein-3 in glucose and lipid metabolism. Annals of pediatric endocrinology & metabolism. vol 18. issue 1. 2014-06-24. PMID:24904844. |
more recent study in igfbp-3 ko mice with a high-fat diet demonstrated that igfbp-3 ko mice exhibited elevated fasting glucose and insulin, but normal response to glucose challenge, suggesting that igfbp-3 ko mice may induce insulin resistance even though preserved insulin sensitivity. |
2014-06-24 |
2023-08-13 |
mouse |
| Juan Jose Ramos-Rodriguez, Oscar Ortiz, Margarita Jimenez-Palomares, Kevin R Kay, Esther Berrocoso, Maria Isabel Murillo-Carretero, German Perdomo, Tara Spires-Jones, Irene Cozar-Castellano, Alfonso Maria Lechuga-Sancho, Monica Garcia-Alloz. Differential central pathology and cognitive impairment in pre-diabetic and diabetic mice. Psychoneuroendocrinology. vol 38. issue 11. 2014-06-13. PMID:23790682. |
in the present study we analyzed central nervous system (cns) morphological and functional consequences of long-term insulin resistance and t2d in db/db mice (leptin receptor ko mice). |
2014-06-13 |
2023-08-12 |
mouse |
| Richard M O'Brie. Moving on from GWAS: functional studies on the G6PC2 gene implicated in the regulation of fasting blood glucose. Current diabetes reports. vol 13. issue 6. 2014-06-12. PMID:24142592. |
this conclusion is supported by studies on g6pc2 knockout (ko) mice showing that g6pc2 represents a negative regulator of basal glucose-stimulated insulin secretion that acts by hydrolyzing glucose-6-phosphate, thereby reducing glycolytic flux and opposing the action of glucokinase. |
2014-06-12 |
2023-08-12 |
mouse |
| Arijeet K Gattu, Andreas L Birkenfeld, Yasuko Iwakiri, Steven Jay, Mark Saltzman, Jennifer Doll, Petr Protiva, Varman T Samuel, Susan E Crawford, Chuhan Chun. Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling. Endocrinology. vol 155. issue 4. 2014-05-19. PMID:24456163. |
in vivo, pedf restoration reduced hyperglycemia and improved hepatic insulin signaling in pedf ko mice. |
2014-05-19 |
2023-08-12 |
mouse |
| Anna M D'souza, Ali Asadi, James D Johnson, Scott D Covey, Timothy J Kieffe. Leptin deficiency in rats results in hyperinsulinemia and impaired glucose homeostasis. Endocrinology. vol 155. issue 4. 2014-05-19. PMID:24467741. |
islets from 12-week-old ko rats secreted more insulin when stimulated than islets from wt littermates. |
2014-05-19 |
2023-08-12 |
mouse |
| Xin-An Wang, Ran Zhang, Zhi-Gang She, Xiao-Fei Zhang, Ding-Sheng Jiang, Tao Wang, Lu Gao, Wei Deng, Shu-Min Zhang, Li-Hua Zhu, Sen Guo, Ke Chen, Xiao-Dong Zhang, De-Pei Liu, Hongliang L. Interferon regulatory factor 3 constrains IKKβ/NF-κB signaling to alleviate hepatic steatosis and insulin resistance. Hepatology (Baltimore, Md.). vol 59. issue 3. 2014-04-28. PMID:24123166. |
the global knockout (ko) of irf3 significantly promotes chronic high-fat diet (hfd)-induced hepatic insulin resistance and steatosis; in contrast, adenoviral-mediated hepatic irf3 overexpression preserves glucose and lipid homeostasis. |
2014-04-28 |
2023-08-12 |
mouse |
| Xin-An Wang, Ran Zhang, Zhi-Gang She, Xiao-Fei Zhang, Ding-Sheng Jiang, Tao Wang, Lu Gao, Wei Deng, Shu-Min Zhang, Li-Hua Zhu, Sen Guo, Ke Chen, Xiao-Dong Zhang, De-Pei Liu, Hongliang L. Interferon regulatory factor 3 constrains IKKβ/NF-κB signaling to alleviate hepatic steatosis and insulin resistance. Hepatology (Baltimore, Md.). vol 59. issue 3. 2014-04-28. PMID:24123166. |
importantly, inhibitor of nuclear factor kappa b kinase beta subunit / nuclear factor kappa b (ikkβ/nf-κb) signaling is repressed by irf3, and hepatic overexpression of the inhibitor of κb-α (iκbα) reverses hfd-induced insulin resistance and steatosis in irf3 ko mice. |
2014-04-28 |
2023-08-12 |
mouse |
| Xuemei Shi, Fuguo Zhou, Xiaojie Li, Benny Chang, Depei Li, Yi Wang, Qingchun Tong, Yong Xu, Makoto Fukuda, Jean J Zhao, Defa Li, Douglas G Burrin, Lawrence Chan, Xinfu Gua. Central GLP-2 enhances hepatic insulin sensitivity via activating PI3K signaling in POMC neurons. Cell metabolism. vol 18. issue 1. 2014-03-18. PMID:23823479. |
central glp-2 suppresses basal hgp and enhances insulin sensitivity, which are abolished in pomc-p110α ko mice. |
2014-03-18 |
2023-08-12 |
mouse |
| Jessica Drost, David Nonis, Florian Eich, Oliver Leske, Ewa Damrath, Ewout R Brunt, Isabel Lastres-Becker, Rolf Heumann, Joachim Nowock, Georg Auburge. Ataxin-2 modulates the levels of Grb2 and SRC but not ras signaling. Journal of molecular neuroscience : MN. vol 51. issue 1. 2014-03-12. PMID:23335000. |
conversely, atxn2 knockout (ko) mice show hypertrophy and insulin resistance. |
2014-03-12 |
2023-08-12 |
mouse |
| Mini P Sajan, Michael J Jurzak, Varman T Samuels, Gerald I Shulman, Ursula Braun, Michael Leitges, Robert V Fares. Impairment of insulin-stimulated glucose transport and ERK activation by adipocyte-specific knockout of PKC-λ produces a phenotype characterized by diminished adiposity and enhanced insulin suppression of hepatic gluconeogenesis. Adipocyte. vol 3. issue 1. 2014-02-27. PMID:24575365. |
tissue-specific knockout (ko) of atypical protein kinase c-λ (pkc-λ) impairs insulin-stimulated glucose transport in muscle (m) and lipid synthesis in liver (l), thereby producing insulin resistance in mλko mice and insulin-hypersensitivity in lλko mice. |
2014-02-27 |
2023-08-12 |
mouse |
| Juan Carlos Alvarez-Perez, Sara Ernst, Cem Demirci, Gabriella P Casinelli, Jose Manuel D Mellado-Gil, Francisco Rausell-Palamos, Rupangi C Vasavada, Adolfo Garcia-Ocañ. Hepatocyte growth factor/c-Met signaling is required for β-cell regeneration. Diabetes. vol 63. issue 1. 2014-02-24. PMID:24089510. |
importantly, pancmet ko mice showed significantly diminished β-cell mass, decreased glucose tolerance, and impaired insulin secretion compared with wt mice 28 days post-ppx. |
2014-02-24 |
2023-08-12 |
mouse |