| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lynley D Pound, James K Oeser, Tracy P O'Brien, Yingda Wang, Chandler J Faulman, Prasanna K Dadi, David A Jacobson, John C Hutton, Owen P McGuinness, Masakazu Shiota, Richard M O'Brie. G6PC2: a negative regulator of basal glucose-stimulated insulin secretion. Diabetes. vol 62. issue 5. 2013-06-28. PMID:23274894. |
g6pc2 deletion had little effect on insulin sensitivity and glucose tolerance, whereas body fat was reduced in female g6pc2 knockout (ko) mice on both a chow and high-fat diet, observations that are all consistent with human gwas data. |
2013-06-28 |
2023-08-12 |
mouse |
| Lynley D Pound, James K Oeser, Tracy P O'Brien, Yingda Wang, Chandler J Faulman, Prasanna K Dadi, David A Jacobson, John C Hutton, Owen P McGuinness, Masakazu Shiota, Richard M O'Brie. G6PC2: a negative regulator of basal glucose-stimulated insulin secretion. Diabetes. vol 62. issue 5. 2013-06-28. PMID:23274894. |
as a consequence, under fasting conditions in which plasma insulin levels were identical, blood glucose levels were reduced in g6pc2 ko mice, again consistent with human gwas data. |
2013-06-28 |
2023-08-12 |
mouse |
| Yoshinori Nagai, Yasuharu Watanabe, Kiyoshi Takats. The TLR family protein RP105/MD-1 complex: A new player in obesity and adipose tissue inflammation. Adipocyte. vol 2. issue 2. 2013-06-28. PMID:23805400. |
recently, we reported that rp105 knockout (ko) or md-1 ko mice have less high-fat diet (hfd)-induced obesity, adipose tissue inflammation and insulin resistance than wild-type (wt) or tlr4 ko mice. |
2013-06-28 |
2023-08-12 |
mouse |
| Christoffer Clemmensen, Sanela Smajilovic, Andreas N Madsen, Anders B Klein, Birgitte Holst, Hans Bräuner-Osborn. Increased susceptibility to diet-induced obesity in GPRC6A receptor knockout mice. The Journal of endocrinology. vol 217. issue 2. 2013-06-19. PMID:23428581. |
moreover, diet-induced obese gprc6a ko mice had increased circulating insulin and leptin levels relative to wt animals, thereby demonstrating that endocrine abnormalities associate with the reported disturbances in energy balance. |
2013-06-19 |
2023-08-12 |
mouse |
| Yuji Nakamura, Takanori Kanai, Keita Saeki, Miho Takabe, Junichiro Irie, Jun Miyoshi, Yohei Mikami, Toshiaki Teratani, Takahiro Suzuki, Naoteru Miyata, Tadakazu Hisamatsu, Nobuhiro Nakamoto, Yoshiyuki Yamagishi, Hajime Higuchi, Hirotoshi Ebinuma, Shigenari Hozawa, Hidetsugu Saito, Hiroshi Itoh, Toshifumi Hib. CCR2 knockout exacerbates cerulein-induced chronic pancreatitis with hyperglycemia via decreased GLP-1 receptor expression and insulin secretion. American journal of physiology. Gastrointestinal and liver physiology. vol 304. issue 8. 2013-06-17. PMID:23449669. |
acute cerulein-administered ccr2-knockout (ko) mice showed suppressed infiltration of cd11b(+)gr-1(low) macrophages and pancreatic inflammation and significantly upregulated insulin secretion compared with paired wild-type (wt) mice. |
2013-06-17 |
2023-08-12 |
mouse |
| Yun Sok Lee, Hidetaka Morinaga, Jane J Kim, William Lagakos, Susan Taylor, Malik Keshwani, Guy Perkins, Hui Dong, Ayse G Kayali, Ian R Sweet, Jerrold Olefsk. The fractalkine/CX3CR1 system regulates β cell function and insulin secretion. Cell. vol 153. issue 2. 2013-06-17. PMID:23582329. |
cx3cr1 knockout (ko) mice exhibited a marked defect in glucose and glp1-stimulated insulin secretion, and this defect was also observed in vitro in isolated islets from cx3cr1 ko mice. |
2013-06-17 |
2023-08-12 |
mouse |
| Seung-Hoon Yeo, Jung-Ran Noh, Yong-Hoon Kim, Gil-Tae Gang, Sang-Woo Kim, Kyoung-Shim Kim, Jung Hwan Hwang, Minho Shong, Chul-Ho Le. Increased vulnerability to β-cell destruction and diabetes in mice lacking NAD(P)H:quinone oxidoreductase 1. Toxicology letters. vol 219. issue 1. 2013-05-23. PMID:23458895. |
nqo1 knockout (ko) mice showed hyperglycemia, body weight loss, impaired glucose clearance rate and a lower plasma insulin level after mlds treatment. |
2013-05-23 |
2023-08-12 |
mouse |
| Seung-Hoon Yeo, Jung-Ran Noh, Yong-Hoon Kim, Gil-Tae Gang, Sang-Woo Kim, Kyoung-Shim Kim, Jung Hwan Hwang, Minho Shong, Chul-Ho Le. Increased vulnerability to β-cell destruction and diabetes in mice lacking NAD(P)H:quinone oxidoreductase 1. Toxicology letters. vol 219. issue 1. 2013-05-23. PMID:23458895. |
moreover, β-cell mass and pancreatic insulin content were significantly lower in ko mice than in wild-type (wt) mice after mlds treatment. |
2013-05-23 |
2023-08-12 |
mouse |
| Li Yuan, Ying Wang, Chunli Lu, Xiaoya L. Angiotensin-Converting Enzyme 2 Deficiency Aggravates Glucose Intolerance via Impairment of Islet Microvascular Density in Mice with High-Fat Diet. Journal of diabetes research. vol 2013. 2013-05-15. PMID:23671869. |
there was no difference of body weight, area under curve of glucose (aucg), area under curve of insulin from 0 to 5 min (augi0-5), mvd, and rvc (relative content of vegf) between wt and ace2 ko mice with regular chow diet. |
2013-05-15 |
2023-08-12 |
mouse |
| Tolunay Beker Aydemir, Shou-Mei Chang, Gregory J Guthrie, Alyssa B Maki, Moon-Suhn Ryu, Afife Karabiyik, Robert J Cousin. Zinc transporter ZIP14 functions in hepatic zinc, iron and glucose homeostasis during the innate immune response (endotoxemia). PloS one. vol 7. issue 10. 2013-04-26. PMID:23110240. |
the zip14 ko mice exhibited decreased circulating il-6 with increased hepatic socs-3 following lps, suggesting socs-3 inhibited insulin signaling which produced the hypoglycemia in this genotype. |
2013-04-26 |
2023-08-12 |
mouse |
| Lijun Li, R Mayuri Garikepati, Susanna Tsukerman, Donald Kohan, James B Wade, Swasti Tiwari, Carolyn M Ecelbarge. Reduced ENaC activity and blood pressure in mice with genetic knockout of the insulin receptor in the renal collecting duct. American journal of physiology. Renal physiology. vol 304. issue 3. 2013-03-25. PMID:23195676. |
chronic insulin infusion reduced heart rate in the wt, but not in the ko, and modestly reduced bp in the wt only. |
2013-03-25 |
2023-08-12 |
mouse |
| Jodi F Evans, Shahidul Islam, Yoshihiro Urade, Naomi Eguchi, Louis Ragoli. The lipocalin-type prostaglandin D2 synthase knockout mouse model of insulin resistance and obesity demonstrates early hypothalamic-pituitary-adrenal axis hyperactivity. The Journal of endocrinology. vol 216. issue 2. 2013-03-11. PMID:23151358. |
because the lipocalin-type prostaglandin d(2) synthase (l-pgds) knockout (ko) mouse is a model of accelerated insulin resistance, glucose intolerance, and obesity, it was further hypothesized that hpa activity would be greater in this model. |
2013-03-11 |
2023-08-12 |
mouse |
| Jihong Lian, Enhui Wei, Shu Pei Wang, Ariel D Quiroga, Lena Li, Alba Di Pardo, Jelske van der Veen, Simonetta Sipione, Grant A Mitchell, Richard Lehne. Liver specific inactivation of carboxylesterase 3/triacylglycerol hydrolase decreases blood lipids without causing severe steatosis in mice. Hepatology (Baltimore, Md.). vol 56. issue 6. 2013-02-28. PMID:22707181. |
augmented hepatic tg levels in chow-fed l-tgh ko mice did not affect glucose tolerance or glucose production from hepatocytes, but impaired insulin tolerance was observed in female mice. |
2013-02-28 |
2023-08-12 |
mouse |
| Lucia A Seale, Ann C Hashimoto, Suguru Kurokawa, Christy L Gilman, Ali Seyedali, Frederick P Bellinger, Arjun V Raman, Marla J Berr. Disruption of the selenocysteine lyase-mediated selenium recycling pathway leads to metabolic syndrome in mice. Molecular and cellular biology. vol 32. issue 20. 2013-01-03. PMID:22890841. |
insulin challenge of scly ko mice results in attenuated akt phosphorylation but does not decrease phosphorylation levels of amp kinase alpha (ampkα). |
2013-01-03 |
2023-08-12 |
mouse |
| Liping Huang, Catherine P Kirschke, Yu-An E Lay, Lauren B Levy, Danielle E Lamirande, Patrick H Zhan. Znt7-null mice are more susceptible to diet-induced glucose intolerance and insulin resistance. The Journal of biological chemistry. vol 287. issue 40. 2012-12-14. PMID:22854958. |
the activity of the insulin signaling pathway was down-regulated in myocytes isolated from the femoral muscle of znt7 knock-out (ko) mice. |
2012-12-14 |
2023-08-12 |
mouse |
| Liping Huang, Catherine P Kirschke, Yu-An E Lay, Lauren B Levy, Danielle E Lamirande, Patrick H Zhan. Znt7-null mice are more susceptible to diet-induced glucose intolerance and insulin resistance. The Journal of biological chemistry. vol 287. issue 40. 2012-12-14. PMID:22854958. |
insulin tolerance tests showed that male znt7 ko mice were insulin-resistant. |
2012-12-14 |
2023-08-12 |
mouse |
| Liping Huang, Catherine P Kirschke, Yu-An E Lay, Lauren B Levy, Danielle E Lamirande, Patrick H Zhan. Znt7-null mice are more susceptible to diet-induced glucose intolerance and insulin resistance. The Journal of biological chemistry. vol 287. issue 40. 2012-12-14. PMID:22854958. |
diet-induced insulin resistance in male znt7 ko mice was paralleled by a reduction in mrna expression of insr, irs2, and akt1 in the primary skeletal myotubes isolated from the ko mice. |
2012-12-14 |
2023-08-12 |
mouse |
| Liping Huang, Catherine P Kirschke, Yu-An E Lay, Lauren B Levy, Danielle E Lamirande, Patrick H Zhan. Znt7-null mice are more susceptible to diet-induced glucose intolerance and insulin resistance. The Journal of biological chemistry. vol 287. issue 40. 2012-12-14. PMID:22854958. |
we conclude that a combination of decreased insulin secretion and increased insulin resistance accounts for the glucose intolerance observed in znt7 ko mice. |
2012-12-14 |
2023-08-12 |
mouse |
| Barbara C Fam, Laura J Rose, Rebecca Sgambellone, Zheng Ruan, Joseph Proietto, Sofianos Andrikopoulo. Normal muscle glucose uptake in mice deficient in muscle GLUT4. The Journal of endocrinology. vol 214. issue 3. 2012-12-10. PMID:22736482. |
basally, plasma glucose and plasma insulin were significantly lower in the ko compared with control mice, which conferred normal glucose tolerance. |
2012-12-10 |
2023-08-12 |
mouse |
| Barbara C Fam, Laura J Rose, Rebecca Sgambellone, Zheng Ruan, Joseph Proietto, Sofianos Andrikopoulo. Normal muscle glucose uptake in mice deficient in muscle GLUT4. The Journal of endocrinology. vol 214. issue 3. 2012-12-10. PMID:22736482. |
high-fat feeding did not alter glucose tolerance in the ko mice but led to elevated plasma insulin levels during the glucose tolerance test. |
2012-12-10 |
2023-08-12 |
mouse |