| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Gustavsson, T Seah, Y Lao, G K Radda, T C Südhof, W Ha. Delayed onset of hyperglycaemia in a mouse model with impaired glucagon secretion demonstrates that dysregulated glucagon secretion promotes hyperglycaemia and type 2 diabetes. Diabetologia. vol 54. issue 2. 2011-05-02. PMID:20978738. |
in this study, we tested the relative contribution of dysregulated glucagon secretion and reduced insulin release in the development of hyperglycaemia and type 2 diabetes by using synaptotagmin-7 knockout (ko) mice, which exhibit glucose intolerance, reduced insulin secretion and nearly abolished ca(2+)-stimulated glucagon secretion. |
2011-05-02 |
2023-08-12 |
mouse |
| Goji Hasegaw. Decreased senescence marker protein-30 could be a factor that contributes to the worsening of glucose tolerance in normal aging. Islets. vol 2. issue 4. 2011-03-31. PMID:21099321. |
insulin levels in sd-fed ko mice were significantly decreased by 37% at 30 min postglucose compared to sd-fed wt mice. |
2011-03-31 |
2023-08-12 |
mouse |
| Goji Hasegaw. Decreased senescence marker protein-30 could be a factor that contributes to the worsening of glucose tolerance in normal aging. Islets. vol 2. issue 4. 2011-03-31. PMID:21099321. |
interestingly, an insulin tolerance test showed a greater glucose lowering effect in sd-fed ko mice. |
2011-03-31 |
2023-08-12 |
mouse |
| Goji Hasegaw. Decreased senescence marker protein-30 could be a factor that contributes to the worsening of glucose tolerance in normal aging. Islets. vol 2. issue 4. 2011-03-31. PMID:21099321. |
collectively, these data indicate that impairment of the early phase of insulin secretion underlies glucose intolerance in ko mice. |
2011-03-31 |
2023-08-12 |
mouse |
| Gregory R Steinberg, Hayley M O'Neill, Nicolas L Dzamko, Sandra Galic, Tim Naim, René Koopman, Sebastian B Jørgensen, Jane Honeyman, Kimberly Hewitt, Zhi-Ping Chen, Jonathan D Schertzer, John W Scott, Frank Koentgen, Gordon S Lynch, Matthew J Watt, Bryce J W van Denderen, Duncan J Campbell, Bruce E Kem. Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity. The Journal of biological chemistry. vol 285. issue 48. 2010-12-30. PMID:20855892. |
we generated c57bl/6 mice with germline deletion of ampk β2 (β2 ko) and examined ampk expression and activity, exercise capacity, metabolic control during muscle contractions, aminoimidazole carboxamide ribonucleotide (aicar) sensitivity, and susceptibility to obesity-induced insulin resistance. |
2010-12-30 |
2023-08-12 |
mouse |
| Pengxiang She, Yingsheng Zhou, Zhiyou Zhang, Kathleen Griffin, Kavitha Gowda, Christopher J Lync. Disruption of BCAA metabolism in mice impairs exercise metabolism and endurance. Journal of applied physiology (Bethesda, Md. : 1985). vol 108. issue 4. 2010-11-16. PMID:20133434. |
their plasma lactate and lactate-to-pyruvate ratio in skeletal muscle during exercise and lactate release from hindlimb perfused with high concentrations of insulin and glucose were significantly higher in ko than wild-type (wt) mice. |
2010-11-16 |
2023-08-12 |
mouse |
| Thaddeus T Schug, Qing Xu, Huiming Gao, Ashwin Peres-da-Silva, David W Draper, Michael B Fessler, Aparna Purushotham, Xiaoling L. Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress. Molecular and cellular biology. vol 30. issue 19. 2010-11-15. PMID:20647536. |
consistent with increased proinflammatory gene expression, mac-sirt1 ko mice challenged with a high-fat diet display high levels of activated macrophages in liver and adipose tissue, predisposing the animals to development of systemic insulin resistance and metabolic derangement. |
2010-11-15 |
2023-08-12 |
mouse |
| Min Lu, PingPing Li, Jan Pferdekamper, WuQiang Fan, Maziyar Saberi, Simon Schenk, Jerrold M Olefsk. Inducible nitric oxide synthase deficiency in myeloid cells does not prevent diet-induced insulin resistance. Molecular endocrinology (Baltimore, Md.). vol 24. issue 7. 2010-09-23. PMID:20444886. |
when mice were treated with the inos inhibitor, n6-(1-iminoethyl)-l-lysine hydrochloride (l-nil), we observed a significant and comparable improvement of glucose homeostasis and insulin sensitivity in both wild-type and inos bmt ko mice. |
2010-09-23 |
2023-08-12 |
mouse |
| Erik J Zmuda, Ling Qi, Michael X Zhu, Raghavendra G Mirmira, Marc R Montminy, Tsonwin Ha. The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction. Molecular endocrinology (Baltimore, Md.). vol 24. issue 7. 2010-09-23. PMID:20519332. |
however, atf3 deficiency significantly reduced serum insulin levels in the ko mice without affecting insulin sensitivity, suggesting reduced beta-cell function in the ko mice. |
2010-09-23 |
2023-08-12 |
mouse |
| Erik J Zmuda, Ling Qi, Michael X Zhu, Raghavendra G Mirmira, Marc R Montminy, Tsonwin Ha. The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction. Molecular endocrinology (Baltimore, Md.). vol 24. issue 7. 2010-09-23. PMID:20519332. |
analyses using ins-1 cells and primary islets support the notion that this defect is due, at least partly, to reduced insulin gene transcription in the ko islets without detectable reduction in glucose-induced calcium influx, a critical step for insulin secretion. |
2010-09-23 |
2023-08-12 |
mouse |
| Ana B Ropero, Sergi Soriano, Eva Tudurí, Laura Marroquí, Noelia Téllez, Birgit Gassner, Pablo Juan-Picó, Eduard Montanya, Ivan Quesada, Michaela Kuhn, Angel Nada. The atrial natriuretic peptide and guanylyl cyclase-A system modulates pancreatic beta-cell function. Endocrinology. vol 151. issue 8. 2010-09-08. PMID:20555029. |
pancreatic islets from gc-a ko mice responded to increasing glucose concentrations with enhanced insulin secretion compared with wild type (wt). |
2010-09-08 |
2023-08-12 |
mouse |
| Ana B Ropero, Sergi Soriano, Eva Tudurí, Laura Marroquí, Noelia Téllez, Birgit Gassner, Pablo Juan-Picó, Eduard Montanya, Ivan Quesada, Michaela Kuhn, Angel Nada. The atrial natriuretic peptide and guanylyl cyclase-A system modulates pancreatic beta-cell function. Endocrinology. vol 151. issue 8. 2010-09-08. PMID:20555029. |
remarkably, islets from gc-a ko mice were smaller, presented lower beta-cell mass and decreased insulin content. |
2010-09-08 |
2023-08-12 |
mouse |
| Ana B Ropero, Sergi Soriano, Eva Tudurí, Laura Marroquí, Noelia Téllez, Birgit Gassner, Pablo Juan-Picó, Eduard Montanya, Ivan Quesada, Michaela Kuhn, Angel Nada. The atrial natriuretic peptide and guanylyl cyclase-A system modulates pancreatic beta-cell function. Endocrinology. vol 151. issue 8. 2010-09-08. PMID:20555029. |
glucose and insulin tolerance tests were similar in wt and gc-a ko mice. |
2010-09-08 |
2023-08-12 |
mouse |
| Vicent Ribas, M T Audrey Nguyen, Darren C Henstridge, Anh-Khoi Nguyen, Simon W Beaven, Matthew J Watt, Andrea L Hevene. Impaired oxidative metabolism and inflammation are associated with insulin resistance in ERalpha-deficient mice. American journal of physiology. Endocrinology and metabolism. vol 298. issue 2. 2010-09-01. PMID:19920214. |
in addition, fasting insulin, leptin, and pai-1 levels were markedly elevated, whereas adiponectin levels were reduced in normal chow-fed ko. |
2010-09-01 |
2023-08-12 |
mouse |
| Vicent Ribas, M T Audrey Nguyen, Darren C Henstridge, Anh-Khoi Nguyen, Simon W Beaven, Matthew J Watt, Andrea L Hevene. Impaired oxidative metabolism and inflammation are associated with insulin resistance in ERalpha-deficient mice. American journal of physiology. Endocrinology and metabolism. vol 298. issue 2. 2010-09-01. PMID:19920214. |
although the relative glucose intolerance and insulin resistance phenotype in ko mice became more severe with high-fat feeding, wt mice were refractory to these dietary-induced effects, and this protection coincided with a marked increase in circulating adiponectin and heat shock protein 72 levels in muscle, liver, and fat. |
2010-09-01 |
2023-08-12 |
mouse |
| Winifred P S Wong, Joseph P Tiano, Suhuan Liu, Sylvia C Hewitt, Cedric Le May, Stéphane Dalle, John A Katzenellenbogen, Benita S Katzenellenbogen, Kenneth S Korach, Franck Mauvais-Jarvi. Extranuclear estrogen receptor-alpha stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 29. 2010-09-01. PMID:20616010. |
whereas 17beta-estradiol (e2) treatment up-regulates pancreatic insulin gene and protein content in control eralpha lox/lox mice, these e2 effects are abolished in peralpha ko(-/-) mice. |
2010-09-01 |
2023-08-12 |
mouse |
| Pengcheng Luo, Hsin-Hsin Chang, Yiqiang Zhou, Shali Zhang, Sung Hee Hwang, Christophe Morisseau, Cong-Yi Wang, Edward W Inscho, Bruce D Hammock, Mong-Heng Wan. Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis. The Journal of pharmacology and experimental therapeutics. vol 334. issue 2. 2010-08-17. PMID:20439437. |
we used two separate approaches, targeted disruption of ephx2 gene [seh knockout (ko)] and a selective inhibitor of seh [trans-4-[4-(3-adamantan-1-ylureido)-cyclohexyloxy]-benzoic acid (t-aucb)], to assess the role of seh in glucose and insulin homeostasis in streptozotocin (stz) mice. |
2010-08-17 |
2023-08-12 |
mouse |
| Pengcheng Luo, Hsin-Hsin Chang, Yiqiang Zhou, Shali Zhang, Sung Hee Hwang, Christophe Morisseau, Cong-Yi Wang, Edward W Inscho, Bruce D Hammock, Mong-Heng Wan. Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis. The Journal of pharmacology and experimental therapeutics. vol 334. issue 2. 2010-08-17. PMID:20439437. |
we also examined the effects of seh ko or t-aucb on glucose-stimulated insulin secretion (gsis) and intracellular calcium levels in islets. |
2010-08-17 |
2023-08-12 |
mouse |
| Pengcheng Luo, Hsin-Hsin Chang, Yiqiang Zhou, Shali Zhang, Sung Hee Hwang, Christophe Morisseau, Cong-Yi Wang, Edward W Inscho, Bruce D Hammock, Mong-Heng Wan. Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis. The Journal of pharmacology and experimental therapeutics. vol 334. issue 2. 2010-08-17. PMID:20439437. |
more important, when insulin levels were assessed by hyperglycemic clamp study, seh ko was found to promote insulin secretion. |
2010-08-17 |
2023-08-12 |
mouse |
| Niamh X Cawley, Tulin Yanik, Alicja Woronowicz, Weizhong Chang, Joan C Marini, Y Peng Lo. Obese carboxypeptidase E knockout mice exhibit multiple defects in peptide hormone processing contributing to low bone mineral density. American journal of physiology. Endocrinology and metabolism. vol 299. issue 2. 2010-07-21. PMID:20460579. |
studies on cpe knockout (ko) mice revealed poor prohormone processing, resulting in deficiencies in peptide hormones/neuropeptides such as insulin, gonadotropin-releasing hormone, and cocaine- and amphetamine-regulated transcript (cart). |
2010-07-21 |
2023-08-12 |
mouse |