| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katrina MacAulay, Bradley W Doble, Satish Patel, Tanya Hansotia, Elaine M Sinclair, Daniel J Drucker, Andras Nagy, James R Woodget. Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism. Cell metabolism. vol 6. issue 4. 2007-12-06. PMID:17908561. |
we conclude that gsk-3 isoforms exhibit tissue-specific physiological functions and that gsk-3alpha ko mice are insulin sensitive, reinforcing the potential of gsk-3 as a therapeutic target for type ii diabetes. |
2007-12-06 |
2023-08-12 |
mouse |
| Hiroaki Moriyama, Masao Nagata, Takashi Arai, Yasuyo Okumachi, Katsumi Yamada, Reiko Kotani, Hisafumi Yasuda, Kenta Hara, Koich Yokon. Insulin as a T cell antigen in type 1 diabetes supported by the evidence from the insulin knockout NOD mice. Diabetes research and clinical practice. vol 77 Suppl 1. 2007-11-13. PMID:17459508. |
we have established insulin 1 or insulin 2 knockout (ko) non-obese diabetic (nod) colonies in the animal institute of kobe university and evaluated anti-insulin autoimmunity. |
2007-11-13 |
2023-08-12 |
mouse |
| Bart M De Taeye, Tatiana Novitskaya, Owen P McGuinness, Linda Gleaves, Mousumi Medda, Joseph W Covington, Douglas E Vaugha. Macrophage TNF-alpha contributes to insulin resistance and hepatic steatosis in diet-induced obesity. American journal of physiology. Endocrinology and metabolism. vol 293. issue 3. 2007-10-24. PMID:17578885. |
tnf-alpha(-/-) -->ko mice exhibited enhanced insulin sensitivity compared with that observed in tnf-alpha(+/+)-->ko mice; remarkably, no protection against insulin resistance was provided by transplanting tnf-alpha(-/-) bone marrow in wt mice compared with tnf-alpha(+/+)-->wt. |
2007-10-24 |
2023-08-12 |
mouse |
| Bart M De Taeye, Tatiana Novitskaya, Owen P McGuinness, Linda Gleaves, Mousumi Medda, Joseph W Covington, Douglas E Vaugha. Macrophage TNF-alpha contributes to insulin resistance and hepatic steatosis in diet-induced obesity. American journal of physiology. Endocrinology and metabolism. vol 293. issue 3. 2007-10-24. PMID:17578885. |
the preserved insulin sensitivity seen in tnf-alpha(-/-)-->ko mice provided protection against the development of hepatic steatosis. |
2007-10-24 |
2023-08-12 |
mouse |
| Jackson Souza-Menezes, Marcelo M Morales, Deepali N Tukaye, Sandra E Guggino, William B Guggin. Absence of ClC5 in knockout mice leads to glycosuria, impaired renal glucose handling and low proximal tubule GLUT2 protein expression. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 20. issue 5. 2007-09-27. PMID:17762172. |
we observed that, the blood glucose concentration (n=12, p<0.01) and the fractional excretion of glucose and insulin (n=6, p<0.05) were higher in ko mice. |
2007-09-27 |
2023-08-12 |
mouse |
| Jackson Souza-Menezes, Marcelo M Morales, Deepali N Tukaye, Sandra E Guggino, William B Guggin. Absence of ClC5 in knockout mice leads to glycosuria, impaired renal glucose handling and low proximal tubule GLUT2 protein expression. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 20. issue 5. 2007-09-27. PMID:17762172. |
however, no peripheral tissue insulin resistance was observed following an intraperitoneal injection of insulin (n=9) in the ko mice. |
2007-09-27 |
2023-08-12 |
mouse |
| Jackson Souza-Menezes, Marcelo M Morales, Deepali N Tukaye, Sandra E Guggino, William B Guggin. Absence of ClC5 in knockout mice leads to glycosuria, impaired renal glucose handling and low proximal tubule GLUT2 protein expression. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 20. issue 5. 2007-09-27. PMID:17762172. |
elisa analysis demonstrated low plasma insulin concentrations after a 12 hour fasting period and also following glucose injection in ko mice. |
2007-09-27 |
2023-08-12 |
mouse |
| Jackson Souza-Menezes, Marcelo M Morales, Deepali N Tukaye, Sandra E Guggino, William B Guggin. Absence of ClC5 in knockout mice leads to glycosuria, impaired renal glucose handling and low proximal tubule GLUT2 protein expression. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 20. issue 5. 2007-09-27. PMID:17762172. |
the total insulin released during a 2 hour period following glucose challenge was significantly lower in ko mice (n=6, p<0.05). |
2007-09-27 |
2023-08-12 |
mouse |
| Jackson Souza-Menezes, Marcelo M Morales, Deepali N Tukaye, Sandra E Guggino, William B Guggin. Absence of ClC5 in knockout mice leads to glycosuria, impaired renal glucose handling and low proximal tubule GLUT2 protein expression. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 20. issue 5. 2007-09-27. PMID:17762172. |
our results suggest that low plasma insulin concentration together with renal function changes observed in ko mice significantly contribute towards the glucose intolerance and documented glycosuria observed in this animal. |
2007-09-27 |
2023-08-12 |
mouse |
| Arend Bonen, Xiao-Xia Han, Daphna D J Habets, Maria Febbraio, Jan F C Glatz, Joost J F P Luike. A null mutation in skeletal muscle FAT/CD36 reveals its essential role in insulin- and AICAR-stimulated fatty acid metabolism. American journal of physiology. Endocrinology and metabolism. vol 292. issue 6. 2007-07-30. PMID:17264223. |
in general, in muscles of ko mice, 1) insulin sensitivity and 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (aicar) sensitivity were normal, 2) key enzymes involved in fatty acid oxidation were altered minimally or not at all, and 3) except for an increase in soleus muscle fatp1 and fatp4, these fatty acid transporters were not altered in red and white gastrocnemius muscles, whereas plasma membrane-bound fatty acid binding protein was not altered in any muscle. |
2007-07-30 |
2023-08-12 |
mouse |
| Arend Bonen, Xiao-Xia Han, Daphna D J Habets, Maria Febbraio, Jan F C Glatz, Joost J F P Luike. A null mutation in skeletal muscle FAT/CD36 reveals its essential role in insulin- and AICAR-stimulated fatty acid metabolism. American journal of physiology. Endocrinology and metabolism. vol 292. issue 6. 2007-07-30. PMID:17264223. |
in ko muscles perfused under basal conditions (i.e., no insulin, no aicar), rates of hindquarter fatty acid oxidation were reduced by 26%. |
2007-07-30 |
2023-08-12 |
mouse |
| Arend Bonen, Xiao-Xia Han, Daphna D J Habets, Maria Febbraio, Jan F C Glatz, Joost J F P Luike. A null mutation in skeletal muscle FAT/CD36 reveals its essential role in insulin- and AICAR-stimulated fatty acid metabolism. American journal of physiology. Endocrinology and metabolism. vol 292. issue 6. 2007-07-30. PMID:17264223. |
when muscles were perfused with insulin, the net increase in fatty acid esterification was threefold greater in the oxidative muscles of wt mice compared with the oxidative muscles in ko mice. |
2007-07-30 |
2023-08-12 |
mouse |
| Martin G Latour, Thierry Alquier, Elizabeth Oseid, Caroline Tremblay, Thomas L Jetton, Jian Luo, Daniel C-H Lin, Vincent Poitou. GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo. Diabetes. vol 56. issue 4. 2007-07-19. PMID:17395749. |
to this aim, we generated gpr40 knockout (ko) mice and examined glucose homeostasis, insulin secretion in response to glucose and intralipid in vivo, and insulin secretion in vitro after short- and long-term exposure to fatty acids. |
2007-07-19 |
2023-08-12 |
mouse |
| Martin G Latour, Thierry Alquier, Elizabeth Oseid, Caroline Tremblay, Thomas L Jetton, Jian Luo, Daniel C-H Lin, Vincent Poitou. GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo. Diabetes. vol 56. issue 4. 2007-07-19. PMID:17395749. |
our results show that gpr40 ko mice have essentially normal glucose tolerance and insulin secretion in response to glucose. |
2007-07-19 |
2023-08-12 |
mouse |
| Martin G Latour, Thierry Alquier, Elizabeth Oseid, Caroline Tremblay, Thomas L Jetton, Jian Luo, Daniel C-H Lin, Vincent Poitou. GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo. Diabetes. vol 56. issue 4. 2007-07-19. PMID:17395749. |
islets from gpr40 ko mice were as sensitive to fatty acid inhibition of insulin secretion upon prolonged exposure as islets from wild-type animals. |
2007-07-19 |
2023-08-12 |
mouse |
| Lola Rahib, Nicole K MacLennan, Steve Horvath, James C Liao, Katrina M Dippl. Glycerol kinase deficiency alters expression of genes involved in lipid metabolism, carbohydrate metabolism, and insulin signaling. European journal of human genetics : EJHG. vol 15. issue 6. 2007-07-16. PMID:17406644. |
to define gk's role in insulin resistance, we examined gene expression in brown adipose tissue in a glycerol kinase knockout (ko) mouse model using microarray analysis. |
2007-07-16 |
2023-08-12 |
mouse |
| Michal M Masternak, Khalid A Al-Regaiey, Marc Michael Del Rosario Lim, Vanesa Jimenez-Ortega, Jacob A Panici, Michael S Bonkowski, John J Kopchick, Zhihui Wang, Andrzej Bartk. Caloric restriction and growth hormone receptor knockout: effects on expression of genes involved in insulin action in the heart. Experimental gerontology. vol 41. issue 4. 2007-06-11. PMID:16524678. |
we examined expression of genes involved in insulin action, ir, irs1, irs2, igf1, igf1r, glut4, ppars and rxrs in the hearts of normal and ghr-/- (ko) mice fed ad libitum or subjected to 30% caloric restriction (cr). |
2007-06-11 |
2023-08-12 |
mouse |
| Decheng Ren, Yingjiang Zhou, David Morris, Minghua Li, Zhiqin Li, Liangyou Ru. Neuronal SH2B1 is essential for controlling energy and glucose homeostasis. The Journal of clinical investigation. vol 117. issue 2. 2007-04-04. PMID:17235396. |
systemic deletion of the sh2b1 gene resulted in metabolic disorders in sh2b1(ko) mice, including hyperlipidemia, leptin resistance, hyperphagia, obesity, hyperglycemia, insulin resistance, and glucose intolerance. |
2007-04-04 |
2023-08-12 |
mouse |
| Olivier Le Bacquer, Emmanuel Petroulakis, Sabina Paglialunga, Francis Poulin, Denis Richard, Katherine Cianflone, Nahum Sonenber. Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2. The Journal of clinical investigation. vol 117. issue 2. 2007-04-04. PMID:17273556. |
increased insulin resistance in 4e-bp1 and 4e-bp2 double ko mice was associated with increased ribosomal protein s6 kinase (s6k) activity and impairment of akt signaling in muscle, liver, and adipose tissue. |
2007-04-04 |
2023-08-12 |
mouse |
| Stephen J Lolait, Lesley Q Stewart, David S Jessop, W Scott Young, Anne-Marie O'Carrol. The hypothalamic-pituitary-adrenal axis response to stress in mice lacking functional vasopressin V1b receptors. Endocrinology. vol 148. issue 2. 2007-02-27. PMID:17122081. |
to investigate the role of avp in the hypothalamic-pituitary-adrenal axis response to stress, we measured plasma acth and corticosterone (cort) levels in avpr1b knockout (ko) mice and wild-type controls in response to two acute (restraint and insulin administration) and one form of chronic (daily restraint for 14 d) stress. |
2007-02-27 |
2023-08-12 |
mouse |