| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhanguo Gao, Zhong Wang, Xiaoying Zhang, Andrew A Butler, Aamir Zuberi, Barbara Gawronska-Kozak, Michael Lefevre, David York, Eric Ravussin, Hans-Rudolf Berthoud, Owen McGuinness, William T Cefalu, Jianping Y. Inactivation of PKCtheta leads to increased susceptibility to obesity and dietary insulin resistance in mice. American journal of physiology. Endocrinology and metabolism. vol 292. issue 1. 2007-02-16. PMID:16896164. |
at 8 wk on hfd, severe insulin resistance was detected in the ko mice with hyperinsulinemic euglycemic clamp and insulin tolerance test. |
2007-02-16 |
2023-08-12 |
mouse |
| Zhanguo Gao, Zhong Wang, Xiaoying Zhang, Andrew A Butler, Aamir Zuberi, Barbara Gawronska-Kozak, Michael Lefevre, David York, Eric Ravussin, Hans-Rudolf Berthoud, Owen McGuinness, William T Cefalu, Jianping Y. Inactivation of PKCtheta leads to increased susceptibility to obesity and dietary insulin resistance in mice. American journal of physiology. Endocrinology and metabolism. vol 292. issue 1. 2007-02-16. PMID:16896164. |
insulin action in both hepatic and peripheral tissues was reduced in the ko mice. |
2007-02-16 |
2023-08-12 |
mouse |
| Young Hun Choi, Sunhee Park, Steven Hockman, Emilia Zmuda-Trzebiatowska, Fredrik Svennelid, Martin Haluzik, Oksana Gavrilova, Faiyaz Ahmad, Laurent Pepin, Maria Napolitano, Masato Taira, Frank Sundler, Lena Stenson Holst, Eva Degerman, Vincent C Manganiell. Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice. The Journal of clinical investigation. vol 116. issue 12. 2007-01-22. PMID:17143332. |
glucose, alone or in combination with glucagon-like peptide-1, increased insulin secretion more in isolated pancreatic ko islets, although islet size and morphology and immunoreactive insulin and glucagon levels were unchanged. |
2007-01-22 |
2023-08-12 |
mouse |
| Young Hun Choi, Sunhee Park, Steven Hockman, Emilia Zmuda-Trzebiatowska, Fredrik Svennelid, Martin Haluzik, Oksana Gavrilova, Faiyaz Ahmad, Laurent Pepin, Maria Napolitano, Masato Taira, Frank Sundler, Lena Stenson Holst, Eva Degerman, Vincent C Manganiell. Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice. The Journal of clinical investigation. vol 116. issue 12. 2007-01-22. PMID:17143332. |
the beta(3)-adrenergic agonist cl 316,243 (cl) increased lipolysis and serum insulin more in ko mice, but blood glucose reduction was less in cl-treated ko mice. |
2007-01-22 |
2023-08-12 |
mouse |
| Young Hun Choi, Sunhee Park, Steven Hockman, Emilia Zmuda-Trzebiatowska, Fredrik Svennelid, Martin Haluzik, Oksana Gavrilova, Faiyaz Ahmad, Laurent Pepin, Maria Napolitano, Masato Taira, Frank Sundler, Lena Stenson Holst, Eva Degerman, Vincent C Manganiell. Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice. The Journal of clinical investigation. vol 116. issue 12. 2007-01-22. PMID:17143332. |
insulin resistance was observed in ko mice, with liver an important site of alterations in insulin-sensitive glucose production. |
2007-01-22 |
2023-08-12 |
mouse |
| Young Hun Choi, Sunhee Park, Steven Hockman, Emilia Zmuda-Trzebiatowska, Fredrik Svennelid, Martin Haluzik, Oksana Gavrilova, Faiyaz Ahmad, Laurent Pepin, Maria Napolitano, Masato Taira, Frank Sundler, Lena Stenson Holst, Eva Degerman, Vincent C Manganiell. Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice. The Journal of clinical investigation. vol 116. issue 12. 2007-01-22. PMID:17143332. |
in ko mice, liver triglyceride and camp contents were increased, and the liver content and phosphorylation states of several insulin signaling, gluconeogenic, and inflammation- and stress-related components were altered. |
2007-01-22 |
2023-08-12 |
mouse |
| Kirsten Dahl, Karsten Buschard, Dorte X Gram, Anthony J F d'Apice, Axel K Hanse. Glucose intolerance in a xenotransplantation model: studies in alpha-gal knockout mice. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. vol 114. issue 11. 2007-01-11. PMID:17078862. |
here we report for the first time that alpha-gt ko mice have impaired glucose tolerance (p<0.001) and decreased insulin sensitivity (p<0.0001). |
2007-01-11 |
2023-08-12 |
mouse |
| Suresh T Mathews, Sanjay Rakhade, Xiaohua Zhou, Graham C Parker, Donald V Coscina, George Grunberge. Fetuin-null mice are protected against obesity and insulin resistance associated with aging. Biochemical and biophysical research communications. vol 350. issue 2. 2006-12-04. PMID:17011519. |
earlier we have shown that fetuin-null (ko) mice demonstrate improved insulin sensitivity and resistance to diet-induced obesity. |
2006-12-04 |
2023-08-12 |
mouse |
| Suresh T Mathews, Sanjay Rakhade, Xiaohua Zhou, Graham C Parker, Donald V Coscina, George Grunberge. Fetuin-null mice are protected against obesity and insulin resistance associated with aging. Biochemical and biophysical research communications. vol 350. issue 2. 2006-12-04. PMID:17011519. |
since aging is associated with insulin resistance and impaired glucose handling, we tested the hypothesis that fetuin-null (ko) mice are resilient to changes in insulin sensitivity associated with aging. |
2006-12-04 |
2023-08-12 |
mouse |
| Suresh T Mathews, Sanjay Rakhade, Xiaohua Zhou, Graham C Parker, Donald V Coscina, George Grunberge. Fetuin-null mice are protected against obesity and insulin resistance associated with aging. Biochemical and biophysical research communications. vol 350. issue 2. 2006-12-04. PMID:17011519. |
in comparison to wt mice, fetuin ko mice demonstrated a lower fasting insulin resistance index, and significantly lower blood glucose and insulin levels, following a 4h fast. |
2006-12-04 |
2023-08-12 |
mouse |
| Suresh T Mathews, Sanjay Rakhade, Xiaohua Zhou, Graham C Parker, Donald V Coscina, George Grunberge. Fetuin-null mice are protected against obesity and insulin resistance associated with aging. Biochemical and biophysical research communications. vol 350. issue 2. 2006-12-04. PMID:17011519. |
an insulin tolerance test confirmed the increased insulin sensitivity of aged fetuin ko mice. |
2006-12-04 |
2023-08-12 |
mouse |
| Yun Ning, Alwin G P Schuller, Sheri Bradshaw, Peter Rotwein, Thomas Ludwig, Jan Frystyk, John E Pinta. Diminished growth and enhanced glucose metabolism in triple knockout mice containing mutations of insulin-like growth factor binding protein-3, -4, and -5. Molecular endocrinology (Baltimore, Md.). vol 20. issue 9. 2006-09-28. PMID:16675541. |
metabolically, triple ko mice showed normal insulin tolerance, but a 37% expansion (p < 0.05) of beta-cell number and significantly increased insulin secretion after glucose challenge, which leads to enhanced glucose disposal. |
2006-09-28 |
2023-08-12 |
mouse |
| Hajime Kanda, Sanshiro Tateya, Yoshikazu Tamori, Ko Kotani, Ken-ichi Hiasa, Riko Kitazawa, Sohei Kitazawa, Hitoshi Miyachi, Sakan Maeda, Kensuke Egashira, Masato Kasug. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. The Journal of clinical investigation. vol 116. issue 6. 2006-08-01. PMID:16691291. |
furthermore, insulin resistance, hepatic steatosis, and macrophage accumulation in adipose tissue induced by a high-fat diet were reduced extensively in mcp-1 homozygous ko mice compared with wt animals. |
2006-08-01 |
2023-08-12 |
mouse |
| Li-Xin Li, Patrick E MacDonald, Diane S Ahn, Gavin Y Oudit, Peter H Backx, Patricia L Brubake. Role of phosphatidylinositol 3-kinasegamma in the beta-cell: interactions with glucagon-like peptide-1. Endocrinology. vol 147. issue 7. 2006-07-24. PMID:16574789. |
in vivo, glucose and insulin responses were similar in pbs- and ex4-treated ko and wild-type (wt) mice. |
2006-07-24 |
2023-08-12 |
mouse |
| Koji Ohashi, Shinji Kihara, Noriyuki Ouchi, Masahiro Kumada, Koichi Fujita, Aki Hiuge, Toshiyuki Hibuse, Miwa Ryo, Hitoshi Nishizawa, Norikazu Maeda, Kazuhisa Maeda, Rei Shibata, Kenneth Walsh, Tohru Funahashi, Iichiro Shimomur. Adiponectin replenishment ameliorates obesity-related hypertension. Hypertension (Dallas, Tex. : 1979). vol 47. issue 6. 2006-06-08. PMID:16651465. |
the direct role of adiponectin on blood pressure regulation under insulin resistance-free state was investigated in adiponectin-knockout (ko) mice. |
2006-06-08 |
2023-08-12 |
mouse |
| Koji Ohashi, Shinji Kihara, Noriyuki Ouchi, Masahiro Kumada, Koichi Fujita, Aki Hiuge, Toshiyuki Hibuse, Miwa Ryo, Hitoshi Nishizawa, Norikazu Maeda, Kazuhisa Maeda, Rei Shibata, Kenneth Walsh, Tohru Funahashi, Iichiro Shimomur. Adiponectin replenishment ameliorates obesity-related hypertension. Hypertension (Dallas, Tex. : 1979). vol 47. issue 6. 2006-06-08. PMID:16651465. |
adiponectin ko mice developed hypertension when maintained on a high-salt diet (8% nacl) without insulin resistance. |
2006-06-08 |
2023-08-12 |
mouse |
| Claude Knauf, Patrice D Cani, Christophe Perrin, Miguel A Iglesias, Jean François Maury, Elodie Bernard, Fadilha Benhamed, Thierry Grémeaux, Daniel J Drucker, C Ronald Kahn, Jean Girard, Jean François Tanti, Nathalie M Delzenne, Catherine Postic, Rémy Burceli. Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage. The Journal of clinical investigation. vol 115. issue 12. 2006-02-06. PMID:16322793. |
this effect did not require muscle insulin action, as it also occurred in muscle insulin receptor ko mice. |
2006-02-06 |
2023-08-12 |
mouse |
| Lauren Jacobson, Karel Pacá. Combined corticotropin-releasing hormone and glucocorticoid deficiency does not enhance counterregulatory responses after recurrent hypoglycemia in mice. Metabolism: clinical and experimental. vol 54. issue 9. 2005-11-01. PMID:16125539. |
lente insulin doses had to be reduced (50-75 u/kg per day) for crh ko mice to survive repeated hypoglycemia. |
2005-11-01 |
2023-08-12 |
mouse |
| Xinran Hu, David Friedman, Salisha Hill, Richard Caprioli, Wendell Nicholson, Alvin C Powers, Lawrence Hunter, Lee E Limbir. Proteomic exploration of pancreatic islets in mice null for the alpha2A adrenergic receptor. Journal of molecular endocrinology. vol 35. issue 1. 2005-10-27. PMID:16087723. |
the present studies extend recent findings that mice null for the alpha(2a) adrenergic receptor (alpha(2a) ar ko mice) lack suppression of exogenous secretagogue-stimulated insulin secretion in response to alpha(2) ar agonists by evaluating the endogenous secretagogue, glucose, ex vivo, and providing in vivo data that baseline insulin levels are elevated and baseline glucose levels are decreased in alpha(2a) ar ko mice. |
2005-10-27 |
2023-08-12 |
mouse |
| Xinran Hu, David Friedman, Salisha Hill, Richard Caprioli, Wendell Nicholson, Alvin C Powers, Lawrence Hunter, Lee E Limbir. Proteomic exploration of pancreatic islets in mice null for the alpha2A adrenergic receptor. Journal of molecular endocrinology. vol 35. issue 1. 2005-10-27. PMID:16087723. |
although agonist stimulation of islets from wild type (wt) mice did not significantly alter islet protein profiles, several proteins were enriched in islets from alpha(2a) ar ko mice when compared with those from wt mice, including an enzyme participating in insulin protein processing. |
2005-10-27 |
2023-08-12 |
mouse |