| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toshiyuki Hibuse, Norikazu Maeda, Tohru Funahashi, Kaori Yamamoto, Azumi Nagasawa, Wataru Mizunoya, Ken Kishida, Kazuo Inoue, Hiroshi Kuriyama, Tadashi Nakamura, Tohru Fushiki, Shinji Kihara, Iichiro Shimomur. Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 31. 2005-09-20. PMID:16009937. |
the ko mice developed obesity and insulin resistance even at a young age after consumption of high-fat/high-sucrose diet. |
2005-09-20 |
2023-08-12 |
mouse |
| N Wierup, W G Richards, A W Bannon, M J Kuhar, B Ahrén, F Sundle. CART knock out mice have impaired insulin secretion and glucose intolerance, altered beta cell morphology and increased body weight. Regulatory peptides. vol 129. issue 1-3. 2005-09-14. PMID:15927717. |
to study the role of cart in islet function, we used cart null mutant mice (cart ko mice) and examined insulin secretion in vivo and in vitro, and expression of islet hormones and markers of beta-cell function using immunocytochemistry. |
2005-09-14 |
2023-08-12 |
mouse |
| N Wierup, W G Richards, A W Bannon, M J Kuhar, B Ahrén, F Sundle. CART knock out mice have impaired insulin secretion and glucose intolerance, altered beta cell morphology and increased body weight. Regulatory peptides. vol 129. issue 1-3. 2005-09-14. PMID:15927717. |
consistent with this, cart ko mice displayed impaired glucose-stimulated insulin secretion both in vivo after an intravenous glucose challenge and in vitro following incubation of isolated islets in the presence of glucose. |
2005-09-14 |
2023-08-12 |
mouse |
| Brian T Noronha, Jian-Mei Li, Stephen B Wheatcroft, Ajay M Shah, Mark T Kearne. Inducible nitric oxide synthase has divergent effects on vascular and metabolic function in obesity. Diabetes. vol 54. issue 4. 2005-06-03. PMID:15793247. |
obese inos ko mice were protected against the development of resistance to insulin's glucoregulatory and vascular effects (insulin-dependent reduction in maximal phenylephrine response: obese wild-type 11.2 +/- 15.0 vs. obese inos ko -20.0 +/- 7.7%; p = 0.02). |
2005-06-03 |
2023-08-12 |
mouse |
| Tania Costoli, Andrea Sgoifo, Donatella Stilli, Gabriele Flugge, Walter Adriani, Giovanni Laviola, Eberhard Fuchs, Thierry Pedrazzini, Ezio Muss. Behavioural, neural and cardiovascular adaptations in mice lacking the NPY Y1 receptor. Neuroscience and biobehavioral reviews. vol 29. issue 1. 2005-04-25. PMID:15652259. |
in a mouse model lacking npy y1 receptor (ko), the ability of npy to potentiate noradrenaline-induced vasoconstriction is abolished during stress but normal in baseline conditions, locomotor activity and metabolic rate are lowered, blood insulin levels and glucose storage activity are increased. |
2005-04-25 |
2023-08-12 |
mouse |
| Maria S Remedi, Joseph C Koster, Kamelia Markova, Susumu Seino, Takashi Miki, Brian L Patton, Michael L McDaniel, Colin G Nichol. Diet-induced glucose intolerance in mice with decreased beta-cell ATP-sensitive K+ channels. Diabetes. vol 53. issue 12. 2005-04-14. PMID:15561946. |
partial suppression of beta-cell k(atp) channels in transgenic (aaa) mice causes hypersecretion of insulin and enhanced glucose tolerance, whereas complete suppression of these channels in kir6.2 knockout (ko) mice leads to hyperexcitability, but mild glucose intolerance. |
2005-04-14 |
2023-08-12 |
mouse |
| Mikael Bjursell, Emil Egecioglu, Anna-Karin Gerdin, Lennart Svensson, Jan Oscarsson, David Morgan, Michael Snaith, Jan Törnell, Mohammad Bohlooly-. Importance of melanin-concentrating hormone receptor for the acute effects of ghrelin. Biochemical and biophysical research communications. vol 326. issue 4. 2005-02-18. PMID:15607734. |
after ghrelin administration, the serum levels of insulin increased only in wt mice whereas the serum levels of corticosterone increased both in wt and mchr ko mice. |
2005-02-18 |
2023-08-12 |
mouse |
| José L Ramírez, M Grant, M Norman, X P Wang, S Moldovan, F J de Mayo, C Brunicardi, U Kuma. Deficiency of somatostatin (SST) receptor type 5 (SSTR5) is associated with sexually dimorphic changes in the expression of SST and SST receptors in brain and pancreas. Molecular and cellular endocrinology. vol 221. issue 1-2. 2005-01-18. PMID:15223137. |
pancreatic sst-li and sst mrna, as well as immunoreactivity for insulin were reduced in male but not in female ko mice. |
2005-01-18 |
2023-08-12 |
mouse |
| Niamh X Cawley, Jiechun Zhou, Joanna M Hill, Daniel Abebe, Sylvie Romboz, Tulin Yanik, Ramona M Rodriguiz, William C Wetsel, Y Peng Lo. The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits. Endocrinology. vol 145. issue 12. 2004-12-23. PMID:15358678. |
the ko mice showed impaired glucose clearance and were insulin resistant. |
2004-12-23 |
2023-08-12 |
mouse |
| Jason K Kim, Jonathan J Fillmore, Mary Jean Sunshine, Bjoern Albrecht, Takamasa Higashimori, Dong-Wook Kim, Zhen-Xiang Liu, Timothy J Soos, Gary W Cline, William R O'Brien, Dan R Littman, Gerald I Shulma. PKC-theta knockout mice are protected from fat-induced insulin resistance. The Journal of clinical investigation. vol 114. issue 6. 2004-12-14. PMID:15372106. |
skeletal muscle and hepatic insulin action as assessed during hyperinsulinemic-euglycemic clamps did not differ between wt and pkc-theta ko mice following saline infusion. |
2004-12-14 |
2023-08-12 |
mouse |
| Rohit N Kulkarni, Ulupi S Jhala, Jonathon N Winnay, Stan Krajewski, Marc Montminy, C Ronald Kah. PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. The Journal of clinical investigation. vol 114. issue 6. 2004-12-14. PMID:15372107. |
here we show that the compensatory islet-growth response to insulin resistance in 2 models--insulin receptor (ir)/ir substrate-1 (irs-1) double heterozygous mice and liver-specific ir ko (lirko) mice--is severely restricted by pdx-1 heterozygosity. |
2004-12-14 |
2023-08-12 |
mouse |
| Naoto Kubota, Yasuo Terauchi, Kazuyuki Tobe, Wataru Yano, Ryo Suzuki, Kohjiro Ueki, Iseki Takamoto, Hidemi Satoh, Toshiyuki Maki, Tetsuya Kubota, Masao Moroi, Miki Okada-Iwabu, Osamu Ezaki, Ryozo Nagai, Yoichi Ueta, Takashi Kadowaki, Tetsuo Nod. Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus. The Journal of clinical investigation. vol 114. issue 7. 2004-11-22. PMID:15467830. |
we previously demonstrated that insulin receptor substrate 2 (irs2) ko mice develop diabetes associated with hepatic insulin resistance, lack of compensatory beta cell hyperplasia, and leptin resistance. |
2004-11-22 |
2023-08-12 |
mouse |
| Josep A Villena, Benoit Viollet, Fabrizzio Andreelli, Axel Kahn, Sophie Vaulont, Hei Sook Su. Induced adiposity and adipocyte hypertrophy in mice lacking the AMP-activated protein kinase-alpha2 subunit. Diabetes. vol 53. issue 9. 2004-10-26. PMID:15331533. |
unlike impaired glucose homeostasis observed on normal diet feeding, when fed a high-fat diet ampkalpha2 ko mice did not show differences in glucose tolerance and insulin sensitivity compared with wild-type mice. |
2004-10-26 |
2023-08-12 |
mouse |
| Takayuki Masaki, Seiichi Chiba, Hitoshi Noguchi, Tohru Yasuda, Kazuyuki Tobe, Ryo Suzuki, Takashi Kadowaki, Hironobu Yoshimats. Obesity in insulin receptor substrate-2-deficient mice: disrupted control of arcuate nucleus neuropeptides. Obesity research. vol 12. issue 5. 2004-10-06. PMID:15166310. |
disturbances in insulin signaling have been shown to induce obesity and/or hyperphagia in brain insulin receptor or insulin receptor substrate-2 (irs-2) knockout (ko) mice. |
2004-10-06 |
2023-08-12 |
mouse |
| Norikazu Maeda, Tohru Funahash. [Adiponectin knockout mice]. Nihon rinsho. Japanese journal of clinical medicine. vol 62. issue 6. 2004-08-10. PMID:15206143. |
adiponectin knockout mice (ko) exhibited severe diet-induced insulin resistance with reduced irs-1-associated p13-kinase activity in muscle. |
2004-08-10 |
2023-08-12 |
mouse |
| Rohit N Kulkarni, Michael G Roper, Gabriella Dahlgren, David Q Shih, Lisa M Kauri, Jennifer L Peters, Markus Stoffel, Robert T Kenned. Islet secretory defect in insulin receptor substrate 1 null mice is linked with reduced calcium signaling and expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2b and -3. Diabetes. vol 53. issue 6. 2004-08-04. PMID:15161756. |
mice with deletion of insulin receptor substrate (irs)-1 (irs-1 knockout [ko] mice) show mild insulin resistance and defective glucose-stimulated insulin secretion and reduced insulin synthesis. |
2004-08-04 |
2023-08-12 |
mouse |
| Rohit N Kulkarni, Michael G Roper, Gabriella Dahlgren, David Q Shih, Lisa M Kauri, Jennifer L Peters, Markus Stoffel, Robert T Kenned. Islet secretory defect in insulin receptor substrate 1 null mice is linked with reduced calcium signaling and expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2b and -3. Diabetes. vol 53. issue 6. 2004-08-04. PMID:15161756. |
these changes were paralleled by a lower number of exocytotic events in the ko beta-cells in response to the same secretagogues, indicating reduced insulin secretion. |
2004-08-04 |
2023-08-12 |
mouse |
| May Faraj, Katherine Cianflon. Differential regulation of fatty acid trapping in mouse adipose tissue and muscle by ASP. American journal of physiology. Endocrinology and metabolism. vol 287. issue 1. 2004-07-22. PMID:15191884. |
in conclusion, novel data in this study suggest that 1) there is little intrinsic difference between ko and wt tissue in the parameters examined and 2) asp differentially regulates in situ lpl activity and nefa trapping in wat and skeletal muscle, which may promote optimal insulin sensitivity in vivo. |
2004-07-22 |
2023-08-12 |
mouse |
| Bo Ahrén, Giovanni Pacini, David Wynick, Nils Wierup, Frank Sundle. Loss-of-function mutation of the galanin gene is associated with perturbed islet function in mice. Endocrinology. vol 145. issue 7. 2004-07-14. PMID:15044363. |
intravenous 2-deoxy-glucose, which activates both the sympathetic and parasympathetic branches of the autonomic nervous system, caused an initial (1-5 min) inhibition of insulin secretion that was impaired in galanin ko mice (p = 0.027), followed by a subsequent stimulation of insulin secretion that was augmented in galanin ko mice (p < 0.01). |
2004-07-14 |
2023-08-12 |
mouse |
| Bo Ahrén, Giovanni Pacini, David Wynick, Nils Wierup, Frank Sundle. Loss-of-function mutation of the galanin gene is associated with perturbed islet function in mice. Endocrinology. vol 145. issue 7. 2004-07-14. PMID:15044363. |
in contrast, galanin ko mice had a reduced insulin response to glucose, both in vivo (p < 0.001) and in isolated islets (p < 0.001), and to arginine, both in vivo (p = 0.012) and in vitro (p = 0.018). |
2004-07-14 |
2023-08-12 |
mouse |