| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mathias Z Strowski, Martin Kohler, Howard Y Chen, Myrna E Trumbauer, Zhihua Li, Deborah Szalkowski, Shobhna Gopal-Truter, Jill K Fisher, James M Schaeffer, Allan D Blake, Bei B Zhang, Hilary A Wilkinso. Somatostatin receptor subtype 5 regulates insulin secretion and glucose homeostasis. Molecular endocrinology (Baltimore, Md.). vol 17. issue 1. 2003-07-17. PMID:12511609. |
sst(5) ko mice exhibited decreased blood glucose and plasma insulin levels and increased leptin and glucagon concentrations compared with wt mice. |
2003-07-17 |
2023-08-12 |
mouse |
| Mathias Z Strowski, Martin Kohler, Howard Y Chen, Myrna E Trumbauer, Zhihua Li, Deborah Szalkowski, Shobhna Gopal-Truter, Jill K Fisher, James M Schaeffer, Allan D Blake, Bei B Zhang, Hilary A Wilkinso. Somatostatin receptor subtype 5 regulates insulin secretion and glucose homeostasis. Molecular endocrinology (Baltimore, Md.). vol 17. issue 1. 2003-07-17. PMID:12511609. |
furthermore, sst(5) ko mice displayed decreased susceptibility to high fat diet-induced insulin resistance. |
2003-07-17 |
2023-08-12 |
mouse |
| Jai Parkash, Muhammad A Chaudhry, Ayman S Amer, Sylvia Christakos, William B Rhote. Intracellular calcium ion response to glucose in beta-cells of calbindin-D28k nullmutant mice and in betaHC13 cells overexpressing calbindin-D28k. Endocrine. vol 18. issue 3. 2003-04-21. PMID:12450313. |
this article describes studies on the glucose-induced responses of intracellular ca2+ concentration ([ca2+]i), insulin release, and redistribution of calbindin-d28k, a calcium-binding regulatory protein, in beta-cells of pancreatic islets of calbindin-d28k knockout (ko) and wild-type mice (c57bl6) as well as in betahc-13 control cells and betahc-13 cabp40 cells (beta-cell line overexpressing calbindin-d28k). |
2003-04-21 |
2023-08-12 |
mouse |
| Yu-Hua Tseng, Kohjiro Ueki, Kristina M Kriauciunas, C Ronald Kah. Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulin. The Journal of biological chemistry. vol 277. issue 35. 2002-10-17. PMID:12082100. |
to define their roles in the anti-apoptotic function of igf-1 and insulin, we established brown pre-adipocyte cell lines from wild-type and irs knockout (ko) animals. |
2002-10-17 |
2023-08-12 |
Not clear |
| Yu-Hua Tseng, Kohjiro Ueki, Kristina M Kriauciunas, C Ronald Kah. Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulin. The Journal of biological chemistry. vol 277. issue 35. 2002-10-17. PMID:12082100. |
at this early time point, igf-1 and insulin were able to protect both wild-type and irs-1 ko cells from death by 85-90%. |
2002-10-17 |
2023-08-12 |
Not clear |
| Yu-Hua Tseng, Kohjiro Ueki, Kristina M Kriauciunas, C Ronald Kah. Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulin. The Journal of biological chemistry. vol 277. issue 35. 2002-10-17. PMID:12082100. |
after a longer period of serum deprivation, the protective ability of insulin and igf-1 was decreased, and this was especially reduced in the irs-1 ko cells. |
2002-10-17 |
2023-08-12 |
Not clear |
| Yu-Hua Tseng, Kohjiro Ueki, Kristina M Kriauciunas, C Ronald Kah. Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulin. The Journal of biological chemistry. vol 277. issue 35. 2002-10-17. PMID:12082100. |
phosphorylation of the transcription factors camp response element-binding protein and fkhr by igf-1 and insulin was markedly reduced in irs-1 ko cells. |
2002-10-17 |
2023-08-12 |
Not clear |
| Suresh T Mathews, Gurmant P Singh, Mollie Ranalletta, Vivian J Cintron, Xiaoling Qiang, Anton Scott Goustin, Kai-Lin Catherine Jen, Maureen J Charron, Willi Jahnen-Dechent, George Grunberge. Improved insulin sensitivity and resistance to weight gain in mice null for the Ahsg gene. Diabetes. vol 51. issue 8. 2002-08-21. PMID:12145157. |
glucose and insulin tolerance tests in fetuin ko mice indicate significantly enhanced glucose clearance and insulin sensitivity. |
2002-08-21 |
2023-08-12 |
mouse |
| Suresh T Mathews, Gurmant P Singh, Mollie Ranalletta, Vivian J Cintron, Xiaoling Qiang, Anton Scott Goustin, Kai-Lin Catherine Jen, Maureen J Charron, Willi Jahnen-Dechent, George Grunberge. Improved insulin sensitivity and resistance to weight gain in mice null for the Ahsg gene. Diabetes. vol 51. issue 8. 2002-08-21. PMID:12145157. |
fetuin ko mice subjected to euglycemic-hyperinsulinemic clamp show augmented sensitivity to insulin, evidenced by increased glucose infusion rate (p = 0.077) and significantly increased skeletal muscle glycogen content (p < 0.05). |
2002-08-21 |
2023-08-12 |
mouse |
| Suresh T Mathews, Gurmant P Singh, Mollie Ranalletta, Vivian J Cintron, Xiaoling Qiang, Anton Scott Goustin, Kai-Lin Catherine Jen, Maureen J Charron, Willi Jahnen-Dechent, George Grunberge. Improved insulin sensitivity and resistance to weight gain in mice null for the Ahsg gene. Diabetes. vol 51. issue 8. 2002-08-21. PMID:12145157. |
when fed a high-fat diet, fetuin ko mice are resistant to weight gain, demonstrate significantly decreased body fat, and remain insulin sensitive. |
2002-08-21 |
2023-08-12 |
mouse |
| Norikazu Maeda, Iichiro Shimomura, Ken Kishida, Hitoshi Nishizawa, Morihiro Matsuda, Hiroyuki Nagaretani, Naoki Furuyama, Hidehiko Kondo, Masahiko Takahashi, Yukio Arita, Ryutaro Komuro, Noriyuki Ouchi, Shinji Kihara, Yoshihiro Tochino, Keiichi Okutomi, Masato Horie, Satoshi Takeda, Toshifumi Aoyama, Tohru Funahashi, Yuji Matsuzaw. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nature medicine. vol 8. issue 7. 2002-08-05. PMID:12068289. |
the ko mice exhibited severe diet-induced insulin resistance with reduced insulin-receptor substrate 1 (irs-1)-associated phosphatidylinositol 3 kinase (pi3-kinase) activity in muscle. |
2002-08-05 |
2023-08-12 |
mouse |
| Norikazu Maeda, Iichiro Shimomura, Ken Kishida, Hitoshi Nishizawa, Morihiro Matsuda, Hiroyuki Nagaretani, Naoki Furuyama, Hidehiko Kondo, Masahiko Takahashi, Yukio Arita, Ryutaro Komuro, Noriyuki Ouchi, Shinji Kihara, Yoshihiro Tochino, Keiichi Okutomi, Masato Horie, Satoshi Takeda, Toshifumi Aoyama, Tohru Funahashi, Yuji Matsuzaw. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nature medicine. vol 8. issue 7. 2002-08-05. PMID:12068289. |
viral mediated adiponectin/acrp30 expression in ko mice reversed the reduction of fatp-1 mrna, the increase of adipose tnf-alpha mrna and the diet-induced insulin resistance. |
2002-08-05 |
2023-08-12 |
mouse |
| Norikazu Maeda, Iichiro Shimomura, Ken Kishida, Hitoshi Nishizawa, Morihiro Matsuda, Hiroyuki Nagaretani, Naoki Furuyama, Hidehiko Kondo, Masahiko Takahashi, Yukio Arita, Ryutaro Komuro, Noriyuki Ouchi, Shinji Kihara, Yoshihiro Tochino, Keiichi Okutomi, Masato Horie, Satoshi Takeda, Toshifumi Aoyama, Tohru Funahashi, Yuji Matsuzaw. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nature medicine. vol 8. issue 7. 2002-08-05. PMID:12068289. |
our results indicate that adiponectin/acrp30 deficiency and high tnf-alpha levels in ko mice reduced muscle fatp-1 mrna and irs-1-mediated insulin signaling, resulting in severe diet-induced insulin resistance. |
2002-08-05 |
2023-08-12 |
mouse |
| Michael Norman, Stefan Moldovan, Victor Seghers, Xiao-Ping Wang, Francesco J DeMayo, F Charles Brunicard. Sulfonylurea receptor knockout causes glucose intolerance in mice that is not alleviated by concomitant somatostatin subtype receptor 5 knockout. Annals of surgery. vol 235. issue 6. 2002-06-19. PMID:12035032. |
to examine the long-term effects of sur ko, sstr5 ko, and double sur/sstr5 ko on insulin secretion and glucose regulation. |
2002-06-19 |
2023-08-12 |
mouse |
| W G Aschenbach, Y Suzuki, K Breeden, C Prats, M F Hirshman, S D Dufresne, K Sakamoto, P G Vilardo, M Steele, J H Kim, S L Jing, L J Goodyear, A A DePaoli-Roac. The muscle-specific protein phosphatase PP1G/R(GL)(G(M))is essential for activation of glycogen synthase by exercise. The Journal of biological chemistry. vol 276. issue 43. 2001-12-07. PMID:11522787. |
21, 2683-2694) that insulin activates gs in muscle of r(gl)(g(m)) knockout (ko) mice similarly to the wild type (wt). |
2001-12-07 |
2023-08-12 |
mouse |
| W G Aschenbach, Y Suzuki, K Breeden, C Prats, M F Hirshman, S D Dufresne, K Sakamoto, P G Vilardo, M Steele, J H Kim, S L Jing, L J Goodyear, A A DePaoli-Roac. The muscle-specific protein phosphatase PP1G/R(GL)(G(M))is essential for activation of glycogen synthase by exercise. The Journal of biological chemistry. vol 276. issue 43. 2001-12-07. PMID:11522787. |
these results indicate that although pp1g/r(gl) is not necessary for activation of gs by insulin, it is essential for regulation of glycogen metabolism under basal conditions and in response to contractile activity, and may explain the reduced muscle glycogen content in the r(gl) ko mice, despite the normal insulin activation of gs. |
2001-12-07 |
2023-08-12 |
mouse |
| J K Kim, A Zisman, J J Fillmore, O D Peroni, K Kotani, P Perret, H Zong, J Dong, C R Kahn, B B Kahn, G I Shulma. Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4. The Journal of clinical investigation. vol 108. issue 1. 2001-08-09. PMID:11435467. |
surprisingly, insulin's ability to stimulate adipose tissue glucose uptake and suppress hepatic glucose production was significantly impaired in muscle glut4 ko mice. |
2001-08-09 |
2023-08-12 |
mouse |
| S D Dufresne, C Bjørbaek, K El-Haschimi, Y Zhao, W G Aschenbach, D E Moller, L J Goodyea. Altered extracellular signal-regulated kinase signaling and glycogen metabolism in skeletal muscle from p90 ribosomal S6 kinase 2 knockout mice. Molecular and cellular biology. vol 21. issue 1. 2001-01-18. PMID:11113183. |
while insulin and exercise significantly increased erk phosphorylation in skeletal muscle from both wt and ko mice, the increases were twofold greater in the ko animals. |
2001-01-18 |
2023-08-12 |
mouse |
| S D Dufresne, C Bjørbaek, K El-Haschimi, Y Zhao, W G Aschenbach, D E Moller, L J Goodyea. Altered extracellular signal-regulated kinase signaling and glycogen metabolism in skeletal muscle from p90 ribosomal S6 kinase 2 knockout mice. Molecular and cellular biology. vol 21. issue 1. 2001-01-18. PMID:11113183. |
ko mice had 18% less muscle glycogen in the fasted basal state, and insulin increased glycogen synthase activity more in ko than wt mice. |
2001-01-18 |
2023-08-12 |
mouse |
| S D Dufresne, C Bjørbaek, K El-Haschimi, Y Zhao, W G Aschenbach, D E Moller, L J Goodyea. Altered extracellular signal-regulated kinase signaling and glycogen metabolism in skeletal muscle from p90 ribosomal S6 kinase 2 knockout mice. Molecular and cellular biology. vol 21. issue 1. 2001-01-18. PMID:11113183. |
c-fos mrna was increased similarly in muscle from wt and ko mice in response to insulin (2. |
2001-01-18 |
2023-08-12 |
mouse |